• 제목/요약/키워드: Artificial Organs

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A Study on the Quantitative Evaluation Method of Quality Control using Ultrasound Phantom in Ultrasound Imaging System based on Artificial Intelligence (인공지능을 활용한 초음파영상진단장치에서 초음파 팬텀 영상을 이용한 정도관리의 정량적 평가방법 연구)

  • Yeon Jin, Im;Ho Seong, Hwang;Dong Hyun, Kim;Ho Chul, Kim
    • Journal of Biomedical Engineering Research
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    • v.43 no.6
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    • pp.390-398
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    • 2022
  • Ultrasound examination using ultrasound equipment is an ultrasound device that images human organs using sound waves and is used in various areas such as diagnosis, follow-up, and treatment of diseases. However, if the quality of ultrasound equipment is not guaranteed, the possibility of misdiagnosis increases, and the diagnosis rate decreases. Accordingly, The Korean Society of Radiology and Korea society of Ultrasound in Medicine presented guidelines for quality management of ultrasound equipment using ATS-539 phantom. The DenseNet201 classification algorithm shows 99.25% accuracy and 5.17% loss in the Dead Zone, 97.52% loss in Axial/Lateral Resolution, 96.98% accuracy and 20.64% loss in Sensitivity, 93.44% accuracy and 22.07% loss in the Gray scale and Dynamic Range. As a result, it is the best and is judged to be an algorithm that can be used for quantitative evaluation. Through this study, it can be seen that if quantitative evaluation using artificial intelligence is conducted in the qualitative evaluation item of ultrasonic equipment, the reliability of ultrasonic equipment can be increased with high accuracy.

In-Vitro Thrombosis Detection of Mechanical Valve using Artificial Neural Network (인공신경망을 이용한 기계식 판막의 생체외 모의 혈전현상 검출)

  • 이혁수;이상훈
    • Journal of Biomedical Engineering Research
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    • v.18 no.4
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    • pp.429-438
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    • 1997
  • Mechanical valve is one of the most widely used implantable artificial organs of which the reliability is so important that its failure means the death of patient. Therefore early noninvasive detection is essentially required, though mechanical valve failure with thrombosis is the most common. The objective of this paper is to detect the thrombosis formation by spectral analysis and neural network. Using microphone and amplifier, we measured the sound from the mechanical valve which is attached to the pneumatic ventricular assist device. The sound was sampled by A/D converter(DaqBook 100) and the periodogram is the main algorithm for obtaining spectrum. We made the thrombosis models using pellethane and silicon and they are thrombosis model on the valvular disk, around the sewing ring and fibrous tissue growth across the orifice of valve. The performance of the measurment system was tested firstly using 1 KHz sinusoidal wave. The measurement system detected well 1KHz spectrum as expected. The spectrum of normal and 5 kinds of thrombotic valve were obtained and primary and secondary peak appeared in each spectrum waveform. We find that the secondary peak changes according to the thrombosis model. So to distinguish the secondary peak of normal and thrombotic valve quantatively, 3 layer back propagation neural network, which contains 7, 000 input node, 20 hidden layer and 1 output was employed The trained neural network can distinguish normal and valve with more than 90% probability. As a conclusion, the noninvasive monitoring of implanted mechanical valve is possible by analysing the acoustical spectrum using neural network algorithm and this method will be applied to the performance evaluation of other implantable artificial organs.

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Frog-inspired programmable nano-architectures for skin patches and medical applications

