• Biomolecules & Therapeutics
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• 제19권4호
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• pp.371-389
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• 2011

A new strategy for cancer therapy has emerged during the past decade based on molecular targets that are less likely to be essential in all cells in the body, therefore confer a wider therapeutic window than traditional cytotoxic drugs which mechanism of action is to inhibit essential cellular functions. Exceptional heterogeneity and adaptability of cancer impose significant challenges in oncology drug discovery, and the concept of complex tumor biology has led the framework of developing many anticancer therapeutics. Protein kinases are the most pursued targets in oncology drug discovery. To date, 12 small molecule kinase inhibitors have been approved by US Food and Drug Administration, and many more are in clinical development. With demonstrated clinical efficacy of bortezomib, ubiquitin proteasome and ubiquitin-like protein conjugation systems are also emerging as new therapeutic targets in cancer therapy. In this review, strategies of targeted cancer therapies with inhibitors of kinases and proteasome systems are discussed. Combinational cancer therapy to overcome drug resistance and to achieve greater treatment benefit through the additive or synergistic effects of each individual agent is also discussed. Finally, the opportunities in the future cancer therapy with molecularly targeted anticancer therapeutics are addressed.

• 동양고전연구
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• 제67호
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• pp.297-325
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• 2017

이 글은 묵가의 의리관과 그것을 기초로 한 "겸애"에 대한 분석을 통해서 묵가의 이념적 특성을 고찰한 것이다. 공자와 묵자를 비롯한 제자 백가에서 의리관이 주요 의제가 되기 이전에도 이미 이에 대한 논의가 있었으며, 그것은 대체로 "의"와 "리"를 본말(本末) 혹은 체용(體用) 관계로 파악하였다. 이러한 경향을 계승하고 개인의 도덕적 표준으로 설정한 것이 공자를 비롯한 유가의 입장이었다. 물론 유가의 눈높이는 당시의 위정자 혹은 지도자에 초점을 맞춘 것이다. 이에 비해 묵가에서는 자기 집단의 구성원의 입장을 대변하여 개인보다는 집단과 사회의 공동의 이익 추구를 도모하였다. 따라서 유가에서 "의"를 "리"보다 중시한 데 비해, 묵가는 양자를 통일적으로 이해할 수 있었다. 묵가가 전국시대에 가장 왕성하게 활동할 수 있었던 결정적인 이유는 "하늘의 뜻"에 그것의 형이상학적 기반을 두었기 때문이다. 이에 수반하여 내부적으로 묵가의 의리관은 "겸애"를 비롯한 묵가의 핵심적인 주장에 그대로 반영되었다. 그것이 이른바 "겸상애, 교상리", 말하자면 "서로 사랑하는 것이 곧 서로 이롭게 해주는 일이다." 한편 묵가의 의리관, 나아가 겸애를 비롯한 십대 주장의 이념적 기반이 "하늘의 뜻"이었다는 것은 양날의 검이 되었다. 왜냐하면 그것은 당시 묵가 구성을 비롯한 노동자, 농민, 수공업자들의 눈높이에는 쉽게 수용될 수 있었지만, 진한(秦漢) 봉건제국이 성립되면서부터는 오히려 쇠망의 길로 들어서는 계기가 되었기 때문이다. 봉건제국에서는 개별집단으로의 묵가의 이념과 활동은 용납되기 어려웠다. 예컨대 "최고 통치자" 위에 "하늘"(상제)을 설정하는 방식은 정권의 정당성과 합리성에 결정적 제약이 되었을 것이다. 또한 묵가의 "절용", "절장", "비악" 등의 주장은 기득권으로서는 더욱 받아들이기 어려웠다. 따라서 이후 청대 서세동점(西勢東漸)에 이르기까지 묵가는 유가와 달리 학파로서의 활동은 거의 보이지 않게 되었다. 요컨대 역사적으로 묵가의 겸애를 비롯한 이념은 유토피아적 구상에 그치고 말았지만, 유가와 상대적으로 사회적 약자의 입장에서 상호간의 사랑과 배려, 아울러 상호 이익을 공유한다는 이념은 오늘날에도 음미할 만한 가치가 있다.

