• Journal of Life Science
• /
• v.26 no.7
• /
• pp.868-874
• /
• 2016

Receptor-interacting protein kinase 1 (RIPK1) and RIPK3 are members of the serine or threonine protein kinase superfamily that phosphorylates the hydroxyl group of serine or threonine through the highly conserved kinase region. The RIPK family plays a crucial role not only in inflammation and innate immunity, but also in mediating programmed cell death, such as apoptosis and necroptosis. The interaction between RIPK1 and other TNFR1-related proteins has been shown to assemble a signaling complex I that controls activation of the pro-survival transcription factor NF-κB upon binding of cytokines to TNF receptor 1 (TNFR1). Moreover, RIPK1 and RIPK3 interact through their RIP homotypic interaction motifs (RHIMs) to mediate programmed necrosis, which has long been considered an accidental and uncontrolled cell death form with morphological characteristics differing from those of apoptosis. Highly conserved sequences of RHIM in RIPK1 and RIPK3 were shown to regulate their binary interaction, leading to assembly of a cytosolic amyloid complex termed the “necrosome”. The necrosome also contains mixed lineage kinase domain-like protein (MLKL), which has been found recently to be a substrate of RIPK3 to mediate downstream signaling. This review provides an overview of the functional and physiological characteristics of RIPKs and MLKL in TNF signaling.

• Journal of KIISE:Software and Applications
• /
• v.29 no.7
• /
• pp.476-486
• /
• 2002

CBD(Component Based Development) has become the best strategical method for the business application. Because CBD is a new development paradigm which makes it possible to assemble the software components for application, it copes with the rapid challenge of business process and meets the increasing requirements for productivity. Since the business process is rapidly changing, CBD technology is the promising way to solve the productivity. Especially, the repository is the most important part for the development, distribution and reuse of components. In component repository, we can store and manage the related work-products produced at each step of component development as well as component itself. In this paper, we suggested a practical approach for repository construction to support and realize the CBD process and developed the CRMS(Component Repository Management System) as implementation product of the proposed techniques. CRMS can manage a variety of component products based on component architecture, and help software developers to search a candidate component for their project and to understand a variety of information for the component. In the paper, a practical approach for component repository was suggested, and a supporting environment was constructed to make CBD to be working efficiently. We expect this work wall be valuable research for component repository and the entire supporting Component Based Development Process.

• Journal of Aerospace System Engineering
• /
• v.11 no.4
• /
• pp.48-53
• /
• 2017

Liquid rocket engines (LREs) are very complex systems that include combustion chambers, turbopumps, gas generators, ducts and tubes, valves and etc. Most components of the LREs require higher than or equal to level 6 IT (ISO Tolerance). The components along with pipe line and/or tubing must dispose not to interfere each other. In addition, effectiveness of maintenance and service after assembling should be considered when the allocation of the components are determined. Especially at the stage of the development, tolerance accumulations or unpredictable errors may result in misalignment and/or mismatches at interfaces of the parts. Namely, it is the engine assembling process that many inherent risks are realized and crises or incidents occur. Therefore, a rapid reaction system should be prepared. In this research, 7 tonf class liquid rocket assembling process was studied and actual building steps were introduced.

• The Journal of the Korea Contents Association
• /
• v.18 no.11
• /
• pp.508-515
• /
• 2018

The purpose of this study was to analyze the errors of the built - in dose area product and the calibrated moving dose area product when using automatic exposure controller of the interventional equipment. And then, the importance of the dosimeter calibration and the necessity of the calibration guideline were investigated. The experimental method was to assemble the phantom into Thin, Normal, and Heavy Adult according to the NEMA Phantom manual and to measure the dose area with the built-in dose area product and the moving dose area product. As a result, in all thicknesses, the built-in dose area product showed higher doses than the moving dose area product, and the thicker the thickness, the larger the difference. In addition, paired t-test was performed for each item and there was a significant difference in each item between p<0.05. In conclusion, considering the intervention which is highly exposed to the radiation exposure, it is that we have to know the accurate dose when using the AEC of the equipment. And there is no calibration guide for the built-in dose area meter, thus calibration guidelines should be prepared.

