• Annals of Clinical Neurophysiology
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• v.4 no.1
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• pp.70-73
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• 2002

Acute autonomic neuropathy is a rare disease. Since the first case was reported by Young et.al., in 1969, a number of similar cases have been described, with some variation of the accompanied neurologic deficits. Acute autonomic and sensory neuropathy(AASN) is characterized by the acute onset of autonomic dysfunction and sensory disturbances. A 16-year-old girl experienced high fever($40^{\circ}C$) and erythematous rash on whole trunk and face followed by pain and sensory loss over the whole body, dysphagia, ataxia, urinary retention, and postural hypotension. There was no evidence of limb weakness. The electrophysiologic studies of this patient revealed sensory polyneuropathy and the various autonomic function test showed autonomic dysfunction. The recovery of her autonomic and sensory symptoms is incomplete, three months after the onset of the symptoms. The etiology of the acute autonomic and sensory neuropathy is not known. Most previous authors have suggested the dysautonomia may be an acute immunological damage to peripheral fibers of the autonomic nervous system. We report a case of acute autonomic and sensory neuropathy.

• Korean Journal of Psychosomatic Medicine
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• v.21 no.1
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• pp.55-61
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• 2013

Objectives : Alzheimer's disease(AD) and mild cognitive impairment(MCI) affect several nervous structures involved with the autonomic nervous system. Association between neuropsychiatric deficits and heart rate variability has been observed. But cardiac autonomic function in AD has been scarcely studied and the results reported are conflicting. We investigated autonomic function in normal control, MCI, AD using heart rate variability(HRV) technique. Methods : Time and frequency-domain variability of 5-min R-R interval series was comparatively evaluated in 26 normal control subjects, 22 MCI subjects and 34 AD subjects. Analysis of variance(ANOVA) was used to compare the differences across groups. Correlations between MMSE-KC and HRV components were performed using Pearson's correlation coefficient. Results : No significant difference was observed among the groups in time, frequency-domain analysis of HRV(p>0.05). HRV were not found to be significantly correlated with the degree of cognitive impairment. Conclusions : There were no differences in HRV with MCI, AD subjects when compared with normal controls. Further investigation is required to use HRV technique as noninvasive parameters of MCI and AD.

• Journal of the Korean neurological association
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• v.36 no.4
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• pp.396-398
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• 2018

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.1
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• pp.49-59
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• 2023

Metabolic syndrome (MetS) involves multi-factorial conditions linked to an elevated risk of type 2 diabetes mellitus and cardiovascular disease. Pre-metabolic syndrome (pre-MetS) possesses two MetS components but does not meet the MetS diagnostic criteria. Although cardiac autonomic derangements are evident in MetS, there is little information on their status in pre-MetS subjects. In this study, we sought to examine cardiac autonomic functions in pre-MetS and to determine which MetS component is more responsible for impaired cardiac autonomic functions. A total of 182 subjects were recruited and divided into healthy controls (n=89) and pre-MetS subjects (n=93) based on inclusion and exclusion criteria. We performed biochemical profiles on fasting blood samples to detect pre-MetS. Using standardized protocols, we evaluated anthropometric data, body composition, baroreflex sensitivity (BRS), heart rate variability (HRV), and autonomic function tests (AFTs). We further examined these parameters in pre-MetS subjects for each MetS component. Compared to healthy controls, we observed a significant cardiac autonomic dysfunction (CAD) through reduced BRS, lower overall HRV, and altered AFT parameters in pre-MetS subjects, accompanied by markedly varied anthropometric, clinical and biochemical parameters. Furthermore, all examined BRS, HRV, and AFT parameters exhibited an abnormal trend and significant correlation toward hyperglycemia. This study demonstrates CAD in pre-MetS subjects with reduced BRS, lower overall HRV, and altered AFT parameters. Hyperglycemia was considered an independent determinant of alterations in all the examined BRS, HRV, and AFT parameters. Thus, hyperglycemia may contribute to CAD in pre-MetS subjects before progressing to MetS.

• Journal of Oriental Neuropsychiatry
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• v.19 no.3
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• pp.45-54
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• 2008

Objective: To treat psychogenic headache patients, doctors have to amplify on the headache caused by emotional stress to patients, and assist the patients to cope with difficulties. So, we investigated HRV of the headache patients caused by Chiljungsang and would like to apply to the clinical treatment. Method: Our study measured time and frequency domain HRV indicies(5-min resting study) of 123 headache patients caused by emotional stress. Standardized tests of HRV allow a quantitative estimation of autonomic nervous system function. Results & Conclusions: 1. The study classed as aspects of the head pain showed the differences in RMS-SD(square root of mean squared difference of successive NN intervals) band, HF(high frequency) band significantly. 2. The male headache patients showed higher all the indicies except heart rate compared to the female patients, significantly in SDNN(standard deviation of NN interval), TP(total Power), HF band. 3. As the patients grow older, SDNN, RMS-SD band was lower and LF(low frequency) band, LF/HF ratio higher significantly. The beginning age lower, SDNN, RMS-SD band was higher significantly. The duration of the disease longer, LF band, LF/HF ratio was higher significantly.

