• Journal of Life Science
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• v.29 no.10
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• pp.1152-1158
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• 2019

Rudbeckia laciniata var. hortensis Bailey is used in home remedy for colic and gastritis in South Korea. Although Rudbeckia laciniata var. hortensis Bailey is used extensively for home remedies, no single study on its efficacy exists. In this study, we investigated the anti-obesity effects of Rudbeckia laciniata var. hortensis Bailey. The anti-obesity effect of a 70% ethanol extract from Rudbeckia laciniata var. hortensis Bailey on the differentiation of 3T3-L1 pre-adipocytes to adipocytes was investigated with an Oil Red O assay, western blot analysis, and mRNA analysis. Compared to the control (only treated with DM), the 70% ethanol extract of Rudbeckia laciniata var. hortensis Bailey significantly inhibited adipocyte differentiation and intracellular triglyceride (TG) levels at a concentration of $100{\mu}g/ml$. To determine how the TG content was reduced, we measured the level of protein and mRNA expression of obesityrelated agents, such as peroxisome proliferators-activated receptor ${\gamma}$ ($PPAR{\gamma}$), CCAAT/enhancer- binding protein ${\alpha}$ ($C/EBP{\alpha}$), AMP-activated protein kinase (AMPK) phosphorylation, LPL, and FAS. As a result, the 70% ethanol extract of Rudbeckia laciniata var. hortensis Bailey significantly increased the expression of AMPK and decreased the expression of genes related to adipogenesis and fat storage, such as $PPAR{\gamma}$, $C/EBP{\alpha}$, LPL, and FAS.

• Journal of the Korean Applied Science and Technology
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• v.36 no.1
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• pp.84-89
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• 2019

To characterize the molecular structure of BzO-gal synthesized using Escherichia coli ${\beta}$-gal, NMR ($^1H$- and $^{13}C$-) spectroscopy and mass spectrometry of BzO-gal were conducted. $^1H$ NMR spectrum of BzO-gal showed multiple peaks corresponding to the galactosyl group, which is an evidence of galactosylation on BzOH. Five proton peaks around the aromatic region at ${\delta}_H$ 7.43 ~ 7.24 ppm and 2 peaks from ${\delta}_H$ 4.93 and 4.67 ppm were evidence of the presence of the benzyl group. Seven proton peaks at ${\delta}_H$ 4.32 ~ 3.46 ppm showed the presence of a monosaccharide and were indicative of galactosylation on BzOH. $^{13}C$ NMR spectrum also revealed the presence of 11 carbons suggestive of BzO-gal. The mass value (sodium adduct ion of BzO-gal, m/z = 293.0994) from mass spectrometry analysis of BzO-gal, and $^1H$ and $^{13}C$ NMR spectral data were in good agreement with the expecting structure of BzO-gal. We are expecting that through future study it will eventually be able to develop a new additive of low cytotoxicity.

• Journal of the Korean Dietetic Association
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• v.27 no.4
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• pp.248-262
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• 2021

This study examined the effect of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet of the Korean multi-domain dementia prevention program on the cognitive functions of the elderly with dementia risk factors. We developed the program including nutrition, exercise, cognitive training, vascular disease prevention, and motivation. One- hundred and fifty-three participants aged 60~79 years with at least 1 dementia risk factor were randomly assigned in a 1:1:1 ratio to the facility-based intervention (FMI), home-based intervention (HMI), and the control group. The nutrition education program consisted of 10 classes over 24 weeks: the FMI received 7 group sessions and three 1:1 sessions, the HMI received 4 group sessions and three 1:1 sessions with 3 homework sessions. The Nutrition Quotient for Elderly (NQ-E) and the Mini Nutritional Assessment (MNA) were used to evaluate nutritional status. The Repeatable Battery for the Assessment Neuropsychological Status (RBANS), Korean Mini-Mental State Examination (K-MMSE), and the Cognitive Complaint Interview (CCI) were used to evaluate cognitive functions. A total of 136 people completed the program with an 11.1% dropout rate. The NQ-E (P=0.009) and RBANS (P=0.001) scores significantly increased in the FMI (N=45) and HMI (N=49) groups compared to the control group (N=42) after the study. The changes in the score of MNA and CCI did not differ significantly between groups. In conclusion, the nutritional intervention which focused on the MIND diet as a part of a multi-domain intervention program had a positive effect on the improvement of healthy eating habits and cognitive function scores in the high-risk dementia group.