• 사회복지연구
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• 제39호
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• pp.365-393
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• 2008

이 연구는 연금개혁 정치에서 노동조합의 영향력, 전략, 그리고 이것이 연금개혁에 가져온 결과에 관한 것이다. 분석 사례는 1994년부터 2004년 사이의 이탈리아 연금개혁이다. 노조의 영향력 면에서 1990년대에 이탈리아 노조는 연금개혁의 중요한 행위자였으나 2004년 개혁에서는 노조의 영향력이 약화되었다. 이는 좌파분열이라는 권력자원의 변화뿐만 아니라 1990년대 노조주도의 연금 삭감을 경험하고 노조가 연금정책에서 노조원의 이익 보호를 강조한데 따라 연금이슈의 성격이 달라졌기 때문이다. 전략 면에서 이탈리아 사례는 노조가 코포라티즘적 협의를 추구하느냐 대중적 저항을 선택하느냐는 기본적으로 정부 태도에 달려있음을 보여준다. 1994년 연금개혁 실패로 촉발된 정권교체를 경험한 후 이탈리아 정부는 사회적 합의를 추구하였다. 협의절차가 강조된 1995년 디니개혁에서 이탈리아 노조는 협의에서 주도권을 가졌을 뿐만 아니라 노조내 민주주의를 적극적으로 추구하였다. 노조는 토론과 전체 투표 등을 활용하여 전투적 노조부문의 반대를 누르고 정부와의 협의 결과에 대한 승인을 얻었다. 한편 연금개혁 정치에 노조가 참여한 결과 면에서, 노조는 장기가입자의 기득권 보호에 집중된 성과를 얻었다. 소기업 노동자들의 연금 미가입 문제와 젊은 세대의 급여적절성 등은 연금개혁에서 도외시되었다. 노동조합이 주도하는 타협이라는 호조건과 노조민주주의를 실현하는 가운데에서도 노조의 제도개혁에 대한 영향력은 제한되었다.

• 한국지역지리학회지
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• 제15권2호
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• pp.250-260
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• 2009

본 연구의 목적은 레저 스포츠 이벤트 활동 참가추구목적에 따른 관광자원 개발 선호 방안을 도출하기 위한 방법으로 다차원 척도법 (MDS)을 이용하였다. 따라서 이에 따른 관광자원개발 선호도에 대한 세분시장별 특성을 파악해 보고자 한다. 연구 분석을 위해 전국 인라인 마라톤 대회 참여자 330부를 이용하였으며, 연구 방법은 SPSS 15.0 for Windows 통계 프로그램을 이용하였다. 결과분석에서는 첫째, 레저 스포츠 활동 참가자의 참가목적에 따른 세분집단을 군집화한 결과 '금전획득 참가목적자', '보통 자아실현참가 목적자', '강한 자아실현참가 목적자' 등 3개의 집단으로 세분화되었으며, 분석결과 세분화된 3집단은 관광자원개발에 영향을 주는 집단으로 밝혀졌다. 따라서 세분화된 집단특성에 따른 만족도를 높이기 위해서는 이들의 선호특성에 맞는 관광자원 개발의 필요성이 요구된다.

• 한국의사학회지
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• 제31권1호
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• pp.13-22
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• 2018

Understanding the purpose and results of a Korean Envoy's medical bureaucrat (attendant) travel to China. Unlike other Envoy's medical bureaucrats, envoy's trade made profits for those who participated. This article investigates the protocols of a Korean Envoy's medical attendant which include: (1) A prominent family member or high-ranking official does not participate in the Envoy's medical bureaucrat, either himself or his descendants. This denies the general theory that the medicinal material trade helped the economic status of medical officials. (2) Envoy's medical bureaucrat is a high percentage of interpreter bureaucrat in the households of father, mother, and wife. This suggests that the information about the envoy schedule and the benefit of the envoy may have been exposed in advance. This is related to the fact that the interpreter bureaucrat is the center of the envoy trade. (3) In the nineteenth century, envoy's medical bureaucrats were more frequent among close relatives, such as father-son relationship, than in the previous century. This study restored the lineage and purpose to the medical bureaucrat's travel to China, and provides a list of Envoy's medical bureaucrat through historical data, and analyzed the household and previous office. In this regard, it can be seen that some households, which are not dominant medical bureaucracies, have pursued profit through medicinal material trade. However, it is difficult to generalize to the whole of the medical bureaucracy.

