• The Journal of the Korea Contents Association
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• v.22 no.4
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• pp.1-12
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• 2022

Since the early 20th century, along with the interest and development of alternative psychotherapy, the field of art therapy has also been developed and expanded. In particular, the recent development of technology and the untact era brought about by the COVID-19 Pandemic is accelerating the development of new digital art therapy contents. Among them, the hot interest in virtual reality is raising expectations and questions about the effectiveness of psychotherapy given by new media beyond traditional art therapy. In this study, the characteristics of VRAT (Virtual Reality Art Therapy) content therapeutic factors were investigated through qualitative literature analysis based on the conceptual framework and therapeutic components of ETC (Expressive Therapies Continumm), an integrated art therapy theory. As a result of the study, VRAT contents showed mostly therapeutic factors in the left hemisphere that triggered the user's dynamic, perceptual, and cognitive factors, and the therapeutic factors in the right hemisphere, which focused on sensory, emotional, and symbolic factors, were relatively few. The reason seems to be due to the nature of the experimental stage, the absence of active intervention by the therapist and long-term session composition, and the fear, clumsiness, and unfamiliarity of users about VRAT in addition to the characteristics and technical limitations of the VRAT medium. The limitations of the study include the small number of documents to be analyzed and the insufficient form of current VRAT to be called art therapy. It is expected that the characteristics of the therapeutic factors of VRAT content media and environment derived as a result of this study will be usefully used for the appropriate development of VRAT content in the future.

• Microbiology and Biotechnology Letters
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• v.49 no.1
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• pp.75-87
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• 2021

Type I Interferons (IFNα) are known for their role as biological anticancer agents owing to their cell-apoptosis inducing properties. Development of an appropriate, cost-effective host expression system is crucial for meeting the increasing demand for proteins. Therefore, this study aims to develop codon-optimized IFNα-2b in L. lactis NZ3900. These cells express extracellular protein using the NICE system and Usp₄₅ signal peptide. To validate the mature form of the expressed protein, the recombinant IFNα-2b was screened in a human colorectal cancer cell line using the cytotoxicity assay. The IFNα-2b was successfully cloned into the pNZ8148 vector, thereby generating recombinant L. lactis pNZ8148-SP_Usp45-IFNα-2b. The computational analysis of codon-optimized IFNα-2b revealed no mutation and amino acid changes; additionally, the codon-optimized IFNα-2b showed 100% similarity with native human IFNα-2b, in the BLAST analysis. The partial size exclusion chromatography (SEC) of extracellular protein yielded a 19 kDa protein, which was further confirmed by its positive binding to anti-IFNα-2b in the western blot analysis. The crude protein and SEC-purified partial fraction showed IC₅₀ values of 33.22 ㎍/ml and 127.2 ㎍/ml, respectively, which indicated better activity than the metabolites of L. lactis NZ3900 (231.8 ㎍/ml). These values were also comparable with those of the regular anticancer drug tamoxifen (105.5 ㎍/ml). These results demonstrated L. lactis as a promising host system that functions by utilizing the pNZ8148 NICE system. Meanwhile, codon-optimized usage of the inserted gene increased the optimal protein expression levels, which could be beneficial for its large-scale production. Taken together, the recombinant L. lactis IFNα-2b is a potential alternative treatment for colorectal cancer. Furthermore, its activity was analyzed in the WiDr cell line, to assess its colorectal anticancer activities in vivo.

• The Journal of the Society of Stroke on Korean Medicine
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• v.23 no.1
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• pp.25-40
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• 2022

■Objectives This study aimed to collect and analyze clinical studies on the significance of acupuncture in the treatment of hypertension among Korean patients. ■Methods Among Korean patients with a blood pressure (BP) of 120 mmHg or higher and a diastolic BP of 80 mmHg or higher, those, treated with acupuncture only, were included. A literature search was conducted through 'Embase', 'Medline', 'Science and Technology Information Integration Service (NDSL)', 'Traditional Korean Knowledge Portal (OASIS)', 'PubMed', and 'Scopus'. The search keywords were (hypertension OR 'blood pressure') AND acupuncture. The papers, published before the day of the search (02. January 2022), were included in this study. ■Results Among the 12 selected papers, seven involved randomized controlled trial (RCT), four before-and-after studies, and one case series. The number of RCTs has increased yearly. The treatment methods used in the studies included needle acupuncture in eight studies, auricular acupuncture in two, pharmacopuncture in one, and si-acupuncture in one. The average numbers of patients enrolled in RCTs, before-and-after studies, and case series were 21.1, 30, and 23 respectively. Six studies were conducted on prehypertensive patients, two on stage 1 hypertension patients, and four on stage 2 hypertension patients. The involved acupoints have been reported to be ST36 in eight papers, LI11 in four papers, and PC6 in three papers. The treatment period lasted for < 1 week in eight studies and 8 weeks in four studies. Acupuncture successfully lowered blood pressure in nine out of 12 studies ■Conclusions Acupuncture is a viable alternative treatment option for prehypertensive patients, who are not taking medications. Additionally, it is also useful in further lowering the BP of patients with stage 1 and stage 2 hypertension in the short term. Large-scale and long-term studies on acupuncture for hypertension should be conducted.

