• Parasites, Hosts and Diseases
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• v.54 no.2
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• pp.155-161
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• 2016

Toxoplasma gondii is an important opportunistic pathogen that causes toxoplasmosis, which has very few therapeutic treatment options. The most effective therapy is a combination of pyrimethamine and sulfadiazine; however, their utility is limited because of drug toxicity and serious side effects. For these reasons, new drugs with lower toxicity are urgently needed. In this study, the compound, (Z)-1-[(5-nitrofuran-2-yl)methyleneamino]-imidazolidine-2,4-dione (nitrofurantoin), showed anti-T. gondii effects in vitro and in vivo. In HeLa cells, the selectivity of nitrofurantoin was 2.3, which was greater than that of pyrimethamine (0.9). In T. gondii-infected female ICR mice, the inhibition rate of T. gondii growth in the peritoneal cavity was 44.7% compared to the negative control group after 4-day treatment with 100 mg/kg of nitrofurantoin. In addition, hematology indicators showed that T. gondii infection-induced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, biochemical parameters involved in liver injury, were reduced by nitrofurantoin significantly. Moreover, nitrofurantoin exerted significant effects on the index of antioxidant status, i.e., malondialdehyde (MDA) and glutathione (GSH). The nitrofurantoin-treated group inhibited the T. gondii-induced MDA levels while alleviating the decrease in GSH levels. Thus, nitrofurantoin is a potential anti-T. gondii candidate for clinical application.

• International Commerce and Information Review
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• v.11 no.3
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• pp.265-286
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• 2009

Dumping describes the practice of international price discrimination whereby a producer or exporter sells merchandise in an export market at less than fair value. The U.S. antidumping statutory framework is embodied in the Tariff Act of 1930. The Act states that "dumping" refers to the sale or likely sale of goods at less than fair value. 19 U.S.C. $\S$ 1677(34). The Commerce Department and the Commission are jointly responsible for administering the antidumping law. Commerce determines whether foreign merchandise is being sold in the United States at less than fair value, and the Commission determines whether a domestic industry producing a product like the imported merchandise has been materially injured or threatened with material injury by reason of imports of that product. Recently, in U.S. v. Eurodif, the Supreme Court held the question whether the Commerce can reasonably determin that foreign merchandise has been sold within the meaning of the antidumping law in U.S.. Should 19 U.S.C. Section 1673, which calls for "antidumping" duties on foreign goods, but not services, that sell at less than fair value in the U.S., apply to imported low enriched uranium? Yes. In a unanimous opinion written by Justice David H. Souter, the Supreme Court held that the Commerce Department's view of imported low enriched uranium, as the sale of goods rather than services, was permissible. It reasoned that, since 19 U.S.C. Section 1673 did not specify whether it applied to the production of low enriched uranium, it was left to the reasonable interpretation of the Commerce Department to determine. Accordingly, the Court found the Commerce Department interpreted the statute reasonably.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.25 no.2
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• pp.39-46
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• 2019

Background: Ground repulsion or impact on the ground during daily activities, sports, or occupational activities may cause injury to the knee when walking. Non-elastic taping is effective in treating these problems in previous studies. Non-elastic taping strengthens the structure of the soft tissues of the injured knee joint to maintain constant tension, improves muscle rearrangement and function, and improves proprioception. Based on previous studies, we intended to see the therapeutic changes of non-elastic taping in patients with patellofemoral joint pain syndrome. Methods: The non-elastic taping application method was applied to the patient three times for five hours for one week. Non-elastic taping was applied to the patellar tendon with little space above the skin segment of the patellar femur, with both sides fixed by taping. Muscle strength and gait change were evaluated with non-elastc taping. Results: The knee flexion, extension strength and gait evaluation of the knee joint with inelastic taping showed significant differences after treatment. There was a significant difference in the comparison between the two groups after the treatment method was applied (p<.05). Conclusion: As a result, this study confirms that the non-elastic taping method applied for the treatment of patellar femoral joint pain syndrome is effective in the treatment.