• 대한예방한의학회지
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• 제1권1호
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• pp.137-148
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• 1997

The Serial Securities and the Social Welfare, as the national policy aimed at securing generals' lives, are the policies or systems for the stabilization in lift; especially of law-incomers and workers, for which the povernment has to establish the Social Security System. No wonder the Social Insurance System is a part of the Social Security System and the most important. The Social Insurance System, along with Public Assistance, is underlying the Social Security System. Social Security System includes medical insurance, industrial accident Compensation insurance, national pention insurance and employment insurance. The study is on 'The Oriental Medical Insurance and the Industrial Accident Compensation in the Social Security System' . The rate of industrial accident in Korea marks the highest rank in the world. for laborer, industrial accident do not merely mean the loss of health but the question of the right to live in terms of their loss of opportunity of life. The industrial accident compensation system should be established as the es post facto remedy system to guarantee the injured worker and his/her family's life. The oriental medical insurance system which began to operate in 1987 in Korea is based on unionism and divided into 3 parts; one part for the worker, a second part for the community inhabitants, and a third part for the public service personnel and private school personnel. Today the medical problem must be the most important social assignment to be considered. The medical system of contemporary industrial society has began greatly stood out in relief as a part of social welfare not emphasized on gainings of physicians. Accordingly systematization of the oriental medical insurance was strongly Pursued and it was developed to to the extent of entire nation insurance. Though the history of it is very short, most of the people are getting benefit from the insurance system by the social security system method. This study develops the Oriental Medical Insurance, the Workmen's Accident Compensation Insurance, the Pension System in relation to the industrial accident compensation of Employees, along with the ideas and principles of social insurance.

• 화약ㆍ발파
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• 제15권3호
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• pp.14-19
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• 1997

Koreans have emphasized education as the primary means to reconstruct our country means to reconstruct our country after two catastrophic events-the Japanese occupation and the Korean War(1950-1953). A Strong belief- in education coupled with sheer deter-mination spurred the period of industrial and eeonomic development that started in the early 1970-'s. The "can-do" attitude of the general public was matched and aided by small S & T communities. Scientists and engineers provided the neeessary expertise to manufacture goods and process the many raw materials imported from overseas. After nearly three decades of reconst-ructing our completely devastated country, Korea has become a modern, cosmo-politan, fast-paced and dynamic country. In order to further increaser our manufac- turing capabilities and double the per-capita income by the beginning of the 21st century, we must improve productivitiy and encourage creatitivity in all sectors of our country. The S & T community's efforts in research and development. education, and interna-tional cooperation will be invaluable in determining our direction and reaching these goals. The general public is eager to peacefully unite our foreign powers since 1945. Toward that end. members of the S & T community are willing to coope-rate with our north Korean counterparts in all areas of S & T with the exception of defense related endeavors. Establi-shing scientific ties with north Korea will result in mutual economic benefit and greater regional stability in East Asia. In particular. scientists and manu-facturers in each province are eager to initiate cordial and professional relation-ships with north Korea in the hopes of securing these benefits. The Korean Federation of Science and Technology Societies(KOFST) has played an important role both in developing S & T policies, and in gostering the frowty of S & T societies. A non-governmental umbrella organization composed of over 251 professional societies, KOFST facili-tates the transfer of research outcomes and technology from research institutions to the various industries. KOFST also seeks to increase cooperation between the countries of the Pacific Rim. As evidence of that, we have pursued joint research and industrial ventures with China. Established projects include those on environmental conditions in the Yellow Sea, and improvement of aircraft manufacturing, telecommunica-tion equipment, and agricultural produ-cts. Increased cooperation between the Pacific Rim countries, particularly in S & T, would foster social and economic development for the region as a whole.

• 토지주택연구
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• 제8권2호
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• pp.33-53
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• 2017

The UK Government's approach to how to deliver regeneration in its towns and cities has changed considerably in recent years. Traditionally, urban regeneration policy focused on reversing physical, economic and social decline in an area where market forces would not do this without intervention. Since 2010 urban regeneration has become a vital part of the Government's approach to increasing local growth and competitiveness and building a strong and balanced economy. The current emphasis is on a place-based approach to regeneration that builds on the particular strengths of different places to drive growth and addresses the factors that hold them back. This paper outlines the key features of current UK urban regeneration policy and how interventions to support regeneration and growth are being pursued at different spatial scales to ensure all parts of the country benefit. They include pan regional initiatives like the Northern Powerhouse and Midlands Way, to groups of local authorities operating at a sub regional level (combined authorities/city regions), Local Enterprise Partnerships, and a variety of smaller scale programmes delivering regeneration in areas of economic and social decline. The paper explains some of the policy instruments and funding programmes available to support regeneration, and provides case studies of some major urban regeneration projects that illustrate the new approach including housing and infrastructure improvements like the planned High Speed Rail 2 line. These are supporting regeneration through the creation of strategic partnerships involving government, places and investors. The paper concludes with some lessons from past and future regeneration schemes to improve their effectiveness and impact on places and enhance local growth potential.

