• Advances in Traditional Medicine
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• v.9 no.2
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• pp.186-191
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• 2009

Eriocaulon sieboldianum (ES) is used in traditional oriental medicine for various medicinal purposes including headache, toothache, and inflammation. However, the anti-cancer effect of the ES is still not fully understood. In the present study, the human leukemia cell line HL-60 was used to characterize the apoptotic effects of ES. ES induced cytotoxicity of HL-60 cells in a dose- and time-dependent manner. ES induced the generation of reactive oxygen species, and the release of cytochrome c in a dose-dependent manner. In addition, we showed that ES-induced apoptosis was accompanied by activation of caspase-3. Taken together, our results demonstrate that ES possesses anti-cancer activity in HL-60 cells.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.41 no.9
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• pp.17-28
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• 2004

Since the Internet has grown into a large communication infrastructure, the network management system to systematically manage the large number of network components has become an essential part of the Internet. The rapid growth of network size has brought into question the scalability of the existing centralized model, such as SNMP (Simple Network Management Protocol) and CMIP (Common Management Information Protocol). Thus, for efficient network management, researches about mobile agent have also been performed recently. This paper presents analytical models of centralized approach based on SNMP protocol, distributed approach based on mobile agent, and mixed mode to make up for shortcomings of SNMP and mobile agent. We compare the performance of these analytical models based on network management response time. Experiment results show that performance of mobile agent and the mixed mode is less sensitive to the delay in WAN network environment. However, SNMP is more efficient for the simple network environment like LAN.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.28 no.5
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• pp.543-551
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• 2015

Polyurethane Foam(PUF), a outstanding thermal insulation material, is used for various structures as being composed with other materials. These days, PUF composed with glass fiber, Reinforced PUF(R-PUF), is used for a insulation system of LNG Carrier and performs function of not only the thermal insulation but also a structural member for compressive loads like a sloshing load. As PUF is a porous material made by mixing and foaming, mechanical properties depend on volume fraction of voids which is a dominant parameter on density. Thus, In this study, density is considered as the effect parameter on mechanical properties of Polyurethane Foam, and mechanical behavior for compression of the material is described by using modified Gurson damage model.

• Journal of Radiation Protection and Research
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• v.32 no.2
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• pp.71-78
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• 2007

The purpose of this study is to analyze the social behavior, especially, the evacuation-related social behavior, of the transients in the radiological emergency planning zone(EPZ) of nuclear power plants. So, the meaning and kinds of the evacuation and the significance of the trip generation time(TGT) have been reviewed. The characteristics of the social behavior of the transient around Ulchin, Wolsong and Kori sites was analyzed through field surveys by using the questionnaire. The major findings of this research implications are as follows. First, for securing the safe evacuation, the alternatives to effectively provide the information on the evacuation warning may be prepared. Second, it is necessary to establish the education and training of transient's evacuation. Third, it is needed that the cause and background of the evacuation refusal are identified and the new response plan to secure transient's safety is prepared.

• Journal of Ginseng Research
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• v.41 no.3
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• pp.277-283
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• 2017

Background: The ginseng berry has various bioactivities, including antidiabetic, anticancer, antiinflammatory, and antioxidative properties. Moreover, we have revealed that the active antiaging component of the ginseng berry, syringaresinol, has the ability to stimulate longevity via gene activation. Despite the many known beneficial effects of ginseng, its effects on skin aging are poorly understood. In this study, we investigated the effects of ginseng and the ginseng berry on one of the skin aging processes, melanogenesis, and age-related pigment lipofuscin accumulation, to elucidate the mechanism of action with respect to antiaging. Methods: The human melanoma MNT1 cell line was treated with ginseng root extract, ginseng berry extract, or syringaresinol. Then, the cells were analyzed using a melanin assay, and the tyrosinase activity was estimated. The Caenorhabditis elegans wild type N2 strain was used for the life span assay to analyze the antiaging effects of the samples. A lipofuscin fluorescence assay was performed during 10 passages with the syringaresinol treatment. Results: A 7-d treatment with ginseng berry extract reduced melanin accumulation and tyrosinase activity more than ginseng root extract. These results may be due to the active compound of the ginseng berry, syringaresinol. The antimelanogenic activity was strongly coordinated with the activation of the longevity gene foxo3a. Moreover, the ginseng berry extract had more potent antiaging effects, caused a life span extension, and reduced lipofuscin accumulation. Conclusion: Taken together, our results suggest that these antimelanogenic effects and antiaging effects of ginseng berry mediate the activation of antioxidation-FoxO3a signaling.

