• The Korean Journal of Food And Nutrition
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• v.9 no.3
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• pp.331-335
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• 1996

In this study, the attempts were made to Investigate the effect of squalene (200 ppm) on the autooxidation of soybean oil The effect of mixed tocopherols (200 ppm) was also studied In the same way and the results of the study were compared with those of squalene. A put of a commercial soybean oil was stored at 45.0$\pm$0.5t for their autooxidation. The extent of the autooxidation was estimated from the changes of the peroxide value and % conjugated dienoic acid content of the ell substrates The results of the autooxidation, squalene In the soybean oil substrate showed antioxidant activity but the activity was weaker than that of mixed-tocopherols nth the same concentration. The induction periods of the control and substrates with the same concentration. The Induction periods of the control and substrates with squalene and mixed-tocopherols were 448.5 504.9 and 668.9 hours, respectively. Time required to Tech a POV of 30meq/kg oil.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.22 no.2
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• pp.193-200
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• 1996

In eastern Asian region, cosmetic preparations containing the molecues possessing the whitening activity are promising. In this study, 100 plant extracts were screened in order to elucidate the whitening effects using in vitro tyrosinase assay and DOPA autooxidation. Several plant extracts such as Morus alba, Glycyrrhiza glabra showed the inhibitory activity (>50%) against mushroom tyrosinase at the concentration 333$mu extrm{m}$/ml. And plant extracts including Morus alba and Bupleurum falcatum showed the inhibitory activity (>50%) at the concentration of 500($\mu\textrm{g}$/ml against DOPA autooxidation. The IC50 values of the several extracts were also found.

• Proceedings of the Zoological Society Korea Conference
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• 1994.10a
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• pp.204.1-204
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• 1994

No Abstract, See Full Text

• Bulletin of the Korean Chemical Society
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• v.16 no.11
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• pp.1013-1014
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• 1995

• Journal of Food Hygiene and Safety
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• v.2 no.2
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• pp.83-88
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• 1987

Effects of the extraction-methods and solvents on some minor components in crude rapeseed-oil and the autooxidation of the oils were examined in this study. The contents of unsaponifiable matters and sterols were not significantly variied depending on the extraction-methods and solvents. Chlorophyll-contents were elevated with the increasing molecular weights of extractionsolvents. Any significant effect of the extraction-temperature on the yield of chlorophyll was not observed. Autoxidation-tendency of the oils was found to be dependent on the boiling points of extraction-solvents.

• Journal of Ginseng Research
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• v.11 no.2
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• pp.101-110
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• 1987

This study was investigated and analyzed the physiological reaction mechanisms and the factors of the chlorophyll bleaching phenomenon on leaf burning-disease of the Ginseng (Panax ginseng C.A. Meyer). Chlorophyll bleaching phenomenon was mainly caused by the photooxidation of singlet oxygen and the autooxidation of hydrogen peroxide($H_2O_2$) accumulation resulted from inactivation of catalase and peroxidase. Chlorophyll bleaching phenomenon was remarkably accelerated by addition of saponin.

• Proceedings of the Korean Society of Toxicology Conference
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• 2001.10a
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• pp.114-114
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• 2001

Tetrahydropapaveroline (THP), a dopamine-derived 6, 7-dihydroxy-1-(3' ,4'-dihydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline, has been suspected as a possible dopaminergic neurotoxin to elicit Parkinsonism. Autooxidation or enzymatic oxidation of THP and subsequent generation of reactive oxygen species (ROS) may contribute to the degeneration of dopaminergic neurons induced by this isoquinoline alkaloid.(omitted)

• Journal of the Society of Cosmetic Scientists of Korea
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• v.38 no.2
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• pp.155-162
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• 2012

Steamed ginseng is well known as a tonic medicine for restoring and enhancing human health. Steamed ginseng had more pharmacologically activity than white ginseng. The effects of steamed ginseng on transplantable tumors, proliferation of lymphocyte and rat liver lipid peroxidation were studied. This study was performed to evaluate the antioxidation and antiwrinkle effects of three ginseng extracts. Raw ginseng (RGS) and dried ginseng (DGS) mature like red ginseng in addition to the ready-made red ginseng (GS) purchased in the market, were steamed and extracted by red ginseng extractor. Three extracts of steamed ginseng were investigated to determine effects of superoxide radical scavenging activity, hydroxyl radical scavenging activity, autooxidation inhibition of linoleic acid, collagenase inhibition and collagen synthesis in normal fibroblast. RGS showed not only the highest superoxide radical scavenging activity at a concentration of 100 ug/mL but also the hydroxyl radical scavenging activity higher than vitamin C. Also RGS showed the highest activity in inhibition of autooxidation of linolic acid, collagen synthesis, and collagenase inhibition.

• Environmental Mutagens and Carcinogens
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• v.20 no.1
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• pp.7-13
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• 2000

The mechanisms of benzene toxicity is not fully elucidated, although the metabolism of benzene is very well understood. In order to study the mechanism of benzene toxicity, we investigated DNA damage induced by benzene metabolite, 1,2,4-benzenetriol (BT) in HL-60 cells by alkaline comet assay. To investigate the mechanism of cellular DNA damage induced by BT, the cells were treated with antioxidant such as vitamin C, SOD, catalase, and chelating agent such as deferoxamine (DFO), bathocuproinedisulfonic acid (BCDS). BT induced DNA damage in dose-dependent manner at concentration between 10$\mu\textrm{m}$ and 100$\mu\textrm{m}$. The antioxidant vitamin C itself induced DNA damage at higher concentration. The DNA damage induced by BT in HL-60 cells was protected at low concentraiton of vitamin C whereas no protective effect was found at high concentration. In hibitory effect of SOD on DNA damage by BT was observed and this suggested that BT produce superoxide anion (O2-) causing DNA damage. Catalase protected BT-induced DNA damage suggesting that BT produce H2O2 during autooxidation of BT. Both Fe(II)-specific cheiating agent, deferoxamine (DFO) and Cu(I)-specific chelating agent, bathocuproinedisulfonic acid (BCDS) inhibited BT0induced DNA damage. This suggested that DNA damage was caused by active species which was produced DAN damage. This suggested that DNA damage was caused by active species which was produced by the autooxidation of BT in the presence of Cu(II) and Fe(III). These findings suggest that reactive oxygen species play an important role in the mechanism of toxicity induced by benzene metabolites.

• Journal of the Korean Society of Food Science and Nutrition
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• v.27 no.6
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• pp.1047-1052
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• 1998

The effects of antioxidants such as ascorbyl palmitate(AP), tocopherol( Toc), BHA and ascorbyl palmitate＋ tocopherol(AP＋ Toc) on lipid peroxide formations in lard have been investigated during storage at 50oC after gamma irradiation with the dose of 1~10kGy. Immediately gamma irradiation greatly increased the initiative oxidation of lard as expected. But antioxidants were found to be greatly effective in minimizing the radiation induced peroxidation of lard. The decreasing order of effects on their antioxidative activities was AP>AP＋ Toc>BHA> Toc. Oxidation of lard during storage at 50oC after irradiation induced the acceleration of autooxidation. But the additions of an tioxidants inhibited the formation of peroxides. Their antioxidative activities during storage were BHA> AP＋ Toc> Toc>AP. Especially AP＋ Toc mixture was not significantly different from BHA (p>0.05).