Proceedings of the Korean Society of Machine Tool Engineers Conference (한국공작기계학회:학술대회논문집)
- 2005.05a
- /
- Pages.3-8
- /
- 2005
Effects of Microfiber Substrate and Shear Stress on the Outgrowth of PC-12 Cells
신경세포의 Outgrowth 향상을 위한 마이크로 파이버 지지체와 전단응력의 영향
- Kim In Ae ;
- Park Su A ;
- Kim Young Jick ;
- Kim Su-Hyang ;
- Shin Ho Joon ;
- Lee Yong Jae ;
- Shin Ji Won ;
- Shin Jung-Woog
- 김인애 (인제대학교 의용공학과) ;
- 박수아 (인제대학교 의용공학과) ;
- 김영직 (부산카톨릭대학교 치기공과) ;
- 김수향 (인제대학교 의용공학과) ;
- 신호준 (인제대학교 의용공학과) ;
- 이용재 (인제대학교 의용공학과) ;
- 신지원 (인제대학교 의용공학과) ;
- 신정욱 (인제대학교 의용공학과)
- Published : 2005.05.01
Abstract
We introduced mechanical stimuli and micropatterned substrate with micro fibers to investigate the effects of those on neurite outgrowth along with nerve growth factor (NGF) in vitro. Microfiber substrates were fabricated using an electrospinning process. And PC-12 cells cultured on substrates were simulated with nerver growth factor and laminar flow shear stress in a fluid flow system The results suggest that microfiber substrates and fluid-induced shear stress are promising for simulating neuronal regeneration in a desired direction.
Keywords
- Microfiber substrate;
- Neurite outgrowth;
- PC-12 cells;
- Electrospinning;
- Shear stress;
- Neuronal regeneration