• 한국전기전자재료학회논문지
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• 제16권12호
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• pp.1071-1076
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• 2003

The nonlinear properties and their stability of ZPCCD- based varistors, which are composed of ZnO P $r_{6}$ $O_{ll}$ - CoO-C $r_2$ $O_3$-D $y_2$ $O_3$-based ceramics, were investigated in the D $y_2$ $O_3$ content range of 0.0∼2.0 mol%. The incorporation of D $y_2$ $O_3$ greatly affected the nonlinear properties and the best nonlinearity was obtained from 0.5 mol% D $y_2$ $O_3$ with nonlinear exponent of 66.6 and leakage current of 1.2 $\mu$A. Further addition of D $y_2$ $O_3$ deteriorated the nonlinear properties. In stability against DC accelerated aging stress state: 0.95 $V_{1mA}$/15$0^{\circ}C$/24 h, the 0.5 mol％ D $y_2$ $O_3$-doped varistor exhibited the highest stability, in which the variation rate of varistor voltage and nonlinear exponent are -1.9% and 10.5%, respectively. The remainder varistors resulted in thermal runaway due to low density of ceramics.s.s.

• Biotechnology and Bioprocess Engineering:BBE
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• 제5권1호
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• pp.44-47
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• 2000

Cell growth and DNA synthesis were studied from a cultured early- and late- pas- sage mouse aorta smooth muscle cell (MASMC) because the proliferation of vascular smooth muscle cell (VSMC) is a key factor in development of atherosclerosis. In this study, the cells were cultured in fetal bovine serum (FBS) and stimulated by growth factors such as thrombin and platelet-derived growth factor-BB (PDGF-BB). Compared to the number of early-passage MASMC (passage 3 to 9) the number of late-passage MASMC (passage 30 to 40) in a normal serum state was increased 2 fold at Day 1, 3 and 6 in culture, respectively. Incorporation of $[^3H]$ thymidine into DNA induced by serum, PDGF and thrombin in late-passage MASMC was greater than those in early-passage MASMC. We also examined whether intracellular zinc levels would be an aging factor or not. The intracellular zinc level in early- and late-passage MASMC was monitored by using the zinc probe dye N-(6-methoxy-8-quinolyl)-p-toluenesulfonamide. It is interested that late-passage MASMC increased the intracellular fluorescence level of zinc, more than the early passage MASMC did. The alterations of intracellular zinc level occur concurrently with changes in MASMC proliferation rate during aging. This data suggest that the age-associated changes in zinc concentrations may provide a new in vitro model for the study of smooth muscle cell differentiation.

• 한국콘텐츠학회논문지
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• 제12권9호
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• pp.257-269
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• 2012

본 연구는 다양한 건강상태에 놓여 있는 노인들의 성공노화를 실현하기 위한 통합적인 건강서비스 제공의 근간이 되는 포괄적 노인평가 패키지를 개발하기 위한 목적으로 시행된 방법론적 연구이다. 노인평가도구들에 대한 임상 및 지역사회에서의 사용 실례와 관련문헌 고찰을 통해, 총 9개 평가 영역으로 나누어 관련 평가항목과 평가도구들을 1차적으로 선정하였다. 이후 관련 전문가 3인의 자문 결과와 노인 15명을 대상으로 한 예비조사 실시 결과를 토대로 포괄적 노인평가의 영역과 항목들을 수정 보완하였다. 최종적으로 기본평가, 정신기능평가, 신체기능평가, 생활습관평가, 주관적 건강수준평가, 환경평가로 이루어진 6개의 평가영역에서 각 해당 항목의 수행지침이 포함된 29개 평가항목으로 구성된 포괄적 노인평가 패키지가 구축되었다.

• 디지털융복합연구
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• 제10권4호
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• pp.37-43
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• 2012

LED TV 통합검사유닛은 LED BLU의 구동과 동시에 이상 유무 체크, AGING 작업 등 LED BLU를 테스트하기 위한 검사 장비이다. 기존 검사 유닛은 LCD의 종류와 크기에 따라 생산라인에서 검사 유닛을 교체해야 하는 불편한 점이 있어 본 연구에서는 한 가지 LED TV BLU 모델이 아닌 32 ~ 52인치의 다양한 LED TV BLU 모델을 수용할 수 있는 멀티형(통합형) 검사유닛으로 개발한다. 멀티형으로 개발하기 위해서 멀티 LED TV 통합검사유닛의 출력 전류를 80mA ~ 215mA의 범위로 다양한 출력이 되도록 만들고, LED BLU의 상태를 확인 하는 기능, 디밍(밝기 조절)기능 및 장시간 사용 시 열 발생 완화 기능 등을 구현한다. 또한 펌웨어 프로그램을 개발하고 업그레이드 할 수 있도록 하여 새로운 패널에 대해서도 지원할 수 있도록 개발한다.