• Industry Promotion Research
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• v.6 no.2
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• pp.1-10
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• 2021

The content of the information age does not simply convey content but includes all the transactions that arise from its interaction. The types and forms of information being traded through this interaction are recognized differently from the contents that have been passed on to mankind so far by creating new meaningful content. Because the distribution of interactive content transcending the concept of time-to-time in the network environment is an important component of access to added value in the new world, unlike the content of simple concepts seen in the products of communication so far. In this study, the purpose of this study is to recognize the current status and problems of the Korean digital content industry and to seek ways to revitalize the Korean digital content industry to lead the global market in the future. Specifically, first, we want to learn about the concept of digital content. Second, we would like to look at the industrial trends of digital content at home and abroad. Third, we present a plan to streamline digital content. Fourth, derive research results and implications. In this work, the following results are derived: First, in order for Korea to enter a digital content powerhouse, each government department must first break away from the selfishness of the ministry and actively cooperate to efficiently establish and implement various policies. Second, e-books should be introduced just as current paper and CD-ROM titles are exempt from VAT, and security solutions, related technology development, and copyright issues should be urgently addressed to revitalize the market. Third, the demand for high-quality content should increase as information infrastructure such as high-speed information and communication networks and satellite broadcasting is established.

• Tuberculosis and Respiratory Diseases
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• v.84 no.2
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• pp.148-158
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• 2021

Background: Radiotherapy is a common treatment option for lung or esophageal cancer, particularly when surgery is not feasible for patients with poor lung function. However, radiotherapy can affect pulmonary function and thereby induce pneumonitis or pneumonia, which can be fatal in patients with respiratory impairment. The purpose of this study is to evaluate if reductions in pulmonary function after radiotherapy can be minimized through simultaneous pulmonary rehabilitation (PR). Methods: In this matched case control study, we retrospectively analyzed patients who had undergone radiotherapy for thoracic malignant disease between January 2018 and June 2019. We analyzed results from pulmonary function tests and 6-minute walking tests (6MWT) conducted within the six months before and after radiotherapy treatment. Results: In total, results from 144 patients were analyzed, with 11 of the patients receiving PR and radiotherapy simultaneously. Of the 133 patients in the control group, 33 were matched with 11 patients in the PR group. Changes in forced expiratory volume in one second (FEV₁) and FEV₁/forced vital capacity were significantly different between the PR group and the matched control group (240 mL vs. -10 mL, p=0.017 and 5.5% vs. 1.0%, p=0.038, respectively). The median distance of 6MWT in the PR group also increased significantly, from 407.5 m to 493.0 m after radiotherapy (p=0.017). Conclusion: Simultaneous PR improved pulmonary function, particularly in measures of FEV₁, and exercise capacity for patients with lung or esophageal cancer even after radiotherapy treatment. These findings may provide an important base of knowledge for further large population studies with long-term follow-up analysis in the identification of the PR's effects during thoracic radiotherapy.

• (The) Research of the performance art and culture
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• no.34
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• pp.73-109
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• 2017

This article studies Hur Gyu's Wanpan-Changgeuk Heungbojeon (1982) and Heungboga (1984), with a specific focus on the dramaturgy of Changgeuk and its meaning as transformed from Pansori Heungboga. The dramaturgy of Wanpan-Changgeuk Heungbojeon and Heungboga served to express criticism toward selling oneself. Beyond their former classical theme of brotherly affection, these productions elicited sorrow at the sight of poverty through a dramaturgy integrating modern theatricality with the Korean dramatic style. The theme of grief for poverty in these Changgeuk plays simultaneously aroused spectators' sympathy and critical thinking about economic aspects. Moreover, the Korean drama style and humor were not used simply as a tool but to exhilarate an emotional response to a life of coexistence. This paper found that Hur Gyu's Wanpan-Changgeuk Heungbojeon and Heungboga recreated a new Changgeuk dramaturgy based on the director's integration of western thinking and Korean traditional culture on stage. Through this, Hur Gyu tried to expand spectators' sympathy and to achieve artistic and popular success. Thus, these value of Hur Gyu's Wanpan-Changgeuk lay not only in its long running-time, but in its dramaturgy of integrating thinking for his Minjokgeuk (nationalist theater).

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.12
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• pp.192-199
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• 2020

The blower erosion phenomenon was investigated to develop a long-life blower with a volume flow rate of 10,000 ㎥/min with the required total pressure efficiency of 83% or more. The blower performance and blower erosion were predicted through numerical analysis by computational fluid dynamics(CFD). The conditions used for numerical analysis were an air volume of 16,200 ㎥/min, a rotation speed of 893 rpm, and a temperature of 330℃. The specific gravity, particle size, and amount of the dust was 3.15, 90 ㎛~212 ㎛, and is 265 kg/min, respectively. To examine the effects of a dust deflector on erosion, erosion analysis was performed by comparing the models with and without a dust deflector. Numerical analysis showed that when the dust deflector is installed, the average tended to decrease by 167% in the impeller and 133% in the boss. CFD using the Finne's model for erosion revealed a parallel restitution coefficient of 1 and a perpendicular restitution coefficient of 0.1. The blower performance of case 5 was 691.7 mmAq, and the efficiency was 83.3% when the rotation speed and the air volume flow rate were 880 rpm and 16,200 ㎥/min, respectively.

