• 대한한의학방제학회지
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• 제5권1호
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• pp.184-202
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• 1997

The results of immune response and antiallergic reaction were as follows. 1. Hemagglutinin titer and hemolysin titer were increased in case of AMR, AR, SNH. But the results were not recognized as having significance. 2. PFC was increased in case of AMR, AR. But the results were not recognized as having significance. 3. RFC was increased in all groups, and the results in the AR, SNH were significant. 4. In experimentation of phagocytic activity in peritoneal exudate cells, AR and SNH showed significant increase. In spleen cells AR and SNH showed significant increase. In monolymphocytus cells AMR, AR and SNH were increased, but result of AMR was of no significance. 5. I examined promotion on spleen cells transformation. As these results, AMR showed increase in $50{\mu}g/m{\ell}$, $5000{\mu}g/m{\ell}$ in comparison with control group. And in $500{\mu}g/m{\ell}$ AMR showed increase in case of 24 hours, 72 hours incubation, but showed decrease in case of 48 hours incubation. AR showed increase in all. In $50{\mu}g/m{\ell}$ SNH showed increase in comparison with control group. And in $500{\mu}g/m{\ell}$, $5000{\mu}g/m{\ell}$ SNH showed increase in case of 24 hours, 48 hours incubation, but showed decrease in case of 72 hours incubation. 6. I examined proliferation of spleen cells. As these results AMR and SNH showed the highest increase in $50{\mu}g/m{\ell}$, but showed the lowest increase in $5000{\mu}g/m{\ell}$. AR showed the highest increase in $500{\mu}g/m{\ell}$, but this result was the almost same in $50{\mu}g/m{\ell}$, $5000{\mu}g/m{\ell}$. And AMR, AR, SNH showed higher activity in Lipopolysaccharide than Concanavalin A. 7. In all groups results of PCA were decreased in 2 week. In 4 week AR and SNH showed decrease, but AMR didn't show change. In 6 week AR and SNH showed decrease, but on the contrary AMR showed increase. 8. In experimentation on histamine contents, AMR showed significant increase at first agent contact. And AR, SNH showed decrease at first agent contact, but these results were of no importance. At second agent contact AMR showed decrease, but was of no importance. AR, SNH showed significant decrease. At third agent contact, AMR showed significant increase. AR, SNH showed decrease, but these results were of no importance. From above these results, AR and SNH showed good effects on immunoreaction. And all the herb medicines in this examination showed good effects in promotion on spleen cells transformation and proliferation of spleen cells, especially activated B-cells. AR, SNH showed good effects on anti-allergic reaction, but AMR was almost inefficient. Accordingly I think that AR shall be used in disease bringing about a lowering of immunity, that is, AR shall be used in strengthening the body resistance. And I think that SNH shall be used in eliminating pathogenic factors with strengthening the body resistance. It is necessary to a deep study in future.

• Asian-Australasian Journal of Animal Sciences
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• 제20권2호
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• pp.184-193
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• 2007

In mammalian ovary, steroidogenic acute regulatory (StAR) protein mediates the true rate-limiting step of transport of cholesterol from outer to inner mitochondrial membrane. Appropriate expression of StAR gene represents an indispensable component of steroidogenesis and its regulation has been found to be species specific. However, limited information is available regarding StAR gene expression during estrous cycle in buffalo ovary. In the present study, expression, localization and hormonal regulation of StAR mRNA were analyzed by semi-quantitative RT-PCR in buffalo ovary and partial cDNA was cloned. Total RNA was isolated from whole follicles of different sizes, granulosa cells from different size follicles and postovulatory structures like corpus luteum and Corpus albicans. Semi-quantitative RT-PCR analyses showed StAR mRNA expression in the postovulatory structure, corpus luteum. No StAR mRNA was detected in total RNA isolated from whole follicles of different size including the preovulatory follicle (>9 mm in diameter). However, granulosa cells isolated from preovulatory follicles showed the moderate expression of StAR mRNA. To assess the hormonal regulation of StAR mRNA, primary culture of buffalo granulosa cells were treated with FSH (100 ng/ml) alone or along with IGF-I (100 ng/ml) for 12 to 18 h. The abundance of StAR mRNA increased in cells treated with FSH alone or FSH with IGF-I. However, effect of FSH with IGF-I on mRNA expression was found highly significant (p<0.01). In conclusion, differential expression of StAR messages was observed during estrous cycle in buffalo ovary. Also, there was a synergistic action of IGF-I on FSH stimulation of StAR gene.

