• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제24권1호
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• pp.21-27
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• 2013

Objectives : Dysregulation of the central noradrenergic system may be involved in the pathophysiology of attention-deficit hyperactivity disorder (ADHD). The aim of this study was to examine the differences in pre- and post-treatment cerebral perfusion according to the MspI polymorphisms of the alpha-2A-adrenergic receptor gene (ADRA2A) in children with ADHD. Methods : Thirty seven drug-naive ADHD children (8.9+1.8 years old, M=32, F=5) were genotyped. Baseline single-photon emission computed tomography (SPECT) and clinical assessments were performed for ADHD children. After treatment with methylphenidate for eight weeks, SPECT and clinical assessment were repeated. Results : No differences in baseline clinical assessments or cerebral perfusion were observed according to the MspI genotype. However, after treatment, ADHD children with the G/G genotype at the MspI polymorphism showed hyperperfusion in the right cerebellar declive (p=.001, uncorrected) and hypoperfusion in the left lentiform nucleus and left cingulate gyrus (p<.001 and p=.001, uncorrected), compared to children without the G/G genotype. Conclusion : Although the results of this study should be interpreted cautiously, they suggest a possible role of the MspI polymorphisms of the ADRA2A gene in methylphenidate-induced changes in cerebral perfusion.

• 동의신경정신과학회지
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• 제21권4호
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• pp.79-97
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• 2010

Objectives : The objective of this study is to investigate the effects of Jajun-maum-dom-movement program on the attention and hyperactivity of middle school students, Methods: Jajun-maum-dom-movement program was applied to 14 middle school students for 8 weeks, To measure the improvement of attention and decrease of hyperactivity, these tests were used - ADHD Diagnostic System(hereinafter ADS), Parent's Abbreviated Conners Rating Scale(hereinafter ACRS), Teacher's Korean ADHD Rating Scale(hereinafter K-ARS). For each variable in the 3 test methods, the results of before and after program were measured and then, the results were assessed by paired t-test, Interrelations between the resulted values of 10 variables were analyzed in these three groups: scores before program, scores after program, and change in scores before and after program, Among 10 variables, for variable showing significant difference by t-test, it was assessed by ANCOVA whether change in scores before and after program is affected by the grade and gender. Results: As for the changed score between before-the-program and after-the-program, in the ADS test, it was found that there is a significant effect in the "commission error" which is one of the indices showing the degree of hyperactivity, and "sensitivity(d')" which is one of the indices showing attention, and it was found that there is a significant effect in ACRS and K -ARSC total), Among the correlations of the 4 variables, "ACRS" and "K-ARSC total) ", which show the comprecessive criteria, have the positive correlation of significance in before-the-program, after-the-program and the changed score between before-the-program and after-the-program, However, there was no specific correlations among sub-variables about attention or hyperactivity, and in all of 4 variables, there was no significant degree of change according to grade or gender. Conclusions : As the results of assessment by ADHD Diagnostic System, Parent's Abbreviated Conners Rating Scale, Teacher's Korean ADHD Rating Scale to study the effects of Jajun-maum-dom-movement program on attention and hyperactivity, it is known that the program is helpful for improvement of attention and decrease of hyperactivity for the participated students.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제10권1호
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• pp.15-20
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• 1999

