• Asian Pacific Journal of Cancer Prevention
• /
• 제15권3호
• /
• pp.1241-1245
• /
• 2014

Cinobufacin is used clinically to treat patients with many solid malignant tumors. However, the mechanisms underlying action remain to be detailed. Our study focused on miRNAs involved in cinobufacin inhibition of GC cell proliferation. miRNA microarray analysis and real time PCR identified miR-494 as a significant cinobufacin-associated miRNA. In vivo, ectopic expression of miR-494 inhibited the proliferation and induced apoptosis of BGC-823 cells on CCK-8 and flow cytometry analysis. Further study verified BAG-1 (anti-apoptosis gene) to bea target of miR-494 by luciferase reporter assay and Western blotting. In summary, our study demonstrated that cinobufacin may inhibit the proliferation and promote the apoptosis of BGC-823 cells. Cinobufacin-associated miR-494 may indirectly be involved in cell proliferation and apoptosis by targeting BAG-1, pointing to use as a potential molecular target of cinobufacin in gastric cancer therapy.

• 오토저널
• /
• 제13권5호
• /
• pp.1-12
• /
• 1991

선진국에서 승용차의 에어백 장착이 의무화되기 시작하면서 저렴하고 성능이 우수한 에어백의 국산화 개발이 시급하게 되었다. 에어백 장착시 대당 $300-$1000이 추가로 소요되므로, 전량 수입에 의존하는 대신에 저렴한 국산 에어백의 필요성이 심각하다 하겠다. 지금까지는 국내 자동차 업계에서의 에어백에 대한 관심이 높지 않으나 앞으로는 이에 대한 연구개발이 시급한 실정이다. 본 연구에서는 에어백 개발에 있어서 중요한 기본 기술에 대한 survey가 행하여지며, 앞으로 산업체 등에서 제품 개발시 실질적인 도움을 줄수 있을 것으로 생각한다.

• 한국버섯학회지
• /
• 제10권4호
• /
• pp.179-183
• /
• 2012

잎새버섯 적정 배지량 구명시험에서 배지량별 균사배양 소요일수는 1kg 30일, 2kg 39일, 2.5kg 42일 및 3kg 45일로서 배지량이 많을수록 배양일수가 늘어났고, 수확 소요일수 또한 93일에서 104일로 늘어났다. 수량에서는 1kg 봉지에서는 103.3g, 2kg 봉지 227.2g, 2.5kg 봉지 245.5g, 그리고 3kg 봉지 312.0g으로 배지량이 증가할수록 수량이 증가하였다. 잎새버섯 발효톱밥 첨가효과 구명시험에서 균사배양 소요일수는 발효톱밥을 첨가한 처리에서 4~7일 정도 빨랐고, 수량은 발효 참나무톱밥을 첨가한 처리에서 함박 1kg 봉지당 145.2g, 잎새1호 121.2g으로 가장 높게 나타났다. 발효활엽수 톱밥 첨가율에 따른 시험관칼럼배지를 이용한 균사생장속도조사에서는 발효활엽수 톱밥을 60%까지 증가시켰을 경우 생장속도가 점점 빨라졌으며, 80% 첨가에서는 다소 낮아지는 경향이었다.

• 한국산학기술학회논문지
• /
• 제16권3호
• /
• pp.2012-2019
• /
• 2015

본 연구의 목적은 세 가지 가방 휴대 방법에 따라 세 가지 가방의 무게를 달리하여 보행하는 동안 신체의 압력중심점의 변위와 보행률의 변화를 분석하고자 2013년 6월 3일부터 2014년 1월 20일까지 시행하였다. 38명의 건강한 성인(평균 연령: $26.10{\pm}5.32$세, 연령 범위: 22-30세)이 본 연구에 참여하였다. 첫 번째 조건은 한쪽 어깨에 가방을 메고 보행하였고, 두 번째 조건은 한쪽으로 가로질러 가방을 메고 걸었으며, 세 번째 조건은 양쪽 어깨에 가방을 메고 걸었다. 보행의 운동 형상학적 변수와 보행 시 압력중심점의 변위를 측정하기 위하여 3차원 동작분석기와 지면 반력기를 사용하였다. 각 세 가지 조건에 모든 대상자가 참가하였고, 모든 대상자는 각각 세 가지 조건에서 3kg, 5kg, 7kg의 무게를 지닌 가방을 휴대하여 6m를 걸었다. 본 연구 결과, 양쪽 어깨로 가방을 메고 걸을 때 3kg, 5kg, 7kg의 가방의 무게에 따라 전-후 및 내측-외측 방향의 압력중심점과 보행률 변수에서 통계학적으로 유의한 차이가 있었다. 따라서 양쪽 어깨에 가방을 메고 걷는 것이 다른 조건보다 더 효율적으로 보행할 수 있을 것으로 사료된다.