• Journal of Acupuncture Research
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• v.19 no.6
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• pp.1-11
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• 2002

Objective : Korean medicine treatment method is noted as alternative in treating traffic accidents(TA) victims recently. The main purpose of this research is to make a survey of the effective way of the Korean medicine treatment about TA victims. Methods : In following research, 389 cases of traffic victims who hospitalized in the Youngsaeng Korean Medicine Hospital & Youngsaeng Clinic from March 1, 2001 to November 30, 2001 were surveyed. The research is focused on finding out the distribution, such as sex and age, damaged part of the body of 389 TA victims, nature of damage of 389 TA victims, chief complaint of 389 TA victims, nature of damage by Korean medicine code classification, treatment given to 389 TA victims, Extract(Ex) medicine given to 389 TA victims, days in hospital of 389 TA victims. Results : The patients reached korean medicine hospital in fewer numbers from most of TA victims. As neck pain and L-spin sprain, most of symptoms was light and the treatment of medicine as well was limited for TA. The treatment method which was used for treating TA was acupuncture, cupping therapy, physical therapy, Ex medicine. Few ways could use the Ex medicine as well. Conclusions : The achieving rate of treatment was marked highly by using Haenggi(行氣) Hwalhyeol(活血) Guyea(祛瘀) and we confirmed a possibility for the treatment of TA in korean medicine treatment method. It needs to increase all kinds of treatment-ways which can treat successfully and needs to come into application of insurance. Korean medicine method will have possibility to take part in TA injury admission, by presenting basis to prove effectiveness of treatment-ways.

• Journal of Chest Surgery
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• v.43 no.3
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• pp.304-307
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• 2010

A 5-day-old neonate (body weight=2.4 kg) with coarctation of the aorta and critical aortic stenosis underwent an interventional balloon valvuloplasty for aortic stenosis. During the intervention, cardiac arrest occurred due to injury of the right carotid artery by the guide wire. An extracorporeal membrane oxygenator (ECMO) was applied. After 1 day's support, total surgical correction was achieved; however, in the immediate postoperative period, cardiac function was severely depressed. We applied a bi-ventricular assist device (bi-VAD) instead of an ECMO and we were able to wean the patient off the bi-VAD device after 3 days' support. The patient was discharged without severe complications.

• The Journal of Korean Medicine
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• v.32 no.2
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• pp.63-78
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• 2011

Objective: This study aimed to evaluate the protective effects of Maekmundong-tang (MMDT) on an elastase-induced COPD model. Materials and Methods: The extract of MMDT was treated to A549 cells and elastase-induced COPD mice model. Then, various parameters such as cell-based cytoprotective activity and histopathological findings were analyzed. Results: MMDT showed a protective effect on elastase-induced cytotoxicity in A549 cells. This effect was correlated with analysis for caspase 3 levels, collagen and elastin contents, protein level of Cdk1, and gene expression of TNF-${\alpha}$ and IL-$1{\beta}$ in A549 cells. MMDT treatment also revealed a protective effect on the elastase-induced COPD mice model. This effect was evidenced via histopathological finding including immunofluorescence stains against elastin, collagen, and caspase 3, and protein level of Cdc2 in lung tissue. Conclusion: These data suggest that MMDT has pharmaceutical properties on COPD. This study can provide scientific evidence for the efficacy of MMDT for clinical application to patients with COPD.

• The Journal of Korean Physical Therapy
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• v.24 no.4
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• pp.268-275
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• 2012

Purpose: This study is to identify how eye movement influences the static balance and fall efficacy of the elderly who have experienced fall-related injuries. Methods: Thirty nine elderly who scored 24 points in the Korean mini mental state examination, were able to walk, and had no specific disease, were selected as the research subjects among elderly who have experienced fall-related injury more than once in the past year. Thus, 20 for the experimental group, and 19 for the control group were selected as subjects. The experiment was conducted for 6 weeks, including periods of evaluation before and after intervention. Results: The results with respect to the dependent variables are as follows: Substitute sample t-testing showed significant differences between each group in eye movement to check difference in balance performance and fall efficacy. When independent sample t-tests were conducted to compare static balancing performance and fall efficacy between the two groups after intervention, they showed significant differences in statistical terms (p<0.05). Conclusion: From the above results of the study, it was found that the application of eye movement combined with diverse fall prevention programs is effective, when enhancing static balance performance power and improving fall efficacy.

