Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Brain death and organ transplantation

뇌사와 심폐사 그리고 장기이식

  • Nam, Sang-Ook (Division of Neurology, Pusan National University Children's Hospital, Department of Pediatrics, School of Medicine, Pusan National University)
  • 남상욱 (부산대학교 의학전문대학원 소아과학교실,부산대학교 어린이병원 뇌신경클리닉)
  • Received : 2009.06.30
  • Accepted : 2009.07.17
  • Published : 2009.08.15
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Abstract

Cardiopulmonary arrest has long been accepted as an unquestionable definition of death. An advent of cardiopulmonary resuscitation and artificial ventilation along with the development of organ transplantation has prompted the emergence of the concept of brain death. The criteria for brain death are based mainly on the clinical examination of coma, apnea and total loss of brain stem function. Although organ transplantation by donor brain death has increased in Korea over recent years, there is still a substantial shortage of donor organs compared to the demand. Improvement of government policies and changes of social culture for organ donation are needed for the activation of organ transplantation by donor brain death. Pediatricians have an important role for the search of potential donors in cases of brain death and optimal medical care for successful organ transplantation.

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Acknowledgement

Supported by : Pusan National University

References

  1. Mollaret P, Goulon M. Le coma depasse. Rev Neurol 1959; 101:3
  2. Alexandre GPJ. From the early days of human kidney allotransplantation to prospective xenotransplantation. In: Terasaki PI, ed. History of transplantation: thirty five collections. Los Angeles: University of California Irvine Tissue Typing Laboratory, 1991;337-48
  3. Beecher HA. Definition of irreversible coma. Special communication: Report of the Ad Hoc Committee of the Harvard Medical School to examine the definition of brain death. JAMA 1968;205:337-40 https://doi.org/10.1001/jama.205.6.337
  4. Mohandas A, Chow SN. Brain death: a clinical and pathological study. J Neurosurg 1971;35:211-8 https://doi.org/10.3171/jns.1971.35.2.0211
  5. Guidelines for the determination of death: Report of the Medical Consultants on the Diagnosis of Death to the President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research. JAMA 1981;246:2184-6 https://doi.org/10.1001/jama.246.19.2184
  6. American Academy of Pediatrics: Report of special task force: guidelines for the determination of brain death in children. Pediatrics 1987;80:298-300
  7. Report of the Quality Standards Subcommittee of the American Academy of Neurology: Practice parameters for determining brain death in adults. Neurology 1995;45:1012-4
  8. Regulation of determining and oran donation of brain death. Korean Medical Association, 1998
  9. Fischbeck KII, Simon RP. Neurological manifestations of accidental hypothermia. Ann Neurol 1981;10:384-7 https://doi.org/10.1002/ana.410100411
  10. Wijdicks, Eelco FM. Determining brain death in adults. Neurology 1995;45:1003-11
  11. Snavely SR, Hodges GT: The neurotoxicity of antibacterial agents. Ann Intern Med 1984;101:92-104

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