• Journal of Pharmaceutical Investigation
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• v.21 no.1
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• pp.23-32
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• 1991

Dissolution profiles of ketoconazole in solid dispersion system (SDS) were investigated in the second fluid (pH 6.8) for the dissolution test (KPV). PVP K-30 and methyl cellulose were used as carriers in SDS, and chloroform as a solvent. Computer optimization technique was applied to obtain an optimum formula of SDS, and the following results were obtained; 1) Dissolution rate of ketoconazole in SDS was larger than that of pure ketoconazole in the second fluid of pH 6.8. 2) PVP K-30 and methyl cellulosr were good carriers for SDS of ketoconazole. Moerover PVP K-30 was better than methyl cellulose. 3) The optimum formula of ketoconazole SDS obtained from computer optimization technique was chloroform 175 ml, PVP K-30 5g and methyl cellulose 0.2g per 1g of ketoconazole. 4) The experimental value of $A_{60}$ (Amount released from ketoconazole tablet during 60 minutes) obtained from SDS by optimum formula agreed well with the value calculated by polynomial regression equation.

• Journal of The Korean Society of Integrative Medicine
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• v.4 no.4
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• pp.53-65
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• 2016

Purpose : The purpose of this study is to evaluate the effects of virtual reality based exercise program on gross motor function and balance of children with spastic cerebral palsy. Method : Subjects of this study, among the children who received the diagnosis spastic cerebral palsy, for children total of 8 people have agreed to research. Experimental group 4 people, control group 4 people, was a total of 8 people. Group-specific arbitration method, was applied to Nintendo Wii Fit game (experimental group) and exercise program (control group). Each training courses 30 minutes for 4 weeks, examined the changes in Gross Motor Function Measure(GMFM) and Pediatrics Balance Scale(PBS) ability to examine a total of 4-week course effectively. The intervention were compared by measuring before and after. Result : There were significant improvements in the subscales of the gross motor function and balance test of those who practiced with the Nintendo Wii Fit game, while the control group showed no significant changes. Conclusion : Therefore, the virtual based on exercise is effective in improvement of to improve the gross motor function and balance in children with spastic cerebral palsy.

• Journal of The Korean Society of Integrative Medicine
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• v.6 no.2
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• pp.45-57
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• 2018

Purpose : This study was conducted to evaluate the effects of an task oriented training program combined with action-observation on balance and gait ability of patients with chronic stroke. Method : The subjects of this study were 30 patients with hemiplegia who agreed to participate and were picked up. Participants were randomly divided into equal groups; namely, an experimental group that underwent task oriented training combined with action-observation for at least 30 minutes/day for 6 weeks and a control group that underwent general task-oriented training. Patients' balance was assessed using the Sway Length, Sway Area and Limit of Stability test. In addition, gait ability was assessed using the 10 Meter Walking Test to measure the taken to walk 10 meters. Gait time and speed taken to walk 10 meters were used to examine gait ability. Results : There were significant improvements in the subscales of the balance and gait ability test of those who participated in the action-observational training program, while the control group showed only significant changes in the evaluation items of the sway length in eyes opened condition and gait time. Conclusion : Therefore, Action-observational training program effectively improved the balance and gait ability in patients with stroke.

• Journal of Korean Academy of Rural Health Nursing
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• v.1 no.1
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• pp.49-58
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• 2006

Purpose: This study was done to investigate the effects of **the Thera-band exercise program on the lower extremities muscle strength and balance in rural female farmers. Method: The participants were 19 rural women age of 40 or over who were living in the area within the jurisdiction of a public health center in North Chung Province and who agreed to participate in the study. The Thera-band exercise program was implemented for 10 weeks from Jan 17. to Mar 31. 2005. Total time was 60 minutes, 5 times a week. Paired t-test was used to analyze the data using the SPSS program. Result: The results of study showed that thigh muscle strength(t= 6.718, p <.001) and the dynamic balance(t=4.934, p <.001) decreased significantly. Ankle muscle strength(t=-6.739, pp <.001) and static balance (t=-2.395, p=.025) increased significantly. Conclusion: The results suggest that the Thera-band exercise program could be effective in improving thigh muscle strength, ankle muscle strength, the static balance, and the dynamic balance of rural female farmers. Further study is needed to compare strength and balance before and after the exercise program and to use a control group for comparison. Also it is needed to do more study on the appropriate length of time that the intervention should be given in order to achieve maximum results.

• Journal of Korean Critical Care Nursing
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• v.10 no.2
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• pp.45-55
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• 2017

Purpose: This study was intended to standardize the Kangaroo care protocol for fathers, and to determine the effect of fathers' Kangaroo care experience on paternal attachment. Methods: The data was collected from February to April, 2013. The study subjects were 34 fathers (17 experimental group subjects, 17 control group subjects) of premature babies, bornatatertiaryhospitalinSeoul, who agreed to participate . The standardized Kangaroo care protocol, which consisted of at least three 60-minutes sessions during the hospitalization period in a neonatal intensive care unit, was carried out with the experimental group. The data was analyzed by a $x^2$-test and Mann-Whitney U test. Results: The results were as follows: 1) There were no between-group differences in the general characteristics of babies and their fathers. 2) The Kangaroo care fathers showed higher scores of paternal attachment than the control group (Z=-3.657, p=0.008). Conclusion: Fathers who attended the Kangaroo care sessions showed stronger paternal attachment than those who did not. Therefore, use of a Kangaroo care program for fathers of premature babies at neonatal intensive care units is recommended.

