• 대한조선학회논문집
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• 제45권2호
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• pp.213-220
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• 2008

The aim of this paper is to build up the design model using ASMOD(Adaptive Spline Modeling of Observation Data) for the optimum scale of fleet, ship particulars and ship speed, etc. ASMOD, which define membership functions of fuzzy rule as B-spline basis function, represents a whole system as the sum of the sub-model. As it reduces the number of division of the space generated by the fuzzy set of input variables, it has a advantage of simplification to model structure and is efficient to represent the non-linear model.

• Molecules and Cells
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• 제27권6호
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• pp.651-656
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• 2009

The formation of ${\beta}$-amyloid peptide ($A{\beta}$) is initiated from cleavage of amyloid precursor protein (APP) by a family of protease, ${\alpha}$-, ${\beta}$-, and ${\gamma}$-secretase. Sub W, a substrate peptide, consists of 10 amino acids, which are adjacent to the ${\beta}$-cleavage site of wild-type APP, and Sub M is Swedish mutant with double mutations on the left side of the ${\beta}$-cleavage site of APP. Sub W is a normal product of the metabolism of APP in the secretary pathway. Sub M is known to increase the efficiency of ${\beta}$-secretase activity, resulting in a more specific binding model compared to Sub W. Three-dimensional structures of Sub W and Sub M were studied by CD and NMR spectroscopy in water solution. On the basis of these structures, interaction models of ${\beta}$-secretase and substrate peptides were determined by molecular dynamics simulation. Four hydrogen bonds and one water-mediated interaction were formed in the docking models. In particular, the hydrogen bonding network of Sub M-BACE formed spread over the broad region of the active site of ${\beta}$-secretase (P5-P3'), and the side chain of P2- Asn formed a hydrogen bond specifically with the side chain of Arg235. These are more favorable to the cleavage of Sub M by ${\beta}$-secretase than Sub W. The two substrate peptides showed different tendency to bind to ${\beta}$-secretase and this information may useful for drug development to treat and prevent Alzheimer's disease.

• 대한수의학회지
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• 제36권4호
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• pp.887-894
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• 1996

Cyclopiazonic acid(CPA) known as stimulating the release of intracellular calcium, aflatoxin $B_1(AFB_1)$ causing gastrointestinal hemorrhage frequently were used as model toxic mycotoxins in these studies. First of all, the effects of various mycotoxins on the platelet aggregation response were determined. The effects of mycotoxins on the ATP release from platelet by aggregating factors were investigated. The results and conclusions obtained from these studies are : 1) CPA promoted ADP, collagen, thrombin, A.A. and PAF-induced rabbit platelet aggregation. $AFB_1$ inhibited collagen, A.A. and PAF-induced rabbit platelet aggregation only. 2) CPA increased both aggregation and disaggregation time, whereas $AFB_1$ decreased in a dose dependent manner. 3) CPA increased ADP, thrombin, A.A. and PAF-induced ATP release. $AFB_1$ increased A.A.-induced ATP release and decreased PAF-induced release in a dose dependent manner. In conclusion, CPA promoted platelet aggregation by the increase of ATP. Antiaggregating effects of AFB1 may be due to decreases of ATP. These data provide the basis for the future study of roles of ATP release in platelet aggregation.

• Bulletin of the Korean Chemical Society
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• 제26권4호
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• pp.585-588
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• 2005

Bipyridine and its derivatives have been widely used as the ligands in transition metal complexes. The proton affinities of pyridine derivatives were calculated using an ab initio quantum mechanical method (B3LYP with various double zeta and triple zeta basis sets) in combination with the Poisson-Boltzmann continuum solvation model. Van der Waals radii of the atoms in the heterocyclic rings for the solvation energy calculation were set to values determined to reproduce the $pK_a$ values of guanine and oxoguanine derivatives and that of chlorine was optimized to reproduce the experimental values of relating compounds. The $pK_a$ values for the heterocyclic ring compounds were in agreement with the experimental values with a mean unsigned error of 0.45 $pK_a$ units.

• Transactions on Electrical and Electronic Materials
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• 제4권5호
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• pp.33-37
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• 2003

This study was performed to investigate the deposition mechanism of SiO$_2$ by ArF excimer laser(l93nm) CVD with Si$_2$H$\_$6/ and N$_2$O gas mixture and evaluate laser CVD quantitatively by modeling. With ArF excimer laser CVD, thin films can be deposited at low temperature(below 300$^{\circ}C$), with less damage and good uniformity owing to generation of conformal reaction species by singular wavelength of the laser beam. In this study, new model of SiO$_2$ deposition process by laser CVD was introduced and deposition rate was simulated by computer with the basis on this modeling. And simulation results were compared with experimental results measured at various conditions such as reaction gas ratio, chamber pressure, substrate temperature and laser beam intensity.