• Journal of Korean Tunnelling and Underground Space Association
• /
• v.21 no.3
• /
• pp.323-345
• /
• 2019

It is essential to predict ground conditions ahead of a tunnel face in order to successfully excavate tunnels using a shield TBM. This study proposes a forward prediction method for a mixed soil ground and/or a ground containing core stones by using electrical resistivity and induced polarization exploration. Soil conditioning in EPB shield TBM is dependent upon the composition of mixed soils; a special care need to be taken when excavating the core-stoned soil ground using TBM. The resistivity and chargeability are assumed to be measured with four electrodes at the tunnel face, whenever the excavation is stopped to assemble one ring of a segment lining. Firstly, the mixed ground consisting of weathered granite soil, sand, and clay was modeled in laboratory-scale experiments. Experimental results show that the measured electrical resistivity considerably coincides with the analytical solution. On the other hand, the induced polarization has either same or opposite trend with the measured resistivity depending on the mixed ground conditions. Based on these experimental results, a method to predict the mixed soil ground that can be used during TBM tunnel driving is suggested. Secondly, tunnel excavation from a homogeneous ground to a ground containing core stones was modeled in laboratory scale; the irregularity of the core stones contained in the soil layer was modeled through random number generation scheme. Experimental results show that as the TBM approaches the ground that contains core stones, the electrical resistivity increases and the induced polarization fluctuates.

• Korean Chemical Engineering Research
• /
• v.60 no.3
• /
• pp.446-451
• /
• 2022

In this study, to improve capacity and cycle stability, the pitch coated nano silicon sheets/CNT composites were prepared through electrostatic bonding of nano silicon sheets and CNT. Silica sheets were synthesized by hydrolyzing TEOS on the crystal planes of NaCl, and then nano silicon sheets were prepared by using magnesiothermic reduction method. To fabricate the nano silicon sheets/CNT composites, the negatively charged CNT after the acid treatment was used to assemble the positively charged nano silicon sheets modified with APTES. THF as a solvent was used in the coating process of PFO pitch. The physical properties of the prepared anode composites were analysed by FE-SEM, XRD and EDS. The electrochemical performances of the synthesized anode composites were performed by current charge/discharge, rate performances, differential capacity and EIS tests in the electrolyte LiPF₆ dissolve solvent (EC:DMC:EMC = 1:1:1 vol%). It was found that the anode material with high capacity and stability could be synthesized when high composition of silicon and conductivity of CNT were used. The pitch coated nano silicon sheets/CNT anode composites showed initial discharge capacity of 2344.9 mAh/g and the capacity retention ratio of 81% after 50 cycles. The electrochemical property of pitch coated anode material was more improved than that of the nano silicon sheets/CNT composites.

• Applied Chemistry for Engineering
• /
• v.33 no.2
• /
• pp.188-194
• /
• 2022

This work presents a non-destructive and straightforward approach to assemble a large-scale conductive electronic film made of a pre-treated single-walled carbon nanotube (SWCNT) solution. For effective electron transfer between the immobilized enzyme and SWCNT electronic film, we optimized the pre-treatment step of SWCNT with p-terphenyl-4,4"-dithiol and dithiothreitol. Glucose oxidase (GOx, a model enzyme in this study) was immobilized on the SWCNT electronic film following the positively charged polyelectrolyte layer deposition. The glucose detection was realized through effective electron transfer between the immobilized GOx and SWCNT electronic film at the negative potential value (-0.45 V vs. Ag/AgCl). The SWCNT electronic film-based glucose biosensor exhibited a sensitivity of 98 ㎂/mM·cm². In addition, the SWCNT electronic film biosensor showed the excellent selectivity (less than 4 % change) against a variety of redox-active interfering substances, such as ascorbic acid, uric acid, dopamine, and acetaminophen, by avoiding co-oxidation of the interfering substances at the negative potential value.

