• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.24 no.2
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• pp.28-34
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• 2011

Background & Objectives : Allergic rhinitis is an inflammation or irritation of the mucous membranes that line the nose. Common symptoms include sneezing, a stuffy or runny nose, itchy eyes, nose and throat, and watery eyes. We aimed to determine therapeutic effects of Tribulus terrestris by observing changes of total IgE level and the scratching or rubbing around the nose behavior. Materials and Methods : Fifteen BALB/c mice were divided into three groups : AR group(allergic rhinitis elicitated), TT group(which ate herbal medicine) and AH group(which ate antihistamine). Allergic rhinitis was induced in the three groups by intraperitoneal and intranasal sensitization with 0.1% ovalbumin solution. Then Tribulus terrestris was orally administered only to the TT group of 28days, while the AH group was given antihistamine. We observed changes of total IgE level and the scratching or rubbing around the nose behavior. We used Kruskal-Wallis test statistically(p<0.05). Results : 1. Tribulus terrestris showed significantly decreased IgE level on the serum of the rat model. 2. Tribulus terrestris showed significantly decreased scratching or rubbing around the nose behaviors of the rat model. Conclusion : According to the above results, it is considered that Tribulus terrestris has an inhibitory effect on the process of allergic rhinitis and it can be used in relieving symptoms of allergic rhinitis.

• The Journal of Korean Academic Society of Nursing Education
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• v.25 no.2
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• pp.173-185
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• 2019

Purpose: This study was conducted to develop and test effects of flipped learning on a health education program for allergic rhinitis patients. Methods: The study was a nonequivalent control group pretest-posttest design, with 38 participants (experimental group: 19, control group: 19). The education program for allergic rhinitis patients with flipped learning developed for this study was conducted in pre-class, in-class, and post-class stages for a total of 12 weeks. For the in-class stage, a TREAT model suitable for patient education program was developed. Data were analyzed with an independent t-test and repeated measures ANOVA. Results: The experimental group showed significant improvement in knowledge (F=15.029, p<.001), self-efficacy (F=6.814, p<.001) and self-care behavior (F=41.761, p<.001). In addition, subjective symptoms (F=61.453, p<.001) and quality of life (F=52.413, p<.001) improved. Conclusion: The results of this study show that flipped learning in an education program is an effective method for those in their twenties persistent moderate-severe allergic rhinitis. Therefore, the education program for allergic rhinitis developed by this study is actively recommended for nurses or health managers at universities to educate subjects in their twenties with allergic rhinitis.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.6
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• pp.1217-1222
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• 2002

This study was aimed to find out Kami-Chungsangboha-tang's effects on allergic asthma using Egg-White Implant(EWI) method model recommended by Siqueira et al. Kami-Chungsangboha-tang has widely been prescribed and used in Oriental Medicine for controlling and curing of the symptoms of Asthma(dyspnea, wheezing, cough, sputum, chest discomfort). The Previous studies have demonstrated that Kami-Chungsangboha-tang had analgesic, sedative, anticonvulsive and antihistamine effects. But it was uncertain whether Kami-Chungsangboha-tang could inhibit the allergic reaction, so alleviate the symptoms of allergic asthma. With such aim, the respiratory patterns and eosinophil infiltration in the tracheal mucosa of rats with experimentally induced allergic asthma (using EWI method) were mainly observed. The results are as follows ; 1. Kami-Chungsangboha-tang decreased the number of malformed respiration with respect to control group (p<0.02). 2. Kami-Chungsangboha-tang decreased the number of eosinophils infiltrated in tracheal mucosa with respect to control group (p<0.05). Depending upon above results, it is considered that Kami-Chungsangboha-tang has the inhibitory effects on the process of allergic asthma and suggested that it could be used in relieving patients of the symptoms caused by allergic asthma.

• Research in Community and Public Health Nursing
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• v.11 no.1
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• pp.262-277
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• 2000

