Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.240.1-240.1
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- 2003
Drug Interaction between Nifedipine and Paclitaxel in Rats
- Kim, Hyung-Jung (Korean Food and Drug Association) ;
- Choi, Jun-Shik (College of Pharmacy, Chosun Uncversity)
- Published : 2003.10.01
Abstract
The purpose of this study was to investigate the effect of nifedipine (10 mg/kg) on the pharmacokinetic parameters and the bioavailability of paclitaxel (50 mg/kg) orally coadministered and pretreated in rats. The plasma concentration of paclitaxel in combination with nifedipine was significantly (p<0.05 at 10 mg/kg coadmin., p<0.01 at pretreat.) increased compared to that of control, from 2 hr to 24 hr. Area under the plasma concentration-time curve (AUC) of paclitaxel with nifedipine was significantly (p<0.05 at 10 mg/kg coadmin., p<0.01 at pretreat.) higher than that of control (omitted)
Keywords