• Clinical and Experimental Vaccine Research
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• 제13권3호
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• pp.253-258
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• 2024

Purpose: The immunogenicity of vaccines containing the canine adenovirus (CAdV) type 2 (CAdV-2) variant has not yet been reported. We prepared a novel inactivated CAdV-2 variant vaccine using the CAV2232-41 strain, and evaluated its safety and immunogenicity in raccoon dogs. Materials and Methods: The growth kinetics of CAV2232-41 were determined using Madin-Darby Canine Kidney (MDCK) cells. The nucleotide sequences of CAV2232 and CAV2232-41 were determined by next-generation sequencing. To generate the CAdV-2 variant vaccine, CAV2232-41 propagated in the MDCK cells was inactivated with 0.1% formaldehyde. Two vaccines were prepared by blending inactivated CAV2232-41 with Cabopol and Rehydragel adjuvants. Safety and immunogenicity of the CAV2232C and CAV2232R vaccines were evaluated in guinea pigs. Safety and immunogenicity of the CAV2232C vaccine were also evaluated in raccoon dogs. The virus neutralizing antibody (VNA) titer against CAV2232-41 was measured in sera collected from immunized guinea pigs and raccoon dogs. Results: CAV2232-41 showed the highest viral titer on days 4-6 post-inoculation and had a deletion in the E3 gene, which was confirmed as a CAdV-2 variant. Guinea pigs inoculated with CAV2232C showed slightly higher VNA titers than those inoculated with CAV2232R 2 weeks after booster vaccination. Raccoon dogs immunized with the CAV2232C vaccine developed high mean VNA titers, while non-vaccinated raccoon dogs were antibody-negative. Conclusion: The CAV2232C vaccine is safe and induces a protective VNA titer in raccoon dogs.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2010년도 춘계학술대회
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• pp.555-556
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• 2010

연안 수역에서의 해상교통 환경변화에 부응하고 나아가 대형 해양사고 방지와 인명사고 예방을 위해 필요한 해양기상신호표지 시스템 구축을 위하여 해양기상 관측 및 항로표지 정보제공 시스템을 도입, 통항선박에게 안전항해에 필요한 정보를 제공함으로서 해양교통 안전을 확보하고자 한다. 인천 연안의 팔미도를 포함한 15개 항로표지시설에 기상(온습도, 풍향/풍속, 기압) 및 해양(유향/유속, 수온, 파고/파향) 관측시스템을 설치하고 항로표지용 AIS (AtoN AIS) 통신시스템을 이용하여 육상 정보수집 처리서버 및 항행 선박에게 해양기상관측자료를 실시간 전송하는 시스템을 구축하였다.

• Journal of Pharmaceutical Investigation
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• 제23권2호
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• pp.97-102
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• 1993

Hospital pharmacy services are divided into dispensing affairs for inpatients and outpatients, pharmaceutical service, stock control, intravenous admixture service, drug information service, pharmacokinetic consultation service, education and research work, etc. But among those affairs, dispensing affair for outpatient is perceived as the most important work in Korea, because it is linked directly with hospital service for patients. Therefore, total computer system for dispensing area was adopted from opening point of hospital in 1989 in Asan Medical Center. Utilization of computer system for outpatient dispensing area is as follows; 1) Order communication system of prescription by Total Hospital Information System, 2) Automatic print-out system of direction for use by sticker connected with on-line net work, 3) Use of automatic tablet counting and packaging machines connected with on-line net work. Those computer system resulted in curtailment of pharmacy manpower and shortening of waiting-time for outpatient.

• 약학회지
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• 제50권2호
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• pp.70-77
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• 2006

A cost effective analysis was performed for comparing leflunomide+methotrexate, etanercept monotherapy and etanercept+methotrexate for 6 months. For the patients with methotrexate-resistant RA, ACR20 data were extracted from the published clinical trials searched from Pubmed. The direct medical cost was estimated based on ACR guideline and Korean National Health Insurance reimbursement. Combination therapy of etanercept+methotrexate was found to be more cost-effective than etanercept monotherapy, which meant it was a better therapeutic strategy for methotrexate- resistant RA.

