• 정보보호학회논문지
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• 제20권6호
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• pp.237-249
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• 2010

최근 다양한 사이버 침해사고의 개인정보 유출 사례를 살펴보면 공격 대상이 서비스 제공자를 대상으로 하고 있지만 실제적인 피해 대상은 사용자라고 할 수 있다. 정당한 서비스 계약을 체결하였음에도 불구하고 정상적인 서비스를 받을 수 없거나 서비스를 위해 제공한 개인정보가 유출되는 피해가 발생하고 있다. 이에 따라 사업자 및 사용자간 제공되는 서비스에 대한 SLA와 관련하여 보안SLA가 크게 주목받고 있다. 특히 안타바이러스 서비스를 제공하는 서비스 제공자의 경우 보안SLA를 통해 보다 높은 수준의 보안서비스를 제공해야 한다. 그러나 국내에서는 보안SLA와 관련된 연구가 미비하여 유지보수 수준의 SLA만 제공되는 상황이다. 따라서 본 논문에서는 안티바이러스 시스템의 보안 기능을 분석하여, 보안SLA의 지표를 개발하고 보안기능별 등급화 방안을 제안한다.

• Journal of Microbiology and Biotechnology
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• 제29권8호
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• pp.1184-1192
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• 2019

The influenza A virus is a highly infectious respiratory pathogen that sickens many people with respiratory disease annually. To prevent outbreaks of this viral infection, an understanding of the characteristics of virus-host interaction and development of an anti-viral agent is urgently needed. The influenza A virus can infect mammalian species including humans, pigs, horses and seals. Furthermore, this virus can switch hosts and form a novel lineage. This so-called zoonotic infection provides an opportunity for virus adaptation to the new host and leads to pandemics. Most influenza A viruses express proteins that antagonize the antiviral defense of the host cell. The non-structural protein 1 (NS1) of the influenza A virus is the most important viral regulatory factor controlling cellular processes to modulate host cell gene expression and double-stranded RNA (dsRNA)-mediated antiviral response. This review focuses on the influenza A virus NS1 protein and outlines current issues including the life cycle of the influenza A virus, structural characterization of the influenza A virus NS1, interaction between NS1 and host immune response factor, and design of inhibitors resistant to the influenza A virus.

• Bulletin of the Korean Chemical Society
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• 제34권10호
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• pp.3013-3016
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• 2013

Two new isoflavanones, (3R) 7,2',4'-trihydroxy-3'-methoxy-5-methoxycarbonyl-isoflavanone (1) and (3R) 7,2'-dihydroxy-3',4'-dimethoxy-5-methoxycarbonyl-isoflavanone (2), together with six known isoflavanones (3-8), were isolated from the stems of Cassia siamea. The structure of 1-8 was elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. Compounds 1, 2, 5-8 were evaluated for their anti-tobacco mosaic virus (Anti-TMV) activity. The results showed that compounds 1 and 6 showed potential anti-TMV activity with inhibition rates of 24.6% and 26.9%, respectively. Compounds 2, 5, 7, 8 also showed anti-TMV activity with inhibition rates in the range of 11.8-18.6%.

• Journal of Ginseng Research
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• 제40권4호
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• pp.309-314
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• 2016

Korean Red Ginseng (KRG) is a heat-processed ginseng developed by the repeated steaming and air-drying of fresh ginseng. Compared with fresh ginseng, KRG has been shown to possess greater pharmacological activities and stability because of changes that occur in its chemical constituents during the steaming process. In addition to anticancer, anti-inflammatory, and immune-modulatory activities, KRG and its purified components have also been shown to possess protective effects against microbial infections. Here, we summarize the current knowledge on the properties of KRG and its components on infections with human pathogenic viruses such as respiratory syncytial virus, rhinovirus, influenza virus, human immunodeficiency virus, human herpes virus, hepatitis virus, norovirus, rotavirus, enterovirus, and coxsackievirus. Additionally, the therapeutic potential of KRG as an antiviral and vaccine adjuvant is discussed.

• IMMUNE NETWORK
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• 제3권1호
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• pp.23-28
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• 2003

Background: Intracellular antibody specific to hepatitis B virus X protein (HBx) might be useful for studying the role of HBx in hepatocellular carcinogenesis and HBV replication. Methods: With variable region genes for H7 monoclonal anti-HBx Ab, we constructed a vector for bacterial expression of single chain Ab (scFv) and a vector for eukaryotic cell expression of it. The expression of H7 scFv and its binding activity against HBx was examined by immunoblotting and immunofluorescence microscopy. Results: H7 scFv expressed in bacterial cells retained reactivity to HBx. We demonstrated its intracytoplasmic expression in CosM6 eukaryotic cells. Conclusion: This is the first study showing the expression of intracellular anti-HBx Ab in eukaryotic cells. H7 scFv may be a good tool to study the function of HBx in HBV infection.