• Archives of Reconstructive Microsurgery
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• v.22 no.1
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• pp.33-37
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• 2013

Purpose: The concept and development of perforator free flaps have led to significant advances in microsurgery. Ongoing developments in perforator free flap surgery are aimed at reducing complications and improving surgical outcomes. The aim of this study was to evaluate the effectiveness and application of supermicrosurgery in free flap surgery. Materials and Methods: A total of 267 patients with soft tissue defects of the lower extremity due to various etiologies from January, 2007 to January, 2013. The patients received either an anterolateral thigh free flap (n=83), a superficial circumflex iliac artery free flap (n=152), an upper medial thigh free flap (n=19), or a superior gluteal artery perforator free flap (n=13). Microanastomosis was performed using a perforator-to-perforator technique, either end-to-end or end-to-side. Results: The mean postoperative follow up period was eight months (range: one to 16 months) and flap loss occurred in 11 cases out of 267. All cases of flap loss occurred within two weeks of surgery due to either arterial insufficiency (n=5) or venous congestion (n=6). Conclusion: Supermicrosurgery enables the selection of the most efficient perforator for microanastomosis at the defect site. It also reduces the time required for dissection of recipient vessels, and reduces the possibility of injury to major vessels. Microsurgery using a vessel of less than 1 mm has been reported to increase the risk of flap failure; however, using the most advanced surgical tools and developing experience in the technique can produce success rates similar to those found in the literature.

• Journal of the Ergonomics Society of Korea
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• v.35 no.3
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• pp.125-133
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• 2016

Objective: The aim of this study is to figure out the level of Functional Movement Screen (FMS) of 122 automobile manufacturing workers and to set the FMS score for predicting risk of musculoskeletal disorders. Background: Although today's industrial sites have been becoming automated rapidly, the risks of work-related musculoskeletal disorders (WMSDs) have been on the rise. In the case of WMSDs, it is important to control WMSDs at the early stage. Early detection of WMSDs is very important for the successful treatment. However, the medical examination puts a great financial burden on most workers. To reduce their burden, there is one test to check the musculoskeletal functional condition and to predict the risk of injury, which is called FMS. Method: This research tested the FMS score of 122 workers at a motor company, and also conducted a questionnaire survey of individual characteristics and job characteristics. Results: For the 122 subjects, the average score of FMS is $14.63{\pm}2.27$. There is a negative correlation between FMS and their ages and BMI (p <0.05). FMS is higher when exercising regularly (p <0.05). The FMS scores of musculoskeletal disorder patients are lower than those of normal workers (p <0.05). While it is more likely to become a musculoskeletal disorder patient when FMS score is less than 14, it is more likely to become a normal worker when FMS score is more than or equal to 14. Conclusion: According to the result of FMS test, there is a score difference between individuals with musculoskeletal disorders and normal ones. FMS scores can also predict and identify workers with risk of the musculoskeletal disorders. Application: According to this study, FMS can be expected to have a positive effect on the prevention of WMSDs in worksites.

• Journal of the Korea Convergence Society
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• v.10 no.11
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• pp.95-100
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• 2019

In this paper, autonomous vehicles of service with existing vehicle accident for the prevention of the vehicle communication technology, self-driving techniques, brakes automatic control technology, artificial intelligence technologies such as well and developed the vehicle accident this occur to death or has been techniques, can prepare various safety cases intended to minimize the injury. In this paper, it is a study to secure safety in autonomous vehicles. This is determined according to spatial factors such as chip signals for general low-power short-range wireless communication and micro road AI. On the other hand, in this paper, the safety of boarding is improved by checking the signal from the electronic chip, up to "recognition of the emotion from residence time in the sensing area" to the biological electronic chip. As a result of demonstrating the reliability of the world countries the world, inducing safety autonomous system of all passengers in terms of safety. Unmanned autonomous vehicle riding and commercialization will lead to AI systems and biochips (Verification), linked IoT on the road in the near future, and the safety technology reliability of the world will be highlighted.