In order to find out the sex- and age-related prevalence rate of allergic diseases in the community. as well as the causes of those diseases. questionnaires were given to 2.415 subjects (1.206 males and 1.209 females) from May to June. 1998. As a second stage. skin tests were given to 452 of the original subjects between July and August. 1998. Finally. from March to November 1999. the results of the tests were compared with those of other countries to make a comparative analysis of epidemiological research on allergic diseases. The results of this study were as follows: The frequency of allergic symptoms by sex was 50.1% in males and 56.7% in females. respectively, which displayed significant difference between males and females(p<.01). By age, the frequency of allergic symptoms in males was highest for those under the age of 9 at 60.6%, whereas in females the highest frequency was between the ages of 30 to 39 at 75.1 %. The relationship between economic level of the subjects and their frequency of allergic diseases showed significant difference (P<.05). There was a high degree of correlation between family history and the frequency of allergic diseases(P<.01). In allergic symptoms, the highest prevalence in both males and females occurred with urticaria, itch and skin rash (33.6% with males and 38.0% with females). Rhinitis, nasal blocking and sneezing had the second highest frequency in both sexes (11.8% of males and 14.0% of females). With regard to the causes of allergic symptoms among the people with allergies, the rate in males was 30.1% in food. 25.0% in pollen, and among females the rate was 30.7% in food, 26.6% in pollen. The frequency of food allergies by sex was 25.6% in males and 25.8% in females, with little difference between males and females, and by age, males of the ages between 40 to 49 and females of the ages between 30 and 39 showed the highest frequency, 31.8% and 32.6% respectively. Among 585 people with food allergies, the sympoms occurring with the allergy in males were 81.5% with urticaria, itch and skin rash. 5.9% with diarrhea and stomachache, and 5.2% with rhinitis, nasal blocking and sneezing. Among females with food allergies, the symptoms were 82.6% with urticaria, itch, skin rash, 9.1% with diarrhea and stomachache, and 4.7% with rhinitis, nasal blocking and sneezing. The type of food most often causing allergy in males was mackerel (6.6%) and females peaches (7.4%). In respect to a positive rate in the skin test by sex, of the 379 males taking the skin test, 21.4% were positive for allergies, whereas 14.7% of the 346 females tested were positive. Among food items found to cause positive allergic reactions, hops had the highest frequency in males (58.9%) and whole eggs had the greatest effect on females (36.4%). The estimated prevalence of food allergies in terms of skin tests was 5.0% of 1.206 males and 3.6% of 1.209 females. In the estimated frequency of food allergy by age group, males of the ages between 40 and 49 and females of the ages from 30 to 39 had the highest rate (6.5% with males and 4.5% with females). In a comparative analysis of epidemiological research on allergic diseases by country group, allergic diseases occurred in 18-50% of each population studied, and the occurrence of allergic diseases when categorized according to symptoms displayed the following as such: allergic rhinitis (3.8-52%), allergic asthma (1.6-17%), and atopy dermatitis (0.33-20.4%). The prevalence of food-related allergies was 6.6-64.9% and the foods causing allergies frequently included milk, eggs, eggs, peanuts, fish, etc.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.19 no.2
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• pp.233-241
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• 2006

Background : Bojungikgitang is a typical prescription that helps to replenish the spleen and stomach, and its effect proved positive on allergic rhinitis by experiment. But there is only a few clinical thesis on allergic rhinitis to which Bojungikgitang was administered. Objective : The prevalence of allergic rhinitis appear to be increasing. The experimental study on allergic rhinitis has occasionally been reported, but the clinical study on various cases on treatment of using herbal medicine is not many. The aim of this study was to investigate effect of Bojungikgitang-Gamibang on allergic rhinitis. Methods : The treatment effect was analyzed over fifty patients who visited and had treatment with Bojungikgitang-Gamibang on allergic rhinitis in the hospital of Sangji University from June, 2003 to September, 2005. Result : After we analyzed 50 cases of allergic rhinitis by administering Bojungikgitang-Gamibang, we concluded that the shorter duration of disease and high dosage were the main factors which improved the symptoms effectively. Conclusion : Bojungikgitang-Gamibang was the effective treatment of allergic rhinitis.

• The Journal of Korean Medicine
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• v.27 no.1 s.65
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• pp.155-164
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• 2006

Objectives : The aim of this study is to review allergic rhinitis and to help make full use of oriental medical therapy in this disease. Methods : We investigated the published papers with the key word 'allergic rhinitis' and refered to several important old records Results : 1. Allegic rhinitis in Oriental Medicine is known as bigu, bunche and the main symptoms is rhinorrhea, sneezing, nasal obstruction. 2. The cause of allergic rhinitis in Oriental Medicine is dysfunctions of the spleen, lung and kidney systems bring weakness to the vital energy(正氣) making wind and cold(風寒邪氣) energy easy to intrude. 3. Determination of the patient's constitution and understanding of the weakness of spleen, lung and kidney systems helps improve the treatment rate, it is used to treat allergic rhinits with herbal medicines, acupunctures and so on. 4. In acupuncture therapy, the mainly used acupuncture points are 迎香(younghyang), 印堂(yindang), 鼻通(bitong), 上星(sangsung), 合谷(habgouk). Conclusions : The Oriental Medicine treatment principal of rhinitis is strengthening the body resistance and eliminating the pathogenic factors according to the individual characters of each patients and the symptoms.

