• Journal of Pharmaceutical Investigation
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• v.17 no.2
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• pp.95-98
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• 1987

The drug interaction between probenecid and lithium carbonate was studied pharmacokinetically in rabbits. The blood level and the area under the concentration curve (AUC) of lithium carbonate administered orally were elevated by coadministration of probenecid. Probenecid inhibited the urinary excretion of lithium carbonate in rabbits. Biological half-life and $t_{max}$ of lithium carbonate were prolonged by coadministration of probenecid. From these results, dosage regimen of lithium carbonate is considered to be adjusted for effective and safe therapy in the coadministration of probenecid.

• YAKHAK HOEJI
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• v.27 no.2
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• pp.133-138
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• 1983

The interaction between nalidixic acid and probenecid was studied pharmacokinetically in rabbits. The blood level and the area under the concentration curve(AUC) of nalidixic acid administered orally in dose of 100mg/kg was elevated by the coadministration of probenecid. Probenecid inhibited both the urinary excretion and the biliary excretion of nalidixic acid. Therefore, biological half-life of nalidixic acid was prolonged by the coadministrarion of probenecid. It was considered that the coadmini-stration of probenecid is more desirable than the single administration of nalidixic acid for the therapeutic effect.

• YAKHAK HOEJI
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• v.29 no.4
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• pp.216-219
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• 1985

The phormacokinetics of acetaminophen were investigated in rabbits with folate-induced renal failure. The blood level, the area under the blood concentraction curve(AUC) and the biological half-life were increased significantly, and the urinary excretion was decreased significantly as compared with those of normal rabbits. Serum creatinine concentration and AUC, creatinine clearance and renal clearance have linear relationship respectively. Dosage regimen of acetaminophen was considered to be adjusted in renal failure.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.411.1-411.1
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• 2002

The purpose of this study was to investigate the effect of quercetin on the bioavailability of paclitaxel orally coadministered in rats Paclitaxel is reported to be metabolized by cytochrome p-450(CYP3.A,)in both the liver and epithelial cells of small intestine and also absorption of paclitaxel is inhibited by p-glycoprotein efflux Pump in the intestinal mucosa. This resulted in poor orall bioavailability of paclitaxel. Area under the plasma concentration-time curve (AUC) of paclitaxel in combination with quercetin were significantly (p＜ 0.01) higher than those of control. (omitted)

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.419.1-419.1
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• 2002

The purpose of this study was to report the pharmacokinetic changes of cyclosporine after oral administration of cyclosporine. 10 mg/kg. in rabbits coadministered or pretreated twice per day for 3 days with nimodipine. dose of 5 mg/kg, The area under the plasma concentration-time curve (AUC) of cyclosporine was significantly higher in rabbits pretreated with nimodipine than in control rabbits (p＜0.01). showing about 149% increased relative bioavailability. (omitted)

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.240.1-240.1
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• 2003

The purpose of this study was to investigate the effect of nifedipine (10 mg/kg) on the pharmacokinetic parameters and the bioavailability of paclitaxel (50 mg/kg) orally coadministered and pretreated in rats. The plasma concentration of paclitaxel in combination with nifedipine was significantly (p<0.05 at 10 mg/kg coadmin., p<0.01 at pretreat.) increased compared to that of control, from 2 hr to 24 hr. Area under the plasma concentration-time curve (AUC) of paclitaxel with nifedipine was significantly (p＜0.05 at 10 mg/kg coadmin., p＜0.01 at pretreat.) higher than that of control (omitted)

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.241.2-241.2
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• 2003

The purpose of this study was to investigate the effect of quercetin(2.0, 10, 20 mg/kg; combined or pretreated) on the pharmacokinetic parameters and the bioavailability of diltiazem(15mg/kg) orally to rabbits. The plasma concentration of diltiazem pretreated with quercetin(pretreated group) were increased significantly (p<0.01) compared to that of control, but those of diltiazem combined with quercetin(combined group) were not affected. Area under the plasma concentration-time curve (AUC) of diltiazem pretreated with quercetin was significantly ( p<0.01) higher than that of control (omitted)

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.245.3-246
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• 2003

The purpose of this study was to investigate the effect of quercetin(2.0, 10, 20 mg/kg; combined or pretreated) on the pharmacokinetic parameters and the bioavailability of paclitaxel(50mg/kg) orally in rats. The plasma concentration of paclitaxel pretreated with quercetin(pretreated group) were increased significantly (p＜0.01) compared to that of control, but those of paclitaxel combined with quercetin(combined group) were not affected. Area under the plasma concentration-time curve (AUC) of paclitaxel pretreated with quercetin was significantly (p＜0.01) higher than that of control. (omitted)

• Journal of the Korean Society of Radiology
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• v.10 no.8
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• pp.645-652
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• 2016

In this study, based on the analysis of texture feature values of statistical properties. And we examined the normal and the applicability of the computer-aided diagnosis of cerebral infarction in the brain computed tomography images. The experiment was analyzed to evaluate the ROC curve recognition rate of disease using six parameters representing the feature values of the texture. As a result, it showed average mean 88%, variance 92%, relative smoothness 94%, uniformity of 88%, a high disease recognition rate of entropy 84%. However, it showed a slightly lower disease recognition rate and 58% for skewness. In the analysis using ROC curve, the area under the curve for each parameter indicates 0.886 (p = 0.0001) or more, resulted in a meaningful recognition of the disease. Further, to determine the cut-off values for each parameter are determined to be the prediction of disease through the computer-aided diagnosis.

• The Korean Journal of Health Service Management
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• v.11 no.2
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• pp.105-115
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• 2017

Objectives : The aim of this study was to suggest the optimal cut off for best, very good, good, slightly bad, and bad grades. Methods : The subjects were recruited from 4 areas of South Korea and 487 questionnaires were analyzed. The nominal and continuous self-rated health questions were used to reveal the optimal cut off and the Short Form-12 Health Survey questionnaire (SF-12) was additionally used. Frequency, Pearson's correlation coefficient, and ROC-curve analysis were used; the significance level was <.05. Results : Subjects assigned 15(3.1%), 90(18.5%), 237(48.7%), 130(26.7%), and 15(3.1%) to best, very good, good, slightly bad and bad groups respectively. The self-rated health score was associated with total Component (r=.563, p<.001), Physical Component (r=.520, p<.001) and Mental Component of SF-12 (r=.303, p<.001). The optimal cut off was 80.5, 70.5, 53.5, and 40.5 for best, very good or more, good or more, and under slightly bad respectively and area under curve was 0.898, 0.908, 0.945, and 0.908 accordingly. Conclusions : This study suggests that the self-rated health score and grade could be integrated with the optimal cut off.