요 약：본 연구의 목적은 주의력 결핍/과잉행동 장애 아동의 실행 능력을 비교 집단인 신경증 집단과 비교하고자 하였으며, 특히 연령 변화에 따른 실행 능력의 변화를 비교 고찰하였다. 방 법：대상은 DSM-IV 진단준거에 의하여 ADHD로 진단 받은 아동들로, 연령 범위는 6세에서 16세까지의 아동 87명(남자 77명, 여자 10명)이다. 대조군은 경미한 우울 장애, 경미한 불안 장애를 보이는 19명의(남자 14명, 여자 5명) 아동들로 이하 신경증 집단으로 분류하였다. 모든 아동에게 1：1로 WCST를 실시하였으며, Heaton(1981)의 방식을 computer version으로 실시하였다. 연구에서 측정한 WCST의 종속측정치는 총시도횟수, 정반응수, 오반응수, 보속반응수, 보속오류수, 첫 범주를 마치는데 요구된 시도수, 유지실패수, 완성된 범주수 이다. 이때, 연령 및 진단을 함께 고려하여 이원변량분석(2-way ANOVA) 및 t-test 검증을 실시하였다. 결 과：ADHD 집단과 Neurosis 집단 간에 WCST의 수행을 비교한 결과는 정반응수, 오반응수, 비보속 오류수, 개념반응, 완성된 범주수에서 두 집단 간에 유의미한 차이를 나타내었다. 연령에 따라 WCST의 수행을 비교한 결과 총시행수, 오반응수, 보속 반응수, 보속 오류수, 비보속 오류수, 완성된 범주수, 첫범주 완성 시도수에서, 의미있는 차이를 나타내었다. 결 론：ADHD 집단은 대조군에 비하여, 외부 feedback에 맞춰 자신의 반응을 수정해 가는 능력이 부족하며, 자기-통제를 하지 못한 채 무작위적인 반응을 했을 가능성을 시사하고 있다. 하지만 보속 오류수, 보속 반응수에서는 차이가 나타나지 않고 있어 이에 대한 해석에 주의를 요하고 있다. 또한 연령 변화에 따라 실행 능력 전반에 걸쳐 변화가 나타나고 있다는 것은 실행 능력을 연구할 때 발달적인 측면이 꼭 고려되어야 함을 시사한다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제18권1호
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• pp.26-30
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• 2007

This practice parameter for non-pharmacological treatment for attention-deficit hyperactivity disorder (ADHD) review the domestic and international literature on the psychosocial treatment of children and adolescents with ADHD. This parameter include the parental training & education, cognitive behavior therapy(group or individual), social skill training, family therapy, play therapy (individual psychotherapy) and non-traditional therapy (art therapy, herbal therapy et al). Among them, there is some proven evidence only in parental training & education and cognitive behavior therapy. So, this parameter describes some details only in the field of parental training & education and cognitive behavior therapy. The efficacy or effectiveness, especially, cost-effectiveness of specific psychosocial treatment method for ADHD cannot be fairly assessed due to the scarcity of controlled clinical data. Based on the clinical expert consensus and limited evidence, we cautiously suggest the practice recommendations about the non-pharmacological psychosocial treatment fur children and adolescents with ADHD.

• 생물정신의학
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• 제25권3호
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• pp.53-59
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• 2018

Objectives The purpose of this study is to investigate the differences between a attention deficit hyperactivity disorder (ADHD) group and a general student group in terms of the perception of the residential environment and periodic activities outside the classroom. Methods The patient group consisted of 62 outpatients or inpatients at the Department of Pediatric Psychiatry, and 49 patients diagnosed with ADHD were selected. For the control group, 3727 youths in elementary schools, middle schools, and high schools of one city were asked to fill out questionnaires. Of the 1717 respondents who responded to the questionnaires, 245 were selected for a patient-controlled study. The differences between the patient group and the control group were compared using the chi-squared test (${\chi}^2$ test). Results There was a significant difference between the patient group and the control group in areas where students responded by "My neighborhood is dirty and littered (p < 0.05)". There was also a significant difference between the patient group and the control group in terms of having more than one club activity per month (p < 0.05). Conclusions It was found that the patients with ADHD are more aware of perceived negative aspects of the area in which they reside, thus reflecting their anxiety. In addition, it was also found that the patient group did not partake in as many social activities as the control group.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제23권4호
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• pp.196-203
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• 2012