• The Journal of Korean Obstetrics and Gynecology
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• v.28 no.4
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• pp.46-56
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• 2015

Objectives : Cold hypersensitivity has been regarded to be associated with Autonomic Nervous System (ANS). This study aims to investigate the indicator of cold hypersensitivity of hands and evaluate the correlation between indicator of coldness of hands and Heart Rate Variability (HRV). Methods : We studied 55 patients with cold hypersensitivity of hands who visited in SeMyung University Hospital from 17 August 2015 to 21 August 2015. Thermometer and VAS scale were used for the diagnosis of cold hypersensitivity. After careful examination to rule out other disease which may affect thermometer and HRV data, patients were taken thermometer, those with thermal difference between upper arm (L4) and palm(P8), also asked to answer a VAS scale of cold hypersensitivity of hands, VAS more than 4 were enrolled for evaluation. Results : There was significant correlation between L4-P8 temperature difference and VAS score of cold hypersensitivity. In HRV data, normalized high frequency (HF normal) was significantly correlated with L4-P8 temperature difference, which was objective indicator of cold hypersensitivity of hands. Conclusions : L4-P8 temperature difference using thermometer is objective indicator of cold hypersensitivity, based on VAS scale. Cold hypersensitivity is highly related with ANS, regulating body heat and temperature. HRV is considered to be widely used in cold hypersensitivity in hands for evaluation of ANS.

• The Journal of the Society of Stroke on Korean Medicine
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• v.6 no.1
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• pp.9-16
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• 2005

Objective : The heart rate variability is very useful indicator to study the function of the autonomic nervous system(ANS), and the physiologic signals can be observed based on the changes of the ANS of the heart. In order to assay the effects of the laser exposing to healthy subjects, the double blind test has been performed. Methods : This study included 62 healthy adults who have not any ANS disease and had normal sinus rhythm in electrocardiogram. The control group consisted of 31 subjects, laser group consisted of 31 subject. HRV was measured for 5 minutes before laser irradiation, sham and real laser irradiated for 30 minutes and than HRV remeasured for 5 minutes. Statistical significance was evaluated by independent T-test. Results : Mean HRV, Ln(VLF), Ln(HF), Ln(TP) of both groups at post-laser period decreased compared with that of the pre-laser period. Ln(LF) of both groups at post-laser period increased compared with that of the pre-laser period. LF/HF, SDNN of real laser group decreased and sham group decreased. Conclusions : There is no difference between two groups. The reason is presumed that all the studied subjects are healthy adults, and also the short and single transcutaneous laser irradiation would not influence upon changes of the ANS. The further study must be followed.

• Journal of Biomedical Engineering Research
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• v.35 no.6
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• pp.197-202
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• 2014

The cognitive rehabilitation training is important for treating many cognitive impairment conditions, including Parkinson's disease, stroke, and ADHD. In this study, we developed a new evaluation system to improve the measurement of the conventional evaluation systems for cognitive rehabilitation training. The developed system measured the activity of dopamine(DA) and an autonomic nervous system(ANS) with photoplethysmography and electromyography. The results demonstrated that the cognitive capacity was increased but the activity of DA was decreased with unbalanced ANS by short-term stress. Based on the results, the effect of short-term stress should be recognized for the cognitive rehabilitation training.

• Journal of Industrial Convergence
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• v.21 no.2
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• pp.85-92
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• 2023

Abnormal spinal disease and function, in addition to simple musculoskeletal problems, can disrupt homeostasis and cause direct and indirect physiological side effects. Part or all of the immune function can be compromised, exposing you to more disease, especially if the nerves running through your spine do not deliver the proper signals to the organs that regulate your immune system. This study focuses on basic anatomic and physiological knowledge and seeks to consider potential mechanisms by which spinal function may potentially help maintain or improve immune function. To this end, we examine the roles of the spine in relation to hematopoiesis, stress, respiration, spine-nerve relationships, and the immune system, and confirm that these roles may influence immune function.

• Journal of Acupuncture Research
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• v.22 no.6
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• pp.51-60
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• 2005

Objectives : This study was designed to evaluate the effect of inbalance of autonomic nerve system on peripheral facial palsy patients in comparison of Heart Rate Variability results of healthy control group with that of peripheral facial palsy group. Methods : The peripheral facial palsy patiens who visited the Dongguk university Bundang oriental medicine hospital from April to June in 2005 were tested Heart Rate Variability items which are Mean Heart Rate(MHRT), Standard Deviation of all the Normal RR intervals (SDNN), Root Mean Square of Successive Differences Between The Normal Heart Beats(RMSSD), Total Power(TP), Low Frequency, High Frequency, ratio between the Low Frequency and High Frequency power(LF/HF ratio). The Heart Rate Variability test results of peripheral facial palsy group were compared with the HRV test results of healthy control group who didn't have nervous disease, musculoskeletal disease, heart problem and pain for the past 6 months. Results : 1. MHRT was not significantly different between peripheral facial palsy group and healthy control group(P=0.18). 2. SDNN was not significantly different between peripheral facial palsy group and healthy control group(P=0.41). 3. RMSSD was not significantly different between peripheral facial palsy group and healthy control group(P=0.93). 4. TP was not significantly different between peripheral facial palsy group and healthy control group(P=094). 5. LF and HF were not significantly different between peripheral facial palsy group and healthy control group((P=0.34, 0.30). 6. LF/HF ratio was significantly different between peripheral facial palsy group and healthy control group(P=0.04). Conclusion : LF/HF ratio is generally used as autonomic nerve system evaluation and there was significantly statistical difference between peripheral facial palsy group and healthy control group.