• Biomolecules & Therapeutics
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• v.21 no.3
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• pp.241-245
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• 2013

Aging is the single most important risk factor that increases susceptibility to many forms of diseases. As such, much effort has been put forward to elucidate the mechanisms behind the processes of aging and to discover novel compounds that retain anti-aging activities. Korean red ginseng has been used for a variety of medical purposes in eastern countries for several thousands of years. It has been shown that Korean red ginseng affects a number of biological activities including, but not limited to, anti-inflammatory, anti-oxidative and anti-diabetic pathways. However, few studies have been performed to evaluate its anti-aging effects with an in vivo system. Here Drosophila melanogaster as an in vivo model organism demonstrates that Korean red ginseng tonic extends lifespan, increases resistance to starvation stress and prevents weight gain. This data suggest that Korean red ginseng may regulate organisms' metabolism in favor of extending lifespan.

• Nuclear Engineering and Technology
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• v.53 no.6
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• pp.1909-1923
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• 2021

We experimentally investigated the effects of thermal aging and cold work on the microstructure, mechanical properties, and primary water stress corrosion cracking (PWSCC) initiation time for Alloy 182 welds. The effects of thermal aging and cold work on the PWSCC initiation time of Alloy 182 were modeled based on the plastic energy concept and the PWSCC initiation data of this study and previous reports by considering censored data. Based on the results, it is estimated that the PWSCC resistance of the Alloy 182 weld firstly increases and then decreases with thermal aging time when the applied stress is kept constant.

• Elastomers and Composites
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• v.52 no.2
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• pp.105-113
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• 2017

The curing behavior, mechanical properties, hot-air aging resistance, abrasion properties,thermal properties, etc., of EVM/EPM/APP (ammonium polyphosphate)/DPER (dipentaerythritol)/EG (expandable graphite) and EVM/EPM/ATH (aluminium trihydroxide) flame retarding systems in ethylene vinyl acetate rubber (EVM) blends with EPM (ethylene propylene rubber) were sequentially examined. For both flame retarding systems, the torque values increased with the content of EPM rubber and with the vulcanization time. As the content of EPM rubber increased, the scorch time became shorter, whereas the optimum cure time followed an increasing trend. For the EVM/EPM/APP/DPER/EG flameretarding system, as the content of EPM rubber increased, the hardness did not change,whereas the tensile strength and elongation at break decreased. A hot-air aging resistance test at $150^{\circ}C$ showed that the heat resistance decreased with the EPM content regardless of the kinds and contents of flame retardants. As the EPM content increased, the abrasion rate became higher and the abrasion resistance of the EVM/EPM/APP/DPER/EG flame retarding systems exceeded that of the EVM/EPM/ATH flame retarding counterparts. In comparison with the EVM/EPM/ATH flame retarding systems, the thermal stability of the EVM/EPM/APP/DPER/EG flame retarding system showed an increasing tendency.

• Nutrition Research and Practice
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• v.18 no.1
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• pp.46-61
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• 2024

BACKGROUND/OBJECTIVES: An increasing life expectancy in society has burdened healthcare systems substantially because of the rising prevalence of age-related metabolic diseases. This study compared the effects of animal protein hydrolysate (APH) and casein on metabolic diseases using aged mice. MATERIALS/METHODS: Eight-week-old and 50-week-old C57BL/6J mice were used as the non-aged (YC group) and aged controls (NC group), respectively. The aged mice were divided randomly into 3 groups (NC, low-APH [LP], and high-APH [HP] and fed each experimental diet for 12 weeks. In the LP and HP groups, casein in the AIN-93G diet was substituted with 16 kcal% and 24 kcal% APH, respectively. The mice were sacrificed when they were 63-week-old, and plasma and hepatic lipid, white adipose tissue weight, hepatic glucose, lipid, and antioxidant enzyme activities, immunohistochemistry staining, and mRNA expression related to the glucose metabolism on liver and muscle were analyzed. RESULTS: Supplementation of APH in aging mice resulted in a significant decrease in visceral fat (epididymal, perirenal, retroperitoneal, and mesenteric fat) compared to the negative control (NC) group. The intraperitoneal glucose tolerance test and area under the curve analysis revealed insulin resistance in the NC group, which was alleviated by APH supplementation. APH supplementation reduced hepatic gluconeogenesis and increased glucose utilization in the liver and muscle. Furthermore, APH supplementation improved hepatic steatosis by reducing the hepatic fatty acid and phosphatidate phosphatase activity while increasing the hepatic carnitine palmitoyltransferase activity. Furthermore, in the APH supplementation groups, the red blood cell (RBC) thiobarbituric acid reactive substances and hepatic H₂O₂ levels decreased, and the RBC glutathione, hepatic catalase, and glutathione peroxidase activities increased. CONCLUSIONS: APH supplementation reduced visceral fat accumulation and alleviated obesity-related metabolic diseases, including insulin resistance and hepatic steatosis, in aged mice. Therefore, high-quality animal protein APH that reduces the molecular weight and enhances the protein digestibility-corrected amino acid score has potential as a dietary supplement for healthy aging.