• Archives of Pharmacal Research
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• 제29권2호
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• pp.165-171
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• 2006

Osteoarthritis is thought to be induced by the ageing-related loss of homeostatic balance between degeneration and repair mechanism around cartilage tissue in which inflammatory mediators such as reactive oxygen species, cytokines and prostaglandins are prone to overproduction under undesirable physiological conditions. Phlorotannins are unique polyphenolic compounds bearing dibenzo-1,4-dioxin skeleton which are not found in terrestrial plants but found only in some brown algal species such as Ecklonia and Eisenia families. Phlorotanninrich extracts of Ecklonia cava including LAD103 showed significant antioxidant activities such as DPPH radical scavenging, ferric ion reduction, peroxynitrite scavenging, and inhibition of LDL oxidation, indicating their possible antioxidative interference both in onset and downstream consequences of osteoarthritis. LAD103 also showed significant down regulation of $PGE_2$ generation in LPS-treated RAW 246.7 cells, and significant inhibition of human recombinant interleukin-$1{\alpha}$-induced proteoglycan degradation, indicating its beneficial involvement in pathophysiological consequences of osteoarthritis, the mechanism of which needs further investigation. Since LAD103 showed strong therapeutic potentials in arthritic treatment through several in vitro experiments, it is highly encouraged to perform further mechanistic and efficacy studies.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 추계학술대회 논문집 전기물성,응용부문
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• pp.251-254
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• 2004

The aging diagnosis technique using partial discharge detection method detects partial discharge signals cause of power equipment failuer and able to forecast the aging state of insulation system through analysis algorithm, in this paper accumulates HFPD signal during constant scheduled cycles to build HFPD pattern and then analyzes HFPD pattern using statistical parameters and ${\Delta}F$ pattern. The 3D pattern is composed of detected signal frequency, amplitude and repeated number and the FRPDA(frequency resolved partial discharge analysis) technique is used in 3D pattern construction. The ${\Delta}F$ pattern shows variation characteristics of amplitude gradient of consecutive HFPD signal Pulses and able to classify discharge types-internal discharge, surface discharge and coronal discharge etc. Fractal mathematics applied to ${\Delta}F$ pattern quantification and neural networks is used in aging diagnostic algorithm.

• 한국발생생물학회지:발생과생식
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• 제11권1호
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• pp.13-20
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• 2007

암컷 포유동물의 노화 과정에서 생식계는 체내 여러 시스템 가운데 가장 먼저 기능 저하가 나타난다. 생식 노화(reproductive aging) 과정 중인 암컷 포유동물은 비록 종 특이성이 있지만 주기성(cyclicity)의 소실과 같은 생식 능력의 감소와 함께 여러 기능들의 변화가 동반되면서 궁극적으로 인간의 폐경 현상과 같은 생식 능력 상실이 나타난다. 본 증설은 암컷 포유동물의 생식호르몬 축, 특히 신경내분비 회로의 노화에 대한 정보들과 노화 연구에 유용한 설치류 모델들을 소개하고자 한다. 암컷 설치류의 중년(middle age, 생후 $8{\sim}12$개월)은 인간의 폐경기 진입 직전에 해당되는 시기로, 이 시기에 시상하부 GnRH 분비의 맥동성과 급등(surge)이 현저히 지연되기 시작하고, 곧 이어 뇌하수체 LH 분비의 맥동성과 급등이 역시 약화 내지 지연된다. 노화와 관련된 GnRH-LH 신경내분비 활성의 결손은 시상하부 GnRH 뉴런의 활성을 조절하는 여러 자극(예, glutamate)들의 변화와 밀접하게 연관되어 있다. 많은 연구자들이 이러한 '시상하부 결손(hypothalamic defects)'이 생식 노화의 주된 요인임을 지지하지만, inhibin과 같은 난소 요인의 변화 역시 생식 노화의 유도와 관련된 것으로 보인다. 생식 노화를 연구함에 유용한 몇몇 설치류 모델이 있다; FSH 수용체 녹아웃(follitropin receptor knockout; FORKO) 생쥐 모델의 경우는 homozygous(null) 뿐만 아니라 heterozygous(haploinsufficient) 상태도 노화에 따른 난자/난포의 고갈을 나타낸다. Dioxin/aryl hydrocarbon 수용체 녹아웃 (AhRKO) 생쥐 모델도 유사한 상태를 유발할 수 있다. 생식 노화의 기작에 관한 연구는 삶의 질을 높이기 위한 수단들, 예를 들어 호르몬 보충요법(HRT)의 장단점을 평가하고 안전성을 제고하는데 도움이 될 것이다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2003년도 하계종합학술대회 논문집 V
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• pp.2745-2748
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• 2003

In this paper, we implement the photoplethysmo-graphy system that have three channel pulse wave detects and one channel ECG amplifier. In order to detect the artery state, we measured the pulse waves at different positions, simultaneously. In general, arterial vascular system suffers the decrease of compliance, increase of resistance, and decrease of distensibility through aging. Therefore, we compared and analyzed variation of tile Pulse waves parameter both in time and frequency domains that is concerned with the changes of arterial characteries. And then evaluated the correlation coefficients between the parameters variation and the age group. As the result of experiment, we found that the Parameters have a significant correlation about aging.

• 한국시스템다이내믹스연구
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• 제17권1호
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• pp.107-134
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• 2016

Accelerated ageing with low fertility is one of the most critical problems in Korea. Because of ageing via low fertility, Korea will face a serious demographic cliff. This research primarily focus on the analyzing the dynamics of the marginal ageing state and decreasing population especially in Eup and Myeon region. This study based on the system dynamics approaches for finding causal loop structure of marginal ageing and critical mass of population disappearing. The results of this study are summarized as follows. First, demographic marginalization trends have already begun in the Eups and Myons of Gun. Second, marginal aging speed in Eup/Myeon areas is causing an population disappearing in the near future. Third, critical mass of population disappearing will begin when the rate of marginal aging is exceed 82% after 2023.

• 전기학회논문지
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• 제58권7호
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• pp.1380-1385
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• 2009

This paper was studied about the aging judgment method by ultraviolet rays image to happen in electric power equipment using ultraviolet rays camera. We established the aging judgment method as follows; 20% within of risk factor of insulation state of electrical facility that ultraviolet rays image does not show is "good or recognition". 30$^{\sim}$50% within of risk factor is "check", 50$^{\sim}$60% within of risk factor is "inspection" and 60% above of risk factor is "replacement". This method will be utilized for the inspection about electrical facilities.