• Title/Summary/Keyword: An Hyang

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Analysis of Spironolactone Use in Chronic Heart Failure

  • Park, Kyu-Won;Lee, Suk-Hyang
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.250.1-250.1
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    • 2003
  • Background Aldosterone has an important role in the pathophysiology of heart failure. Aldosterone promotes the retention of sodium, the loss of magnesium and potassium, sympathetic activation, parasympathetic inhibition, myocardial and vascular fibrosis, baroreceptor dysfunction, and vascular damage and impairs arterial compliance. Objectives We investigated the effects of additional spironolactone to angiotensin-converting enzyme inhibitor (ACEI) / angiotensin-II receptor blocker (ARB) in patients with heart failure. (omitted)

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Proteomic characterization of differentially expressed proteins associated with no stress in retinal ganglion cells

  • Kim, Jum-Ji;Kim, Yeon-Hyang;Lee, Mi-Young
    • BMB Reports
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    • v.42 no.7
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    • pp.456-461
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    • 2009
  • Proteomic analyses of differentially expressed proteins in rat retinal ganglion cells (RGC-5) following S-nitrosoglutathione (GSNO), an NO donor, treatment were conducted. Of the approximately 314 protein spots that were detected, 19 were differentially expressed in response to treatment with GSNO. Of these, 14 proteins were up-regulated and 5 were down- regulated. Notably, an increase in GAPDH expression following GSNO treatment was detected in RGC-5 cells through Western blotting as well as proteomics. The increased GAPDH expression in response to GSNO treatment was accompanied by an increase in Herc6 protein, an E3 ubiquitin ligase. Moreover, GSNO treatment resulted in the translocation of GADPH from the cytosol to the nucleus and its subsequent accumulation. These results suggest that NO stress-induced apoptosis may be associated with the nuclear translocation and accumulation of GAPDH in RGC-5 cells.

The reinterpretation and visualization for methods of solving problem by Khayyam and Al-Kāshi for teaching the mathematical connection of algebra and geometry (대수와 기하의 수학적 연결성 지도를 위한 Khayyam과 Al-Kāshi의 문제 해결 방법 재조명 및 시각화)

  • Kim, Hyang Sook;Park, See Eun
    • East Asian mathematical journal
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    • v.37 no.4
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    • pp.401-426
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    • 2021
  • In order to propose ways to implement mathematical connection between algebra and geometry, this study reinterpreted and visualized the Khayyam's geometric method solving the cubic equations using two conic sections and the Al-Kāshi's method of constructing of angle trisection using a cubic equation. Khayyam's method is an example of a geometric solution to an algebraic problem, while Al-Kāshi's method is an example of an algebraic a solution to a geometric problem. The construction and property of conics were presented deductively by the theorem of "Stoicheia" and the Apollonius' symptoms contained in "Conics". In addition, I consider connections that emerged in the alternating process of algebra and geometry and present meaningful Implications for instruction method on mathematical connection.