• Nutritional Sciences
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• v.9 no.1
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• pp.14-19
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• 2006

Breast cancer may be the consequence of free radical damage, which is partially caused by the excessive intake of dietary fat and imbalances in antioxidant scavenger system;. In this experiment, we examined! the effects of dietary peroxidizability index (PI) values on hepatic thiobmbituric acid reaction substances (TBARS) and antioxidant enzyme activities in rats treated with 7,12-dimethylbenz[$\alpha$]anthracene (DMBA). Female Sprague-Dawley rats were used and 7,12-DMBA (20 mg/kg body weight) was gastrically intubated at seven weeks of age in order to induce mammary tumors (MT). The levels of dietary PI were 36, 81, 126 and 217 (LPI, MLPI, MHPI and HPI), while dietary polyunsaturated/saturated fatty acids ratio was maintained at the same level (1.0). Fat used in the experiment was mixed with soybean oil, com oil, palm oil, perilla oil, sesame oil, fish oil, and beef tallow. Experimental diets were given for the following 20 weeks. We measured tumor numbers and weights, and then assayed the hepatic TBARS levels and antioxidant enzyme activities such as superoxide dismutase (SOD), catalase, glutathione peroxidase, glutathione-S-transferase (GST) and glutathione reductase (GR). The incidence of Mr was the lowest in the MHPI group. The hepatic TBARS level was significantly raised with increasing dietary PI value. The hepatic SOD and GR activities were differed significantly by dietary PI value. The hepatic SOD activity was negatively correlated with dietary PI value and GR activity was the highest in the rats fed the MHPI diet. When the dietary P/S ratio is kept at 1.0, adequate dietary PI value (PI value of 126) may reduce the incidence and growth of Mr, but this benefit may be lost with higher dietary PI value. These results suggest that the awareness of dietary PI values may help to decrease breast cancer incidence and growth.

• Journal of Korean Medical Science
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• v.33 no.53
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• pp.343.1-343.8
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• 2018

Background: Linkage of public healthcare data is useful in stroke research because patients may visit different sectors of the health system before, during, and after stroke. Therefore, we aimed to establish high-quality big data on stroke in Korea by linking acute stroke registry and national health claim databases. Methods: Acute stroke patients (n = 65,311) with claim data suitable for linkage were included in the Clinical Research Center for Stroke (CRCS) registry during 2006-2014. We linked the CRCS registry with national health claim databases in the Health Insurance Review and Assessment Service (HIRA). Linkage was performed using 6 common variables: birth date, gender, provider identification, receiving year and number, and statement serial number in the benefit claim statement. For matched records, linkage accuracy was evaluated using differences between hospital visiting date in the CRCS registry and the commencement date for health insurance care in HIRA. Results: Of 65,311 CRCS cases, 64,634 were matched to HIRA cases (match rate, 99.0%). The proportion of true matches was 94.4% (n = 61,017) in the matched data. Among true matches (mean age 66.4 years; men 58.4%), the median National Institutes of Health Stroke Scale score was 3 (interquartile range 1-7). When comparing baseline characteristics between true matches and false matches, no substantial difference was observed for any variable. Conclusion: We could establish big data on stroke by linking CRCS registry and HIRA records, using claims data without personal identifiers. We plan to conduct national stroke research and improve stroke care using the linked big database.

• Osong Public Health and Research Perspectives
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• v.9 no.6
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• pp.314-324
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• 2018

Objectives: The aim of this study was to analyze research and development projects in mental health services in Korea, using priority evaluation of mental health promotion policies to determine direction of the service. Methods: An online survey was conducted that targeted experts in the mental health service regarding promotion of mental health in Korea in 2016. The survey was based on 32 policy projects that resulted from 12 strategies according to 4 policy objectives. Results: Analysis of 32 mental health projects were assessed regarding the possibility of technology development success, magnitude of the ripple effect, and necessity of a national response. It was observed that 3 policy projects relevant to suicide, had a high relative priority. This was followed by policies for improvement of health insurance and the medical benefit cost system, and policies for reinforcement of crisis psychological support such as those for disaster victims. Conclusion: The prioritization of mental health services should place an emphasis on promotion of a healthy mental lifestyle, rehabilitation support for patients with serious mental illness, and reinforcement of social safety networks for suicide prevention.

