• Fisheries and Aquatic Sciences
• /
• 제13권1호
• /
• pp.12-17
• /
• 2010

This study was conducted to evaluate the potential of a microbial fermentation procedure to improve the functional qualities of seaweeds. Aspergillus oryzae, which has been used in traditional Korean fermented foods, was inoculated and cultivated in an aqueous extract of sea tangle (Laminaria japonica). Fermentation of the sea tangle extract by A. oryzae for 4 days resulted in a 3-fold increase in $\gamma$-aminobutyric acid (GABA) content. GABA is known to be a bioactive compound. Fungal fermentation of the extract also enhanced its antioxidant activity and increased its total content of phenolic compounds. It was assumed that these changes stemmed from the biodegradation of active compounds of the sea tangle packaged within its rigid structural matrix or occurred as result of fungal fermentation. These results suggested that the application of microbial fermentation to the processing of seaweeds will help in the development of processed foods to meet consumer demands.

• Archives of Pharmacal Research
• /
• 제23권4호
• /
• pp.407-412
• /
• 2000

The presence of the nitric oxide synthase (NOS) enzyme from Salmonella typhimurium (S. typhimurium) was identified by measuring radiolabeled L-$[^3H]$citrulline and NO, and Western blot analysis. NOS was partially purified by both Mono Q ion exchange and Superose 12HR size exclusion column chromatography, sequentially. The molecular weight of NOS was estimated to be 93.3 kDa by Western blot analysis. The enzyme showed a significant dependency on the typical NOS cofactors; an apparent Km for L-arginine of 34.7 mM and maximum activity between $37^{\circ}C$ and $43^{\circ}C$. The activity was inhibited by NOS inhibitors such as aminoguanidine and $N^{G}$ $N^{G}$-dimethyl-L-arginine. taken together, partially purified NOS in S. typhimurium is assumed to be a different isoform of mammalian NOSs.OSs.

• Archives of Pharmacal Research
• /
• 제28권11호
• /
• pp.1224-1227
• /
• 2005

Here we report the cytotoxic activity of three known compounds isolated for the first time from Corydalis pallida (Papaveraceae). An isoquinoline alkaloid, berberine, exhibited cytototoxic activity against two human cancer cell lines, HT-1080 (human fibrosarcoma) and SNU-638 (human stomach adenocarcinoma), with $IC_{50}$ values of 3.2 and 3.4 $\mu$g/mL, respectively. N­trans-feruloyltyramine and N-trans-feruloylmethoxytyramine were also isolated from this plant but were inactive.

• 임상간호연구
• /
• 제23권1호
• /
• pp.1-8
• /
• 2017

Purpose: The purpose of this study was to provide basic data required to improve nursing resources management and nurse organizations. Methods: The data were collected using a questionnaire. Participants were 294 nurses who were working at 8 hospitals with more than 500 beds located in G and C cities, Korea. Data analysis was done using t-test, ANOVA, $Scheff{\acute{e}}$ test, Pearson correlation coefficient and stepwise multiple regression analysis with SPSS. Results: There were significant correlations between self-leadership, clinical competence, job satisfaction and job involvement. Factors affecting job involvement were job satisfaction, self-leadership, length of clinical career and length of career in current department. Job satisfaction was the most influential factor with an explanatory power of 41%. Conclusion: Findings show that to strengthen job involvement, identification and management of factors that affect job satisfaction and self-leadership are required and relevant training and strategies should be developed and used.

• 아동학회지
• /
• 제30권3호
• /
• pp.55-69
• /
• 2009

The purpose of this study was to describe preschoolers' perceptions of fear from their own perspective. Qualitative data from 213 preschoolers 4 to 6 years of age were obtained by semi-structured interviews. The fear inventory was analyzed by content analysis and frequency. The most common fears of preschoolers in this study were fear of ferocious animals and imaginary figures, such as tigers, lions, snakes, spirits and ghosts. Fear of ghosts was the primary fear of both boys and girls. Results showed that most fears were caused by disgust-related visual images. Worry about injury and pain was another common pathway to fear. At-risk preschoolers scored significantly higher than normal preschoolers on fears of criticism and getting an injection.

• 음성과학
• /
• 제10권4호
• /
• pp.221-227
• /
• 2003

Diadochokinetic (DDK) speech task has been utilized as an evaluating tool for speakers with dysarthria for many years. This study attempted to differently diagnose multiple system atrophy (MSA) from idiopathic Parkinson's disease (PD) using patients' performance of DDK (i.e., alternate motion rate (AMR)). The subjects included 11 cases of pathologically confirmed MSA and 16 IPD patients who commonly presented with parkinsonian syndrome. The speech sample of each patient was analyzed acoustically using the MSPTM(Motor Speech Profile, a module of CSL). The results showed that the average DDK rate was significantly faster in the IPD than the MSA groups in all three syllables (i.e., /puh/, /tuh/. and /kuh/). We propose the average DDK rate variable as a core clinical trait in differentiating the two pathological conditions.

• 한국사회복지학
• /
• 제47권
• /
• pp.243-271
• /
• 2001

This study examines family relationship among North Korean migrant families in early adaptation (approximately, up to $5{\sim}6$ years after arrival in the South). Family cohesion, communication, power relationship, and conflicts and domestic violence among family members were examined by the perceptions of 67 male and female householders and their spouses. In the four areas of family relationship, the subjects have quite positive perceptions and shows no critically significant difference on the perceptions between before and after arrival. However, positive perception on family relationship gradually decreases as the length of time of in the South increases with linear or nonlinear patterns according to subcategories of family relationship. These findings suggest several social work practice implications in resettlement assistance for the North Korean migrant families.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2000년도 하계학술대회 논문집 D
• /
• pp.2763-2765
• /
• 2000

The interactions between the excavation tool and the excavation environment are dynamic, unstructured and complex. In addition. operating modes of an excavator depend on working conditions, which makes it difficult to derive the exact mathematical model of excavator. Even after the exact mathematical model is established, it is difficult to design of a controller because the system equations are highly nonlinear and the state variable are coupled. The objective of this study is to design a fuzzy logic controller (FLC) which controls the position of excavator's attachment. This approach enables the transfer of human heuristics and expert knowledge to the controller. Expeiments are carried out to check the performance of the FLC.

• 한국공작기계학회:학술대회논문집
• /
• 한국공작기계학회 2005년도 춘계학술대회 논문집
• /
• pp.3-8
• /
• 2005

We introduced mechanical stimuli and micropatterned substrate with micro fibers to investigate the effects of those on neurite outgrowth along with nerve growth factor (NGF) in vitro. Microfiber substrates were fabricated using an electrospinning process. And PC-12 cells cultured on substrates were simulated with nerver growth factor and laminar flow shear stress in a fluid flow system The results suggest that microfiber substrates and fluid-induced shear stress are promising for simulating neuronal regeneration in a desired direction.

• 동서간호학연구지
• /
• 제21권2호
• /
• pp.133-139
• /
• 2015

Purpose: The purpose of this study was to identify the effects of thermotherapy on abdominal distension and pain during colonoscopy. Methods: This study used a nonequivalent control group and a non-synchronize design. Twenty-nine participants were assigned in an experimental group and 29 in the control group. For the experimental group, electronic heating pad was applied before test throughout the entire procedure. Results: Abdominal distension and total time required for colonoscopy significantly were lower in the experimental group than those in the control group. Conclusion: The results suggest that thermotherapy can be effective to improve abdominal distension and colonoscopy time in patients with colonoscopy. Therefore, thermotherapy can be recommended for those patients undergoing of colonoscopy.