• 한국축산식품학회지
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• 제40권5호
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• pp.860-861
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• 2020

• Molecules and Cells
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• 제37권1호
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• pp.24-30
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• 2014

Inductive expression of early growth response 1 (Egr-1) in neurons is associated with many forms of neuronal activity. However, only a few Egr-1 target genes are known in the brain. The results of this study demonstrate that Egr-1 knockout (KO) mice display impaired contextual extinction learning and normal fear acquisition relative to wild-type (WT) control animals. Genome-wide microarray experiments revealed 368 differentially expressed genes in the hippocampus of Egr-1 WT exposed to different phases of a fear conditioning paradigm compared to gene expression profiles in the hippocampus of KO mice. Some of genes, such as serotonin receptor 2C (Htr2c), neuropeptide B (Npb), neuronal PAS domain protein 4 (Npas4), NPY receptor Y1 (Npy1r), fatty acid binding protein 7 (Fabp7), and neuropeptide Y (Npy) are known to regulate processing of fearful memories, and promoter analyses demonstrated that several of these genes contained Egr-1 binding sites. This study provides a useful list of potential Egr-1 target genes which may be regulated during fear memory processing.

• 한국치위생학회지
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• 제21권6호
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• pp.813-820
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• 2021

Objectives: This study was conducted to verify the effectiveness of the VR-applied head and neck anatomy class and to be used as basic data for the development of a teaching method using VR in the basic dental hygiene field. Methods: A convenience sample was extracted from 128 students and graduates who completed the head and neck anatomy class at the department of dental hygiene at a university in Gwangju. From June 1 to July 31, 2021, an online survey was conducted on class attitude and satisfaction, and statistical analysis was performed using frequency analysis and independent sample t-test. Results: Class attitude (3.79), interest (3.64), attention (3.88), learning motivation (3.80), and achievement motivation (3.84) were all high in the head and neck anatomy VR application group (p<0.01). Satisfaction (3.99), relevance of class content (4.06) and class achievement (3.96) were high in the head and neck anatomy VR application group (p<0.01). The suitability of class attitude (3.65) and class content (sub-item of class satisfaction) (4.13) was high in the group with the 4th industrial revolution education experience (p<0.05). Conclusions: The effect of VR application in the head and neck anatomy class was confirmed to increase students' class attitude and satisfaction. In the basic dental hygiene curriculum, it will be necessary to develop and utilize teaching methods related to the 4th industrial revolution and VR application classes.

• Journal of information and communication convergence engineering
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• 제17권4호
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• pp.274-278
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• 2019

It is important that students are provided opportunities to practice their skills in acquiring radiographic images. However, these opportunities are currently limited because of the risk of radiation exposure. To overcome this limitation, a new augmented reality-based radiography simulator was developed that enables students to practice radiographic techniques as part of self-directed learning without time and space constraints. Subsequently, cross-sectional images of a manikin phantom head obtained via computed tomography were reconstructed into a three-dimensional object. An image marker that could be recognized by a mobile device and could allow users to practice dental radiography techniques was devised. The three-dimensional object was augmented to the mobile device; consequently, among 106 stored dental radiographs on the device, a radiograph corresponding to specific imaging conditions was opened when users performed radiographic procedures. This technology could improve dental students' understanding of dental anatomy and contribute to improving their competency in acquiring dental radiographs.

• Journal of Korean Neurosurgical Society
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• 제64권3호
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• pp.340-345
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• 2021

Humans do not have tails; however, a congenital anomaly named "human tail" has been recognized since old times. In contrast with its impactful name, the anomaly itself is not fatal, and thus it has not been considered as a clinically serious symptom. However, many case reports suggested that retention of "the tail" is closely associated with spinal cord malformation and should be treated with care by neurosurgeons. Therefore, this review summarizes our knowledge regarding the anatomy, function, and development of the tail as a general structure in mammals. Learning the basic knowledge regarding tail anatomy and development would help clinicians to understand the "human tail" more concisely and to select more appropriate examinations or treatments in relation to this congenital anomaly.

• 치위생과학회지
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• 제24권1호
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• pp.37-53
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• 2024

Background: To train dental hygienists to utilize knowledge in practice, an integrated curriculum based on the competencies of dental hygienists is expanding; however, in the field of basic dental hygiene the curriculum is still fragmented and based on segmented knowledge. This study developed an integrated curriculum based on the competencies of dental hygienists in Anatomy, Histology & Embryology, Physiology, which are subjects for basic dental hygiene that have high linkage and overlap. Methods: After selecting the learning objectives for the integrated curriculum from those of Anatomy, Histology & Embryology, Physiology, the duties of the dental hygienist in relation to the learning objectives were analyzed. Learning objectives were combined with the duties of a dental hygienist to derive competencies for an integrated curriculum. Referring to the syllabus and learning objectives for each subject, the weekly educational content, learning objectives, and credits of the integrated curriculum were derived. After conducting a Delphi survey to validate the competency and content of the derived integrated curriculum, an integrated curriculum was developed. Results: By using the first and second Delphi surveys, four competencies were developed for dental hygienists that can be achieved through an integrated basic dental hygiene curriculum. In addition, an integrated curriculum including the courses Anatomy, Histology & Embryology, Physiology, Structure and Function of the Human Body/Head/Neck, and Structure and Function of the Oral Cavity was established. Conclusion: This study presents a specific example for developing a competency-based integrated curriculum that can be used as a framework to derive a competency-based integrated curriculum among subjects that can be integrated according to the linkage of learning contents and the competencies that can be achieved.

