• Bulletin of the Korean Mathematical Society
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• v.48 no.1
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• pp.169-182
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• 2011

The main object of this paper is to introduce and investigate new subclasses of normalized analytic functions in the open unit disc $\mathbb{U}$, which generalize the familiar class of k-starlike functions. The various properties and characteristics for functions belonging to these classes derived here include (for example) coefficient inequalities, distortion theorems involving fractional calculus, extreme points, integral operators and integral means inequalities.

• Bulletin of the Korean Chemical Society
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• v.31 no.12
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• pp.3632-3638
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• 2010

2-Iminopyrimidines (1a-e) and 2-thioxopyrimidine (2) were synthesized using the Biginelli three component cyclocondensation reaction of an appropriate $\beta$-diketone, arylaldehyde, and guanidine (for 1a-e) or thiourea (for 2). The electrochemical properties of the novel systems were investigated by CV and DPV. Moreover, B3LYP/6-31G(d,p) method was applied to the present structures in order to gather some structural and physicochemical data.

• Digital Contents
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• no.6 s.133
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• pp.123-127
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• 2004

1989년 배트맨(Batman), 2000년 엑스맨(X-man), 2002년 스파이더맨(Spider-man), 2003년 헐크(Hulk). 21세기 들어 매년 전세계 극장가는‘맨(Man)’의 바람으로 한차례 술렁인다. 이 영화들의 메인 캐릭터는 모두 인간보다 우월한 호모슈피리얼(homosuperial)들이다. 폭풍과도 같은‘맨’류 영화의 공통점은 무엇일까. 우선 미국의 만화 출판사의 양대 산맥인‘마블(Marvel)’과‘DC코믹스’의 스테디셀러라는 점이다. 둘째로 2004년의 시점에서도 끊임없이 후속 영화를 기획하고 연출한다는 점이고, 셋째로 게임시장에서 다양한 형태로 활용된다는 점을 들 수 있다. 그리고 마지막으로 캐릭터 상품으로 이어진다는 점이다. 원 소스 멀티 유즈(One Source Multi Use)를 최고의 가치로 여기는 21세기 문화시장에 있어서 이들은 그야말로 모범답안이요 보증수표라 할 만 하다. 이 모범답안을 적극 활용하기 위해서는 표면의 흥행요소뿐만 아니라, 심층의 이야기 확장 가능성을 짚어볼 필요가 있다.

• Communications of the Korean Mathematical Society
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• v.37 no.3
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• pp.939-955
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• 2022

In this paper, we study a first-order non-linear singularly perturbed Volterra integro-differential equation (SPVIDE). We discretize the problem by a uniform difference scheme on a Bakhvalov-Shishkin mesh. The scheme is constructed by the method of integral identities with exponential basis functions and integral terms are handled with interpolating quadrature rules with remainder terms. An effective quasi-linearization technique is employed for the algorithm. We establish the error estimates and demonstrate that the scheme on Bakhvalov-Shishkin mesh is O(N^-1) uniformly convergent, where N is the mesh parameter. The numerical results on a couple of examples are also provided to confirm the theoretical analysis.

• Cartoon and Animation Studies
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• s.49
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• pp.53-85
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• 2017

This study deals with the production system of the superhero animation that are based on DC comic books and are produced by Warner Brothers company, and tries to find out ways in order to vitalize the new window of the animation market. 28 superhero animations released from 2007 until 2017 are analyzed. Several critical points are drawn out and can be applied to the Korean animation industry. There are two categories, one is about the management of the production system, and the other is about the subcontract system. In managing the production system, there are three points: First, there are several people who play the role of either a producer or a director many times. Second, producers used to work as a group. Third, some people work not only as a producer but also as a director. In carrying out outsourcing contracts, there are six points: First, only Korean and Japanese companies participate as subcontract companies. Second, about two companies used to take part in the subcontract production in a year. Third, in case of number of people involved in production, there are more Japanese than Korean. Fourth, Japanese companies deal with some parts of the pre-production as well as the main production in . Fifth, a Japanese company has a sub-subcontract with a Korean company in one episode of . Sixth, Korean companies mostly focus on the production part of key animation. Important points that the Korean production system has to consider are also suggested under the two categories. In the production system management, there are two points. It is needed to make use of the group producer system, and it is critical to develop the story line of universe type such as DC Universe. In case of the outsourcing production system, it is essential to keep up educating 2D type of animation and, at the same time, to participate actively in the global outsourcing production. By considering these crucial points, it is expected to keep producing animation that can be used for the media window such as IPTV.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.6
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• pp.3461-3463
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• 2013

Background: Non-Hodgkin lymphoma (NHL) is a solid tumour of lymphocytes, important elements in the immune system. According to 2006 data, in Turkey the incidence was 6.5 per 100,000 in males, and 4.4 in females. The relationship between the use of pesticides and development of NHL has been extensively investigated in many studies, and it has been demonstrated that the risk of NHL is increased by exposure to such compounds. Antalya is a region of intensive agricultural activity. In this study, the relationship between the incidence of lymphoma in Antalya and the amount of pesticides employed was investigated. Materials and Methods: The study used data from 1995 to 2010 on the patients from the databank of TR Ministry of Health, Antalya Provincial Health Directorate, Cancer Registration Center and the patients who were histopathologically diagnosed with NHL during these years. Results: The relationship between the amount of pesticide used and the incidence was studied with the Spearman correlation analysis and the p value was found as 0.05. The correlation coefficient was 0.497. An increase in the NHL incidence over the years was identified, with a 2.42-fold increment found from 1995 to 2005 and a 2.77 fold elevation from 1995 to 2010. The use of pesticides increased 1.89 fold over the same period. Conclusions: Our study investigated the relationship of the pesticides used with NHL patients diagnosed during the same year. Since the time elapsing after exposure to pesticides until the development of cancer is not clear, no comparison can be made at present. We believe that the increase in use of pesticides since 1995 may be associated with the increase in the incidence of NHLand therefore that further studies on the issue including measurements of serum pesticide levels, are required.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.3
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• pp.1041-1045
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• 2015