Objectives:We analyzed the usefulness of intelligence test in assessing attention-deficit hyperactivity disorder (ADHD). Methods:The medical records of 312 patients with ADHD who visited the child psychiatry department in one university hospital in Seoul, Korea, were reviewed. Demographic data and scores on the Korean Wechsler Intelligence Scale for Children-III (K-WISC-III) and Korean-Conners' Parent Rating Scale (K-CPRS) were analyzed. To assess the relationship with comorbidities, AD-HD subjects were classified as; externalizing disorders, internalizing disorders, tic disorders, and no comorbidities. Results:Verbal intelligence quotient (VIQ) was significantly higher than performance IQ (PIQ)($102.6{\pm}14.44$, $99.2{\pm}14.48$, p<.001). Using mean scatter method, subtest scores such as 'information, similarities, digit span and coding' were significantly lower than mean scores of sum of subtests of VIQ or PIQ (p<.05). Regarding comorbidities, children with externalizing disorders exhibited. Lower scores on 'information and vocabulary' than other groups (p=.008). Children with no comorbidities exhibited higher scores on 'similarities and object assembly' than children with externalizing/internalizing disorders (p=.001) and also on 'comprehension' than children with externalizing disorders (p=.006). For subtypes of ADHD, children with hyperactive-impulsive type had higher scores on 'comprehension' than children with inattentive and combined type (p=.004). Conclusion:These results suggested that intelligence test might provide useful information for assessing ADHD.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제31권3호
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• pp.154-160
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• 2020

Objectives: It remains unclear whether methylphenidate (MPH) has yadverse effects on growth in children. This study aimed to investigate the association of MPH with serum biological markers of growth in children with attention-deficit/hyperactivity disorder (ADHD). Methods: The present study included 103 children with ADHD (64 drug-naive children, 39 MPH-treated children) and 112 control subjects. Children with ADHD were diagnosed on the basis of a semi-structured interview. Levels of biochemical markers of growth, including insulin-like growth factor-I, thyroid stimulating hormone (TSH), free T₄, calcium, phosphorus, alkaline phosphatase, vitamin D, hemoglobin, total protein, albumin, total cholesterol, and hematocrit were measured in these individuals. Results: Except in case of TSH, no intergroup differences were found in the levels of the growth markers. The levels of TSH were found to be lower in the MPH-treated boys with ADHD than in the drug-naive and control groups (p<0.05), although the levels of TSH in all the groups were within normal limits. Conclusion: In this cross-sectional study, no significant association was found between MPH and growth markers. This calls for the need to carry out prospective longitudinal research studies in the future that investigate the effect of MPH on the growth trajectory in children.

• 정신신체의학
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• 제14권1호
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• pp.8-17
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• 2006

뉴로피드백(neurofeedback)은 EEG biofeedback, neurotherapy 등의 이름으로 불리기도 하는 새로운 치료법으로, 뇌파를 이용하고 뇌(brain) 자체와 뇌 기능(brain function)을 대상으로 한다는 점에서는 일반적인 바이오피드백(biofeedback)과는 차이가 있다. 따라서 바이오피드백의 한 형태로 출발을 하였지만, 현재는 독자적이고 전문화된 방식의 새로운 치료법으로 자리 메김을 하고 있다. 뉴로피드백에 대한 이해를 도우기 위해 뉴로피드백의 역사와 이론적 배경을 우선 알아본 후, 실제 임상에서 어떻게 사용되고 있는 지를 알아보고자 한다. 뉴로피드백은 임상분야에서 간질(epilepsy)의 치료에 처음으로 도입된 이후 그 효과가 입증되었으며, 주의력결핍과잉행동장애(attention deficit hyperactivity disorder, ADHD), 불안 및 우울장애, 수면장애, 물질의존 등의 많은 정신과 질환에 효과적으로 사용되고 있다. 정신과 질환이외에도 두통, 만성통증, 만성피로증후군 등 많은 다양한 영역에 걸쳐 적용되고 있다. 최근에는 질환들 뿐 만이 아니라, 스포츠와 예술 활동에서의 수행능력(peak performance)의 향상, 인지기능의 향상 등의 분야로 활용범위가 확대되고 있어 뉴로피드백의 효용성과 그 가능성에 대한 기대가 더욱 높아지고 있다.

