• Translational and Clinical Pharmacology
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• v.26 no.4
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• pp.155-159
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• 2018

For regulatory approval of a new drug, the most preferred and reliable source of evidence would be randomized controlled trials (RCT). However, a great number of drugs, being developed as well as already marketed and being used, usually lack proper indications for children. It is imperative to develop properly evaluated drugs for children. And expanding the use of already approved drugs for other indications will benefit patients and the society. Nevertheless, to get an approval for expansion of indications, most often with off-label experiences, for drugs that have been approved or for the development of pediatric indications, either during or after completing the main drug development, conducting RCTs may not be the only, if not right, way to take. Extrapolation strategies and modelling & simulation for pediatric drug development are paving the road to the better approval scheme. Making the use of data sources other than RCT such as EHR and claims data in ways that improve the efficiency and validity of the results (e.g., randomized pragmatic trial and randomized registry trial) has been the topic of great interest all around the world. Regulatory authorities should adopt new methodologies for regulatory approval processes to adapt to the changes brought by increasing availability of big and real world data utilizing new tools of technological advancement.

• Journal of Korea Society of Digital Industry and Information Management
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• v.14 no.4
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• pp.177-187
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• 2018

The purpose of this study is to investigate the influence of learning flow, learning interest, and academic achievement by dividing the time when class was taught by Havruta. The Havruta teaching method is a traditional Jewish method of learning, with a one-on-one discussion with a partner that has a positive impact on each other. Havruta teaches learners through various perspectives and perspectives, helping them to improve their learning ability by attracting new ideas and solutions. In the computer lab, there is a big difference between the students according to the learner's abilities. Therefore, it is thought that the Havruta teaching method will help the learners who have lost interest in learning and improve the learning ability in the conventional way which does not consider personal abilities. do. In this paper, based on the friendship teaching model of the Havruta teaching style, the experimental group was taught through the Havruta practice and the play. Through the pre- and post-test, the students who taught the class with the help of the verbal method improved the learning flow, the learning interest and the academic achievement.

• International Journal of Aerospace System Engineering
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• v.5 no.2
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• pp.1-7
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• 2018

This study examines the history of Korean aviation industry and presents the investment strategy based on the evidence and the 4th industrial revolution. Looking at the evolution of the Korean aviation industry and its technological development will be a great help to support industrial and technological innovation in the future. The modern aviation industry is divided into stages of development, focusing on maintenance of equipment introduced in advanced countries, localization through license assembly, production of products based on technology, and international joint development. The development of aeronautics technology has been progressing towards a general improvement of economic efficiency, aircraft safety efficiency through environmental-friendliness, unmanned operation, and downsizing. The Korea Aerospace Research Institute has secured key technologies through development of several aircrafts such as Experimental Aircraft Kachi, EXPO Unmanned Airship, Twin-engine Composite Aircraft, Canard Aircraft, Multi-Purpose Stratosphere unmanned-airship, Medium Aerostats, Smart UAV, Surion, EAV-2H, KC-100, and OPV. The development strategy is discussed at the level of the evidence-based investment strategy that is currently being discussed, and so the investment priorities in aircraft is high. Current drone usage and development direction are not only producing parts using 3D printer, but also autonomous flight, communication (IoT, 5G), information processing (big data, machine learning). Therefore, the aviation industry is expected to lead the fourth industrial revolution.

• Korean Journal of Remote Sensing
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• v.35 no.1
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• pp.15-28
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• 2019

By applying the method of SAR interferometry to X-band synthetic aperture radar (SAR) image of COSMO-SkyMed, detailed motion patterns of five glaciers in the Parlung Zangbo River basin, Tibetan Plateau, in January 2010 have been derived. The results indicate that flow patterns are generally constrained by the valley geometry and terrain complexity. The maximum of $123.9ma^{-1}$ is observed on glacier No.1 and the minimum of $39.4ma^{-1}$ is found on glacier No.3. The mean values of five glaciers are between 22.9 and $98.2ma^{-1}$. Glaciers No.1, No.2, No.4 and No.5 exhibit high velocities in their upper sections with big slope and low velocities in the lower sections. A moraine lake accelerates the speed of mass exchange leading to a fast flow at the terminal of glacier No.3. These glaciers generally move along the direction of decreased elevation and present a macroscopic illustration of the motion from the northwest to the southeast. The accuracy of DEM and registration conditions of DEM-simulated terrain phases has certain effects on calculations of glacier flow direction and velocity. The error field is relatively fragmented in areas inconsistent with the main flow line of the glaciers, and the shape and uniformity of glacier are directly related to the continuous distribution of flow velocity errors.

