• Reproductive and Developmental Biology
• /
• 제33권4호
• /
• pp.229-236
• /
• 2009

The glycoprotein hormone family represents a class of heterodimers, that includes the placental hormone equine chorionic gonadotropin (eCG) and the anterior pituitary hormones- follitropin (FSH), lutropin (LH), and thyrotropin (TSH). The 4 hormones are heterodimers, with a common $\alpha$-subunit and unique $\beta$-subunits. eCG is the most heavily glycosylated of the known pituitary and placental glycoprotein hormones. Recent observations using single chain glycoprotein hormone analogs in which, the $\beta$-and $\alpha$-subunits are linked, implied that heterodimeric-like quaternary configuration is not a prerequisite for receptor/signal transduction. To study the function and signal transduction of tethered rec-eCG, a single chain eCG molecule was constructed and rec-eCG protein was produced. Molecular mass of the single chain is about 45 kDa. All mice were ovulated by tethered rec-eCG treatment. The dual activity of tethered rec-eCG was determined in receptor cell lines of nonequid species; in fact, this dual activity was proven in species other than horse. Tethered rec-eCG in equids does not bind to FSH receptors, suggesting that eCG is primarily an LH-like hormone in the horse. Taken together, these data suggest that tethered rec-eCG has dual activity in nonequid species in vitro. However, it has only LH-like activity in equid species in vitro.

• 대한건축학회논문집:계획계
• /
• 제36권5호
• /
• pp.83-91
• /
• 2020

Environmental conditions are known to impact human health and behavior, emotions such as pleasure, anxiety, and depression, and reduce stress. Interior design that elevates emotional comfort and satisfaction can help improve mental health and well-being. This study is a systematic review that analyzed previous empirical studies that explored the effect of interior design elements on the user's emotional response which is quantitatively evaluated by bio-signal and qualitatively evaluated through self-reported questionnaire surveys. This paper aims to derive the attributes of interior design and biometric indicators that affect the user's positive emotion through the synthesis of previous studies and to confirm the feasibility of measuring bio-signals as an objective evaluation tool for architectural design and as a quantitative research method. As a result of the review, the biometric data from EEG, fMRI, ECG, EMG, GSR, and eye-tracking were used to measure the participants' emotional responses, which were manifested as positive or negative depending on certain attributes of interior design such as the form, color, lighting, material and furniture. The attributes of interior design related to the positive emotional response were the curved shape, high ceiling, openness of space, and subdued tone colors. Standard lighting conditions and wooden spaces were related to stress reduction in terms of comfort and relaxation. The free arrangement of furniture was related to the user's positive emotions. On the other hand, consistent experimental protocols could not be found, and although the sample sizes of the studies were small, the studies have demonstrated the feasibility of the emotional response measurement by using the biometric data. Therefore this method can be a useful objective tool in the measurement of human-centric data in architectural design, and to develop the evidence-based design to induce positive emotions and minimize stress.

• 한국정보통신학회논문지
• /
• 제26권6호
• /
• pp.859-864
• /
• 2022

매년 교통사고의 가장 큰 원인으로 손꼽히는 졸음운전은 운전자의 수면 부족, 산소 부족, 긴장감의 저하, 신체의 피로 등과 같은 다양한 요인을 동반한다. 졸음 유무를 확인하는 일반적인 방법으로 운전자의 표정과 주행패턴을 파악하는 방법, 심전도, 산소포화도, 뇌파와 같은 생체신호를 분석하는 방법들이 연구되고 있다. 본 논문은 영상을 검출하는 딥러닝 모델과 생체 신호 측정 기술을 이용한 운전자 피로 감지 시스템을 제안한다. 제안 방법은 일차적으로 딥러닝을 이용하여 운전자의 눈 모양과 하품 유무, 졸음으로 예상되는 신체 동작을 파악하여 졸음 상태를 감지한다. 이차적으로 맥파 신호와 체온을 이용하여 운전자의 피로 상태를 파악하여 시스템의 정확도를 높이도록 설계하였다. 실험 결과, 실시간 영상에서 운전자의 졸음 유무 판별이 안정적으로 가능하였으며 각성상태와 졸음 상태에서의 분당 심박수와 체온을 비교하여 본 연구의 타당성을 확인할 수 있었다.