  • Kim, Da Wan;Baik, Sang Yul;Kim, Jungwoo;Kim, Ji Won;Pang, Changhyun
    • Proceedings of the Korean Vacuum Society Conference
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    • 2016.02a
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    • pp.366-366
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    • 2016
  • Nanoscale observation of attachment systems of animals has revealed various exquisite multiscale architectures for essential functions such as gecko's locomotion, beetles' wing fixation, octopuses' sucking and crawling. In particular, the hierarchical 3-dimensional hexanonal nano-architectures in the tree frog's adhesion is known to have the capability of the enhancement of adhesion forces on the wet or rough surfaces due to the conformal contacts against rough surfaces and water-drainable micro channels. Here, we report that tree frog-inspired patches using unique artificial 3-dimensional hexagonal structures can be exploited to form reversibly enhanced adhesion against various highly curved and rough surfaces in dry and wet condition. To investigate the adhesion effect of micro-channels, we changed the arrangement of microstructure and spacing gaps between micro-channels. In addition, we introduced the 3-dimensional hexagonal hierarchical architectures to artificial patches to enhance to conformal contacts on the various rough surfaces such as skin and organs. Using the robust adhesion properties, we demonstrated the self-drainable and comfortable skin-attachable devices which can measure EKG (electrokardiogramme) for in-vitro diagnostics. As a result, bio-inspired programmable nano-architectures can be applied in versatile devices such as, medical patches, skin-attachable electronics etc., which would shed light on future smart, directional and reversible adhesion systems.

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Improvement of Two-Stage Centrifugal Blood Pump for Cardiopulmonary Support System and Evaluation of Anti-Hemolysis Performance

  • Horiguchi, Hironori;Tsukiya, Tomonori;Takemika, Toratarou;Nomoto, Takeshi;Tsujimoto, Yoshinobu
    • International Journal of Fluid Machinery and Systems
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    • v.8 no.1
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    • pp.1-12
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    • 2015
  • In cardiopulmonary support systems with a membrane oxygenation such as a percutaneous cardiopulmonary support (PCPS) or an extracorporeal membrane oxygenation (ECMO), blood pumps need to generate the pressure rise of approximately 200mmHg or higher, due to the high hydraulic resistances of the membrane oxygenation and of the cannula tubing. In order to realize the blood pump with higher pressure rise, higher anti-hemolysis and thrombosis performances, the development of novel centrifugal blood pump composed of two-stage has been conducted by the authors. In the present paper, effective attempts to decrease the wall shear stress and to suppress the stagnation are introduced for the prevention of hemolysis and thrombosis in blood pumps. The hemolysis test was also carried out and it was clarified that the decrease of wall shear stress is effective as a guideline of design of blood pumps for improving the anti-hemolysis performance.

Studies on the Carbohydrate-resources among the Composition of Artificial Diet for for the Silkworm, Bombyx mori L. (누에의 人工飼料 組成分中의 炭水化物源에 關한 硏究)

  • Kim, Joo-Up
    • Journal of Sericultural and Entomological Science
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    • v.23 no.1
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    • pp.38-46
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    • 1981
  • In order to investigate a suitable carbohydrate-resources and the activities of starch decomposing enzymes in artifical diet of silkworm, the experiment was undertaken by adding eight kinds of starch in the diet of silkworm. Major characters and zymograms of amylase in body organs were studied by electrophoresis. The results obtained are as follows: 1. Starches of rice, barey and millet were comparatively good for maintaining practical characters of silkworm. 2. It is assumed that no treatments are need to increas purity of starch resources for artificial diet of silkworm. It was found that starch amounts adding to artificial diet are moeerate ranging 12 to 18 percent as dry weight. 3. Regardless of kinds of starch and varieties of silkwormr sametype of electrophoresis zymogram for amylase was resulted as three bands in hemolymph, four bands in intestine and two bands in intestine and two bands in silkgland. There was no band in the digestive juice. In case of 18 percent addition of starch and check plots, no amylose change was investigated in the hemolymph.

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A Simulation Study of Artificial Cochlea Based on Artificial Basilar Membrane for Improving the Performance of Frequency Separation (인공기저막 기반 인공와우의 주파수 분리 성능향상을 위한 인공기저막 전산모사)

  • Kim, Tae-In;Chang, Seong-Min;Song, Won-Joon;Bae, Sung-Jae;Kim, Wan-Doo;Cho, Maeng-Hyo
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.36 no.4
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    • pp.457-463
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    • 2012
  • The basilar membrane (BM), one of organs of cochlea, has the specific positions of the maximum amplitude at each of related frequencies. This phenomenon is due to the geometry of BM. In this study, as the part of the research for the development of fully implantable artificial cochlea which is based on polymer membrane, parametric studies are performed to suggest the desirable artificial basilar membrane model which can detect wider range of frequency separation. The vibro-acoustic characteristics of the artificial basilar membrane are predicted through finite element analysis using commercial software Abaqus. Simulation results are verified by comparing with experimental results. Various geometric shapes of the BM and residual stress effects on the BM are investigated through the parametric study to enable a wider detectable frequency separation range.

