• Asian Pacific Journal of Cancer Prevention
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• v.15 no.3
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• pp.1241-1245
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• 2014

Cinobufacin is used clinically to treat patients with many solid malignant tumors. However, the mechanisms underlying action remain to be detailed. Our study focused on miRNAs involved in cinobufacin inhibition of GC cell proliferation. miRNA microarray analysis and real time PCR identified miR-494 as a significant cinobufacin-associated miRNA. In vivo, ectopic expression of miR-494 inhibited the proliferation and induced apoptosis of BGC-823 cells on CCK-8 and flow cytometry analysis. Further study verified BAG-1 (anti-apoptosis gene) to bea target of miR-494 by luciferase reporter assay and Western blotting. In summary, our study demonstrated that cinobufacin may inhibit the proliferation and promote the apoptosis of BGC-823 cells. Cinobufacin-associated miR-494 may indirectly be involved in cell proliferation and apoptosis by targeting BAG-1, pointing to use as a potential molecular target of cinobufacin in gastric cancer therapy.

• Microbiology and Biotechnology Letters
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• v.52 no.1
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• pp.55-64
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• 2024

The desire of modern people to maintain a healthy and beautiful appearance is increasing day by day along with the increasing interest in skin health and the demand for functional cosmetics. Accordingly, research on functional cosmetic materials with few side effects and excellent efficacy is being actively conducted. Therefore, this study tried to verify the antioxidant and whitening effects of the mixed extracts of Bixa orellana, Ammi majus, and Glycyrrhiza glabra, whose efficacy has been individually verified. Extracts (BAG-1~4) with different extraction methods such as steaming, fermentation, and ultrasonication were prepared for 3 types of natural plants, and antioxidant and whitening effects of these extracts were confirmed. For this purpose, antioxidant, tyrosinase activity, melanin production and stability experiments were conducted. Extracts (BAG-1~4) had no cytotoxicity, and antioxidant and whitening effects were confirmed. BAG-4 extracted by steaming and fermentation showed the best efficacy. It seems that enzymes such as lipase, protease, and amylase increase phenol components by various yeasts involved in the fermentation process, thereby improving antioxidant and melanin production inhibitory effects. It was confirmed that the three types of natural plant extracts could be used as safe and functional cosmetic materials.

• Journal of the korean Society of Automotive Engineers
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• v.13 no.5
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• pp.1-12
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• 1991

선진국에서 승용차의 에어백 장착이 의무화되기 시작하면서 저렴하고 성능이 우수한 에어백의 국산화 개발이 시급하게 되었다. 에어백 장착시 대당 $300-$1000이 추가로 소요되므로, 전량 수입에 의존하는 대신에 저렴한 국산 에어백의 필요성이 심각하다 하겠다. 지금까지는 국내 자동차 업계에서의 에어백에 대한 관심이 높지 않으나 앞으로는 이에 대한 연구개발이 시급한 실정이다. 본 연구에서는 에어백 개발에 있어서 중요한 기본 기술에 대한 survey가 행하여지며, 앞으로 산업체 등에서 제품 개발시 실질적인 도움을 줄수 있을 것으로 생각한다.

• Journal of Mushroom
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• v.10 no.4
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• pp.179-183
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• 2012

This study was conducted to determine proper amount of media and the effect of fermented sawdust on yield of Grifola frondosa in bag culture. The yield of Grifola frondosa was 227 g for 2 kg of media compared with 103 g for 1kg, 256 g for 2.5 kg, and 312 g for 3 kg. The greatest yield of Grifola frondosa per mass of media was 114 g/kg media for 2 kg of media. Days to harvest for 2 kg of media was 95 days compared with 93 days for 1kg, 99 days for 2.5kg, and 104 days for 3kg. Addition of fermented oak sawdust increased yield from 90 to 145 g/kg bag for Hambak cultivar and from 104 to 121 g/kg bag for Yipsae1ho cultivar. Culture duration was shorten 4-7 days by treating fermented oak sawdust.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.3
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• pp.2012-2019
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• 2015

This study examined the changes in the center of pressure (COP) and cadence according to three types of bags carried and three different bag weights. The experimental period was from June 3, 2013 to January 20, 2014, and thirty eight healthy adults (mean age: $26.10{\pm}5.32$ years, age range: 22-30 years) volunteered under three conditions. In the first condition, the subjects wore a bag over one shoulder and they walked. In the second condition, they carried a bag across the shoulder and walked. With the third condition, they carried a backpack using both shoulders and walked. 3-Dimentional motion analysis system and a force plate were used to measure the kinematic parameters of gait and COP displacement during gait. Each subject walked 6 meters carrying a 3kg, 5kg and 7kg bag under all three conditions. The COP of the antero-posterior and medio-lateral, and cadence variable were significantly different according to the bag weight of 3kg, 5kg and 7kg. These findings suggest that walking while carrying a backpack using both shoulders is more effective on the changes in COP and gait of adults than the other conditions.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.26 no.3
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• pp.230-236
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• 1990

To examine the behavior of yellow tail Seriola quinqueradiata and of file fish Navodon modestus to set net, the 1/30 scale model net of the actual set net used in the east coast of Korea was made of netting and set in the indoor experimental tank(700cm W$\times$700cm L$\times$100cm D), of which the water depth was kept 70cm. Total length of yellow tail examined were 37~45cm and file fish were 18~21cm. The fishes were released as groups of 3 to 20 individuals. The number of fish entered into the pound net or the bag net, escaped from the net was counted every minute and accumulated for 10minutes to check the ratio entered and the ratio escaped. The result obtained can be summarized as follows: 1. In case of yellow tail, even though the ratio entered into the pound net was not so high, that into the bag net was comparatively high. Traces of the fish swimming were comparatively smooth and both entering into the pound net and escaping from it was easily done. 2. In case of file fish, even though the ratio entered into the pound net was higher than that of yellow tail, that into the bag net was lower than that into the pound net. Traces of the fish swimming were roundly meandered. Entering into the bag net was not so smoothly done, even though that into the playground was smoothly done. 3. Both yellow tail and file fish, the ratio escaped from the bag net was almost0 and that from the pound net was less than 10%.

