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Antiviral effect of 18-mer-peptide (1b-4/21-C12) on Japanese encephalitis virus and Akabane virus

  • Yang, Dong-Kun;Park, Yu-Ri;Kwon, Young Do;Kim, Ha-Hyun;Hyun, Bang-Hun
    • Korean Journal of Veterinary Research
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    • v.62 no.3
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    • pp.19.1-19.6
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    • 2022
  • Japanese encephalitis virus (JEV) and Akabane virus (AKAV) are mosquito-borne viruses that cause encephalitis and reproductive disorders in horses and cattle, respectively. There is no treatment for JEV or AKAV infections in animals. Therefore, we evaluated the antiviral activity of 18-mer amphipathic peptides in the 1b-4/21-C series on JEV and AKAV using Vero cells in vitro and evaluated their effects on JEV in mice. Of 6 peptides, 1b-4/21-C12 had the lowest IC50 of 0.313 against JEV and its use as an antiviral against JEV and AKAV was examined. The IC50 of 1b-4/21-C12 against JEV and AKAV was 0.78 and 1.14 µM, respectively. Mice treated with 5 or 2 mg/kg of 1b-4/21-C12 had 32% and 16% survival rates, respectively, and the surviving mice treated with 1b-4/21-C12 began to gain weight beginning 8 days post challenge with the virulent Nakayama strain. Moreover, 20 µM 1b-4/21-C peptide had no cytotoxic effects on Vero cells. Our in vitro and in vivo results indicate that 1b-4/21-C12 has antiviral activity against enveloped JEV and AKAV and might be useful as a therapeutic substance.

100GHz Spacing 16Cchannel Silica AWG Module (100GHz 간격 16 채널 실리카 AWG 모듈)

  • 김현수;정선태
    • Proceedings of the Optical Society of Korea Conference
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    • 1998.08a
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    • pp.152-153
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    • 1998
  • PLC 기술을 이용하여 16 채널 실리카 AWG 모듈을 제작하여 특성을 측정하였다. 입출력 광섬유간의 삽입손신은 3.77~6.55dB, 옆 채널간 crosstalk는 19dB, 채널 사이의 파장 간격은 0.8$\pm$0.02nm으로 측정되엇다. 온습도 주기 시험을 통하여 모듈의 신뢰성을 검증하였다.

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PERIODICITY AND ATTRACTIVITY FOR A RATIONAL RECURSIVE SEQUENCE

  • ZHANG LIJIE;ZHANG GUANG;LIU HUI
    • Journal of applied mathematics & informatics
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    • v.19 no.1_2
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    • pp.191-201
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    • 2005
  • In this paper, the existence of periodic positive solution and the attractivity are investigated for the rational recursive sequence $x_{n+1} = (A + ax_{n_k})/(b + x{n-l})$, where A, a and b are real numbers, k and l are nonnegative integer numbers.

일본 항공기산업의 국제협력

  • 한국항공우주산업진흥협회
    • Aerospace Industry
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    • v.18
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    • pp.13-19
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    • 1994
  • 전후 일본은 YS-11이라는 최초의 일본산 여객기를 만들어 여러나라에 판매한 실적이 있으나 중단했고 다시 YS-X라는 차세대 여객기 개발에 착수한 사실을 지난 6월호에 소개한 바 있으나 이 계획이 중단되었다는 설이 도는 것과 아울러 보잉사의 B-767, B-777 개발에 성공적으로 참여하고 다시 V-2500이라는 제트항공기 엔진의 공동개발을 추진중에 있어 우리에게는 결코 타산지석이 될수 없어 일본업계의 국제 공동개발현황을 요약해 보았다.

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Synthesis Problems of the Nonlinear Systems Via Dynamic Feedback (비선형 시스템의 Dynamic Feedback을 이용한 합성)

  • 이홍기;전홍태
    • Journal of the Korean Institute of Telematics and Electronics B
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    • v.28B no.12
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    • pp.19-26
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    • 1991
  • In this paper, we give a structure algorithm for the synthesis problems of the nonlinear system via dynamic feedback. Using our algorithm, sufficient conditions for the input-output synthesis problems are discussed. The problems we consider in this paper include dynamic input-output decoupling input-output linearization, and immersion into a linear system.

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패전후의 공백기와 업계재편과정 - 일본의 항공기사업(2)

  • 한국항공우주산업진흥협회
    • Aerospace Industry
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    • v.19
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    • pp.18-23
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    • 1994
  • 지난달에는 미국의 보잉사와 더불어 B767, B777 그리고 구미 4개국과 V2500엔진등에 대한 공동개발에 나선 일본의 항공기공업계의 국제협력을 분석한 바 있거니와 이달에는 전후의 공백기로부터 항공기공업계의 재편과정을 살펴보아 항공기산업의 성장 패턴 같은 것을 알아 보았다.