• Journal of the Korean Applied Science and Technology
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• v.38 no.1
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• pp.157-167
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• 2021

This study is a descriptive research study to find out the relationship between degree of Self-Esteem, Anger-Out, Anger-In, Anger-Control and SNS Addiction Tendency of high school students, and the factors that influence SNS addiction tendency. For a total of 10 days from May 18 to 28, 2020, a total of 100 people were collected using online questionnaires to those who were attending high schools in S and G regions and using SNS. As a result of the study, SNS addiction tendency and self-esteem(r=.385, p<.001), anger-control(r=-.354, p<.001) showed a normal inverse correlation, and an anger-out (r=.321, p=.001), anger-in (r=308, p=.002) showed a common net correlation. Factors affecting SNS addiction tendencies were self-esteem(β=-.297, p=.001), gender(β=.266, p=.003), and anger-out(β=.247, p=.007), with 27.7% explanatory power in the regression model(F=12.279, p<.001). Therefore, it is necessary to develop programs to increase high school students' self-esteem and lower their anger-out in order to reduce SNS addiction tendencies, especially for female high school students in gender.

• Journal of Korean Neurosurgical Society
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• v.64 no.5
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• pp.705-715
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• 2021

Objective : Through our previous clinical trials, the demonstrated therapeutic effects of MSC in chronic spinal cord injury (SCI) were found to be not sufficient. Therefore, the need to develop stem cell agent with enhanced efficacy is increased. We transplanted enhanced Wnt3-asecreting human mesenchymal stem cells (hMSC) into injured spines at 6 weeks after SCI to improve axonal regeneration in a rat model of chronic SCI. We hypothesized that enhanced Wnt3a protein expression could augment neuro-regeneration after SCI. Methods : Thirty-six Sprague-Dawley rats were injured using an Infinite Horizon (IH) impactor at the T9-10 vertebrae and separated into five groups : 1) phosphate-buffered saline injection (injury only group, n=7); 2) hMSC transplantation (MSC, n=7); 3) hMSC transfected with pLenti vector (without Wnt3a gene) transplantation (pLenti-MSC, n=7); 4) hMSC transfected with Wnt3a gene transplantation (Wnt3a-MSC, n=7); and 5) hMSC transfected with enhanced Wnt3a gene (1.7 fold Wnt3a mRNA expression) transplantation (1.7 Wnt3a-MSC, n=8). Six weeks after SCI, each 5×10⁵ cells/15 µL at 2 points were injected using stereotactic and microsyringe pump. To evaluate functional recovery from SCI, rats underwent Basso-Beattie-Bresnahan (BBB) locomotor test on the first, second, and third days post-injury and then weekly for 14 weeks. Axonal regeneration was assessed using growth-associated protein 43 (GAP43), microtubule-associated protein 2 (MAP2), and neurofilament (NF) immunostaining. Results : Fourteen weeks after injury (8 weeks after transplantation), BBB score of the 1.7 Wnt3a-MSC group (15.0±0.28) was significantly higher than that of the injury only (10.0±0.48), MSC (12.57±0.48), pLenti-MSC (12.42±0.48), and Wnt3a-MSC (13.71±0.61) groups (p<0.05). Immunostaining revealed increased expression of axonal regeneration markers GAP43, MAP2, and NF in the Wnt3a-MSC and 1.7 Wnt3a-MSC groups. Conclusion : Our results showed that enhanced gene expression of Wnt3a in hMSC can potentiate axonal regeneration and improve functional recovery in a rat model of chronic SCI.

• Land and Housing Review
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• v.13 no.1
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• pp.131-140
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• 2022

A smart window is a new building material that can realize energy savings in a building. Smart windows can freely adjust Visible Light Transmittance (VLT) and solar gain coefficient (g-value) according to the situation. Smart windows include such technologies as Electrochromic (EC), Suspended Particle Device (SPD), and Polymer Dispersed Liquid Crystal (PDLC). Recent research on building energy savings through the VLT and g-value control functions of smart windows is being actively conducted and meaningful results are being drawn. However, since most of the research is focused on energy savings, research on the indoor environment is somewhat lacking. A building is a space where people live and the comfort of life should be prioritized before energy savings. Therefore, in this study, analysis on the daylight performance of an office space was carried out. Through green building standards such as LEED, BREEAM, CASBEE, and G-SEED, the daylight performance was reviewed according to VLT value changes of the smart window. In addition, a study was conducted on the VLT range of the electrochromic façade that can maintain a comfortable indoor environment. The smart window used electrochromic control with a wide range of VLT. The study showed that the minimum VLT of a smart window that can satisfy G-SEED is 25% or more. In addition, it was found that the VLT change of the electrochromic smart window did not significantly affect the uniformity of the room. When the LEED standard was applied, the minimum VLT value of the electrochromic smart window that must be maintained according to each orientation of the building was derived.