• Journal of Life Science
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• v.23 no.5
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• pp.622-628
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• 2013

Diallyl trisulfide (DATS), one of the major organosulfur components of garlic (Allium sativum), has various biological effects such as anti-microbial and anti-cancer activities. However, the molecular mechanisms of growth inhibition related to cell cycle arrest are poorly understood. In this study, we investigated the effects of DATS on cell cycle progression in U937 human leukemia cells. Treatment with DATS in U937 cells resulted in inhibition of cell viability through G2/M arrest and apoptosis. DATS-induced G2/M arrest was associated with up-regulation of cyclin B1 and cyclin-dependent kinase 1 (CDK1). DATS also significantly increased levels of phospho-histone H3, which is a mitosis-specific marker, indicating that DATS induced mitotic arrest but not G2 arrest in U937 cells. DATS treatment also generated the reactive oxygen species (ROS) in U937 cells; however, pretreatment with N-acetyl-l-cysteine (NAC), a ROS scavenger, significantly attenuated DATS-induced mitotic arrest and apoptosis. Taken together, our data indicate that DATS exhibits anti-cancer effects through mitotic arrest and apoptosis in a ROS-dependent manner.

• Journal of Wetlands Research
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• v.16 no.2
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• pp.251-259
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• 2014

Recently, wetland and paddy wetland are being highlighted as the international environmental issues. However, research system which can assess paddy wetland is lacking. Thus, the purpose of this study is to assess the value of paddy wetland by applying RAM to paddy wetland. In addition, we would like to use this study as the data to establish assessment method for paddy wetland. 16 sites were selected as research targets based on altitude and soil. As the results of wetland assessment, 16 research target sites had total score of 212~227 and the average of 2.17~2.50. It was similar to those of Lacustrine Wetlands, Palustrine Wetland and Riverine Wetland which were sites in previous studies. The value could be recognized as the wetland. However, there was no difference in assessment results based on altitude and soil. It was found that all conservation values were the same. The factor the most closely affecting conservation value was the area. However, there was limitation to apply existing wetland assessment system to paddy wetland. In order to assess paddy wetland, factors such as rice farming methods, topography, vegetation, growth environment and biodiversity should be added. It was thought to supplement wetland assessment system through various further studies.

• Journal of Wetlands Research
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• v.22 no.4
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• pp.286-294
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• 2020

This study aims to economically evaluate rice production and various ecological services provided by organic rice paddy carrying out rice-fish mixed farming. It was also conducted to find a stable structure for increasing the income of rice-producing farmers and promoting ecological services by evaluating the economic feasibility of organic rice paddy for rice-fish mixed farming. As a result of the analysis of expected effects by ecological service functions according to the types of agriculture in the rice-fish mixed farming, general conventional paddy fields were evaluated to have an effect of continuously decreasing biodiversity such as amphibian reptiles, aquatic insects, bird habitats, experience and ecological education, and vegetation diversity, while the biodiversity of organic and rice-fish mixed paddy fields was assessed to increase. As a result of evaluating the economic value, as the area for fish production increases compared to the common practice and organic paddy fields, rice production decreases, but fish production increases and total income was analyzed to increase. In addition, if the value of ecosystem service functions is assessed in the future, it will increase further. It is hoped that these findings will be used as basic data for solving oversupply problems in the rice industry, preserving safe farm income, and improving sustainable farming and ecosystem service functions.

• Journal of Periodontal and Implant Science
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• v.36 no.1
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• pp.147-154
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• 2006