• 정신신체의학
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• 제24권2호
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• pp.157-164
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• 2016

Objectives : The objective of this study was to investigate the characteristics of language profiles according to whether or not Korean children with autism spectrum disorder(ASD) also have ADHD, and to examine the relationship with executive function. Methods : Participants in the study were boys with ADHD aged 6 to 11 years who visited the clinic from January 2012 to December 2013. In this study, 25 boys with ASD were included, and completed scales included the Korean version of Autism Diagnostic Interview-Revised(K-ADI-R), Korean version of Autism Diagnostic Observation Schedule(K-ADOS), Korean ADHD Rating Scale(K-ARS), and Korean-Conners' Parent Rating Scale(K-CPRS). They also completed neuropsychological tests and assessed language profiles. Patients were categorized into two groups(with ADHD and without ADHD). T-test and Multivariate analysis of covariance (MANCOVA) was used for analysis. Results : Statistically, no difference was found in receptive and expressive language ability between the ASD groups with and without ADHD. However, a lower score in Test of Problem solving(TOPS) was observed for ASD with ADHD than for ASD without ADHD, with problem solving and finding cues showing significant differences. Conclusions : These findings suggest that language profiles in the ASD group without ADHD could be similar to those in the ASD group with ADHD, but comorbid ADHD could lead to more difficulty in linguistic ability for problem solving and could be related with executive function of the frontal lobe.

• 인간행동과 음악연구
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• 제3권2호
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• pp.1-14
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• 2006

본 연구의 목적은 바이올린 교습 중심의 음악치료 활동이 주의력결핍과잉행동장애 아동들의 집중력과 충동성 조절에 변화를 가져오는지 연구하고 그러한 변화가 일상생활에 전이가 되는지 보고자 하는 것이다. 본 연구는 연령대가 비슷하고 종합병원에서 ADHD라고 진단을 받은 초등학교 2학년, 3학년, 4학년을 대상으로 선정하여, 본 연구자가 8주에 걸쳐 14번의 개별 세션과 마지막 회기의 발표회 연주로 총 15회기를 실시하였다. ADHD 아동의 집중력 향상과 충동성 조절의 변화를 살펴보기 위하여 15회 음악치료 활동 전 후에 실시한 대상 아동의 문제행동측정리스트(K-CBCL) 검사도구 중 주의 집중문제 항목, 단축형 Conners 부모용 평정척도(ACRS), 가정환경 설문지 개정판(CHSQ-R), 개정판 Conners 교사 평정척도(CCTRS-28) 검사 도구의 점수를 비교 분석하였다. 또한, 세션 안에서 보이는 '주의산만행동'과 '학습 외 행동'은 빈도수 기록으로 나타내었으며, '학습 외 행동' 중 가만히 있지 못하고 손발을 움직이는 '손발 행동'은 등간 기록법, '주의집중시간'은 지속 시간 기록법으로 표시하였다. 위의 척도들이 가지는 양적인 데이터의 단점을 보완하기 위하여 아동들이 음악활동에서 보여 준 집중력과 충동 조절에 관한 반응을 질적으로 분석하였다. 그 결과 바이올린 교습 중심의 음악치료 실시 후 ADHD 아동의 집중력과 충동성 조절이 향상되었으며 가정이나 학급에서 발생하는 문제 행동 감소에 효과가 있음이 확인되었다. 본 연구는 선행 연구가 빈약한 분야인 바이올린 교습을 치료적으로 적용하여 실제 ADHD 아동을 대상으로 음악치료 활동의 효과를 입증한 점에서 의의가 있다. 즉 기존의 약물치료와 인지행동치료의 제한점으로 인해 모든 ADHD 아동들에게 그러한 치료를 적용할 수 없다는 한계와 현실적인 한국 상황 내 치료 관행을 고려해 볼 때, 바이올린 교습 중심의 음악치료적 접근이 ADHD 아동에 대한 치료적인 대안이 될 수 있음을 시사한다.