• Educational Technology International
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• 제11권1호
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• pp.27-46
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• 2010

The purpose of this paper is to apply the newly developed SICAT teaching and learning model to the actual scene of teaching and learning and draw a point of discussion for utilizing teaching and learning model, by uncovering the satisfaction of students and the inhibiting/facilitating elements when using the model. SICAT(Scientific Inquiry and Creative Activity with Technology; from here on SICAT), a teaching and learning model custom-built for engineering education, was developed, as more and more people paid attention to the demand for creative engineers. It was developed from the basis of PBL(Problem Based Learning), includes three sub-types which can be applied to the actual theory, design, and experimentation fields within engineering education. The three sub-types, which are ARDA(Analysis-Reasoning Activity & Discussion-Argumentation Activity), CoCD (Collaboration Activity & Capstone Design Activity), and ReSh(Reflection Activity & Sharing Activity), respectively support deductive and argumentation activities, creative design and collaboration activities, and retrospection and sharing activities. However, no research has been conducted to investigate whether or not there are inhibiting or facilitating elements in the application procedure, or what the rate of satisfaction for students is, when applying the SICAT model, which was newly developed to innovate existing engineering education, to the actual site of teaching and learning. Therefore, this research applied three types of SICAT teaching and learning models to the theory, design, and experimentation classes at the department of materials science and engineering at Hanyang University for eight weeks. After application, the students, teachers and tutors were surveyed and interviewed, and then the results analyzed in order to uncover inhibiting/facilitating elements and the rate of satisfaction. The satisfaction rate of students from the SICAT teaching and learning model was 3.78(in a perfect score of 5: The A type-3.65, The C type-3.80, The R type-3.90), and inhibiting/facilitating elements were drawn from the aspects of learning activities, support system. In conclusion, they can be contributed for implications of SICAT teaching and learning model universal use at engineering education in University.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년도 제37회 하계학술대회 논문집 D
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• pp.1858-1859
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• 2006

This paper presents a new fuzzy-neural-network based interacting multiple model (FNNBIMM) algorithm for tracking a maneuvering target. To effectively handle the unknown target acceleration, this paper regards it as additional noise, time-varying variance to target model. Each sub model characterized by the variance of the overall process noise, which is obtained on the basis of each acceleration interval. Since it is hard to approximate this time-varying variance adaptively owing to the unknown acceleration, the FNN is utilized to precisely approximate this time-varying variance. The gradient descendant method is utilized to optimize each FNN. To show the feasibility of the proposed algorithm, a numerical example is provided.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2001년도 추계학술대회 논문집
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• pp.251-254
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• 2001

In this paper, the effect of grain refinement on room temperature ductility of copper was addressed. Recent experimental results have shown that this material, as well as a number of other single-phase metals that are ductile when coarse-grained, loose their ductility with decreasing grain size in the sub micrometer range. A recently developed model in which such materials are considered as effectively two-phase ones (with the grain boundaries treated as a linearly viscous second phase) was applied to analyze stability of Cu against ductile necking. As a basis, Hart's stability analysis that accounts for strain rate sensitivity effects was used. The results confirm the observed trend for reduction of ductility with decreasing grain size. The model can be applied to predicting the grain size dependence of ductility of other metallic materials as well.

• 한국지진공학회:학술대회논문집
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• 한국지진공학회 1998년도 추계 학술발표회 논문집 Proceedings of EESK Conference-Spring 1998
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• pp.335-342
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• 1998

A soil-structure interaction (SSI) experiment is being conducted in a seismically active region in Hualien, Taiwan. To obtain earthquake data for quantifying SSI effects and providing a basis to benchmark analysis methods, a 1/4-th scale cylindrical concrete containment model similar in shape to that of a nuclear power plant containment was constructed in the field where both the containment model and its surrounding soil, surface and sub-surface, are extensively instrumented to record earthquake data. In between September 1993 and May 1996, fifteen earthquakes with Richter magnitudes ranging from 4.2 to 6.2 were recorded. The recorded data were analyzed to provide information on the response characteristics of the Hualien soil-structure system, the SSI effects and the ground motion characteristics. The ground response data were analyzed for their variations with depth, with distance from the model structure, and at the same depths along downhole arrays. Variations of soil stiffness and soil-structure system frequencies were also evaluated against maximum ground motion. In addition, the site soil properties were derived based on correlation analysis of the recorded data and then correlated with those from the geotechnical investigation data.

• 대한토목학회논문집
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• 제39권6호
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• pp.725-733
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• 2019

샌드댐(Sand dam)은 계곡하천을 가로지르는 보에 의해 모래가 쌓이고 그 공극속으로 계곡수가 저장되어 수위가 높아지면서 가뭄때 보조 수자원으로 활용토록 하는 구조물이다. 주로 아프리카 지역 등 건조지역에서 활용되는 이 구조물은 우리나라에는 설치된 사례가 없으며 계곡토석류를 방지하는 일부 사방댐에서 취수를 하는 경우는 찾아볼 수 있다. 본 연구에서는 춘천 서상리 계곡부를 대상으로 기존 취수보 하류부에 샌드댐을 설치하였을 때 물공급 효과를 평가하고자 한다. 이를 위해 유역수문모형과 저수지 추적 모형을 연계한 모델링을 수행하였으며 샌드댐의 규모와 취수량 등에 따른 댐체 내의 수위, 저류량, 방류량의 변화를 케이스별로 제시하였다. 적용 결과 샌드댐 설치로 인한 물공급 능력이 95% 신뢰도에서 제고되는 것을 알 수 있었다. 특히 하루 50톤의 물공급을 목표로 하였을 경우 L × B × H_o = 25 m × 15 m × 1 m 규모로 설치하고, 상류 취수보와 하류 샌드댐 취수량을 (Q₁, Q₂) = (30, 20), (35, 15) ㎥/day로 운영할 때가 가장 효율적인 것으로 나타났다.