• Journal of Pharmaceutical Investigation
• /
• v.41 no.2
• /
• pp.75-82
• /
• 2011

LB71350 is an HIV protease inhibitor with poor aqueous solubility and extensive first pass effect. The purpose of the present study was to test the feasibility of solid dosage form of LB71350 with improved bioavailability utilizing solid dispersion. Three different compositions with varying ratio of (LB71350: Gelucire 44/14: Tween 20) were studied. Capsule filling of these solid dispersion compositions was tested using a semi-automatic capsule filling system. Oral bioavailability in dog was tested. Chemical and physical stability at 4, 25 and $40^{\circ}C$ was monitored by HPLC assay, dissolution test, powder XRD and microscopy. The capsule filling system yielded uniform products of drug loading up to 10%. Oral bioavailability in dog was improved compared to the aqueous suspension of crystalline LB71350. Capsules were chemically stable for up to 6 months at $40^{\circ}C$. However, there were temperature and composition dependent physical changes. Decrease in dissolution rates after storage at $40^{\circ}C$ was due to the polymorphic change. In conclusion, manufacturing process, bioavailability, and physico-chemical stability have been considered to propose a solid dispersion capsule formulation for the HIV protease inhibitor with poor physico-chemical properties. A new less soluble crystalline form identified during the physical stability test warrants further study.

• Korean Journal of Computational Design and Engineering
• /
• v.22 no.1
• /
• pp.59-69
• /
• 2017

Internal capacity of a refrigerator is an important indicator for design and purchasing criteria. The components facing the internal space may have holes or gaps between parts. In traditional way, design engineers manually remodeled the parts to fill the holes and the gaps for enclosed boundary of the internal space. Then they calculated internal volume by subtracting the assembly of parts from its enclosing volume. However, filling holes and gaps is not an automated process requiring a plenty of labor and time. In this research, we have developed a voxel-based method to estimate the internal volume of a refrigerator automatically. It starts transforming all components facing the interior space into voxels and fills all holes and gaps automatically by the developed hole-filling algorithm to form a completely closed boundary of the assembly. Then, it identifies the boundary voxels that are facing to the internal voxels with any part of the component. After getting the intersection points between the boundary voxels and the surfaces of components, it generates the boundary surface of triangular facets with the intersection points. Finally, it estimates the internal volume by adding volume of each tetrahedron composed of a triangle of boundary surface and an arbitrary point.

• Journal of Drive and Control
• /
• v.11 no.3
• /
• pp.47-54
• /
• 2014

Clutches are an integral part of the automatic transmission for changing gears. Modern automatic transmissions make extensive use of wet multiple-disc clutches employing hydraulic actuation mechanism with electronic control. Although nowadays, highly advanced shifting algorithm implements the superior shift quality and transmission efficiency, its performance should be based on smooth, reliable engagement with a reasonably durable friction material as well as stable clutch piston dynamics. Particularly, clutch filling control is the crucial part of shifting process because only the open-loop control is available due to the lack of measurement. In this paper, the effect of clutch-fill control parameters on clutch piston dynamics is experimentally investigated by using clutch piston test equipment which enables the clutch piston to actuate similar to real shifting conditions. The experimental analysis results can be expected to be utilized for the calibration of proportional solenoid valve as reference current profile data in vehicle test.

• Journal of Korean Society for Quality Management
• /
• v.29 no.3
• /
• pp.66-78
• /
• 2001

This paper deals with problem of determining process target value under automated visual inspection(AVI) system. Three independent error sources - digitizing error, illumination error, and positional error - which have a close relationship with the performance of the AVI system, are considered. Assuming that digitizing error is uniformly or normally distributed and illumination and positional errors are normally distributed, respectively, the distribution function for the error of measured lengths is derived when the length of a product is measured by the AVI system. Then, Optimal target values under two error models of AVI system are obtained by minimizing the total expected cost function which consists of give away, rework and penalty cost. To validate two process setting models, AVI system for drinks filling process is made up and test results are discussed.

• Proceedings of the Computational Structural Engineering Institute Conference
• /
• 1992.10a
• /
• pp.112-120
• /
• 1992

The use of Pre-processor for building structural analysis used to rely upon filling up fixed format data, which was ineffective and error-prone. This research attempts to integrate structural analysis system with DBMS and CAD system in order to make it easy to exchange data between pre-process, analysis, and post-process stages. Automatic generation of database from pre-process stage allows easy preparation of main input data for other structural analysis programs. CAD system with some sub-programs written in LISP and C works as a graphic user interface. This approach gives an easy, effective and error-free way of inputing data for structural analysis.