Multi-agent System based on Blackboard System for Soccer Robot Implementation

  • Sanornoi, Nitiwat;Phurahong, Boonchana;Sooraksa, Pitikhate
    • 제어로봇시스템학회:학술대회논문집
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    • 2004.08a
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    • pp.2023-2028
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    • 2004
  • This paper reveals the utilization of the multi-gent system that based on the Blackboard system basis as the controller of Soccer Robot. This system is a portion of developing the Soccer Robot team for Robocup 2004 Competition. In this development, the intelligent control system was initiated by the combination of parallel and distributed blackboard structures with the principle design that generated from human body structures, which consists of the combination of two main systems, the organs system and the brain system. The system is designed using the control system theory based on Blackboard basis. Modification of the initial structures to corroborate the Soccer Robot and the structure's constituents are clarified accordingly. To demonstrate the idea, ITE-old team is given as a case study.

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Brain death and organ transplantation (뇌사와 심폐사 그리고 장기이식)

  • Nam, Sang-Ook
    • Clinical and Experimental Pediatrics
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    • v.52 no.8
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    • pp.856-861
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    • 2009
  • Cardiopulmonary arrest has long been accepted as an unquestionable definition of death. An advent of cardiopulmonary resuscitation and artificial ventilation along with the development of organ transplantation has prompted the emergence of the concept of brain death. The criteria for brain death are based mainly on the clinical examination of coma, apnea and total loss of brain stem function. Although organ transplantation by donor brain death has increased in Korea over recent years, there is still a substantial shortage of donor organs compared to the demand. Improvement of government policies and changes of social culture for organ donation are needed for the activation of organ transplantation by donor brain death. Pediatricians have an important role for the search of potential donors in cases of brain death and optimal medical care for successful organ transplantation.

A Study on the Stimulus control of L-$\alpha$-DLPC Organic Monolayers

  • Song, Jin-Won;Lee, Kyung-Sup
    • 제어로봇시스템학회:학술대회논문집
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    • 2001.10a
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    • pp.181.3-181
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    • 2001
  • Recently, the study on development of electrical and electronic device is done to get miniature, high degrees of integration and efficiency by using inorganic materials. the study of Langmuir-Boldgett(LB) method that uses organic materials because of the limitation for the ultrasmall size. In this paper, to do research for medical artificial organs as well as principal parts living body thin film application, electrical properties of L-$\alpha$-DLPC Langmuir(L) films were investigated a displacement current measuring technique with pressure stimulation. We give pressure stimulation into organic thin films and then manufacture a device under the accumulation condition that the state surface pressure is 20[mN/m]. LB layers of L-$\alpha$-DLPC deposited by LB method ...

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Evaluation of Endothelial Cell Attachment on Polymer Surface (고분자 표면의 혈관내피세포 부착력에 관한 연구)

  • Choi, Jin-Wook;Ryu, Gyu-Ha;Min, Byoung-Goo
    • Journal of Biomedical Engineering Research
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    • v.11 no.1
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    • pp.131-140
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    • 1990
  • To improve antithrombogenicity of polymer that used in vascular graft and artificial organs, seeding of human endothelial cells on the polyurethane was studied. Human endothelial cells were ismlated from human umbilical veins, using type I collagenase, and identified with goat anti vWF antibodies. Human endothilial cell seeding was tried upon the polyurethane which has good mechanical property and resists stresses. The hydrophobic polyurethane surface was changed hydrophilic by corona discharf:e treatment. Surface hydrophilicity was measured with Wilhemly plate method and the goniometer. To evaluate matrix protein adsorption, fibronectin adsorption test was done. To eveluate cell adhesion, human endothelial cell attachment forces were measured rising a perfusion chamber of , ism diamter. Less cells were detached from the hydrophilically treated polyurethane. This showed that corona discharge on the polyurethane could improve matrix adsorption and endothelial cell attachment.

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