• Journal of Power Electronics
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• v.19 no.4
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• pp.1054-1067
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• 2019

This paper systematically investigates the influence of device parameters spread on the current distribution of paralleled silicon carbide (SiC) MOSFETs. First, a variation coefficient is introduced and used as the evaluating norm for the parameters spread. Then a sample of 30 SiC MOSFET devices from the same batch of a well-known company is selected and tested under the same conditions as those on datasheet. It is found that there is big difference among parameters spread. Furthermore, comprehensive theoretical and simulation analyses are carried out to study the sensitivity of the current imbalance to variations of the device parameters. Based on the concept of the control variable method, the influence of each device parameter on the steady-state and transient current distributions of paralleled SiC MOSFETs are verified separately by experiments. Finally, some screening suggestions of devices or chips before parallel-connection are provided in terms of different applications and different driver configurations.

• The Journal of the Korea institute of electronic communication sciences
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• v.14 no.4
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• pp.781-786
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• 2019

We should give a realistic value on the large amounts of relevant data obtained from these studies to achieve effective objectives of the disease study which is dealing with various vital phenomenon today. In this paper, the proposed MKSV algorithm is estimated by optimal probability distribution, and the input pattern is determined. After classifying it into data mining, it is possible to obtain efficient computational quantity and recognition rate. MKSV algorithm is useful for studying the relationship between disease and gene in the present society by simulating the probabilistic flow of gene data and showing fast and effective performance improvement to classify data through the data mining process of big data.

• Korean Journal of Heritage: History & Science
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• v.34
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• pp.4-18
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• 2001

Paekche black potteries are earthenwares begun to be produced at the beginning of Paekche Dynasty, around 3-century. They have typical Paekche style. Representative Paekche earthenwares are burnished black pottery, long oval shaped pots and shoulder pots. Among these, burnished black potteries are limited to Paekche in the occurrence site and age. Their numbers are a few. To reproduce black pottery, their compositions were analyzed. As a result of X-Ray analysis, quarts, feldspar, illite, muscovite, and anorthite were found on their surfaces and imsides spinel and vermiculite were found on their surfaces. Since same constituent minerals were found on surfaces and their insides, special other materials were not added to make surface black. With the showing vermiculite, they were made higher than $800^{\circ}C$. As a result of analysis, fine grained clay bad been influenced by the black smoke. Its luster was appeared by polishing with a big flat wooden spoon. The black color was made of smoking when the hot pot taken off from burning oven was covered with the wet pine leaves.

• Toxicological Research
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• v.35 no.4
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• pp.331-341
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• 2019

Cancer is one of the common causes of death with a high degree of mortality, worldwide. In many types of cancers, if not all, sex-biased disparities have been observed. In these cancers, an individual's sex has been shown to be one of the crucial factors underlying the incidence and mortality of cancer. Accumulating evidence suggests that differentially expressed genes and proteins may contribute to sex-biased differences in male and female cancers. Therefore, identification of these molecular differences is important for early diagnosis of cancer, prediction of cancer prognosis, and determination of response to specific therapies. In the present review, we summarize the differentially expressed genes and proteins in several cancers including bladder, colorectal, liver, lung, and nonsmall cell lung cancers as well as renal clear cell carcinoma, and head and neck squamous cell carcinoma. The sex-biased molecular differences were identified via proteomics, genomics, and big data analysis. The identified molecules represent potential candidates as sex-specific cancer biomarkers. Our study provides molecular insights into the impact of sex on cancers, suggesting strategies for sex-biased therapy against certain types of cancers.

• Journal of The Korea Institute of Healthcare Architecture
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• v.25 no.2
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• pp.27-35
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• 2019

Purpose: This study is to address the spacial composition of a standard ward and bedroom size for sake of infection control and efficient medical service. Methods: Spacial composition of a standard ward has been proposed by comparative analysis of 5 big hospitals' wards. Bedroom sizes have been explored on the ground of Health care facility regulations from Korea, USA, Australia and Canada. Of course, Literature and field survey have been conducted in order to draw out various bedroom sizes. Results: 16 basic and some other additional spaces have been proposed for the composition of hospital standard ward. Area of Single bedroom is $11.6m^2$, and that of multi-beded room is $7.4m^2$. Bed to bed Clearance is 1.5m, spacing between bedsize and hard wall is 0.9m in 1~2 beded room, 0.75m in 4-beded room. Space clearance between Foot side of bed and curtain is proposed as 0.3m and additional 0.9m is necessary for the circulation. Implications: The result of this study can be applied to the new cons.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2019.05a
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• pp.500-501
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• 2019

In the $4^{th}$ generation industry, self-directed learning is very important than Injection learning. Therefore many educational institutions has developed method of self-directed learning. In order for self-directed learning to be effective, it is more important for faculty to manage the overall process of learning rather than being directly involved in the student's academic work. Therefore, learning counseling is an important way to effectively carry out self-directed learning. In this paper, we analyze the status of open data for natural language processing that can implement the learning consultation contents so that various applications can be done through natural language processing.