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A study on the magnetic domain behaviors of the Fe-(Ce-Didymium)-B alloys (Fe-(Ce-Didymium)-B계 영구자석의 자구거동에 관한 연구)

  • 김종오
    • Electrical & Electronic Materials
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    • v.5 no.2
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    • pp.216-223
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    • 1992
  • 큰 보자력(iHc=19,500 Oe)과 큰에너지적[(BH)$_{max}$=32.50MGOe]을 갖는 Fe-(Ce-Didymium)-B 소결자석의 자구를 Bitter법을 개량한 Colloed SEM 법으로 관찰하였다. C축면의 자구는 소자상태에서 3-4.mu.m의 폭을 갖는 Stripe형이고 C축에 평행한 면은 미로형이다.

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Changes of the Boron Fraction in Soil by the Boron Application (붕소시용(硼素施用)이 토양붕소(土壤硼素)의 형태별(形態別) 함량변화(含量變化)에 미치는 영향(影響))

  • Hwang, Ki-Sung;Yoon, Jung-Hui;Park, Yong-Dae;Ho, Qyo-Soon
    • Korean Journal of Soil Science and Fertilizer
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    • v.24 no.4
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    • pp.272-277
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    • 1991
  • To investigate changes of boron fractions in soil with vegetable cultivation affected by boron application Jossangmiho, chinese cabbage was planted in 1/2.000a pot with four different soils which are sandy loam, calcareous, organic and vinyl house soil. Increment of available boron in soil with different boron applications was in the order of vinyl hous soil>organic soil>sandy soil>calcareous soil. The ratio of boron fraction to total boron is highest in $NH_4$-oxalate ext.-B with 19.1 % and lowest in water sol.-B and $CaCl_2$ ext.-B with 0.7% respectively. The boron fraction increment due to the different application ratio was in the order of $NH_4-oxalate$ ext.-B>Mannitol exch.-B> $CaCl_2$ ext.-B> $NH_2OH{\cdpt}HCl$ ext.-B>Water soil.-B. As the concentration of calcium in soil increased. water sol.-B decreased and the other forms of boron increased. In the soil high in organic matter, water sol.-B and $NH_4$-oxalate ext.-B increased significantly. but the other forms of boron not.

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Proposal for a gingival shade guide based on in vivo spectrophotometric measurements

  • Polo, Cristina Gomez;Montero, Javier;Casado, Ana Maria Martin
    • The Journal of Advanced Prosthodontics
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    • v.11 no.5
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    • pp.239-246
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    • 2019
  • PURPOSE. The purpose of this study was to propose and assess a shade guide for pink gingival aesthetics using a Spanish population sample. MATERIALS AND METHODS. The $L^*$, $C^*$, h, $a^*$ and $b^*$ coordinates of 259 participants were measured using a spectrophotometer in 3 standardized points along the attached gingiva of the maxillary central incisors. A hierarchical clustering analysis was applied to obtain separate solutions regarding the number of shade tabs. For each of the solutions obtained, color differences (${\Delta}E^*$) were calculated using the CIELab and CIEDE2000 formulas, and the proposed shade guide was selected considering (1) the color differences between tabs and (2) the coverage error of each of the solutions. RESULTS. The proposed shade guide consisted of 8 gingival shade tabs and achieved CIELab and CIEDE2000 coverage errors of less than the respective 50:50% acceptability thresholds (${\Delta}E^*=4.6$ units and ${\Delta}E_{00}=4.1$). The coordinates for the various gingival shade tabs were as follows: Tab 1: $L^*43.3$, $a^*21.9$, $b^*12.3$ (1.6); Tab 2: $L^*42.9$, $a^*34.1$, $b^*19.1$; Tab 3: $L^*46.5$, $a^*25.8$, $b^*10.9$; Tab 4: $L^*46.5$, $a^*27.3$, $b^*15.1$; Tab 5: $L^*49.6$, $a^*23.5$, $b^*16.8$; Tab 6: $L^*51.5$, $a^*19.7$, $b^*13.6$; Tab 7: $L^*55.9$, $a^*22.0$, $b^*15.0$; and Tab 8: $L^*56.0$, $a^*19.9$, $b^*18.8$. CONCLUSION. The CIELab and CIEDE2000 coverage errors for the 8 shade tabs of the proposed gingival shade guide were significantly lower than those of other guides. Therefore, despite the limitations of this study, the proposed guide is more appropriate for matching gingival shade in the Spanish general population.