• Journal of Life Science
• /
• v.33 no.8
• /
• pp.651-662
• /
• 2023

Peroxisomes, known as microbodies, are a class of morphologically similar subcellular organelles commonly found in most eukaryotic cells. They are 0.2~1.8 ㎛ in diameter and are bound by a single membrane. The matrix is usually finely granular, but occasionally crystalline or fibrillary inclusions are observed. They characteristically contain hydrogen peroxide (H₂O₂) generating oxidases and contain the enzyme catalase, thus confining the metabolism of the poisonous H₂O₂ within these organelles. Therefore, the eukaryotic organelles are greatly dynamic both in morphology and metabolism. Plant peroxisomes, in particular, are associated with numerous metabolic processes, including β-oxidation, the glyoxylate cycle and photorespiration. Furthermore, plant peroxisomes are involved in development, along with responses to stresses such as the synthesis of important phytohormones of auxins, salicylic acid and jasmonic acids. In the past few decades substantial progress has been made in the study of peroxisome biogenesis in eukaryotic organisms, mainly in animals and yeasts. Advancement of sophisticated techniques in molecular biology and widening of the range of genomic applications have led to the identification of most peroxisomal genes and proteins (peroxins, PEXs). Furthermore, recent applications of proteome study have produced fundamental information on biogenesis in plant peroxisomes, together with improving our understanding of peroxisomal protein targeting, regulation, and degradation. Nonetheless, despite this progress in peroxisome development, much remains to be explained about how peroxisomes originate from the endoplasmic reticulum (ER), then assemble and divide. Peroxisomes perform dynamic roles in many phases of plant development, and in this review, we focus on the latest progress in furthering our understanding of plant peroxisome functions, biogenesis, and dynamics.

• The Journal of Korean Institute of Next Generation Computing
• /
• v.13 no.6
• /
• pp.124-131
• /
• 2017

Recently, drone is extending its range of usability. For example, the delivery, agriculture, industry, and entertainment area take advantage of drone mobilities. To control real drones, it needs huge amount of drone control training steps. However, it is risky; falling down, missing, destroying. The virtual drone system can avoid such risks. We reason that what kinds of technologies are required for building the virtual drone system. First, it needs that the virtual drone authoring tool that can assemble drones with the physical restriction in the virtual environment. We suggest that the drone assembly method that can fulfill physical restrictions in the virtual environment. Next, we introduce the virtual drone simulator that can simulate the assembled drone moves physically right in the virtual environment. The simulator produces a high quality rendering results more than 60 frames per second. In addition, we develop the physics engine based on SILS(Software in the loop simulation) framework to perform more realistic drone movement. Last, we suggest the virtual drone controller that can interact with real drone controllers which are commonly used to control real drones. Our virtual drone system earns 7.64/10.0 user satisfaction points on human test: the test is done by one hundred persons.

• Journal of Korean Tunnelling and Underground Space Association
• /
• v.12 no.2
• /
• pp.193-200
• /
• 2010

Due to the characteristic of culvert structure, the standard section of the culvert has been established and applied in field. However, this becomes a limitation in selecting a section design corresponding to various field conditions although it can improve the design and applicability of culvert structure. In order to overcome this limitation, we have developed the design and application technology of culvert structure corresponding to the field conditions that various shapes of culvert structure can be covered by assembly of precast segments. Because the structural characteristics of assembling-type waterway culvert structure, the thickness of structure and amount of reinforcing rods can vary according to the fixation or internal hinge status in the connection part of precast segments. This has a strong influence on the applicability and economic efficiency of culvert structure. Accordingly, in order to suggest a reasonable modeling technique of segment connection parts, this study has conducted the field experiment and numerical analysis. According to the results of field experiment and numerical analysis, the slab, wall and base slab with mortar splice sleeves have shown that the assembling-type of waterway culvert structure behaves like an integrated structure.