• Food Science and Biotechnology
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• v.16 no.1
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• pp.116-122
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• 2007

Four compounds with antioxidant activity were isolated from the MeOH extract of peanut shells (pod) and identified as 5,7-dihydroxychromone (1), eriodictyol (2), 3',4',7-trihydroxyflavanone (3), and luteolin (4) by electron impact-mass spectrometry (EI-MS) and nuclear magnetic resonance (NMR) analyses. The relationship between antioxidant activity and chemical structure of the isolated compounds with their analogues [(-)-epicatechin, quercetin, taxifolin] was examined by measuring 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity and using the 2-deoxy-D-ribose degradation system. The order of antioxidant activity on the basis of DPPH radical-scavenging was quercetin = (-)-epicatechin (6.0 molecules) > taxifolin (4,5 molecules) > 4 (luteolin; 4.0 molecules) > 2 (eriodictyol; 2.5 molecules) > 3 (3',4',7-trihydroxy-flavanone; 2.0 molecules) > 1 (5,7-dihydroxychromone; 0.5 molecules). On the other hand, using the 2-deoxy-D-ribose degradation system, the order of antioxidant activity was quercetin > 4 >> (-)-epicatechin ${\geq}\;2\;{\geq}$ taxifolin > 3 > 1. These compounds from peanut shells may provide defensive measures against oxidative stress and insects in the soil.

• Journal of Life Science
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• v.16 no.7 s.80
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• pp.1195-1198
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• 2006

The importance of wild plant resources along with the development of high biotecyhnology is highlighted for exploitation of new materials which can make the added value. The goal of this study is providing fundamental data bases for developing new materials through the analyses of morphological characteristics, antibiotics and molecular cytogenetics in Baegseon (Dictamnus dasycarpus Turcz.). Baegseon has several characteristics; there are two types of flower color, pink and white, the seed germination starts about February 20th, the maximum flowering season is around May 17th in southern Korea, the growth period is about 60 days. The number of chromosomes are 2n=2x=36, the size of chromosomes in metaphase is $4.2{\sim}8.1{\mu}m$. The amount of 2C nuclear DNA is 1.93pg, and there is no variation of genome size amoung varieties. The extraction juice of baegseon young roots has the excellent antibiotic activity against the mold (Botrytis cinerea).

• Molecules and Cells
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• v.22 no.3
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• pp.353-359
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• 2006

The bone morphogenetic protein (BMP) family has been implicated in control of cartilage development. Here, we demonstrate that BMP-2 promotes chondrogenesis by activating p38 mitogen-activated protein kinase (MAPK), which in turn downregulates $Wnt-7a/{\beta}$-catenin signaling responsible for proteasomal degradation of Sox9. Exposure of mesenchymal cells to BMP-2 resulted in upregulation of Sox9 protein and a concomitant decrease in the level of ${\beta}$-catenin protein and Wnt-7a signaling. In agreement with this, the interaction of Sox9 with ${\beta}$-catenin was inhibited in the presence of BMP-2. Inhibition of the p38 MAPK pathway using a dominant negative mutant led to sustained Wnt-7a signaling and decreased Sox9 expression, with consequent inhibition of precartilage condensation and chondrogenic differentiation. Moreover, overexpression of ${\beta}$-catenin caused degradation of Sox9 via the ubiquitin/26S proteasome pathway. Our results collectively indicate that the increase in Sox9 protein resulting from downregulation of ${\beta}$-catenin/Wnt-7a signaling is mediated by p38 MAPK during BMP-2 induced chondrogenesis in chick wing bud mesenchymal cells.

• Molecules and Cells
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• v.22 no.3
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• pp.300-307
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• 2006

Brassica rapa ssp. pekinensis (Chinese cabbage) is an economically important crop and a model plant for studies on polyploidization and phenotypic evolution. To gain an insight into the structure of the B. rapa genome we analyzed 12,017 BAC-end sequences for the presence of transposable elements (TEs), SSRs, centromeric satellite repeats and genes, and similarity to the closely related genome of Arabidopsis thaliana. TEs were estimated to occupy 14% of the genome, with 12.3% of the genome represented by retrotransposons. It was estimated that the B. rapa genome contains 43,000 genes, 1.6 times greater than the genome of A. thaliana. A number of centromeric satellite sequences, representing variations of a 176-bp consensus sequence, were identified. This sequence has undergone rapid evolution within the B. rapa genome and has diverged among the related species of Brassicaceae. A study of SSRs demonstrated a non-random distribution with a greater abundance within predicted intergenic regions. Our results provide an initial characterization of the genome of B. rapa and provide the basis for detailed analysis through whole-genome sequencing.

• Korean Journal of Construction Engineering and Management
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• v.8 no.4
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• pp.146-154
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• 2007

Recently, the construction wastes increase rapidly due to the revitalization of reconstruction and redevelopment, the development of new urbanization of large housing development, the expansion of social infrastructure, and so on. To solve rapid increase of construction waste, the government established "the rule on the promotion of recycling of construction waste" in December, 2003. According to the rule, construction wastes can be recycled by either processing on commission or discharger of construction waste. This study proved the validation of site recycling for construction waste as economic efficiency is analyzed through the case study of site recycling at large housing development district. Using the sensitivity analysis, factors affecting the cost of site recycling was analyzed and the break-even point for the cost of site recycling was estimated according to the factors.