• Asian Pacific Journal of Cancer Prevention
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• 제16권12호
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• pp.4833-4837
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• 2015

Biomarkers for preclinical diagnosis of cancer are valuable tools for detection of malignant tumors at early stages in groups at risk and screening healthy people, as well as monitoring disease recurrence after treatment of cancer. However the complexity of the body's response to the pathological processes makes it virtually impossible to evaluate this response to the development of the disease using a single biomarker that is present in the serum at low concentrations. An alternative approach to standard biomarker analysis is called immunosignature. Instead of going after biomarkers themselves this approach rely on the analysis of the humoral immune response to molecular changes associated with the development of pathological processes. It is known that antibodies are produced in response to proteins expressed during cancer development. Accordingly, the changes in antibody repertoire associated with tumor growth can serve as biomarkers of cancer. Immunosignature is a highly sensitive method for antibody repertoire analysis utilizing high density peptide microarrays. In the present review we discuss modern methods for antibody detection, as well as describe the principles and applications of immunosignature in research and clinical practice.

• 비교문화연구
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• 제43권
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• pp.207-239
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• 2016

시베리아에서 중앙아시아까지 연결되는 알타이 인문벨트는 문명사적으로 매우 중요하다. 더구나 한반도의 교대문명 형성에도 막대한 영향을 끼쳤다. 따라서 고고학을 비롯하여 민속학과 인류학 등에서는 이에 관해 그동안 다양한 연구를 해왔고, 그 가운데 하나가 구비서사시다. 구비서사시는 한국에서 독특한 전승의 양식으로 남아있지만, 알타이 인문벨트를 구성하는 요소로서 주목하게 된 것은 그리 오래되지 않았다. 최근에 우리에게 중앙아시아와 몽골, 그리고 시베리아의 일부 서사시가 소개된 것도 그런 맥락이라고 할 수 있다. 이 시론의 목적은 시베리아에 위치한 야쿠티아의 구비서사시 올롱호를 국내 학계에 소개하는 데 있다. 올롱호는 최근에야 그 모습을 드러냈지만, 그것이 차지하는 위치는 막중하다. 그동안 서사시 연구가 서구중심의 시각에 매몰되어 있었다면, 올롱호는 서사시 연구에 있어서 보다 글로벌 시각을 제공할 수 있을 것으로 기대된다. 무엇보다도 그 내용이나 구연방식이 서구의 그것과는 크게 다르고, 그 원형이 비교적 잘 보존되어 있어서 새로운 연구 실마리를 내포하고 있기 때문이다. 특히 신화시대에서 영웅시대로 넘어오는 과정에서 인류의 사고와 행동양식이 어떻게 변해왔는지를 설명하고 있기도 하다. 그것은 야쿠티아의 민족역사 뿐만 아니라 10세기를 전후한 알타이 제 국가들의 형성과정까지 보여주고 있다. 따라서 이 시론은 방대한 서사시 올롱호 원문의 한국어 번역을 촉진하고, 본격적인 내용 연구가 이루어질 수 있도록 하는 밑거름이 될 것이다. 특히 중앙아시아와 시베리아와 한반도의 구비서사시 전통을 비교하여 어떻게 같고 다른지를 살필 수 있다면 알타이 인문벨트 형성을 위한 중요한 담론이 될 뿐만 아니라 문명사 연구의 새로운 지평을 열 수 있을 것이다.

• 국제지역연구
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• 제14권3호
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• pp.135-156
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• 2010

알타이라는 명칭은 어족의 이름, 알타이 산맥 일대에 거주하는 민족의 이름 그리고 알타이어족의 사람들과 그들이 거주하는 지역의 이름 등 여러 가지로 쓰이면서도, 그것이 의미있는 단위인가를 둘러싼 논란이 계속되어 왔다. 이 논문에서는 알타이 어족의 분포 지역 전체를 포괄하는 주체가 형성되지 않았다는 데에 이러한 논란의 핵심적인 원인이 있다고 주장한다. 일각에서 주장하듯이, 알타이 문화권이라고 부를만한 문화적인 공통성과 역사적인 접촉이 있었을 수 있지만, 그것이 근대를 겪으면서 의미있는 단위인 민족으로 묶어지지 않았고 또 그러한 의식이 형성되지도 않았기에 문화적 유사성으로만 남게 된 것이다. 이는 한편으로 소비에트적인 근대화를 통한 종족 정체성의 재구성과 러시아, 중국 등 주변 강대국의 강력한 개입, 불교, 기독교등 외래 종교의 뒤늦은 전래 등의 요소가 복합적으로 작용한 결과이기도 하다. 그러나 알타이를 지역 연구의 단위로 설정하는 데 따르는 어려움은 이 지역에 특이한 현상만은 아니다. 이는 지역 설정이 물리적 환경에 따른 자연적인 경계 획정이 아니라, 문화정치적 관계에 따라 인위적으로 권력관계가 분배된 결과이기 때문이다. 따라서 알타이의 사례는 그 지역적 특수성에도 불구하고, 지역연구에서 지역을 균일한 "문화"를 지니는 것으로 미리 전제하는 것의 위험성을 알려주는 함축을 지닌다.