• 한국산업정보학회논문지
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• 제20권2호
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• pp.65-72
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• 2015

안티바이러스는 단말에서 악성소프트웨어를 탐지하는데 있어 널리 사용되는 솔루션이다. 이 중 시그니처 기반 안티바이러스는 가장 기본적인 탐지방법으로 파일과 악성소프트웨어의 시그니처를 비교하여 탐지한다. 최근 악성소프트웨어의 수가 급격히 증가함에 따라 시그니처 기반 안티바이러스의 탐지 시간이 증가하고 시간당 처리량이 줄어들면서 성능 저하 문제가 발생되고 있다. 본 논문에서는 이를 극복하기 위해 제시된 주요 연구 결과를 살펴보고 이를 개선한 새로운 성능향상 솔루션을 제시한다. 특히, 본 논문의 솔루션은 성능향상 수준이 가장 높은 솔루션으로 알려진 SplitScreen과 비교하여, 클라이언트의 작업을 줄이고, 시그니처 서버와의 통신비용을 줄여 안티바이러스 솔루션의 성능향상에 기여하였다.

• Journal of Microbiology
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• 제45권6호
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• pp.528-533
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• 2007

In a previous study we generated an anti-Hepatitis B Virus (HBV) preS1 humanized antibody (HzKR127) that showed in vivo HBV-neutralizing activity in chimpanzees. However, the antigen-binding affinity of the humanized antibody may not be sufficient for clinical use and thus affinity maturation is required for better therapeutic efficacy. In this study, phage display technique was employed to increase the affinity of HzKR127. All six amino acid residues (Glu95-Tyr96-Asp97-Glu98-Ala99-Tyr100) in the heavy (H) chain complementary-determining region 3 (HCDR3) of HzKR127 were randomized and phage-displayed single chain Fv (scFv) library was constructed. After three rounds of panning, 12 different clones exhibiting higher antigen-binding activity than the wild type ScFv were selected and their antigen-binding specificity for the preS1 confirmed. Subsequently, five ScFv clones were converted to whole IgG and subjected to affinity determination. The results showed that two clones (B3 and A19) exhibited an approximately 6 fold higher affinities than that of HzKR127. The affinity-matured humanized antibodies may be useful in anti-HBV immunotherapy.

• Archives of Pharmacal Research
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• 제20권1호
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• pp.58-67
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• 1997

In order to find antiviral compounds against Herpes simplex virus type I (HSV-1) and II (HSV2) from natural products, a convenient virus-induced cytopathic effect (CPE) inhibition assay was introduced. More than 300 fractions were prepared by solvent fractionation from sixty collected plants or purchased herbal medicines, and their anti-herpetic activities were evaluated. Among them, several medicinal plants showed potent anti-herpetic activity. Selective indexes (SI) of the EtOAc extract of Caraganae Radix (Caragana sinica) against HSV-1 and HSV-2 were more than 8.06 and 24.79, SI of the MeOH extract of Acer okamotoanum leaves were 3.92 and 3.51, SI of the $CH_{2}Cl_{2}$ extract of Veratri Rhizoma et Radix (Veratrum patulum) were 5.49 and 1.31 and SI of the MeOH extract of aerial part of Osmundae Rhizoma (Osmunda japonica) were more than 3.45 and 1.25, respectively.

• 한국정보과학회논문지:정보통신
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• 제29권6호
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• pp.663-673
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• 2002

서버 수준의 안티바이러스는 특정 도메인 내에 진입하는 악성코드를 진입점에서 감지하므로 모든 클라이언트를 완벽하게 통제하기 어려운 실제 상황에서 전자우편 서버 등에 유용하게 사용된다. 그러나, 알려지지 않은 악성 코드에 감지에 유용한 행위 감시 기법은 서버에 적용이 어려우므로, 현재의 서버용 안티바이러스들은 이미 알려진 악성 코드에 대한 시그너쳐 기반의 감지, 단순한 필터링 그리고 파일명 변경과 같은 기능만을 수행한다. 본 논문에서는 서버에서의 실행만으로 별도의 안티바이러스가 탑재되지 않은 클라이언트에서도 지속적인 행위 감시가 가능하도록 하는 악성 스크립트 감지 기법을 제안하고 그 구현에 관해 기술한다.

• 가정의학회지
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• 제39권6호
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• pp.360-363
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• 2018

Background: Acute alcoholic intoxication patients (AAIP) are a common public health problem. The aim of this study was to perform a comprehensive laboratory analysis for these patients to investigate the co-morbid medical problem. Methods: We retrospectively reviewed laboratory findings of AAIP who were transferred to the emergency department (ED) from January 2017 to June 2017. Results: A total of 160 male patients were enrolled. Sixteen patients (16/160, 10.0%) and three patients (3/160, 1.9%) had macrocytic anemia and microcytic anemia, respectively. A total of 33 patients (33/160, 20.6%) showed thrombocytopenia ($<150{\times}10^9/L$). Twelve patients (12/159, 7.5%) showed low serum albumin level (<3.5 g/dL). Three patients (3/160, 1.9%) had chronic kidney disease stages 3-4 based on estimated glomerular filtration rate. Six patients (6/27, 22.2%) had high hemoglobin A1c (HbA1c) level (>7.0%). Positive rates of hepatitis B surface antigen and antiHBs antibody (anti-HBs Ab) were 3.5% (5/141) and 49.0% (68/141), respectively. Conclusion: Patients with AAIP who were transferred to ED had various laboratory abnormalities (anemia, thrombocytopenia, high HbA1c). They had low positive rate of anti-HBs Ab. This might be a public health problem, suggesting the need of hepatitis B virus vaccination program for AAIP. Our data suggest the need of further nationwide studies.