• Proceedings of the Korea Water Resources Association Conference
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• 2016.05a
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• pp.194-194
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• 2016

Gansu, located in the northwestern region, is a typical agricultural province of arid, semiarid in China. The shortage of water resources is the biggest obstacle of Gansu Province's development, and the dry farming water-saving is the eternal theme of Gansu agricultural sustainable development. In recent years, intensify reform in Gansu, has walked out a successful way in the agricultural water-saving. Using the integrated river basin governance as opportunity, the total water-using quantity was regarded as rigidity to retrain, distributed to counties (districts), irrigated areas, towns, associations, groups step by step. Agricultural water price was substantially increased, with the surface water price from about $0.1RMB/m^3$ to more than $0.2 RMB/m^3$, and the ground water from zero to more than $0.1RMB/m^3$. Simultaneously, the difference water prices and over-quota water progression price markup were carried out. The transaction of water rights was encouraged to impel the peasant to establish the consciousness of saving-water. The regulatory documents were formulated to standardize the scope, condition, mode, program etc. of agriculture water-rights transaction, to guarantees the transaction of water rights is carries out in order. The pattern of farming was optimized and adjusted, reducing the high water-consumption crop, increasing economic crops with high benefit and low water-consumption, developing industrialized agricultures such as green house. The relative engineering and measuring facility were comprehensively improved, with the anti-seepage of canal system and the enforcement of dynamo-electric well, developing high-efficient water-saving irrigation and overall metering facilities. The water fine-grained management has realized, and obvious water-saving effect has obtained: water-using rate in the irrigation area by river water has brought up to 0.57 from 0.52, and by well water up to 0.84 from 0.76. Although the water price has increased, the proportion that the water rate expenditure accounted for the cost lasts decline, and the farmers' income has gone up. The peasants express, the used water is few, and it is few to till land, but the income is many, and life is better.

• Journal of Convergence for Information Technology
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• v.7 no.2
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• pp.119-124
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• 2017

Information is a valuable asset regardless of the size of the enterprise and information security is an essential element for the survival and prosperity of the enterprise. However, in the case of large corporations, Security is ensured through rapid introduction of information security management system. but In the case of SMEs, security systems are not built or construction is delayed due to complex factors such as budget constraints, insufficient security guidelines, lack of security awareness. In this paper, we analyze the actual situation of information security management of SMEs through questionnaires, and We would like to suggest a comprehensive security plan for SMEs in free or inexpensive ways. We believe that by applying the method presented in this paper, SMEs will be able to implement the lowest cost basic information security and will benefit SMEs who plan to establish an information security plan.

• Journal of Korean Society on Water Environment
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• v.37 no.2
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• pp.128-136
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• 2021

It is generally known that a wastewater treatment plant (WWTP) consumes immense energy even if it can produce energy. With an aim to increase the energy independence rate of WWTP from 3.5% in 2010 to 50% in 2030, the Korean government has invested enormous research funds. In this study, cost-effective operating alternatives were investigated by analyzing the energy efficiency and economic feasibility for biogas and power generation using new and renewable energy. Based on the US EPA Energy Conservation Measures and Korea ESCO projects, energy production and independence rate were also analyzed. The main energy consumption equipment in WWTP is the blower for aeration, discharge pump for effluent, and pump for influent. Considering the processes of WWTP, the specific energy consumption rate of the process using media and MBR was the lowest (0.549 kWh/㎥) and the highest (1.427 kWh/㎥), respectively. Energy-saving by enhancing anaerobic digester efficiency was turned out to be efficient when in conjunction with stable wastewater treatment. The result of economic analysis (B/C ratio) was 2.5 for digestive gas power generation, 0.86 for small hydropower, 0.49 for solar energy, and 0.15 for wind energy, respectively. Furthermore, it was observed that the energy independence rate could be enhanced by installing energy production facilities such as solar and small hydropower and reducing energy consumption via the replacement of high-efficiency operating.

• Journal of Microbiology and Biotechnology
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• v.31 no.4
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• pp.570-583
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• 2021

