• 대한한방종양학회지
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• 제7권1호
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• pp.117-129
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• 2001

Objectives: We compared the therapeutic response, the treatment-related toxicity, and the improvement of subjective symptoms between the chemotherapy alone group and the western-oriental combined treatment group and evaluated the role of oriental medicine for the improvement of chemotherapy-related toxicity in the advanced gastric cancer and hepatocellular carcinoma. Methods: We evaluated 36 gastric cancer or hepatocellular carcinoma patients(chemotherapy alone group 25 patients, combined treatment group 11 patients) who had been treated in Wonju Christian Hospital and Hana Hospital of Oriental Medicine between June 1999 and October 2000. Enrolled patients' general medical records, results of laboratory and imaging studies, treatment-related toxicities, and subjective symptoms were recorded regularly according to the planned protocol. Therapeutic responses were estimated according to the WHO response criteria and the changes of tumor marker value such as CEA, CA 72-4 and AFP. Results: 1. There was no significant difference of therapeutic response by the WHO response criteria between the two groups(p=.459). 2. There was a significant decrease of tumor marker value in the combined treatment group compared to the chemotherapy alone group(p=.023). 3. There was less comprehensive treatment-related toxicity in the combined treatment group compared to the chemotherapy alone group(p=.037), but there was not a significant difference of comprehensive improvement of subjective symptoms between the two groups(p=.091). Conclusions: Based on the above results, we could expect the possibility of improvements in therapeutic response and treatment-related toxicity with the western-oriental combined anticancer treatment.

• 한국항행학회논문지
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• 제16권5호
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• pp.846-852
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• 2012

영상분할 결과는 알고리즘에 관련된 매개변수들에 따라 다르기 때문에 최적 분할을 위하여 시행 착오법이 많이 이용된다. 본 논문에서는 3차원 변량 분석법을 이용하여 영역기반 active contour 방법에 관련된 최적 매개변수들을 결정하는 방법을 제안한다. 3원 변량 분석법에 의해서 추출된 결과와 사용자가 영상에서 직접 그린 결과가 상호 비교된다. 마지막으로 각 매개변수들의 주요 효과와 상호작용 효과를 측정하고 최적 값을 추출하기 위하여 점 추정 및 구간 추정 값을 계산한다. 본 논문에서 제안한 방법은 구간 상수 모델을 대상으로 영상분할시 최적 매개변수들을 추출하는데 큰 도움을 줄 것이다.

• 한국항행학회논문지
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• 제11권2호
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• pp.163-169
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• 2007

본 논문에서는 x-ray 영상시스템의 영상을 획득하기 위하여 x-ray 발생기와 영상획득시스템 사이의 동기를 맞추어 주는 트리거 발생기를 연구분석 하였다. 무선 트리거 발생기는 디지털영상 획득시스템으로부터 영상획득의 시작을 지시할 수 있는 ACQ_START 신호와 영상획득의 끝을 알리는 ACC_END 신호를 발생시킬 수 있도록 설계하였다. 디지털 영상의 획득은 ACQ_START 신호와 ACQ_END 신호 사이의 시간동안에만 정확하게 이루어지며 무선 원격 x-ray 신호의 검출을 통하여 유선통신 프로토콜 없이 정확한 x-ray 영상의 획득이 가능하고 20 mAs 의 x-ray 레벨에서 3.5 line pair /mm 분해능을 나타냄을 확인하였다.

• Radiation Oncology Journal
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• 제35권1호
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• pp.65-70
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• 2017

Purpose: To evaluate the utility of implanted surgical clips for detecting interfractional errors in the treatment of hepatobiliary and pancreatic cancer with postoperative radiotherapy (PORT). Methods and Materials: Twenty patients had been treated with PORT for locally advanced hepatobiliary or pancreatic cancer, from November 2014 to April 2016. Patients underwent computed tomography simulation and were treated in expiratory breathing phase. During treatment, orthogonal kilovoltage (kV) imaging was taken twice a week, and isocenter shifts were made to match bony anatomy. The difference in position of clips between kV images and digitally reconstructed radiographs was determined. Clips were consist of 3 proximal clips (clip_p, ${\leq}2cm$) and 3 distal clips (clip_d, >2 cm), which were classified according to distance from treatment center. The interfractional displacements of clips were measured in the superior-inferior (SI), anterior-posterior (AP), and right-left (RL) directions. Results: The translocation of clip was well correlated with diaphragm movement in 90.4% (190/210) of all images. The clip position errors greater than 5 mm were observed in 26.0% in SI, 1.8% in AP, and 5.4% in RL directions, respectively. Moreover, the clip position errors greater than 10 mm were observed in 1.9% in SI, 0.2% in AP, and 0.2% in RL directions, despite respiratory control. Conclusion: Quantitative analysis of surgical clip displacement reflect respiratory motion, setup errors and postoperative change of intraabdominal organ position. Furthermore, position of clips is distinguished easily in verification images. The identification of the surgical clip position may lead to a significant improvement in the accuracy of upper abdominal radiation therapy.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권3호
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• pp.276-285
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• 2020

