Molecules and Cells

Korean Society for Molecular and Cellular Biology (한국분자세포생물학회)
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Impaired Extinction of Learned Contextual Fear Memory in Early Growth Response 1 Knockout Mice

  • Han, Seungrie (Department of Anatomy and Neuroscience, College of Medicine, Korea University) ;
  • Hong, Soontaek (Department of Anatomy and Neuroscience, College of Medicine, Korea University) ;
  • Mo, Jiwon (Department of Anatomy and Neuroscience, College of Medicine, Korea University) ;
  • Lee, Dongmin (Department of Anatomy and Neuroscience, College of Medicine, Korea University) ;
  • Choi, Eunju (Department of Psychology, Korea University) ;
  • Choi, June-Seek (Department of Psychology, Korea University) ;
  • Sun, Woong (Department of Anatomy and Neuroscience, College of Medicine, Korea University) ;
  • Lee, Hyun Woo (Department of Anatomy and Neuroscience, College of Medicine, Korea University) ;
  • Kim, Hyun (Department of Anatomy and Neuroscience, College of Medicine, Korea University)
  • Received : 2013.07.17
  • Accepted : 2013.11.25
  • Published : 2014.01.31
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Abstract

Inductive expression of early growth response 1 (Egr-1) in neurons is associated with many forms of neuronal activity. However, only a few Egr-1 target genes are known in the brain. The results of this study demonstrate that Egr-1 knockout (KO) mice display impaired contextual extinction learning and normal fear acquisition relative to wild-type (WT) control animals. Genome-wide microarray experiments revealed 368 differentially expressed genes in the hippocampus of Egr-1 WT exposed to different phases of a fear conditioning paradigm compared to gene expression profiles in the hippocampus of KO mice. Some of genes, such as serotonin receptor 2C (Htr2c), neuropeptide B (Npb), neuronal PAS domain protein 4 (Npas4), NPY receptor Y1 (Npy1r), fatty acid binding protein 7 (Fabp7), and neuropeptide Y (Npy) are known to regulate processing of fearful memories, and promoter analyses demonstrated that several of these genes contained Egr-1 binding sites. This study provides a useful list of potential Egr-1 target genes which may be regulated during fear memory processing.

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References

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