• 한국건축시공학회지
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• 제18권6호
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• pp.533-541
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• 2018

콘크리트의 주요 열화 현상 중 하나인 염해는 철근의 부식을 야기하며 이로 인해 철근콘크리트 구조물에 사용성 및 구조성에 문제가 발생한다. 콘크리트 구조물의 유지관리를 위해 표면 함침제를 콘크리트에 적용시키는 방법은 시공성 및 경제성이 우수하다고 알려져 있다. 본 연구에서는 두 가지 종류의 실리케이트 용액을 사용하여 콘크리트의 표면의 공학적 특성을 개선시킨 후 압축강도와 염화물 확산저항성을 평가하였다. 또한, 기존의 연구와 본 실험결과를 기준으로 대상단면의 내구수명 해석을 실시하였다. 실리케이트 함침 후 콘크리트의 강도 및 염화물 확산 저항성은 크게 증가하였으며 내구수명은 실리케이트 A에서는 159%, 실리케이트 B에서는 304%로 크게 평가되었다.

• 산업경영시스템학회지
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• 제42권2호
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• pp.69-77
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• 2019

As information technology advances, the penetration of smart devices connected to the Internet, such as smart phone and tablet PC, has rapidly expanded, and as sensor prices have fallen the Internet of Things has begun to be introduced in the industry. Today's industry is rapidly changing and evolving, requiring companies to respond to the new paradigm of business. In this situation, companies need to actively manage and maintain customer relationships in order to acquire loyal customers who bring them a high return. The purpose of this study is to suggest a method to manage customer relationship using real time IoT data including IoT product usage data, customer characteristics and transaction data. This study proposes a method of segmenting customers through RFM analysis and transition index analysis. In addition, a real-time monitoring through control charts is used to identify abnormalities in product use and suggest ways of differentiating marketing for each group. In the study, 44 samples were classified as 9 churn customers, 10 potential customers, and 25 active customers. This study suggested ways to induce active customers by providing after-sales benefit for product reuse to a group of churn customers and to promote the advantages or necessity of using the product by setting the goal of increasing the frequency of use to a group of potential customers. Finally, since the active customer group is a loyal customer, this study proposed an one-on-one marketing to improve product satisfaction.

• 디지털융복합연구
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• 제17권9호
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• pp.89-95
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• 2019

본 연구의 목적은 소점포를 기반으로 중고서적 거래가 가능한 공유플랫폼 서비스를 제시하고자함에 있다. 도서정가제 실시 이후 중고서적 시장의 규모는 두 배 이상 증가하였고 이에 대형 서점들도 중고 책 시장에 적극 동참하고 있는 실정이다. 중고서적 공유플랫폼은 온라인 중고 책 직거래 개념을 발전시킨 형태로 사용자의 휴대전화에 애플리케이션을 설치함으로써 쉽게 이용 가능하다. 중고서적 공유플랫폼 서비스는 거대한 영리기업을 탄생시키는 공유플랫폼이 아닌, 플랫폼 이용자 모두에게 수익이 돌아갈 수 있는 미래지향적인 공유플랫폼이다. 4차 산업혁명의 중심인 공유플랫폼을 거의 모든 소규모 점포에 적용하여 중고서적 거래의 거점으로 활용한다면, 보다 합리적인 중고서적 거래의 장(場)으로 자리매김하게 될 것이라 판단된다.

• Journal of Korean Neurosurgical Society
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• 제62권1호
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• pp.83-89
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• 2019

Objective : This study is a retrospective cost-benefit analysis of cervical anterior interbody fusion and cervical artificial disc replacement, which are the main surgical methods to treat degenerative cervical disc disease. Methods : We analyzed 156 patients who underwent anterior cervical disc fusion and cervical artificial disc replacement from January 1, 2008 to December 31, 2009, diagnosed with degenerative cervical disc disorder. In this study, the costs and benefits were analyzed by using quality adjusted life year (QALY) as the outcome index for patients undergoing surgery, and a Markov model was used for the analysis. Only direct medical costs were included in the analysis; indirect medical costs were excluded. Data were analyzed with TreeAge Pro $2015^{TM}$ (TreeAge Software, Inc, Williamstown, MA, USA). Results : Patients who underwent cervical anterior fusion had a total cost of KRW 2501807/USD 2357 over 5 years and obtained a utility of 3.72 QALY. Patients who underwent cervical artificial disc replacement received 4.18 QALY for a total of KRW 3685949/USD 3473 over 5 years. The cumulative cost-effectiveness ratio of cervical spine replacement surgery was KRW 2549511/QALY (USD 2402/QALY), which was lower than the general Korean payment standard. Conclusion : Both cervical anterior fusion and cervical artificial disc replacement are cost-effective treatments for patients with degenerative cervical disc disease. Cervical artificial disc replacement may be an effective alternative to obtain more benefits.

