The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Anticathartic Effect of MYRISTICAE SEMEN, GRANATI PERICARPIUM and ALPINIAE KATSUMADAI SEMEN

육두구, 석류피(石榴皮) 및 초두구의 항사하작용(抗瀉下作用)에 관한 연구

  • Lee, Keun-Mee (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Kim, Jin-Sung (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Yoon, Sang-Hyub (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Ryu, Bong-Ha (3rd Department of Internal Medicine, College of Oriental Medicine, Kyunghee University)
  • 이근미 (경희대학교 한의과대학 비계내과학교실) ;
  • 김진성 (경희대학교 한의과대학 비계내과학교실) ;
  • 윤상협 (경희대학교 한의과대학 비계내과학교실) ;
  • 류봉하 (경희대학교 한의과대학 비계내과학교실)
  • Published : 2006.06.30
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Abstract

Objectives: The aim of this experimental study is to investigate the effects of MYRISTICAE SEMEN, GRANATI PERICARPIUM and ALPINIAE KATSUMADAI SEMEN on the anticatharsis by using mice and Guinea pigs. Methods : We evaluated the effect of herbs on the extracted organs contraction, the barium sulfate transport, and the anticathartic action induced by acetylcholine chloride, barium chloride, histamine chloride, neostigmine, castor oil, pilocarpine in the ileums, large intestines, small intestines of animals. Results : In the extracted organs, all herbs showed concentration-dependent inhibitory effect on the constriction of extracted ileum. The transport of barium sulfate in the large and small intestine was increased in comparing with the control group. And every three herbs showed the anticathartic action. Conclusions : These results demonstrate that MYRISTICAE SEMEN, GRANATI PERICARPIUM and ALPINIAE KATSUMADAI SEMEN extracts have an advantageous effects on diarrhea induced by drugs and will contribute to the development of diarrhea treatment through further related studies.

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