• Journal of the Korean Geotechnical Society
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• v.20 no.6
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• pp.137-150
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• 2004

Aging effect of sands showed insignificant result in comparison with that of clay, so that it has not been studied so far. But, as penetration resistance increase has been observed with the lapse of time after deposition and disturbance, aging effect of sands has been actively investigated by field tests, and recently many researchers are performing not oかy field tests but also laboratory tests on sands, so aging effects of sands have been also examined by laboratory tests. In this study, to observe the aging effect of undrained static shear behavior for Nak-Dong River sand, undrained static triaxial tests were performed with changing relative density$(D_r)$, consolidation stress ratio$(K_c)$, and consolidation time. These tests showed that modulus within elastic section increased as consolidation time increased, and in addition, phase transformation point strength$(S_{PT})$ and critical stress ratio point strength $(S_{CSR})$ also increased. But pore water pressure ratio$(u/{p_c}')$ decreased as consolidation time increased, so with this various result, aging effect of static shear for sands can be observed as well.

• 한국노년학
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• v.31 no.2
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• pp.303-315
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• 2011

The purpose of this study was to investigate effect of resistance training on BMD and bone metabolism related markers in aging rats. Thirty male Spraugue-Daweley rats were divided into sedentary (CON; n=10 ) non-load resistance trained(NLRTG; n=10), and load resistance trained(LRTG; n=10) groups at the age of 64 weeks. The rats in the resistance training groups((NLRTG and LRTG) performed the tower climbing exercise 4 times a week. The LRTG groups were conditioned to climb a vertical ladder with weights appended to their tail 4 days/wk for 12 wks. After 12 weeks of exercise, serum osteocalcin, bone mineral density (BMD), breaking force, ash, Ca, and P in the femur were measured. After training, serum osteocalcin (OC) was significantly (p < 0.05) higher in both LRTG and NLRTG when compared to Control. Right femur BMD was significantly (p < 0.05) greater for LRTG when compared to both NLRTG and Control with no significant difference between NLRTG and Conrtol. The breaking force of femur was significantly (p < 0.05) greater for LRTG and NLRTG when compared to Control. The Ash, Ca, content of femur were significantly increased in resistance training groups than control group. These results suggest that the increase in bone mineral density induced by resistance training is mediated by changes in bone microarchitecture as well as training intensity and osteocalcin.

• 한국체육학회지인문사회과학편
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• v.55 no.6
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• pp.691-700
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• 2016

The purpose of this study was to investigate the effects of long-term endurance exercise or resistance exercise training on muscle anabolic/catabolic pathway. 50wks-old male Wistar rats(n=30) were randomly assigned for 3 groups (sedentary, endurance exercise, resistance exercise group). After 12-week of training, plantaris muscles were dissect to measure protein level. Akt/mTOR signal-related proteins were significantly increased only after resistance exercise training, but catabolic signal-related proteins, FoxO1 and MuRF1, were significantly decreased after resistance and endurance exercise training. After endurance exercise training, AMPK and PGC-1α protein levels were significantly increased. Therefore, the endurance exercise training has been shown to affect the protein balance of aging muscle through inhibition of muscle protein catabolism. The present results suggest the possibility that not only resistance exercise but also endurance exercise will be affectable to keep or increase muscle volume and capacity of middle-aged people.