Surgical intervention in the posterior maxillary region requires detailed knowledge of maxillary sinus anatomy and the possible anatomical variations. This study evaluated the incidence, location of maxillary sinus septa by using radiographic (panoramic radiography and computed tomography) findings and comparison of panoramic radography with CT in antral anatomical variation. This study was based on data from 70 sinuses in partial dentate maxilla. The sample consisted of 61 patients(25 women and 36 men, with ages ranging between 19 and 77 years and a mean age of $49.4{\pm}11.3$ years) who were being treatment-planned to receive implant-supported restorations. First, the panoramic images were examined for the presence of antral septa by radiologist and examiner who don't know about CT findings. And incidence of antral septa was evaluated using an axial plane of CT image. The incidence of septa was compared between panoramic radiography and CT. The accuracy of the incidence was compared between radiologists and dentists. A total of 20 septa were found in 70 sinuses on CT image and the prevalence of one or more septa per sinus was found to be 28.6%. The assumed incidence of septa on panoramic radiography was $27.6%{\pm}2.2%$ in radiologist and $31.9%{\pm}5.8%$ in dentists. Erroneous diagnosis rate was 11.42% in radiologist and 15.96% in dentists. 40% of antral septa were located in the anterior(premolar) region, 30% of septa were located in the middle(first molar) and posterior(second molar) region separately. Prior to implant placement, it seems appropriate to consider panoramic radiography as a standard radiographic examination and periapical radiographs may be used to complete the findings in regions not sharply depicted in the panoramic radiograph. And cross-sectional imaging should be used in sites with severe bone loss and close proximity of the maxillary sinus.

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.1
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• pp.86-92
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• 2014

Cordycepin is the major functional component of Cordyceps species and is widely used in traditional oriental medicine. Cordycepin has been shown to possess many pharmacological properties, such as enhancement of immune function along with anti-inflammatory, antioxidant, anti-aging, and anti-cancer effects. Here, we investigated the inhibitory effects of cordycepin on cell migration and invasion, which are two critical cellular processes that are often deregulated during metastasis, using HCT116 human colorectal carcinoma cells. According to our data, cordycepin at non-cytotoxic concentrations markedly inhibited the motility and invasiveness of HCT116 cells in a time-dependent manner. RT-PCR and Western blotting results indicated that cordycepin reduced the levels of claudin proteins, which are major components of tight junctions (TJs), and induced tightening of TJs. Cordycepin also attenuated the expression and activities of matrix metalloproteinases (MMPs)-2 and -9, whereas levels of tissue inhibitor of metalloproteinases (TIMPs)-1 and -2 were simultaneously elevated. These findings suggest that cordycepin reduces the migration and invasion of HCT116 cells by modulating the activities of TJs and MMPs.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2017.05a
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• pp.708-711
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• 2017

The purpose of this study was to examine the perception of abortion and suicide for 115 paramedic students in 2016. The questionnaire consisted of perception of abortion(8items), the perception of suicide(58items), related 6items of the abortion and related 2 items of the suicide. The collected data were analyzed through t-test, Chi-squared test and ANOVA, using SPSS 21.0. As a result, the total perception score against abortion was $20.57{\pm}4.12$ and the total score of suicide perception was $-14.16{\pm}15.76$. The most answer was that pregnant women were abortion decision makers in both male and female students, and abortions were the highest when they might be unwanted pregnancies. The group who had thought about suicide was higher of perceptions of suicide than the group who did not. The female students who had suicide attempt or suicide experience of close acquaintances showed higher suicide perception score than those who did not. Therefore, A bio-ethics education curriculum should be prepared to establish ethics that respects life for future paramedic students who must make decisions at the boundary between death and life. It is necessary to raise the level of positive suicide perceptions through continuing counseling and education focusing on students who have experienced suicide by family members or acquaintances.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.6 no.1
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• pp.133-158
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• 2011

In 2030s, as we enter in to the era of BT (Bio-Technology) market opening up, technologies in all areas such as IT, data analysis, IC and biochemistry are necessitated. New development in technology will be based on "Convergence", especially between IT and BT. In order to have synergy effects from the convergence, those related industries and universities should be physically inter-related in an appropriate location. Until 2009, 819 industrial clusters where many Korean industries and firms are concentrated have been constructed in Korea. They have had supports from various institutions and facilities. However, few systems designed to assist "intellectual property (IP) service" for technology convergence are found in Korea. Thus, by analyzing current problems and challenges of the Korean industrial clusters, this paper suggests a possible answer to maximize the synergy from technology convergence through organic cooperation among companies in industrial clusters. This paper finds that the Korean industrial clusters need to establish IP service supporting center while suggesting its function and concept on organization structure, and work flow, which help firms to develop IP strategies. In addition, the paper provides a direction for current IP system and policies implemented by the Korean government to be more effective to small-and-medium-sized companies located in the industrial clusters.