• Journal of Korean Society for Atmospheric Environment
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• v.31 no.1
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• pp.54-62
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• 2015

Small scale paint overspray booths are being operated nationwidely, for repair of passenger car body parts. paint aerosols are emitted from the paint overspray booth in operations. In paint overspray booth operations without ventilation system and air pollutants collection unit, it may land on nearby equipment. In this study a removal of sticky paint aerosol for application of the small-scale overspray paint booth. it's cause the surface of filter bag from generated sticky paint aerosol. To remove adhesion of paint aerosol the agglomerating agents are injected and mixed with sticky paint aerosols prior to reach the filter bag. The paint spray rate was set as $10{\pm}5g/min$ from air-atomized spray guns in the spray booth, injection rate of agglomerating was $10{\pm}5g/min$ in the mixing chamber. The filtration velocity including air pollutants varied from 0.2 m/min to 0.4 m/min. Bag cleaning air pressure was set as $5.0kg_f/min$ for detaching dust cake from surface of filter bag. Bag cleaning interval at the filtration velocity of 0.2 m/min was around 3 times longer than that of the 0.4 m/min. The residual pressure drop maintained highest value at the highest filtration velocity. Fractional efficiency of 99.952%~99.971% was possible to maintain for the particle size of 2.5 microns. Total collection efficiency at the filtration velocity of 0.2 m/min was 99.42%. During this study we could confirm high collection efficiency and long cleaning intervals for the test with filtration velocity of 0.2 m/min indicating an optimal value for the given dimensions of the test unit and test operating conditions.

• Journal of Trauma and Injury
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• v.26 no.4
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• pp.255-260
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• 2013

Purpose: For the treat hypothermia patients, active warming might be needed. In most emergency departments, IV warm saline infusion is used for treatments. However, during IV warm saline infusion, heat loss from the warm saline may occur and aggravate hypothermia. Thus, in this study, we conducted an experiment on conserving heat loss from warm saline by using a simple method. Methods: Four insulation methods were used for this study. 1) wrapping the set tube for the administration of the IV fluid with a cotton bandage, 2) wrapping the set tube for the administration of the IV fluid with a cotton bandage with aluminum foil, 3) wrapping the warm saline bag and tube with a cotton bandage, and 4) wrapping the warm saline bag and tube with a cotton bandage with aluminum foil. Intravenous fluid was preheated to a temperature between $38-40^{\circ}C$. The temperatures of the saline bag temperature and the distal end of the IV administration set were measured every ten minutes for an hour. The infusion rate was 1000 cc/hr, and to obtain an accurate infusion rate, we used an infusion pump. Results: The mean initial temperature of the saline bag was $39.11^{\circ}C$. An hour later, the fluid temperature at the distal end of the fluid temperature ranged from $39.11^{\circ}C$ to $34.3^{\circ}C$. Without any insulation, the initial temperature of the pre-heated warm saline, $39^{\circ}$ had decreased to $34.8^{\circ}C$ after having been run through the 170-cm-long IV administration tube, and after 1-hour, the temperature was $29.63^{\circ}C$. As we expected, heat loss was prevented most by wrapping both the saline bag and the IV administration set with a cotton bandage and aluminum foil. Conclusion: Wrapping both the saline bag and the IV administration set with a cotton bandage and aluminum foil can prevent heat loss during IV infusion in Emergency departments.

• Journal of Korean Society for Quality Management
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• v.42 no.3
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• pp.291-300
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• 2014

Purpose: The purpose of this study is to provide a statistical method from the data of ASRP's results and to apply to the reliability assessment of 155mm propelling charge, KM4A2. Methods: The accumulated data through ASRP for 155mm propelling charge were analyzed using regression analysis and MINITAB reliability analysis. The analysis methods used for this study were applied to statistical data types such as continuous data, binominal data. Results: The results of this study are as follows; The failure of 155mm propelling charge is mainly due to the broken charge bag, the decline of stabilizer content. The shelf-life(B5) regarding broken charge bag is 21.1years. The stabilizer content decrease with 0.0227%/year and safety storage period of propellant is 34.6years. Conclusion: The shelf-life of 155mm propelling charge determined by charge bag is estimated 21.1years.

• Journal of Korean Society for Atmospheric Environment
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• v.14 no.3
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• pp.237-250
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• 1998

In this study, the characteristics of electrostatic bag filter to overcome the main problems such as the high pressure drop and low collection efficiency for submicron particles are investigated with the experimental parameters. Especially, the experiment is carried out focusing on collection efficiency and pressure drop change mechanism as a function of discharge electrode shapes and filter properties, including the applied voltages, filtration velocities and particle concentrations, etc . Results show that the collection efficiency is improved over 30% for the fine particle below 1 pm and pressure drop reduction ratio (PDRR) increases in the following order 4 mm screwy > 4 mm square > 4mm round discharge electrodes . For the filter properties, Nomex is more effective than PE under the influence of electrostatic force. Applying 30 kV for a screwy discharge electrode, higher overall collection efficiency is maintained in spite of the increment of filtration velocity over four times (8 m/min) in comparison with that of 2 m/min and PDRR are highly shown over 80o1o with various filtration velocities, 5, 8, 11 m/min.