• 한국제4기학회지
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• 제21권2호
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• pp.7-18
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• 2007

• 복식문화학회:학술대회논문집
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• 복식문화학회 2006년도 Seoul The Costume Culture Association & Ars Textrina Joint International Conference
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• pp.55-55
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• 2006

• Journal of Evidence-Based Herbal Medicine
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• 제2권1호
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• pp.7-12
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• 2009

Velvet antlers from Cervus elaphus species are one of most famous, expensive and commonly used medicinal materials in traditional oriental medicine. Some distributor had illegal practice of disguising the origin of antlers in Korea market. Therefore, a test to distinguish antler essential to ensure the healthy development of the herbal industry. In this study, the variation in DNA sequences of the mitochondrial ATPase8 and cytochrome-coxidaseI (COI) genes of Cervus elaphus from China, the Republic of Altai, and Canada were evaluated. In addition, the sequence variation among, Rein deer and Cervus elaphus species was also evaluated. Although the sequences of deer from the Republic of Altai and Canada were very similar, polymorphisms that were conserved in each species were observed in the ATPase8 and COI genes. Therefore, these polymorphic markers could be used to distinguish Cervus elaphus antlers from different locations.

• 한국의류산업학회지
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• 제18권4호
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• pp.424-437
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• 2016

The study will analyze the costumes of the Scythians tribes who lived in the region of Altai in the 3-5 century BC. The purpose of this study is to prepare new material to re-examine the theory, which claims that the origin of the circular motives of korean costumes are to be found in the typology of the Scythian costumes. In this study, we analyzed the most recent reports of archaeological excavation about the unearthed clothes in the Pazyryk region and compared its information with european literature. The conclusion of this study is as follows: The jackets of the Pazyryk region are classified in two types, (1) opened jacket with narrow sleeve and (2) enclosed jacket with narrow sleeve. Trousers were separated by (1) narrow and (2) extreme wide trousers. The enclosed jacket of tunic form and extreme wide trousers are newly excavated. It proves, there was a vivid exchange between the Scythians and their neighboring cultures. It can be noted, that there existed a diverse Scythian culture of costumes, besides the commonly known clothing culture of the "Pazyryk-rider". Based upon the results of the previous research, it can be said that the opened jacket with narrow sleeve and narrow trousers are costume typologies which are common for all Scythian tribes of the whole Eurasian region. The hem of the edge of jacket is proven to be a connective element, which is common to all Scythian tribes.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7935-7941
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• 2015

The aim of this study was to implement massive parallel sequencing (MPS) technology in clinical genetics testing. We developed and tested an amplicon-based method for resequencing the BRCA1 and BRCA2 genes on an Illumina MiSeq to identify disease-causing mutations in patients with hereditary breast or ovarian cancer (HBOC). The coding regions of BRCA1 and BRCA2 were resequenced in 96 HBOC patient DNA samples obtained from different sample types: peripheral blood leukocytes, whole blood drops dried on paper, and buccal wash epithelia. A total of 16 random DNA samples were characterized using standard Sanger sequencing and applied to optimize the variant calling process and evaluate the accuracy of the MPS-method. The best bioinformatics workflow included the filtration of variants using GATK with the following cut-offs: variant frequency >14%, coverage ($>25{\times}$) and presence in both the forward and reverse reads. The MPS method had 100% sensitivity and 94.4% specificity. Similar accuracy levels were achieved for DNA obtained from the different sample types. The workflow presented herein requires low amounts of DNA samples (170 ng) and is cost-effective due to the elimination of DNA and PCR product normalization steps.

• 대기
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• 제31권1호
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• pp.45-60
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• 2021

The synoptic structures and precipitation impact of extratropical cyclones (ETCs) influencing on the three adjacent megacities in East Asia, i.e., Beijing (Beijing ETCs), Seoul (Seoul ETCs) and Tokyo (Tokyo ETCs), are analyzed using ERA-interim reanalysis data from 1979 to 2018. Individual ETC tracks are identified with the automated tracking algorithm applied to 850-hPa relative vorticity field. Among four seasons, ETCs are the most frequent in spring. In this season, Beijing ETCs are mainly generated at the leeside of Altai-Sayan Mountains and primarily develop through interaction between the upper-level trough and lower-level cyclonic circulation. For Seoul ETCs, the leesides of Altai-Sayan Mountains (Seoul-N ETCs) and Tibetan Plateau (Seoul-S ETCs) are main genesis regions and the features of ETCs are different according to the genesis regions. While Seoul-N ETCs mainly develope by the same mechanism of Beijing ETCs, strong diabatic heating due to vapor transport is responsible for the genesis of Seoul-S ETCs. Tokyo ETCs are originated from the leesides of Tibetan Plateau and Kuroshio-Oyashio Extension regions, and strong diabatic heating as well as interaction between upper and lower levels determines the genesis of these ETCs. The precipitation impact resulting from ETCs become strong in the order of Beijing ETCs, Seoul-N ETCs, Seoul-S ETCs, and Tokyo ETCs and accounts for up to 40%, 27%, 52%, and 70% of regional precipitation, respectively.

• 복식
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• 제52권1호
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• pp.117-128
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• 2002

This paper is extended the meaning and period of CONICAL HAT. That is, the race in Central Asia and Western Asia have worn the conical hat before Scytian appeared. One in conical hat puts on the clothes of two-piece style and has the lifestyle. a horse riding and nomadism. Besides the race originate into the Indo-European language family. On the whole the conical hat has relations with the region and is classified into two groups. Scytian and Klin-Yar style. First. the Scytian style of low hat forms the seam of two-piece and is discovered in Southern Russia. Central Asia and East-Northern Asia. Second, the Klin-Yar style of high hat forms the one piece and generally is discovered in Asia Minor and west of Altai. Until now the moaning of the conical hat has focused on the military. However, one in Central Asia and Western Asia is mostly a king. nobility and god. Therefore, in addition to the meaning of military. I estimate that the conical hat may be expressed as the noble status.