• Composites Research
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• v.34 no.6
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• pp.357-372
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• 2021

The energy harvesting device is known to be promising as an alternative to solve the resource shortage caused by the depletion of petroleum resources. In order to overcome the limitations (environmental pollution and low mechanical properties) of piezoelectric elements capable of converting mechanical motion into electrical energy, many studies have been conducted on a polymer matrix-based composite piezoelectric energy harvesting device. In this paper, the output performance and related applications of the reported piezoelectric composites are reviewed based on the applied materials and processes. As for the piezoelectric fillers, zinc oxide, which is advantageous in terms of eco-friendliness, biocompatibility, and flexibility, as well as ceramic fillers based on lead zirconate titanate and barium titanate, were reviewed. The polymer matrix was classified into piezoelectric polymers composed of polyvinylidene fluoride and copolymers, and flexible polymers based on epoxy and polydimethylsiloxane, to discuss piezoelectric synergy of composite materials and improvement of piezoelectric output by high external force application, respectively. In addition, the effect of improving the conductivity or the mechanical properties of composite material by the application of a metal or carbon-based secondary filler on the output performance of the piezoelectric harvesting device was explained in terms of the structure of the composite material. Composite material-based piezoelectric harvesting devices, which can be applied to small electronic devices, smart sensors, and medicine with improved performance, can provide potential insights as a power source for wireless electronic devices expected to be encountered in future daily life.

• Journal of Convergence for Information Technology
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• v.12 no.5
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• pp.237-245
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• 2022

This study examines the social discourse on the characteristics of the learning community in the untact era, and discusses the directions that learning communities for children could explore and consider in the pandemic situation and beyond. For this purpose, big data for one year, from January 20, 2020 to January 20, 2021, were collected through internet portal sites (includingincluding Google News, Daum, Naver and other News surfaces), using two keywords "untact" and "learning community", and analyzed by employing a word frequency and network analysis method. The analysis results show that several important terms, such as 'village education community', 'operation', 'activity', 'corona 19', 'support', and 'online' are closely related to the learning community in the untact era. The findings from this study also have implications for developing the learning community as an alternative model to fill the existing gaps in public care and education for children during the prolonged pandemic and afterwards. In conclusion, the study findings highlight that it is meaningful to identify key terms and concepts through word frequency analysis in order to examine social trends and issues related to the learning community.

• Journal of Convergence for Information Technology
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• v.12 no.5
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• pp.194-201
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• 2022

This study purpose was to know the effects 30 aged females forehead ms by SUKI intervention(4weeks). Total tested group were 18 persons, It used for SUKI intervention of SUKI process C1, SUKI process C2, SUKI process C3, SUKI process C4 were adopted three times a week in 4 weeks. The research conclusion like this. EG was a significant difference in forehead ms. Therefore, to maintaining elasticity on forehead ms. showed as some research of SUKI intervention effects for the forehead ms(p<.05). In this study, even though limited, it was judged that wrinkles due to a decrease in elasticity of the forehead ms located on the upper surface of a woman's face in her 30s could have a profound effect on women's external appearance, so SUKI intervention was applied. In addition, the role of the elastic on the forehead ms was to suggest an alternative semester method that can effectively control the management of external appearance by managing which it suitable for the life cycle of women in their 30s. In conclusion, we hope that in the future, various experiments will be used as new research data on how to prevent females facial skin beauty and wrinkles and help improve elasticity of facial ms around the face.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.32 no.5
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• pp.1019-1034
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• 2022