Background: Paget's disease (PD) is a rare form of intraepithelial adenocarcinoma that involves breast and extramammarian tissues. It is often associated with ductal carcinoma in situ and/or invasive ductal cancer. Molecular pathways that play a role in development of Paget's disease are stil unclear. Expression patterns of Cox-2 and bcl-2 were therefore assessed. Materials and Methods: Patients with a histopathological diagnosis of Paget's disease were included in this study. Patient files were analysed retrospectively. Results: Invasive cancer was diagnosed in 35 (76.1%) of the patients, 7 (15.2%) had ductal carcinoma in situ and 4 (8.7%) patients had no associated neoplasm. Twenty four (52.2%) patients showed COX-2 expression in Paget cells whereas no expression was seen in 22 (47.8%) patients. No relation was found between COX-2 expression and the lesion underlying Paget's disease (p=0.518). Bcl-2 expression in Paget cells was found positive in 12 (26.1%) and negative in 27 (58,7%) cases. There was no relation between Bcl-2 expression and the lesion accompanying Paget's disease (p=0.412). No relation was observed between COX-2 expression and Bcl-2 expression (p=0.389). Conclusions: In breast cancer, COX-2 expression is associated with poor prognostic factors. As COX-2 expression increases the tendency to metastasize also increases. In our study we found a significantly high COX-2 expression in Paget's disease of the breast. We suggest that COX-2 expression and inflammatory processes may play a role in pathogenesis of the Paget's disease of the breast.

• Safety and Health at Work
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• v.13 no.2
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• pp.180-186
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• 2022

Background: In occupational studies, it is a known situation that technical and organizational attempts are used to prevent occupational accidents. Especially in the mining sector, if these attempts cannot prevent occupational accidents, personal protective equipment (PPE) becomes a necessity. Thus, in this study, the main objective is to examine the effects of the variables on the use of PPE and identify important factors. Methods: A questionnaire was implemented and structural equation modeling was conducted to ascertain the significant factors affecting the PPE use of mining employees. The model includes the factors that ergonomics, the efficiency of PPE and employee training, and PPE usage habit. Results: The results indicate that ergonomics and employee training have no significant effect (p > 0.05) on the use of PPE. The efficiency of PPE has a statistically meaningful effect (p < 0.05) on the use of PPE. Various variables have been evaluated in previous studies. However, none of them examined the variables simultaneously. Conclusion: The developed model in the study enables to better focus on ergonomics and employee training in the PPE usage. The effectiveness of a PPE makes its use unavoidable. Emphasizing PPE effectiveness in OHS training and even showing them in practice will increase employees' PPE usage. The fact that a PPE with high effectiveness is also ergonomic means that it will be used at high rates by the employee.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6669-6671
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• 2014

Background: We here examined the awareness of female health employees (doctors, nurses, midwives) working in primary health care service about cervical cancer and its risk factors. Additionally attitude and behavior for gynecologic examination and pap smear screening wwere researched. Materials and Methods: This cross-sectional, descriptive study con cerned female health employees working at primary health care services in two southern cities of Turkey, over a four month period in 2013. Participants were recently or previously sexually active research was explained and verbal informed consent was obtained face to face. The questionnaire consisted of two parts; socio-demographic characteristics and level of knowledge about cervical cancer and its risk factors. Results: The average age of the participants (midwives 43.7%, n=143; nurses 40.4%, n=132; doctors 6.4%, n=21; emergency medical technicians and others, 9.5%, n=31; total, n=327) was $30.9{\pm}6.41$ years. 64.2% (n=210) were working in Diyarbakir and 35.8% (n=117) in Batman. A large proportion reported low knowledge and inadequate screening practice Conclusions: Health employees should be better informed about the importance of screening for cancers, given their preventive roles for the general population.

• BMB Reports
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• v.53 no.3
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• pp.154-159
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• 2020

We investigated the effects of physalin A, B, D, and F on osteoclastogenesis induced by receptor activator of nuclear factor κB ligand (RANKL). The biological functions of different physalins were first predicted using an in silico bioinformatic tool (BATMAN-TCM). Afterwards, we tested cell viability and cell apoptosis rate to analyze the cytotoxicity of different physalins. We analyzed the inhibitory effects of physalins on RANKL-induced osteoclastogenesis from mouse bone-marrow macrophages (BMMs) using a tartrate-resistant acid phosphatase (TRAP) stain. We found that physalin D has the best selectivity index (SI) among all analyzed physalins. We then confirmed the inhibitory effects of physalin D on osteoclast maturation and function by immunostaining of F-actin and a pit-formation assay. On the molecular level, physalin D attenuated RANKL-evoked intracellular calcium ([Ca(2+)](i)) oscillation by inhibiting phosphorylation of phospholipase Cγ2 (PLCγ2) and thus blocked the downstream activation of Ca2+/calmodulin-dependent protein kinases (CaMK)IV and cAMP-responsive element-binding protein (CREB). An animal study showed that physalin D treatment rescues bone microarchitecture, prevents bone loss, and restores bone strength in a model of rapid bone loss induced by soluble RANKL. Taken together, these results suggest that physalin D inhibits RANKL-induced osteoclastogenesis and bone loss via suppressing the PLCγ2-CaMK-CREB pathway.