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Nonparametric Regression with Left-Truncated and Right-Censored Data

  • Park, Jinho
    • Communications for Statistical Applications and Methods
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    • v.6 no.3
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    • pp.791-800
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    • 1999
  • Gross and Lai(1996) proposed a new approach for ordinary regression with left-truncated and right-censored (I.t.r.c) data. This paper shows how to apply nonparametric algorithms such as multivariate adaptive regression splines to 1.t.r.c data.

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A Technique to Improve the Fit of Linear Regression Models for Successive Sets of Data

  • Park, Sung H.
    • Journal of the Korean Statistical Society
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    • v.5 no.1
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    • pp.19-28
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    • 1976
  • In empirical study for fitting a multiple linear regression model for successive cross-sections data observed on the same set of independent variables over several time periods, one often faces the problem of poor R2, the multiple coefficient of determination, which provides a standard measure of how good a specified regression line fits the sample data.

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Development of the Medical Support Service Robot Using Ergonomic Design

  • Cho, Young-Chul;Jang, Jae-Ho;Park, Tong-Jin;Han, Chang-Soo
    • 제어로봇시스템학회:학술대회논문집
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    • 2003.10a
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    • pp.2660-2664
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    • 2003
  • In this study, the concept of autonomous mobility is applied to a medical service robot. The aim of the development of the service robot is for the elderly assisting walking rehabilitation. This study aims that the service robot design parameter is proposed in ergonomic view. The walking assistant path pattern is derived from analyzing the elderly gait analysis. A lever is installed in the AMR in order to measure the pulling force and the leading force of the elderly. A lever mechanism is applied for walking assistant service of the AMR. This lever is designed for measuring the leading force of the elderly. The elderly adjusts the velocity of the robot by applying force to the lever. The action scope and the service mechanism of the robot are developed for considering and analyzing the elderly action patterns. The ergonomic design parameters, that is, dimensions, action scope and working space are determined based on the elderly moving scope. The gait information is acquired by measuring the guide lever force by load cells and working pattern by the electromyography signal.

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An Endoplasmic Reticulum Cyclophilin Cpr5p Rescues Z-type α1-Antitrypsin from Retarded Folding

  • Jung, Chan-Hun;Lim, Jeong Hun;Lee, Kyunghee;Im, Hana
    • Bulletin of the Korean Chemical Society
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    • v.35 no.9
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    • pp.2781-2786
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    • 2014
  • Human α1-antitrypsin (α1-AT) is a natural inhibitor of neutrophil elastases and has several dozens of genetic variants. Most of the deficient genetic variants of human α1-AT are unstable and cause pulmonary emphysema. However, the most clinically significant variant, Z-type α1-AT, exhibits retarded protein folding that leads to accumulation of folding intermediates. These aggregate within the endoplasmic reticulum (ER) of hepatocytes, subsequently causing liver cirrhosis as well as emphysema. Here, we studied the role of an ER folding assistant protein Cpr5p on Z-type α1-AT folding. Cpr5p was induced > 2-fold in Z-type α1-AT-expressing yeast cells compared with the wild type. Knockout of CPR5 exacerbated cytotoxicity of Z-type α1-AT, and re-introduction of CPR5 rescued the knockout cells from aggravated cytotoxicity caused by the α1-AT variant. Furthermore, Cpr5p co-immunoprecipitated with Z-type α1-AT and facilitated its protein folding. Our results suggest that protein-folding diseases may be suppressed by folding assistant proteins at the site of causal protein biosynthesis.

Topical Formulations of Water-Soluble Chitin as a Wound Healing Assistant -Evaluation on Open Wounds Using a Rabbit Ear Model-

  • Han, Sung-Soo
    • Fibers and Polymers
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    • v.6 no.3
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    • pp.219-223
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    • 2005
  • Water-soluble chitin (WSC) was prepared by carefully deacetylating chitins to about 50% of N-acetyl content. Topical formulations based on WSC were prepared and their effects on wound healing were evaluated on a rabbit ear model. Full-thickness, open skin wounds were made on the ears of rabbits and WSC ointments were embedded in the open wounds. The application of WSC ointments significantly accelerated wound healing and wound contraction. The areas of epithelial-ization and granulation tissues in WSC ointment group are remarkably larger than those in control group (no treatment) and in placebo group (treated with ointment-base materials). A large number of grown granulation tissues including dense fibroblast deposition were observed under the thickened epithelium of the wound treated with WSC ointments. The number of inflammatory cells in WSC ointment group was significantly decreased compared with those in control and placebo groups, indicating that WSC would give low stimuli to wounds and prevent excessive scar formation. Neovascularization was the most prominent in WSC ointment group. Wound contraction in WSC ointment group was much larger than those in control and placebo groups. Overall results demonstrate that the topical formulation based on WSC is considered to become an excellent dressing as a wound healing assistant.

The influence of processing condition and assistance gas in microhole machining of Al2O3 ceramics (Al2O3 세라믹의 미세구멍 가공시 가공조건과 보조가스가 미치는 영향)

  • 이광길
    • Journal of the Korean Society of Manufacturing Technology Engineers
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    • v.8 no.5
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    • pp.115-120
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    • 1999
  • This research is a described result of experimental for the parameter's effecting the microhole machining by Nd-Yag laser, The parameters are energy, pulse interval time a kin of assisting gas and its pressure. The result reveals that parameter value of energy 0.08J, pulse 20Hz, interval time of 300 microseconds could be a good machining condition to make upper microhoel that is the diameter range of 50-70{\mu}{\textrm}{m}. At tat time the assistant gas such air, O2, Ar N2, was appelied. Assistant gas of air makes heat affected zone enlarge due to burning of material surface. Also it makes microhole irregular and damageable. Because of refusion caused by chemical reaction with Al2O3 ceramic material . The O2(99.9%) has good characteristics to get good drilling and smooth surface on pressure of 0.2kgf/cm2 but it is expensive. Ar, N2 make material crack and burnning and proved that to be unappropriate but, Ar was a better than N2.

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