• The Journal of Internal Korean Medicine
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• v.27 no.2
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• pp.459-470
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• 2006

Objectives: The aim of this experimental study is to investigate the effects of MYRISTICAE SEMEN, GRANATI PERICARPIUM and ALPINIAE KATSUMADAI SEMEN on the anticatharsis by using mice and Guinea pigs. Methods : We evaluated the effect of herbs on the extracted organs contraction, the barium sulfate transport, and the anticathartic action induced by acetylcholine chloride, barium chloride, histamine chloride, neostigmine, castor oil, pilocarpine in the ileums, large intestines, small intestines of animals. Results : In the extracted organs, all herbs showed concentration-dependent inhibitory effect on the constriction of extracted ileum. The transport of barium sulfate in the large and small intestine was increased in comparing with the control group. And every three herbs showed the anticathartic action. Conclusions : These results demonstrate that MYRISTICAE SEMEN, GRANATI PERICARPIUM and ALPINIAE KATSUMADAI SEMEN extracts have an advantageous effects on diarrhea induced by drugs and will contribute to the development of diarrhea treatment through further related studies.

• The Journal of Internal Korean Medicine
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• v.11 no.1
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• pp.15-27
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• 1990

For the purpose of examing on the efficancy of the Boolwhangumjeonggisan and on the effect of the Boolwhangumjeonggisan, dropsy animals given water boil ding abstraction exgis power. What made an experiment, the motility of isolate ileume, anticathartic action, the action of gastric juice, tied pylous ulcer and inhibited vomitting. 1. Boolwhangumjeonggisan displayed great suppresion effect in regard to automatic movement of the motility of isolated of mice and displayed anti-acethylcholine action, antibarium chloride action. Thus, the origin of muscle relaxation for internal smooth muscle is admitted. 2. It displayed great rexation effect in regard to fraction of rat's stomach and displayed contentional effect in regard to a cetylcholine and barium chloride. 3. It decreased rat of barium sulfate transport through the small intestine of mice. 4. It recognized anti-cathartic action, rat suffered from leading diarrhea by caster oil. 5. Total activity, pepsin secretion decreased and increased the pH of stomach in Shay's method. 6. It recognized powerful prevention effect on tied pylous ulcer. 7. It inhibited vomitting by administration of CuSo4 in frog.

• Korean Journal of Pharmacognosy
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• v.16 no.2
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• pp.73-80
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• 1985

Experimental studies were undertaken to investigate for the effect of Yijin-tang on the digestive system and isolated uterus of rats. Yijin-tang was composed of five crude drugs; Pinelliae Tuber, Aurantii nobilis Pericarpium, Hoelen, Glycyrrhizae Radix and Zingiberis Rhizoma. The results obtained from experiments with water soluble fraction extracted from Yijin-tang were as follows; Spontaneous motilities of isolated ileum of mice and rabbits were suppressed, and contraction of isolated ileum of mice and guinea-pigs induced acetylcholine, barium chloride and histamine were inhibited. The anticathartic action of mice induced by castor oil were significantly observed. The spontaneous motility of isolated uterus of rats was suppressed. Inhibitory effect of gastric juice secretion and antiulcerogenic action were significantly shown in Shay rats.

• The Journal of Internal Korean Medicine
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• v.28 no.2
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• pp.217-229
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• 2007

Objectives : The aim of this experimental study was to investigate the effects of Bojangjisa-tang on anticatharsis by using mice and Guinea pigs. Methods : We observed the actions on gastrointestinal smooth muscles, on the transportability of small and large intestines and on diarrhea induced by castor oil, philocarpine, and barium chloride. Results : Bojangjisa-tang showed alleviation of the contraction of gastrointestinal smooth muscles induced by acetylcholine chloride and barium chloride. The transportability of the large intestine was constrained by Bojangjisa-tang, which also showed substantial anti-cathartic effects on diarrhea induced by castor oil, philocarpine and barium chloride. Conclusion : These results demostrate that Bojangjisa-tang has advantageous effects on drug-induced diarrhea and will contribute to the development of diarrhea treatment through further related studies.