• Journal of rehabilitation welfare engineering & assistive technology
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• v.7 no.1
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• pp.51-58
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• 2013

As it is changing into aging society, rehabilitation, welfare and sports industry markets are being expanded fast. Especially, the field of vital signals interface to control welfare instruments like wheelchair, rehabilitation ones like an artificial arm and leg and general electronic ones is a new technology field in the future. Also, this technology can help not only the handicapped, the old and the weak and the rehabilitation patients but also the general public in various application field. The commercial bio-signal measurement instruments and interface systems are complicated, expensive and large-scaled. So, there are a lot of limitations for using in real life with ease. this thesis proposes a wireless transmission interface system that uses EMG(electromyogram) signals and a control module to manipulate hardware systems with portable size. We have designed a hardware module that receives the EMG signals occurring at the time of wrist movement and eliminated noises with filter and amplified the signals effectively. DSP(Digital Signal Processor) chip of TMS320F2808 which was supplied from TI company was used for converting into digital signals from measured EMG signals and digital filtering. We also have used PCA(Principal Component Analysis) technique and classified into four motions which have right, left, up and down direction. This data was transmitted by wireless module in order to display at PC monitor. As a result, the developed system obtains recognition success ratio above 85% for four different motions. If the recognition ratio will be increased with more experiments. this implemented system using EMG wrist direction signals could be used to control various hardware systems.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.44 no.2
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• pp.111-116
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• 2018

In cosmetics market, anti-pollution products recently come up with new solution for skin health. Environmental oxidation mechanisms are realized as bio-marker of atmospheric pollution upon skin by environmental pollutant such as ozone, UV rays, particulate matter (PM) as well as cigarette smoke. The exposure of cigarette smoke directly or indirectly causes the oxidation of the stratum corneum skin lipids, resulting in the conversion of squalene to squalene monohydroperoxide and/or generation of malondialdehyde (MDA) as a product of lipid peroxidation. The aim of this study is to see whether new cosmetics product containing red beet has anti-oxidation effect on skin exposed by cigarette smoke. So as to determine oxidative damage to human skin at biochemical level, each unit area of volar forearms was exposed to cigarette smoke through device (3.3 cm, diameter) for fifteen minutes, then measured MDA using standardized TBARS assay kit. Compared to negative control (untreated and unexposed area), the level of MDA was significantly increased at positive control (untreated and exposed area) more than 3.7 times, indicating the pollutant induced-oxidative damage on the skin barrier. Whereas, the pre-applied area with the cosmetics products containing red beet revealed a decrease of 25% compared with positive control. As reports, these data demonstrated that cigarette smoke induce peroxidation of stratum corneum skin lipids. Conclusively, we suggest that anti-pollution effect of the cosmetics product containing red beet is beneficial to prevent the oxidation of skin lipids by atmospheric pollution.

• Food Science and Preservation
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• v.20 no.1
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• pp.104-110
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• 2013

Dried leaves of Raphanus sativus L. and Angelica keiskei L. extracts have strong antioxidant potential and in consequence profound effects on ulcerative colitis. Present study was conducted to explore the effect of diet mixtures containing dried leaves of Raphanus sativus and Angelica keiskei powder on ulcerative colitis in mice and antioxidant potential of radish green and Angelica extracts as well. Both dried leaves of Raphanus sativus and Angelica keiskei extracts exhibited higher antioxidant activity due to the presence of polyphenols, favonoids and antioxidant enzymes like superoxide dismutase (SOD). Analyzed data indicate that Angelica keiskei extract had higher polyphenol and flavonoid contents compared with radish green, while maximum SOD activity was noted in dried leaves of Raphanus sativus extract Likewise, higher antioxidant ($348.72{\pm}31.65{\mu}g/mL$) and $ABTS^+$ radical scavenging (17%) activities were noted in dried leaves of Raphanus sativus extract compared with Angelica keiskei.