• Journal of Gynecologic Oncology
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• 제29권6호
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• pp.93.1-93.11
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• 2018

The introduction of checkpoint inhibitors revolutionized immuno-oncology. The efficacy of traditional immunotherapeutics, like vaccines and immunostimulants was very limited due to persistent immune-escape strategies of cancer cells. Checkpoint inhibitors target these escape mechanisms and re-direct the immune system to anti-tumor toxicity. Phenomenal results have been reported in entities like melanoma, where no other therapy was able to demonstrate survival benefit, before the introduction of immunotherapeutics. The first experience in ovarian cancer (OC) was reported for nivolumab, a fully human anti-programmed cell death protein 1 (PD1) antibody, in 2015. While the data are extraordinary for a mono-immunotherapeutic agent and very promising, they do not match up to the revolutionary results in entities like melanoma. The key to exceptional treatment response in OC, could be the identification of the most immunogenic patients. We hypothyse that BRCA mutation could be a predictor of improved response in OC. The underlying DNA-repair-deficiancy should result in increased immunogenicity because of higher mutational load and more neoantigen presentation. This hypothesis was not tested to date and should be subject to future trials. The present article gives an overview of the immunologic background of checkpoint inhibition (CI). It presents current data on nivolumab and other checkpoint-inhibitors in solid tumors and OC specifically and depicts important topics in the management of this novel substance group, such as side effect control, diagnostic PD-1/programmed cell death-ligand 1 (PD-L1) expression assessment and management of pseudoprogression.

• 한국IT서비스학회지
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• 제20권3호
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• pp.41-56
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• 2021

New drug discovery and development research enable clinical treatment that saves human life and improves the quality of life, but the possibility of success with new drugs is significantly low despite a long time of 14 to 16 years and a large investment of 2 to 3 trillion won in traditional methods. As artificial intelligence is expected to radically change the new drug development paradigm, artificial intelligence new drug discovery and development projects are underway in various forms of collaboration, such as joint research between global pharmaceutical companies and IT companies, and government-private consortiums. This study uses the TOE framework and the Value-based Adoption Model, and the technical, organizational, and environmental factors that should be considered for the acceptance of AI technology at the level of the new drug research organization are the value of artificial intelligence technology. By analyzing the explanatory power of the relationship between perception and intention to use, it is intended to derive practical implications. Therefore, in this work, we present a research model in which technical, organizational, and environmental factors affecting the introduction of artificial intelligence technologies are mediated by strategic value recognition that takes into account all factors of benefit and sacrifice. Empirical analysis shows that usefulness, technicality, and innovativeness have significantly affected the perceived value of AI drug development systems, and that social influence and technology support infrastructure have significant impact on AI Drug Discovery and Development systems.

• 한국인터넷방송통신학회논문지
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• 제20권6호
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• pp.151-156
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• 2020

최근 복지서비스의 확대에 힘입어 여러 정부기관에서 복지 관련 서비스를 다양하게 제공하고 있으며 이에 따라 복지관련 서비스의 양과 질의 향상이 동시에 이루어지고 있다. 복지서비스 향상과 더불어 부적정 신청자로 인한 부정·중복수급율도 증가하고 있다. 특히 여러 기관에서 유사하게 추진되는 사업의 경우 기관들 간 시스템 불일치 및 자격검증 지연의 문제 등에 기인한 중복신청 확인이 미흡할 수 있으며 이로 인한 중복수급이 발생할 수 있다. 본 논문에서는 여러기관에서 진행되는 복지서비스 유사사업 관련 중복수급 방지를 위하여, 기관 간 데이터 관리 및 공유의 문제점을 검토하고 블록체인기술의 적용방법을 단계별로 제안하였다. 본 논문의 제안을 통하여 수급대상자의 투명한 데이터 관리가 가능하며 이를 통하여 신뢰기반의 복지급여 관리가 가능할 것이다.