• 수산해양기술연구
• /
• 제26권3호
• /
• pp.230-236
• /
• 1990

정치망에 대한 방어와 쥐치의 행동을 분석하기 위하여 한국 동해안에서 보편적으로 쓰이는 낙망의 1/30크기의 모형정치망을 망지로서 제작하고, 이것을 수면조도 1 lux정도의 실내에 설치된 가로.세로 700cm, 깊이 100cm, 수심 70cm의 수조에 고정했다. 공시어는 정치망에서 어획된 전장 37~45cm짜리 방어와 18~21cm짜리 쥐치이며, 이것을 3~20마리씩 방류하여 통그물에의 입망수, 탈출수 등을 1분 간격으로 조사하고 10분간 누계하여 검토한 결과는 대략 다음과 같다. 1. 방어는 통그물 입망율은 그다지 크지 않으나 원통 입망율은 상당히 크다. 유영궤적은 비교적 원활하며, 입망도 잘하나 탈출도 잘하므로 정치망을 설계할 때는 입망하기가 다소 어렵더라도 탈출하기가 쉽지 않도록 하는 것이 유리할 것 같다. 2. 쥐치는 통그물 입망률은 방어보다 크나 원통입망률은 매우 낮다. 유영궤적은 원활하지 않고 꼬불꼬불 원형으로 맴돌면서 전진하므로 입구가 넓은 헛통에는 잘 입망하나 원통에는 잘 입망하지 않는 것 같다. 따라서 쥐치를 주대상으로 하는 정치망을 설계할 때는 특히 등망부분을 조금 넓게 하여 군이 맴도는데 지장이 없도록 해주는 것이 유리할 것 같다. 3. 방어나 쥐치의 어느 경우에도 원통탈출율은 거의 0이고 헛통탈출율도 거의 10% 이하여서 낙망이 상당히 효과적인 어구임을 보여주고 있다.

• 한국대기환경학회지
• /
• 제31권1호
• /
• pp.54-62
• /
• 2015

Small scale paint overspray booths are being operated nationwidely, for repair of passenger car body parts. paint aerosols are emitted from the paint overspray booth in operations. In paint overspray booth operations without ventilation system and air pollutants collection unit, it may land on nearby equipment. In this study a removal of sticky paint aerosol for application of the small-scale overspray paint booth. it's cause the surface of filter bag from generated sticky paint aerosol. To remove adhesion of paint aerosol the agglomerating agents are injected and mixed with sticky paint aerosols prior to reach the filter bag. The paint spray rate was set as $10{\pm}5g/min$ from air-atomized spray guns in the spray booth, injection rate of agglomerating was $10{\pm}5g/min$ in the mixing chamber. The filtration velocity including air pollutants varied from 0.2 m/min to 0.4 m/min. Bag cleaning air pressure was set as $5.0kg_f/min$ for detaching dust cake from surface of filter bag. Bag cleaning interval at the filtration velocity of 0.2 m/min was around 3 times longer than that of the 0.4 m/min. The residual pressure drop maintained highest value at the highest filtration velocity. Fractional efficiency of 99.952%~99.971% was possible to maintain for the particle size of 2.5 microns. Total collection efficiency at the filtration velocity of 0.2 m/min was 99.42%. During this study we could confirm high collection efficiency and long cleaning intervals for the test with filtration velocity of 0.2 m/min indicating an optimal value for the given dimensions of the test unit and test operating conditions.