• Interdisciplinary Bio Central
• /
• 제3권1호
• /
• pp.5.1-5.5
• /
• 2011

Introduction: Many signal transduction pathways mediate cell's behavior by regulating expression level of involved genes. Abnormal behavior indicates loss of regulatory potential of pathways, and this can be attributed to loss of expression regulation of downstream genes. Therefore, function of pathways should be assessed by activity of a pathway itself and relative activity between a pathway and downstream genes, simultaneously. Results and Discussion: In this study, we suggested a new method to assess pathway's function by introducing concept of 'responsiveness'. The responsiveness was defined as a relative activity between a pathway itself and its downstream genes. The expression level of a downstream gene as a function of an upstream pathway activation characterizes disease status. In this aspect, by using the responsiveness we predicted potential progress in cancer development. We applied our method to predict primary and metastatic status of melanoma cancer. The result shows that the responsiveness-based approach achieves better performance than using gene or pathway information alone. The mean of ROC scores in the responsiveness-based approach was 0.90 for GSE7553 data set, increased more than 40% compared to a gene-based method. Moreover, identifying the abnormal regulatory patterns between pathway and its downstream genes provided more biologically interpretable information compared to gene or pathway based approaches.

• 한국농업기계학회:학술대회논문집
• /
• 한국농업기계학회 2000년도 THE THIRD INTERNATIONAL CONFERENCE ON AGRICULTURAL MACHINERY ENGINEERING. V.II
• /
• pp.300-306
• /
• 2000

This paper introduces a new concept of automation for bio-production with tele-operative system. The proposed system showed practical and feasible way of automation for the volatile bio-production process. Based on the proposition, recognition of the job environment with object identification was performed using computer vision system. A man-machine interactive hybrid decision-making, which utilized a concept of tele-operation was proposed to overcome limitations of the capability of computer in image processing and feature extraction from the complex environment image. Identifying watermelons from the outdoor scene of the cultivation field was selected to realize the proposed concept. Identifying watermelon from the camera image of the outdoor cultivation field is very difficult because of the ambiguity among stems, leaves, shades, and especially fruits covered partly by leaves or stems. The analog signal of the outdoor image was captured and transmitted wireless to the host computer by R.F module. The localized window was formed from the outdoor image by pointing to the touch screen. And then a sequence of algorithms to identify the location and size of the watermelon was performed with the local window image. The effect of the light reflectance of fruits, stems, ground, and leaves were also investigated.

• 한국정밀공학회:학술대회논문집
• /
• 한국정밀공학회 2005년도 춘계학술대회 논문집
• /
• pp.1944-1947
• /
• 2005

In this paper, the control of a prosthetic arm using the flex sensor signal is described. The flex sensors are attached to the biceps and triceps brchii muscle. The signals are passed a differential amplifier and noise filter. And then the signals are converted to digital data by PCI 6036E ADC. From the data, position and velocity of arm joint are obtained. Also motion of the forearm - flexion and extension, the pronation and supination are abstracted from the data by proposed algorithm. A two D.O.F arm with RC servo-motor is designed for experiment. The arm length is 200 mm, weight is 4.5 N. The rotation angle of elbow joint is $120^{\circ}$. Also the rotation angle of the wrist is $180^{\circ}$. Through the experiment, we verified the possibility of the prosthetic arm control using the flex sensor signal. We will try to improve the control accuracy of the prosthetic arm continuously.

• 한국멀티미디어학회논문지
• /
• 제21권12호
• /
• pp.1370-1378
• /
• 2018

There is a problem to measure neutral bio-signals during sleep because of inconvenience of attaching lots of sensors. In this study, we measured single electrocardiogram(ECG) signal and analyzed the correlation with sleep. After R-peak detection from ECG signal, we extracted 9 features from time and frequency domain of heart rate variability(HRV). Mean of HRV, RR intervals differing more than 50ms(NN50), and divided by the total number of all RR intervals(pNN50) have significant differences in each sleep stage. Specially, the mean HRV has an average of 87.8% accuracy in classifying sleep and awake status. In the future, the measurement ECG signal minimizes inconvenience of attaching sensors during sleep. Also, it can be substituted for the standard sleep measurement method.