• The Journal of Pediatrics of Korean Medicine
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• v.25 no.3
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• pp.12-26
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• 2011

Objectives: The purpose of this study is to investigate the effect of traditional Korean medical treatment; acupuncture and herb therapy in pediatric allergic rhinitis patients. Methods: This study population was 69 pediatric allergic rhinitis patients who had been treated in ${\bigcirc\bigcirc}$ hospital. All the patients were asked to answer the questionnaires that consist of 10 questions about symptoms of allergic rhinitis. Results: 1. The total scores from the same questionnaire about allergic rhinitis symptoms were significantly improved after the treatment compared to the scores before the treatment(p<0.01). 2. The Nasal symptom, especially, nasal obstruction rhinorrhea had significantly improved in all groups of patients(p<0.01). 3. The effect of the treatment was better with spending more time with acupuncture. Conclusions: Traditional Korean medical treatment is relatively effective in treating pediatric allergic rhinitis.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.17 no.1
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• pp.45-54
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• 2004

Major symptoms of allergic rhinitis are nasal obstructions, sneezing and watery rhinorrhea. Gamigyeji-tang has been used to treat for watery rhinorrhea, which is one of the symptoms of allergic rhinitis. This experimental study was done to rescarch effects of Gamigyeji-tang. We have studied effect of mice on OVA-induced Production of IL-4, IL-5, IFN-${\gamma}$ by Murine Splenocytes, and effect of OVA-induced total IgE and OVA-Specific IgE. The results were as follows ; 1. In IL-4 study, Gamigyeji-tang treated group was proved significant inhibitory effect(p〈0.005) 2. In IL-5 study, Gamigyeji-tang treated group was proved significant inhibitory effect.(p〈0.05) 3. In IFN-${\gamma}$ study, Gamigyeji-tang treated group was proved significant inhibitory effect(p〈0.000001) 4. In Total IgE, Gamigyeji-tang treated group didn't showed significant inhibitory effect. 5. In OVA-specific IgE, Gamigyeji-tang treated group didn't showed significant inhibitory effect. According to this result, Gamigyejj-tang was concluded to be effective on anti-allergic action. More studies are required to investigate the mechanism of inhibition by herbal medicine in allergic rhinitis model.

• Journal of Biomedical Engineering Research
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• v.40 no.4
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• pp.125-131
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• 2019

As a non-invasive method for alleviating allergic rhinitis, there has been a recent ongoing research in the treatment of light from light emitting diodes (LEDs) and lasers. A total of 15 subjects diagnosed with allergic rhinitis were selected for this study. Red and near infrared light emitted from LEDs with wavelengths of 660nm and 940nm were illuminated three times daily (three minutes per cycle) for a total of two weeks. The degree of nasal congestion, runny nose, sneezing and nasal itching was evaluated by questionnaires before and after the test. Also, the serum IgE (Immunoglobulin E) was measured and compared before and after the test. As a result, the total score of symptoms of allergic rhinitis was decreased by 67% after the test (P<0.01). The level of IgE was decreased by 17% after the test (P<0.05). In conclusion, the non-invasive LED phototherapy method using red and near-infrared LED light was effective in alleviating symptoms of allergic rhinitis. There were no adverse effects or complications reported during and after the test.

• Microbiology and Biotechnology Letters
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• v.50 no.4
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• pp.512-521
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• 2022

Since the main symptoms of COVID-19 involve the respiratory system, the infection rate of this disease is predicted to be higher in patients with other respiratory conditions such as allergic rhinitis. In such a situation, it will be meaningful to conduct research on an allergy treatment that has fewer side effects and can effectively reduce allergy symptoms. Here, we prepared experimental samples under various fermentation conditions with mixed extracts of six medicinal plants. To examine the anti-allergic efficacy of these samples, an egg albumin-induced allergic rhinitis animal model experiment, a serum histamine and IgE experiment, and a COX and LO inhibitory activity experiment were conducted. As a result of animal experiments, OVA+SP-4 showed superior efficacy compared to OVA+SP-1 in nasal rubbing and sneezing experiments and had anti-allergic efficacy similar to that of OVA-cetirizine. The serum histamine concentration of OVA+SP-4 was also 1.3 times higher than that of the OVA+cetirizine group, showing a high histamine reduction ability, and IgE showed the same trend. An analysis of COX inhibitory efficacy also confirmed that COX-1 and COX-2 inhibitory efficacy is high, and the longer the fermentation time, the higher the antiallergic efficacy. The composition proposed by this study is expected to have a significant effect on sustainable allergy prevention and treatment in the future by applying it to human patients.