• Journal of Trauma and Injury
• /
• 제26권4호
• /
• pp.255-260
• /
• 2013

Purpose: For the treat hypothermia patients, active warming might be needed. In most emergency departments, IV warm saline infusion is used for treatments. However, during IV warm saline infusion, heat loss from the warm saline may occur and aggravate hypothermia. Thus, in this study, we conducted an experiment on conserving heat loss from warm saline by using a simple method. Methods: Four insulation methods were used for this study. 1) wrapping the set tube for the administration of the IV fluid with a cotton bandage, 2) wrapping the set tube for the administration of the IV fluid with a cotton bandage with aluminum foil, 3) wrapping the warm saline bag and tube with a cotton bandage, and 4) wrapping the warm saline bag and tube with a cotton bandage with aluminum foil. Intravenous fluid was preheated to a temperature between $38-40^{\circ}C$. The temperatures of the saline bag temperature and the distal end of the IV administration set were measured every ten minutes for an hour. The infusion rate was 1000 cc/hr, and to obtain an accurate infusion rate, we used an infusion pump. Results: The mean initial temperature of the saline bag was $39.11^{\circ}C$. An hour later, the fluid temperature at the distal end of the fluid temperature ranged from $39.11^{\circ}C$ to $34.3^{\circ}C$. Without any insulation, the initial temperature of the pre-heated warm saline, $39^{\circ}$ had decreased to $34.8^{\circ}C$ after having been run through the 170-cm-long IV administration tube, and after 1-hour, the temperature was $29.63^{\circ}C$. As we expected, heat loss was prevented most by wrapping both the saline bag and the IV administration set with a cotton bandage and aluminum foil. Conclusion: Wrapping both the saline bag and the IV administration set with a cotton bandage and aluminum foil can prevent heat loss during IV infusion in Emergency departments.

• 품질경영학회지
• /
• 제42권3호
• /
• pp.291-300
• /
• 2014

Purpose: The purpose of this study is to provide a statistical method from the data of ASRP's results and to apply to the reliability assessment of 155mm propelling charge, KM4A2. Methods: The accumulated data through ASRP for 155mm propelling charge were analyzed using regression analysis and MINITAB reliability analysis. The analysis methods used for this study were applied to statistical data types such as continuous data, binominal data. Results: The results of this study are as follows; The failure of 155mm propelling charge is mainly due to the broken charge bag, the decline of stabilizer content. The shelf-life(B5) regarding broken charge bag is 21.1years. The stabilizer content decrease with 0.0227%/year and safety storage period of propellant is 34.6years. Conclusion: The shelf-life of 155mm propelling charge determined by charge bag is estimated 21.1years.

• 한국대기환경학회지
• /
• 제14권3호
• /
• pp.237-250
• /
• 1998

In this study, the characteristics of electrostatic bag filter to overcome the main problems such as the high pressure drop and low collection efficiency for submicron particles are investigated with the experimental parameters. Especially, the experiment is carried out focusing on collection efficiency and pressure drop change mechanism as a function of discharge electrode shapes and filter properties, including the applied voltages, filtration velocities and particle concentrations, etc . Results show that the collection efficiency is improved over 30% for the fine particle below 1 pm and pressure drop reduction ratio (PDRR) increases in the following order 4 mm screwy > 4 mm square > 4mm round discharge electrodes . For the filter properties, Nomex is more effective than PE under the influence of electrostatic force. Applying 30 kV for a screwy discharge electrode, higher overall collection efficiency is maintained in spite of the increment of filtration velocity over four times (8 m/min) in comparison with that of 2 m/min and PDRR are highly shown over 80o1o with various filtration velocities, 5, 8, 11 m/min.

• 한국응급구조학회지
• /
• 제22권1호
• /
• pp.73-82
• /
• 2018

Purpose: The purpose of this study was to compare the tidal volumes and airway pressures of 3 mask-sealing methods (one hand C-E, two hands C-E, and one hand O-E) for ventilation treatment. Methods: The study subjects were 45 paramedic students. Tidal volume was measured for the three sealing methods by setting a ventilator, connecting it to the masks for 2 minutes, and using Respi-trainer software. Results: Regarding general characteristics, the group of men, in upper grades, and with practical training experience and experience and experience in the implementation of bag-valve-mask ventilation provided higher tidal volumes. Regarding physical characteristics, larger hands and greater grip strength correlated with higher tidal volume. Two hands C-E generated the highest tidal volume of $483.78{\pm}34.14mL$, one hand O-E generated $449.59{\pm}51.09mL$ and one hand C-E generated $394.31{\pm}68.95mL$. Conclusion: Means of tidal volumes were statistically significantly different based on mask sealing methods (p<.001). Two hand C-E was performed by the two-persons task and was suggested as the most effective method. For the one-person task, one hand O-E was the more effective method compared to the previous one hand C-E.