• Journal of the Korean Chemical Society
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• v.14 no.4
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• pp.327-332
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• 1970

A simple and convenient device for deflection-type direct reading the variations in electrolytic conductance is described and applied to the analysis of sulfur by combustion-$H_2O_2$ oxidation method. The apparatus consisted of a high resistance-ratio bridge in which the other adjacent arms are the differential cells. By adopting unusually high a-c voltage source for the bridge excitation, the a-c method for unbalanced bridge is established, decreased sensitivity owing to reduced bridge factor, 0.01, is overcome and also the absolute sensitivity and linearity are greatly improved. Over 50% variations in impedance of the balanced cell, within 1% deviation from the linearity can be attained with a volt (rms)order of output which was detected directly with VTVM without further amplification. Analysis of the bridge shows that these useful features are natural result of the constant current character of the high source impedance generator and the performance of the device agreed with the theoretical predictions. A standard procedure for the rapid analysis of sulfur using the bridge is also given, the analytical accuracy was approximately 1%. A determination takes not more than 5 minutes.

• Women's Health Nursing
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• v.15 no.2
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• pp.121-129
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• 2009

Purpose: The purpose of this study was to examine the effect of the yoga during pregnancy on the maternal weight, delivery experience and infant birth weight. Method: The nonequivalent control group pre test-post test design was used. The participants were the healthy pregnant women, whose pre-pregnancy BMI was normal, gestational period was more than 20 weeks. The final sample consisted of 21 mother-infant dyads for experimental group and 20 dyads for control group and who agreed to participate in this study. Data were collected from February I st to December 15th, 2006. The Qi exercise prenatal program was carried out for 90 minutes a day, 2 times a week for 12 weeks. The data were analyzed using SPSS 16.0 Program. Result: The degree of maternal weight gain(p<.001), labor pain(p<.001), discomfort after delivery(p<.001) and infant's birth weight(p<.00I) were significantly different between two groups. Conclusion: The yoga during pregnancy managed weight gain of mothers. Therefore, this study suggests that yoga during pregnancy to promotes stabilization can be beneficial for maintaining healthy weight, decreasing labor pain and discomfort after delivery for pregnant women and increasing infant's birth weight.

• Journal of The Korean Society of Integrative Medicine
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• v.6 no.4
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• pp.127-137
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• 2018

Purpose : The purpose of this study has been performed to find the effect of horseback riding simulation training on the thickness of abdominal muscles and functional balance in children with down syndrome. Methods : This study included 10 children with down syndrome aged between 7 and 13 years. Both groups received regular neurodevelopmental treatment, also experimental group was performed for additional 15 minutes horseback riding simulation training for twice a week during 8 weeks. We measured the thickness of abdominal muscles by using ultrasonography and measured of functional balance by using Pediatric Berg's Balance for the subjects agreed to the before, after 4 weeks and 8 weeks the training. Results : There were no significant difference in the thickness of the internal oblique and external oblique muscles. There were significant difference in transverse abdominis thickness and functional balance that experimental group had increased average than control group after 4 weeks and 8 weeks training Conclusion : Horseback riding simulation training has a positive effect on the improvement of transverse abdominis muscle thickness and functional balance in children with down syndrome.

• Physical Therapy Rehabilitation Science
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• v.10 no.2
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• pp.197-204
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• 2021

Objective: This study is based on a parallax design before and after a non-equivalent control group to examine the effects of laughter therapy on the anxiety, depression, and stress in patients with cancer admitted to a nursing hospital. Design: A randomized controlled trial. Methods: Data collection was conducted on 34 patients who agreed to participate in the study among patients admitted to E Cancer Hospital from September to November 2018. Laughter treatment interventions were performed three times a week for 50 minutes each and a total of eight times. In this study, a tool developed by Spielberger was used to measure state anxiety, a tool developed by Beck was used to measure depression, and the Perceived Stress Scaled eveloped by Cohen was used to measure stress. Results: Anxiety was significantly lower in the experimental group than in the control group (F=10.74, p=0.003). Depression was lower in both the experimental group and the control group that did not participate in the laughter therapy intervention and was not significant (F=0.58, p=0.451). Stress was significantly lower in the experimental group than in the control group (F=4.36, p=0.045). Conclusions: The results of this study suggest that laughter therapy has a positive effect on reducing anxiety and stress in patients with cancer admitted to nursing hospitals.

• Journal of muscle and joint health
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• v.16 no.1
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• pp.26-35
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• 2009

Purpose: The purpose of this study was to investigate the effects of Tai Chi exercise program on physical fitness, pain, and self-efficacy in patients with osteoarthritis. Method: A preexperimental research design was applied to 22 subjects who dwelled at a welfare institution in C-city and agreed to participate in this study. The Tai Chi exercise was conducted with a duration of 60 minutes per session twice a week for 9 weeks. Outcome measures were physical fitness($VO_{2}max$, strength, flexibility, foot power, agility, balance), pain, and self-efficacy. Data were analyzed by descriptive statistics and paired t-test. Result: After participating in the Tai Chi exercise program, the subjects showed significant improvements in strength, agility, balance, pain and self-efficacy. But there were no significant differences in $VO_{2}max$, flexibility and foot power. Conclusion: The results showed that Tai Chi exercise would partially improve physical fitness and be effective for pain reduction and self efficacy as well. Further studies are needed to confirm the effects of Tai Chi exercise on physical fitness.