Malware attacks become more prevalent in the hyper-connected society of the 4th industrial revolution. To respond to such malware, automation of malware detection using artificial intelligence technology is attracting attention as a new alternative. However, using artificial intelligence without collateral for its reliability poses greater risks and side effects. The EU and the United States are seeking ways to secure the reliability of artificial intelligence, and the government announced a reliable strategy for realizing artificial intelligence in 2021. The government's AI reliability has five attributes: Safety, Explainability, Transparency, Robustness and Fairness. We develop four elements of safety, explainable, transparent, and fairness, excluding robustness in the malware detection model. In particular, we demonstrated stable generalization performance, which is model accuracy, through the verification of external agencies, and developed focusing on explainability including transparency. The artificial intelligence model, of which learning is determined by changing data, requires life cycle management. As a result, demand for the MLops framework is increasing, which integrates data, model development, and service operations. EXE-executable malware and documented malware response services become data collector as well as service operation at the same time, and connect with data pipelines which obtain information for labeling and purification through external APIs. We have facilitated other security service associations or infrastructure scaling using cloud SaaS and standard APIs.

• Journal of Internet of Things and Convergence
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• v.9 no.1
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• pp.89-95
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• 2023

In January 2007, the Remains Excavation and Investigation Team of the Ministry of National Defense was established, and full-scale excavation of remains was promoted. Currently, the scope of the excavation is being expanded to Baekma Hill within the DMZ, where fierce battles were fought during the Korean War. Now, many remains and remains are being excavated in Baekma hill. Most are in damaged condition. Therefore, in this study, the original form of the excavated remains was restored using 3D scanning and 3D modeling. This digital restoration method can be an alternative to compensate for the disadvantages of the manual method. Currently, various digital restorations using 3D technology are active in the field of cultural heritage. Digitally restored materials can be used as basic data for digital heritage. Based on this, various contents related to excavation of remains and patriots and veterans can be developed. Furthermore, if digital human restoration is made based on the excavated remains, it will be possible to reproduce the appearance of the dead.

• Journal of Technology Innovation
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• v.30 no.4
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• pp.1-28
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• 2022

Arguably many studies point out that regional innovation capabilities are accepted as a major source of growth for the sustainable regional economy. Recently, a smart specialisation strategy that should reflect regional characteristics in the policy implementation process of the regional innovation system has been proposed, but empirical studies have only presented limited results. This study attempts to overcome limitations by approaching smart specialisation as a supplementary strategy for existing regional innovation research. To this end, smart specialisation was not an alternative strategy for the regional innovation system, but rather the institutional elements of regional innovation capabilities, and the relationship between regional innovation capabilities and the local economy was analyzed to identify the impact of smart specialisation on the local economy. A study was conducted through a panel model consisting of 16 cities and provinces in Korea and 10 years from 2009-2018, and the FGLS model was finally used through the process of searching for an appropriate panel model. As a result of the study, smart specialisation consisting of industry related variety and non-related variety had a positive effect on the local economy. In addition, other regional innovation capabilities measured by dividing them into base and facilitating factors also had a positive effect on the local economy, reaffirming the results of positive research between existing regional innovation and the local economy. This study is meaningful in that smart specialisation lacking in domestic research was viewed as an institutional element of regional innovation capabilities, and it was measured through regional industry-related variety and non-related variety.

• Membrane Journal
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• v.33 no.4
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• pp.181-190
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• 2023

Wastewater purification is one of the most important techniques for controlling environmental pollution and fulfilling the demand for freshwater supply. Various technologies, such as different types of distillations and reverse osmosis processes, need higher energy input. Capacitive deionization (CDI) is an alternative method in which power consumption is deficient and works on the supercapacitor principle. Research is going on to improve the electrode materials to improve the efficiency of the process. A reverse electrodialysis (RED) is the most commonly used desalination technology and osmotic power generator. Among many studies conducted to enhance the efficiency of RED, MXene, as an ion exchange membrane (IEM) and 2D nanofluidic channels in IEM, is rising as a promising way to improve the physical and electrochemical properties of RED. It is used alone and other polymeric materials are mixed with MXene to enhance the performance of the membrane further. The maximum desalination performances of MXene with preconditioning, Ti₃C₂T_x, Nafion, and hetero-structures were respectively measured, proving the potential of MXene for a promising material in the desalination industry. In terms of osmotic power generating via RED, adopting MXene as asymmetric nanofluidic ion channels in IEM significantly improved the maximum osmotic output power density, most of them surpassing the commercialization benchmark, 5 Wm^-2. By connecting the number of unit cells, the output voltage reaches the point where it can directly power the electronic devices without any intermediate aid. The studies around MXene have significantly increased in recent years, yet there is more to be revealed about the application of MXene in the membrane and osmotic power-generating industry. This review discusses the electrodialysis process based on MXene composite membrane.