• Journal of Drive and Control
• /
• v.17 no.3
• /
• pp.47-56
• /
• 2020

As a shift control of automatic transmission was managed with the electronic control unit (ECU), shift quality which is a measure of shift shock during gear change has markedly improved. However, the initial clutch pressure control of the clutch filling phase should continue to rely on the predetermined control input since the input and output speeds are unchanged until the shifting process attains the inertia phase. It is critical to minimize the clutch response time and control the clutch pressure accurately at the end of clutch fill to achieve quick shift response and smoothness. Advanced transmission companies have adopted an auto calibration method which establishes the databases for the clutch piston fill-up attributes and the frictional characteristics of the disks. In this study, a distinctive auto calibration algorithm for forklift transmission under development is proposed and verified with the real-vehicle test. The experimental calibration results showed consistent turbine dynamics at the initial stage of shifts with the properly calibrated clutch-fill control parameters. By using this technique, it is necessary to finalize the shift control for the various operation conditions.

• Journal of the Korean Society of Manufacturing Process Engineers
• /
• v.9 no.6
• /
• pp.21-28
• /
• 2010

This study shows an optimization procedure for an automatic determination on the gate position to ensure the fill-uniformity within a part cavity by using the injection molding simulation. For an optimization, the maximum pressure-difference within a part cavity induced at the stage of filling is used to evaluate degree of fill-uniformity. In addition, a direct search scheme based on the reduction of design space is developed and applied in the optimization problem. This corresponding proposed methodology was applied in the optimization on the gate location for a CD-tray molding, as a result, showed the improvement of the fill-uniformity within the cavity.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.21 no.45
• /
• pp.201-213
• /
• 1998

We address the problem of choosing the most economic mean value for an automatic filling operation on a production line through the sampling inspection. If quality characteristic of a unit is less than inspection specification then the goods is not accepted. Otherwise, it is accepted. The lots that the numbers of non-conforming units in a sample are larger than the allowable number of non-conforming units are rejected. The non-conforming units in the rejected lots are separated by the screening inspection. The non-conforming units separated are sold in discount price. We assume that quality characteristic is larger-the-better characteristic, the distribution of quality characteristic is normal distribution, and the standard deviation of the distribution is known. This paper presents total expected profit function model considering sales revenue, inspection costs, and material costs. The manufacturing process mean value maximizing total expected profit is determined, and the results of the process target value and total expected profit is analyzed as coefficients change.

• Journal of the Korean Society of Manufacturing Process Engineers
• /
• v.20 no.12
• /
• pp.129-135
• /
• 2021

Injection molding is a manufacturing method of melting the polymer resin and injecting it into a mold to molding it into the desired form. Due to the short molding time and outstanding formability, complex products can be shaped with high precision and it is the most widely used polymer molding method. However, there may be areas that are not filled depending on the location of the injection gate where polymer resin is injected. Formability is determined by deformation and surface precision due to the impact of residual stress after molding. Hence, choosing the location of the injection gate is very important and molding analysis of injection molding is essential to reduce the cost of the mold. This study evaluated the injection formability based on the location of the injection gate of the vertical machining center ATC tool port using injection molding analysis and the results were compared and analyzed. Injection molding analysis was conducted on filling, packing, and deformation according to the location of the gate of the ATC tool port. From each injection gate location, filling time, pressure, and maximum deformation were compared. At gate 2, conditions of molding time and the location of the gate were far superior in production and quality. Gate 2 produced the smallest deformation of 0.779mm with the best quality.

• Journal of Biomedical Engineering Research
• /
• v.12 no.2
• /
• pp.89-98
• /
• 1991

This study is concerned on the automation for cell diagnosis which has better objectivity and speed of test than human beings. Diagnosis is on the basis of shape change of abnormal Cells. Used parameters are nucleus area, nucleus perimeter, nucleus shape, cytoplasm area, nucleus/cytoplsm ratio, which was obtained using image processing technics. A new mode method is proposed on the automatic threshold selection for superior process time compared with Otsu's. Contour of the cytoplasm of abnormal cell is obtained using me- dian filter and sorel operator. The mask to get only original shape of abnormal cells is formed uslng the contour filling algorithm. In the result the normal cells are separated from the abnormal cells and the abnormal cells can be distinguished through screwing of abnormal cell's image with reference data to judge abnormal cells. Owing to this study the number of inspections which the pathologists should examine will be decreased and the time for inspection will be shortened.