Pyrococcus furiosus α-amylase can hydrolyze α-1,4 linkages in starch and related carbohydrates under hyperthermophilic condition (~ 100℃), showing great potential in a wide range of industrial applications, while its relatively low productivity from heterologous hosts has limited the industrial applications. Bacillus subtilis, a gram-positive bacterium, has been widely used in industrial production for its non-pathogenic and powerful secretory characteristics. This study was conducted to increase production of P. furiosus α-amylase in B. subtilis through three strategies. Initial experiments showed that co-expression of P. furiosus molecular chaperone peptidyl-prolyl cis-trans isomerase through genomic integration mode, using a CRISPR/Cas9 system, increased soluble amylase production. Therefore, considering that native P. furiosus α-amylase is produced within a hyperthermophilic environment and is highly thermostable, heat treatment of intact culture at 90℃ for 15 min was performed, thereby greatly increasing soluble amylase production. After optimization of the culture conditions (nitrogen source, carbon source, metal ion, temperature and pH), experiments in a 3-L fermenter yielded a soluble activity of 3,806.7 U/ml, which was 3.3- and 28.2-fold those of a control without heat treatment (1,155.1 U/ml) and an empty expression vector control (135.1 U/ml), respectively. This represents the highest P. furiosus α-amylase production reported to date and should promote innovation in the starch liquefaction process and related industrial productions. Meanwhile, heat treatment, which may promote folding of aggregated P. furiosus α-amylase into a soluble, active form through the transfer of kinetic energy, may be of general benefit when producing proteins from thermophilic archaea.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.18 no.3
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• pp.46-57
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• 2019

Generally speeding appeared to be the most contributing factor of fatalities occurred in work zones, and highway agencies in South Korea have concerned of the safety of workers and drivers in the poor circumstances. In this study, a portable variable message signs (PVMS) system as an alternative of control speeding in work zones was implemented. This study evaluated the safety effectiveness of the PVMS based on speeds and the compliance with the speed limit. Linear regression and logistic regression models were adopted to quantify the safety effect of the PVMS between the 'before' and 'after'. The results showed that most of points had statistically significant speeds reduction experience after PVMS installation. Also, the percentage of vehicle exceeding the speed limit by 10 km/h or more was decreased significantly between 50 and 80% in the 'after' periods compared to the 'before' periods. Therefore, the PVMS would be contributed to benefit safety in work zones which there is a difference in design speed of the adjacent normal section.

• Journal of Korean language education
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• v.25 no.1
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• pp.53-82
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• 2014

This study aims to find the method to promote interaction in L2 classrooms. Active interaction between learner-to-learner and learner-to-teacher in L2 classroom plays an important role in language acquisition. In light of this, L2 classroom would benefit with the help of learning tools such as Clickers which helps learners to express their level of understanding during the process of learning itself. This is because the anonymity of Clickers allows learners to express their needs without the social risks associated with speaking up in the class. It allows for an evaluative feedback loop where both learners and teachers understand the level of progress of the learners, better enabling classrooms to adapt to the learners' needs. Eventually this tool promotes participation from learners, This is in turn, believed to be effective in fostering classroom interaction, allowing learning to take place in a more comfortable yet vibrant way. This study is finalized by presenting the result of an experiment conducted to verify the effectiveness of this approach when teaching pragmatic aspect of the Korean expressions with similar semantic functions. As a result of the research, the learning achievement of learners in the experimental group was found higher than the learners' in a control group. Analyzing the data collected from a questionnaire given to the learners, the study presented data suggesting that this approach increased the scope of interactivity in the classroom, thus enhancing more active participation among learners. This active participation in turn led to a marked improvement in their communicative abilities.

• Steel and Composite Structures
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• v.30 no.4
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• pp.365-382
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• 2019

In steel frame-tube structures (SFTSs) the application of flexural beam is not suitable for the beam with span-to-depth ratio lower than five because the plastic hinges at beam-ends can not be developed properly. This can lead to lower ductility and energy dissipation capacity of the SFTS. To address this problem, a replaceable shear link, acting as a ductile fuse at the mid length of deep beams, is proposed. SFTS with replaceable shear links (SFTS-RSLs) dissipate seismic energy through shear deformation of the link. In order to evaluate this proposal, buildings were designed to compare the seismic performance of SFTS-RSLs and SFTSs. Several sub-structures were selected from the design buildings and finite element models (FEMs) were established to study their hysteretic behavior. Static pushover and dynamic analyses were undertaken in comparing seismic performance of the FEMs for each building. The results indicated that the SFTS-RSL and SFTS had similar initial lateral stiffness. Compared with SFTS, SFTS-RSL had lower yield strength and maximum strength, but higher ductility and energy dissipation capacity. During earthquakes, SFTS-RSL had lower interstory drift, maximum base shear force and story shear force compared with the SFTS. Placing a shear link at the beam mid-span did not increase shear lag effects for the structure. The SFTS-RSL concentrates plasticity on the shear link. Other structural components remain elastic during seismic loading. It is expected that the SFTS-RSL will be a reliable dual resistant system. It offers the benefit of being able to repair the structure by replacing damaged shear links after earthquakes.