• Journal of Information Processing Systems
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• 제12권4호
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• pp.612-630
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• 2016

As mobile augmented reality technologies are spreading these days, many users want to produce augmented reality (AR) contents what they need by themselves. To keep pace with such needs, we have developed a mobile AR contents builder (hereafter referred to as MARB) that enables the user to easily connect a natural marker and a virtual object with various interaction events that are used to manipulate the virtual object in a mobile environment so that users can simply produce an AR content using natural photos and virtual objects that they select. MARB consists of five major modules-target manger, virtual object manager, AR accessory manager, AR content manager, and AR viewer. The target manager, virtual object manager and AR accessory manager register and manage natural target markers, various virtual objects and content accessories (such as various decorating images), respectively. The AR content manger defines a connection between a target and a virtual object with enabling various interactions for the desired functions such as translation/rotation/scaling of the virtual object, playing of a music, etc. AR viewer augments various virtual objects (such as 2D images, 3D models and video clips) on the pertinent target. MARB has been developed in a mobile application (app) format in order to create AR contents simply using mobile smart devices without switching to a PC environment for authoring the content. In this paper, we present the detail organizations and applications of MARB. It is expected that MARB will enable ordinary users to produce diverse mobile AR contents for various purposes with ease and contribute to expanding the mobile AR market based on spread of a variety of AR contents.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2017년도 춘계학술대회
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• pp.297-299
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• 2017

최근 증강 현실(AR)의 응용분야가 급증하고 관련 콘텐츠 또한 수요가 증대되고 있다. 이와 같이 모바일 환경에서 AR 콘텐츠의 서비스를 위해서는 오브젝트 기반의 마커 인식 기능이 필요하다. 이때 마커에 대응하는 정보를 제공하기 위해 특정 마커에 대응하는 가상 오브젝트를 생성하여 서비스하는 기법을 사용한다. 그러나 마커에 대응하는 가상의 오브젝트를 AR 화면상에 유지할 때 카메라의 떨림, 카메라의 이동 등의 다양한 이유로 마커의 오브젝트가 불안정하게 흔들리는 현상이 발생된다. 이와 같이 모바일 디바이스 기반의 AR 서비스는 안정적으로 오브젝트를 표현하기 어렵다는 문제점을 갖는다. 본 논문에서는 모바일 AR 환경에서 고정된 마커를 인식했을 때, 디바이스의 물리적 상태 변화에 대응하는 필터링 방법을 적용하여 안정적인 마커 인식 및 추적 기법을 제안한다.

• 한국자기학회지
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• 제2권2호
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• pp.119-124
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• 1992

조성변조 Co/Pd 초격자 박막 제조시 스퍼터링 Ar기압이 박막의 미세조직에 미치는 방향과 이로 인한 자기 및 자기광학적 특성에 미치는 영향을 조사하였다. 초격자 박막은 dc-magnetron 스퍼터링 방법으로 각 sublayer의 두께가 $2\;\AA-Co/9\;\AA-Pd$일때, 스퍼터링 Ar가스압력을 2에서 30 mTorr 까지 변화시키면서 제조하였다. Ar기압이 10 mTorr 이상에서 초 격자 박막은 주상구조(columnar structure)를 형성시키면서 성장됨이 관측되었다. Ar기압의 증가에 따라 포화자화값, 자기이방성에너지 및 Kerr 회전각등은 감소하고 보자력은 증가함을 보였다. 이러한 자기 및 자기광학적 특성의 변화는 Ar압력에 따른 초격자 박막의 미세구조 변화에 기인되는 현상으로 설명될 수 있다.

• Molecules and Cells
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• 제45권4호
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• pp.202-215
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• 2022

The androgen receptor (AR) is an important therapeutic target for treating prostate cancer (PCa). Moreover, there is an increasing need for understanding the AR-independent progression of tumor cells such as neuroendocrine prostate cancer (NEPC). Menin, which is encoded by multiple endocrine neoplasia type 1 (MEN1), serves as a direct link between AR and the mixed-lineage leukemia (MLL) complex in PCa development by activating AR target genes through histone H3 lysine 4 methylation. Although menin is a critical component of AR signaling, its tumorigenic role in AR-independent PCa cells remains unknown. Here, we compared the role of menin in AR-positive and AR-negative PCa cells via RNAi-mediated or pharmacological inhibition of menin. We demonstrated that menin was involved in tumor cell growth and metastasis in PCa cells with low or deficient levels of AR. The inhibition of menin significantly diminished the growth of PCa cells and induced apoptosis, regardless of the presence of AR. Additionally, transcriptome analysis showed that the expression of many metastasis-associated genes was perturbed by menin inhibition in AR-negative DU145 cells. Furthermore, wound-healing assay results showed that menin promoted cell migration in AR-independent cellular contexts. Overall, these findings suggest a critical function of menin in tumorigenesis and provide a rationale for drug development against menin toward targeting high-risk metastatic PCa, especially those independent of AR.