• 공업화학
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• 제31권6호
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• pp.660-667
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• 2020

본 연구의 대상은 에폭시 레진 생산 공정으로 155 ℃ 이상의 고온 스팀을 열원으로 사용하고 있으며 공정에서 생성되는 응축수는 전량 버려지고 있다. 공정의 일부는 70 ℃ 이하의 저온으로 운전되므로 버려지는 응축수를 재활용하여 저온 공정의 열원으로 사용한다면 스팀 사용량 저감이 가능하다. 따라서 본 연구에서는 응축수 재활용을 통해 폐열을 회수하여 스팀 사용량을 저감할 수 있는 공정을 제시하고 모델을 개발하였다. 최적의 응축수 재활용 공정을 찾기 위한 사례연구를 진행하였고, 각 사례의 연간 자본 비용 및 스팀 저감 비용을 비교하여 경제성 평가를 실시하였다. 제안된 공정에서 응축수 회수를 통해 저온 공정에 사용하는 스팀 사용량을 연간 최대 67.6%까지 저감하여 최대 연 522.1 백만원의 추가 수익의 확보가 가능함을 확인하였다.

• The Korean Journal of Pain
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• 제34권1호
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• pp.4-18
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• 2021

Except for carbamazepine for trigeminal neuralgia, gabapentinoid anticonvulsants have been the standard for the treatment of neuropathic pain. Pregabalin, which followed gabapentin, was developed with the benefit of rapid peak blood concentration and better bioavailability. Mirogabalin besylate (DS-5565, Tarlige®) shows greater sustained analgesia due to a high affinity to, and slow dissociation from, the α2δ-1 subunits in the dorsal root ganglion (DRG). Additionally, it produces a lower level of central nervous system-specific adverse drug reactions (ADRs), due to a low affinity to, and rapid dissociation from, the α2δ-2 subunits in the cerebellum. Maximum plasma concentration is achieved in less than 1 hour, compared to 1 hour for pregabalin and 3 hours for gabapentin. The plasma protein binding is relatively low, at less than 25%. As with all gabapentinoids, it is also largely excreted via the kidneys in an unchanged form, and so the administration dose should also be adjusted according to renal function. The equianalgesic daily dose for 30 mg of mirogabalin is 600 mg of pregabalin and over 1,200 mg of gabapentin. The initial adult dose starts at 5 mg, given orally twice a day, and is gradually increased by 5 mg at an interval of at least a week, to 15 mg. In conclusion, mirogabalin is anticipated to be a novel, safe gabapentinoid anticonvulsant with a greater therapeutic effect for neuropathic pain in the DRG and lower ADRs in the cerebellum.

• 한국농공학회논문집
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• 제64권2호
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• pp.85-96
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• 2022

The study is aimed to investigate the features and socio-economic background of farmland consolidation project with medium-sized paddy plot at irrigation associations during the Japanese colonial period in Korea. Most of farmland consolidation works in the 1940s was composed of independent irrigation and drainage ditches along the short side of field plot. However, the number of farm roads at farmland consolidation zone was much smaller than number of irrigation ditches to decrease reduction in farmland area. The standard field plot was medium-sized (about 20-40 ares) in Korea but small-sized (about 10 ares) in Japan in this period. As the result of farmland consolidation works, the unit water requirement was increased to 0.0035 m³/s/ha, and the unit area drainage discharge was over 2.0 m³/s/km² in many cases. The farmland consolidation with medium-sized plot have been spread under the colonial landlord system, where major landlords occupied a large share of farmland and managed corporate farming to gain more benefit. The reasons for spread of farmland consolidation with medium-sized plot may be as follows: high net profit ratio, an increase in land price, and labor savings in rice farming. The farmland consolidation with medium-sized plot in the colonial period showed intermediate features between the farm consolidation with small-sized plot for an increase in land productivity in Japan and the farm consolidation with medium-sized plot for an increase in labor productivity after the 1960s.