• 한국소음진동공학회논문집
• /
• 제22권11호
• /
• pp.1137-1143
• /
• 2012

This paper presents the correlation between psychological and physiological acoustics for the automotive sound. The research purpose of this paper is to evaluate the sound quality of turn-signal sound of a passenger car based EEG signal. The previous method for the objective evaluation of sound quality is to use sound metrics based on psychological acoustics. This method uses not only psychological acoustics but also physiological acoustics. For this work, the sounds of 7 premium passenger cars are recorded and evaluated subjectively by 30 persons. The correlation between this subjective rating and sound metrics is calculated based on psychological acoustics. Finally the correlation between the subjective rating and the EEG signal measured on the brain is also calculated. Throughout these results the new evaluation system for the sound quality on interior sound of a passenger car has been developed based on bio-signal.

• Plant Biotechnology Reports
• /
• 제3권2호
• /
• pp.147-155
• /
• 2009

Oryza grandiglumis Chitinase IVa (OgChitIVa) cDNA encoding a class IV chitinase was cloned from wild rice (Oryza grandiglumis). OgChitIVa cDNA contains an open reading frame of 867 nucleotides encoding 288 amino acid residues with a predicted molecular weight of 30.4 kDa and isoelectric point of 8.48. Deduced amino acid sequences of OgChitIVa include the signal peptide and chitin-binding domain in the N-terminal domain and conserved catalytic domain. OgChitIVa showed significant similarity at the amino acid level with related monocotyledonous rice and maize chitinase, but low similarity with dicotyledoneous chitinase. Southern blot analysis showed that OgChitIVa genes are present as two copies in the wild rice genome. It was shown that RNA expression of OgChitIVa was induced by defense/stress signaling chemicals, such as jasmonic acid, salicylic acid, and ethephon or cantharidin and endothall or wounding, and yeast extract. It was demonstrated that overexpression of OgChitIVa in Arabidopsis resulted in mild resistance against the fungal pathogen, Botrytis cinerea, by lowering disease rate and necrosis size. RT-PCR analysis showed that PR-1 and PR-2 RNA expression was induced in the transgenic lines. Here, we suggest that a novel OgChitIVa gene may play a role in signal transduction process in defense response against B. cinerea in plants.

• 정보처리학회논문지:소프트웨어 및 데이터공학
• /
• 제7권2호
• /
• pp.43-50
• /
• 2018

생체정보 컴퓨팅은 생체신호 센서와 컴퓨터 정보처리를 융합한 정보시스템에 기초하여 컴퓨팅시스템 뿐만 아니라 빅데이터 시스템에 크게 영향을 미치고 있다. 이러한 생체정보는 지금까지의 텍스트, 이미지, 동영상 등의 전통적인 데이터 형식과는 달리 생체신호의 의미를 부여하는 값은 텍스트 기반으로 표현되고, 중요한 이벤트 순간은 이미지 형식으로 저장하며, 시계열 분석을 통한 데이터 변화 예측 및 분석을 위해서는 동영상 형식 등 비정형데이터를 포함하는 복합적인 데이터 형식을 구성한다. 이러한 복합적인 데이터 구성은 개별 생체정보 응용서비스에서 요구하는 데이터의 특징에 따라 텍스트, 이미지, 영상 형식 등으로 각각 분리되어 요청되거나, 상황에 따라 복잡 데이터 형식을 동시에 요구할 수 있다. 기존 생체정보 컴퓨팅 시스템들은 전통적인 컴퓨팅 구성요소, 컴퓨팅 구조, 데이터 처리 방법 등에 의존하므로 데이터 처리성능, 전송능력, 저장효율성, 시스템안전성 등의 측면에서 많은 비효율성을 내포하고 있다. 본 연구에서는 생체정보 처리 컴퓨팅을 효과적으로 지원하는 생체정보 빅데이터 플랫폼을 구축하기 위해 개선된 바이오센싱 융합 빅데이터 컴퓨팅 아키텍처를 제안한다. 제안 아키텍처는 생체신호관련 데이터의 저장 및 전송 효율성, 컴퓨팅 성능, 시스템 안정성 등을 효과적으로 지원하며, 향후 생체정보 컴퓨팅에 최적화된 시스템 구현 및 생체정보 서비스 구축을 위한 기반을 제공할 수 있다.