• 융합보안논문지
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• 제22권5호
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• pp.107-113
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• 2022

AR/VR 기반의 교육훈련 체계는 전장 환경과 유사한 실전적 훈련 효과뿐 아니라 사고 예방 및 예산 절감에도 큰 기여를 할 것으로 평가되고 있다. AR/VR을 학습에 활용하기 위한 연구는 꾸준히 진행되고 있으며, 교육과 훈련에 활용할 경우 실세계에서 발생할 수 있는 실패의 경험 없이도 기술을 향상시킬 수 있다. 국방 주요선진국들은 이러한 AR/VR 기술의 이점을 일찍부터 인식하고, 개인의 무기체계 운용 숙달에서부터 종합 전투훈련 체계, 전쟁사 교육, 외상 후 스트레스 치료 등 다양한 분야에서 AR/VR을 개발하고 적용하는 노력을 하고 있다. 한국군도 최근 AR/VR 활용 교육훈련 적용방안을 적극적으로 검토하고 있다. 이에 본 연구의 목적은 국방 선진국의 AR/VR 적용 교육훈련 사례들을 살펴보고 한국군에 적용할 시사점을 도출하는 것이다.

• Molecules and Cells
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• 제28권3호
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• pp.189-194
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• 2009

The modulating effect of IGF-I on the regulation of AR gene expression and activation in skeletal muscle cells remains poorly understood. In this study, the effects of IGF-I treatment on AR induction and activation in the absence of AR ligands were examined. Differentiating C2C12 cells were treated with different concentrations (0-250 ng/ml) of IGF-I or for various periods of time (0-60 min) of 250 ng/ml IGF-I. Treatment of C2C12 cells with IGF-I resulted in a dose- and time-dependent increase in total AR and phosphorylated AR (Ser 213). IGF-I treatment also led to significantly increased AR mRNA expression when compared with the control. The levels of skeletal ${\alpha}-actin$ and myogenin mRNA, known target genes of AR, were also significantly upregulated after 5 or 10 min of treatment with IGF-I. Confocal images revealed that IGF-I stimulated nuclear localization of AR in the absence of ligands. In addition, an electrophoretic mobility shift assay indicated that IGF-I stimulated the AR DNA binding activity in a time-dependent manner. The present results suggest that IGF-I stimulates the expression and activation of AR by ligand-independent mechanism in differentiating C2C12 mouse skeletal muscle cells.

• 전기학회논문지P
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• 제51권3호
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• pp.132-136
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• 2002

In this study, we analyzed the luminous efficiencies of Ne-Xe-Ar and He-Ne-Xe-Ar mixing gas in compared with those of Ne-Xe and He-Ne-Xe mixing gas to improve luminous efficiency by adding a small amount of Ar gas. At the Xe 4%, the brightness of Ne-Xe and He-Ne-Xe mixing gas is higher than others. As the Xe % increases, power consumption decreases. Thus, in the Ne-Xe and He-Ne-Xe mixing gas of Xe 4%, we obtained maxium luminous efficiency. The Ar concentration is varied from 0.1% to 0.7% in this study. The luminous efficiency of the Ne-Xe(4%) mixing gas is improved to 1.16 and 1.13 lm/W by adding an Ar concentration of 0.4% and 0.5%, respectively. The luminous efficiency of the He-Ne-Xe(4%) (He : Ne = 7 : 3) mixing gas is considerably improved by adding an Ar concentration of above 0.3%. The maximum luminous efficiency of this mixing gas is 1.38 lm/W at the condition of adding an Ar concentration of 0.5%.

• 암석학회지
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• 제4권2호
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• pp.178-184
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• 1995

증평-덕평 지역에서 산출하는 중부 옥천변성대의 13개 이질 편암에서 구한 K-Ar 흑운모 연대는 한 개 시료를 제외하고는 89-213Ma 의 범위에 속한다. 이들 K-Ar 연령은 쥬라기와 백악관 화강암체어 가까와 질수록 체계적으로 감소하는 경향을 보인다. 쥬라기 백악관 화강암체 부근에서 얻은 K-Ar 흑운모연대는 각각 166Ma와 89Ma이다. 따라서 연구 지역의 흑운모 연대는, 트라이아스가 후기 내지 쥬라기 초기의 광역-열 변성작용 이후, 중생대화강암의 관입에 의한 열적 작용 때문에 부분적으로 또는 거의 완전히 재평형되었음을 알 수 있다.