• 대한간호학회지
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• 제26권2호
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• pp.304-319
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• 1996

It is important to evaluate nutritional status of elderly patients receiving dialysis, since wasting and malnutrition are their common problems. This study aims at assessing their nutritional status by the type and duration of dialysis. The nutritional status such as somatic fat and protein storage was evaluated with anthropometric measure including weight/height ratio, triceps skinfold thickness and midarm muscle circumference. It was also measured with albumin, transferrin, C3 and IGF-1 and calorie and protein intakes. The general clinical condition of patients was evaluated with the severity of uremia and metabolic acidosis. which were measured through the levels of serum urea, creatinine and bicarbonateion. The data were analyzed by using t-test, ANOVA, Wilcoxon-rank sums test, Scheffe test, Kruskal-Wallis test and Pearson correlation coefficients. The results are following : 1. There was no significant difference in the calorie and protein intakes by the type and duration of dialysis received. 2. As for the anthropometric measures, no significant difference was found by the type of dialysis in body mass index triceps skinfold thickness and midarm muscle circumference. Yet these anthropometric measures differed significantly by the duration of dialysis in those elderly patients receiving hemodialysis(HD group), but this finding was not found in those receiving continuous ambulatory peritoneal dialysis(CAPD). 3. Regarding the indicators of uremia and metabolic acidosis, blood urea nitrogen(BUN) and creatinine were lower in the CAPD group than in the HD group, whereas bicarbonate ion was higher in the CAPD group than in the HD group, with no statistical significance. In the HD group, creatinine increased significantly with the increase of the duration of dialysis. 4. Serum trasferrin and C3 were significantly higher in the CAPD group than in the HD group. However. each of biochemical indices did not show statistical significance by the duration of dialysis in both HD and CAPD groups. 5. Anthropometric measures were significantly associated with dietary intake. Significant correlations were observed between biocarbonate ion, BUN and creatinine. In addition, the correlations between serum protein and albumin and between transferrin and C3 were statistically significant. Yet, IGF-1 revealed no significant correlation with other nutritional indices. The above findings indicate that there were no difference in nutritional status measured with protein and calorie intakes between the type and duration of dialysis, but CAPD seems to benefit correcting uremia and metabolic acidosis than HD. Studies of dietary management for dialysis patients need to be pursued in order to improved the quality of aged patients receiving dialysis.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.1863-1867
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• 2012

Background: Maintenance chemotherapy is one strategy pursued in recent years with intent to break through the chemotherapy plateau for advanced non-small cell lung cancer (NSCLC). However, given the toxicity, platinum-based combinations are rarely given for this purpose. We carried out the present prospective study of triplet platinum-based combination sequential chemotherapy in advanced NSCLC to investigate if patients could tolerate and benefit from such intensive treatment. Methods: From Dec 2003 to Dec 2007, 190 stage IIIB and IV NSCLC patients in Sun yat-sen University sequentially received the 3 platinum-based combination (TP-NP-GP) treatment (T: paclitaxol175$mg/m^2$ d1; N: vinorelbine25$mg/m^2$ d1 and 8; G: gemcitabine1$g/m^2$ d1 and 8; P: cisplatin20$mg/m^2$ d1-5; repeated every 3 weeks). Patients were followed up to at least 3 years to obtain survival data. Treatment toxicities and the quality of life (QOL) were assessed during the whole treatment. Results: There were 187 patients evaluable. The TP, NP and GP response rates with sequential use were 42.8% (80/187), 41.1% (65/158) and 28.8% (21/73) respectively. Median survival time was 18.2 months and the 1, 2 and 3 year overall survival (OS) rates were 78.7%, 38.5% and 21.3%. Patients receiving > 6 cycles of chemotherapy had significantly longer OS and TTP (MST 25.3 vs. 14.5 months, TTP 15.1 vs. 9.1 months). The QOL on the whole for the patients was improved after chemotherapy. Conclusions: The sequential chemotherapy strategy with triplet platinum-based combination regimens can improve the survival outcome and the quality of life of advanced non-small cell lung cancer patients.