• 약학회지
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• 제57권3호
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• pp.199-204
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• 2013

This study aimed to quantify antibiotic consumption and expenditures for acute upper respiratory tract infections (URIs) (J00-J06) in outpatients from 2009 to 2011. We used WHO ATC classification and DDDs in measuring antibiotic consumption. National Health Insurance and Medical Aid claims data were analyzed. Antibiotic consumption has decreased from 4.44 DDD/1,000inhabitants/day in 2009, to 4.43 in 2010 and 3.74 in 2011. The estimated expenditures were 8,206 won/1,000inhabitants/day in 2009, 8,379 in 2010, and 7,004 in 2011. Clinics accounted for 89.8% and 86.0% of antibiotic consumption and expenditures respectively for the acute URIs in 2011. We need to monitor antibiotic consumption consistently, and promote judicious antibiotic use.

• 수산해양교육연구
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• 제19권3호
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• pp.329-345
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• 2007

The purpose of this study was to classify the standard classification of fishery occupations base on KECO(Korean Employment Classification of Occupation) in Korea. The result of this study was as follows. First ranks was fisheries duties, second ranks were classified into five categories. That were administration duties management duties financial affairs duties, social service duties marketing duties individual service duties, construction duties civil engineering duties, machinery duties manufacture duties repairing duties, production duties. Third ranks classify based on second ranks. Administration duties management duties financial affairs duties were classified fishery administration, fishery management, fishery financial affairs. Social service duties marketing duties individual service duties were classified fishery social service, fishery marketing, fishery individual service. Construction duties civil engineering duties were classified fishery construction, fishery civil engineering. Machinery duties manufacture duties repairing duties were classified fishery machinery duties, fishery manufacture, fishery repairing. Production duties were classified fishery processing, marine products, fishery environment. Fourth ranks was classified according to third ranks.

• 한국응급구조학회지
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• 제2권1호
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• pp.47-57
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• 1998

Today, Korean Disaster Control System has better change the existed it for substantial prevention and the emergency control system. And it requires the new National Wide Disaster Control System through building up the cooperation system with related posts which are scattered over the National Administration and one-way management for disaster affairs by them. Therefore 119 that might have a lot of technical knowhow should be a center of disaster affairs which will be able to take all rescue, relief(first aid), fire fighting, and preventive affairs. Then it could be a service organization of citizen. Consequently, it will strengthen National Disaster Control ability and it could be a National Wide Disaster Organization which is ready for prevention, preparation, confrontation of all kinds of disasters with absolute reliance by the citizen.

• 한국디지털건축인테리어학회논문집
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• 제11권3호
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• pp.109-113
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• 2011

This study is suggest the test system for BIM(Building Information Modeling) qualification. And this study is the field-based BIM educational program with the acquisition of the qualifying certificates. Since field-based BIM and Curriculum(of University and Junior College) are highly linked to the actual practical affairs, the learning connected to the practical affairs out of the teaching focused on BIM modeling would satisfy students, and it would make the acquisition of the certificates which determinate the capability of the practical affairs. Thus teachers should guide students to get the certificates thoroughly, make them understand the importance of the acquisition of the certificates.

• 디지털융복합연구
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• 제10권4호
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• pp.235-241
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• 2012

최근 교육 수월성 제고와 질적 수준 향상을 위해서 대학에서는 정보화를 추진하고 있으나 개인정보를 비롯한 학사행정과 관련된 중요 정보들이 학사 데이터베이스에 집적되어 있어 그에 따른 보호 대책이 필요하다. 이 논문에서는 학사 데이터베이스 구축에 사용되는 DBMS의 접근제어, 기밀성, 무결성 그리고 보안감사 등이 보장되도록 대학의 현실에 적합한 학사 데이터베이스 통합 보안 모델을 제안한다. 제안 모델은 상당 수 대학들이 데이터베이스 보안 제품을 활용하고 있지 못한 여건을 고려하여 DBMS가 제공하는 기능만으로 보안의 가장 핵심 요소인 기밀성 등을 구현하는 세부 방안을 제시하고 있다.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2006년도 추계학술대회 논문집
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• pp.675-682
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• 2006

The command of Subway is intended to adjust and control the train operation, and to play a key role of the total passenger transport and all kinds of affairs related to the safe train operation. Also, this can be considered as affairs to be controlled and operated by Total Traffic Control. For the purpose of developing the ATO system in using the new control technology by substituting the conventional ATS equipment, this technical document includes the technical points resulted from doing the replacement construction in the entire section of Subway Line 2 by Seoul Metro. The replacement work with the new ATO System should neither stop nor affect the system under operation while operating the current ATS System. The different systems should not interfere with each other while performing their individual affairs, and be composed to share the important data for the parallel operation. This technology is needed to proceed in assurance of a high degree of reliability.