• Journal of Korea Foundry Society
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• v.24 no.4
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• pp.231-237
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• 2004

Bake hardenable steel utilizes the phenomenon of strain aging to provide an increase in the yield strength of formed components. An increase of the carbon content will improve the bake hardening response: more solutes are available to pin mobile dislocations and to form the clusters more rapidly. But aging resistance decrease as increasing solute carbon. In order to under-stand the compatibility between bake hardenability and aging resistance. The optimum solute carbon control methods during manufacture should be determined. In this paper, the effect of continuous heat cycle conditions such as soaking temperature, rapid cooling start temperature, cooling rate on BH(Bake Hardenability), AI(Aging Index), YP-El(Yield Point Elongation) and other mechanical properties have been investigated. and following results were obtained. In the case of soaking temperature, BH increases with higher soaking temperature because of NbC $dissolution(830^{\circ}C)$, Therefore the solute carbon and BH at $850^{\circ}C$ and $870^{\circ}C$ are higher than these at $810^{\circ}C$. But BH at $870^{\circ}C$ is a little lower than that at $850^{\circ}C$ owing to the ferrite grain size. The measurement of amount of dissolution C using IFT(Internal Friction Test) can explain the relation of solute carbon and BH.

• Journal of Advanced Marine Engineering and Technology
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• v.23 no.6
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• pp.761-769
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• 1999

In this paper the effect of aging heat treatment to the Corrosion behavior for the Nimonic 80A superalloy was studied by AC Impedance methods. Tested solution was 3.5% with tempera-ture $25^{\circ}C$ Electro-chemical corrosion test were carried out for the Nimonic 80A super-alloy which solution heat treated at $1080^{\circ}C$ for 8 hours followed by aging heat treated at $650^{\circ}C,\;700^{\circ}C,\;750^{\circ}C\;800^{\circ}C$ and $850^{\circ}C$ with 16hours under vacuum environment. The obtained results were as follows; 1. Base metal and solution-treated materials were exhibited similar corrosion tendency as Ran-dle equivalent cell. The value of passive film resistance was 579 ohms for the base metal and 124,770 ohms for the solutionized metal such a difference was arose by the ${{\gamma}_^'}$ precipitate on the metal surface during heat treatment. 2. The measure value of $R_p$ for heat-treated at $650^{\circ}C,\;700^{\circ}C,\;800^{\circ}C$and $850^{\circ}C$ were 97,943, 93, 111, 26,961, 15,798 and 11,780ohm respectively. Which indicated that the passive film resistance Rp was reduced as aging temperature increased due to the growth of grain size and sensitization at the grain boundary. 3. The similar tendency was exhibited for corrosion behavior of the electro-chemical corrosion polarization method and AC impedance method and confirmed that AC impedance method was useful tool for corrosion research.

• International Journal of Highway Engineering
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• v.8 no.4 s.30
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• pp.135-143
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• 2006

This study evaluated the fatigue resistance characteristics of hot-mix recycled asphalt mixtures which were prepared by a new blending method. Since the binder of RAP shows higher viscosity without being rejuvenated in the ordinary recycled mixture, this new(modified) blending method was developed for obtaining more uniform level of binder viscosity in the recycled mixture. Cold-planned RAP was collected and mix design was performed using 15% RAP content for two virgin aggregate, gneiss and granite. Penetration grade of 60-80 asphalt was used in mixing recycled mixture together with a polymer modifier, LDPE. Indirect tensile fatigue tests were carried out to evaluate characteristics of fatigue resistance of performance of recycled asphalt mixtures. The recycled mixtures with LDPE 6% showed higher repeated loading fatigue life. Fatigue life ratio of new(N) mixing method mixtures was approximately 0.6-0.7 before aging and 0.8-1.0 after aging treatment of ordinary(O) mixing method mixture. This means the N mixture becomes stronger with aging process increase. If further aging is treated, N mixture may be showing stronger resistance than O mixture.