• 한국식품영양과학회지
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• 제39권3호
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• pp.376-382
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• 2010

본 연구는 BF-7이 어린이의 장기 및 단기 기억을 현저하게 촉진시킴을 보여주었다. 기존 임상 시험 결과를 통해 입증된 바와 같이 천연 소재인 BF-7의 안전성을 고려할 때, BF-7은 어린이 장기 및 단기 기억력, 기억유지도 및 기억의 효과적 활용 등 전반적인 기억 수행 능력 향상에 도움을 주는 매우 안전하면서 효과가 탁월한 천연소재임을 확인하였다.

• Journal of Radiation Protection and Research
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• 제47권3호
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• pp.111-133
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• 2022

The exciting advancement related to the "modeling of digital human" in terms of a computational phantom for radiation dose calculations has to do with the latest hype related to deep learning. The advent of deep learning or artificial intelligence (AI) technology involving convolutional neural networks has brought an unprecedented level of innovation to the field of organ segmentation. In addition, graphics processing units (GPUs) are utilized as boosters for both real-time Monte Carlo simulations and AI-based image segmentation applications. These advancements provide the feasibility of creating three-dimensional (3D) geometric details of the human anatomy from tomographic imaging and performing Monte Carlo radiation transport simulations using increasingly fast and inexpensive computers. This review first introduces the history of three types of computational human phantoms: stylized medical internal radiation dosimetry (MIRD) phantoms, voxelized tomographic phantoms, and boundary representation (BREP) deformable phantoms. Then, the development of a person-specific phantom is demonstrated by introducing AI-based organ autosegmentation technology. Next, a new development in GPU-based Monte Carlo radiation dose calculations is introduced. Examples of applying computational phantoms and a new Monte Carlo code named ARCHER (Accelerated Radiation-transport Computations in Heterogeneous EnviRonments) to problems in radiation protection, imaging, and radiotherapy are presented from research projects performed by students at the Rensselaer Polytechnic Institute (RPI) and University of Science and Technology of China (USTC). Finally, this review discusses challenges and future research opportunities. We found that, owing to the latest computer hardware and AI technology, computational human body models are moving closer to real human anatomy structures for accurate radiation dose calculations.

• Journal of Korean Biological Nursing Science
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• 제20권2호
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• pp.92-102
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• 2018

Purpose: The purpose of this study was to analyze the current status of studies related to the learning methods of biological nursing subjects in Korea. Methods: Five databases (KoreaMed, KMbase, NDSL, KISS, KiSTi) and grey literature were searched prior to February 2018. A total 12 studies met the inclusion criteria including 11 articles and 1 proceeding. Results: We included five experimental studies, five non-experimental studies, and two mixed method studies. First, most of the studies that applied a learning method focused on the subject of human anatomy and physiology; team-based learning was the method that was utilized the most. Second, the necessity of well-designed research was confirmed because the quality of included studies was low. Third, the research variables identified were mainly concentrated on the affective domain, and included satisfaction, motivation, self-efficacy, self-directed learning, confidence, attitude. We confirmed the need to develop a learning program that can also improve the cognitive and psychomotor domain variables in future research. Conclusion: The results of this study suggest that further research should be conducted with consideration the domain of research variables evenly. In addition, future studies should apply various learning methods and included randomized controlled trials.

• 한국방사선학회논문지
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• 제14권1호
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• pp.45-51
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• 2020

본 연구에서는 방사선영상학 수업에서 3D 프린팅 해부학 구조물을 이용한 자기주도 학습이 교육 효과에 미치는 영향을 분석하고자 하였다. 대상은 4년제 대학교의 방사선학과 2학년의 32명(남자: 20명, 여자: 12명)으로 방사선영상학 교과목을 수강한 재학생들로서 소극적인 학생 그룹과 적극적인 학생 그룹으로 구분하였다. 학습방법은 3D 프린팅 해부학적 구조물을 이용한 자기주도 학습으로 진행했으며 학습 전·후로 정량적 학습개선효과를 평가하였다. 학생들의 정성적인 평가를 위해 수업의 흥미도, 만족도 그리고 학습효과(해부학 명칭 암기 용이성, X선 영상 해독력, 해부학 구조물 이해도, X선 촬영법 이해도)에 대해서 5점 리커트 5점 척도로 분석하였다. 그 결과 학습개선효과는 평균 65.4%가 향상되었으며 모든 학생들이 모든 변수에서 높은 점수를 얻었다 특히, 흥미도와 X선 영상 해독력을 제외한 모든 변수에서 소극적 학생그룹이 적극적인 학생그룹보다 높은 상관계수를 보였다. 이러한 결과는 3D 프린팅 해부학 구조물을 이용한 자기주도 학습이 방사선학과 학생들에게 긍정적인 교육효과를 기대할 수 있다.