Purpose: Non-alcoholic fatty liver disease (NAFLD) ranges in severity from simple steatosis to steatohepatitis. Early detection of NAFLD is important for preventing the disease from progressing to become an irreversible end-stage liver disease. We developed a nomogram that allows for non-invasive screening for NAFLD in obese children. Methods: Anthropometric and laboratory data of 180 patients from our pediatric obesity clinic were collected. Diagnoses of NAFLD were based on abdominal ultrasonographic findings. The nomogram was constructed using predictors from a multivariate analysis of NAFLD risk factors. Results: The subjects were divided into non-NAFLD (n=67) and NAFLD groups (n=113). Factors, including sex, body mass index, abdominal circumference, blood pressure, insulin resistance, and levels of aspartate aminotransferase, alanine aminotransferase (ALT), γ-glutamyl transpeptidase (γGT), uric acid, triglycerides, and insulin, were significantly different between the two groups (all p<0.05) as determined using homeostatis model assessment of insulin resistance (HOMA-IR). In our multivariate logistic regression analysis, elevated serum ALT, γGT, and triglyceride levels were significantly related to NAFLD development. The nomogram was established using γGT, uric acid, triglycerides, HOMA-IR, and ALT as predictors of NAFLD probability. Conclusion: The newly developed nomogram may help predict NAFLD risk in obese children. The nomogram may also allow for early NAFLD diagnosis without the need for invasive liver biopsy or expensive liver imaging, and may also allow clinicians to intervene early to prevent the progression of NAFLD to become a more advanced liver disease.

• 한국영재학회:학술대회논문집
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• 한국영재학회 2003년도 춘계학술대회
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• pp.137-138
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• 2003

Understanding how and why people differ is a fundamental, if distant, goal of research efforts to bridge psychological and biological levels of analysis. General fluid intelligence (gF) is a major dimension of individual differences and refers to reasoning and novel problemsolving ability. A conceptual integration of evidence from cognitive (behavioral) and anatomical studies suggeststhat gF should covary with both task performance and neural activity in specific brain systems when specific cognitive demands are present, with the neural activity mediating the relation between gF and performance. Direct investigation of this possibility will be a critical step toward a mechanistic model of human intelligence. In turn, a mechanistic model might suggest ways to enhance gF through targeted behavioral or neurobiological intervent ions, We formed two different groups as subjects based on their scholarly attainments. Each group consists of 20 volunteers(aged 16-17 years, right-handed males) from the National Gifted School and a local high school respectively. To test whether individual differences in general intelligence are mediated at a neural level, we first assessed intellectual characteristics in 40 subjects using standard intelligence tests (Raven's Advanced Progressive Matrices, Wechsler Adult Intelligence Scale, Torrance Tests of Creative Thinking) administered outside of the MR scanner. We then used functional magnetic resonance imaging (fMRl) to measure task-related brain activity as participants performed three different kinds of computerized reasoning tasks that were intended to activate the relevant neural systems. To examine the difference of neural activity according to discrepancy in general intelligence, we compared the brain activity of both extreme groups (each, n=10) of the participants based on the standard intelligence test scores. In contrast to the common expectation, there was no significant difference of brain region involved in high-g tasks between both groups. Random effect analysis exhibited that lateral prefrontal, anterior cingulate and parietal cortex are associated with gF. Despite very different task contents in the three high-g-low-g contrasts, recruitment of multiple regions is markedly similar in each case, However, on the task with high 9F correlations, the Prodigy group, (intelligence rank: >99%) showed higher task-related neural activity in several brain regions. These results suggest that the relationship between gF and brain activity should be stronger under high-g conditions than low-g conditions.

• The Journal of Korean Physical Therapy
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• 제25권3호
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• pp.132-135
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• 2013

We presented with a patient who showed injury of the cingulum and fornix by penetration of a foreign body into the brain on diffusion tensor tractography (DTT). A 63-year-old man suffered a brain injury by a part of a power saw blade that was suddenly detached from a power saw during work. A part of the power saw blade penetrated his right frontal skull and advanced to the right posterior horn of the lateral ventricle. This penetration caused traumatic intracerebral hemorrhage in the right frontal lobe and intraventricular hemorrhage in the lateral ventricle. He underwent craniotomy and removal of intracranial foreign bodies (bony pieces and saw blade). The patient's Memory Assessment Scale scores were 74 (4%ile) for global memory, 78 (7%ile) for verbal memory, and 80 (9%ile) for visual memory. DTTs showed disruptions in the anterior portion of the fornical body, right fornical crus, the anterior portion of the right cingulum, and the middle portion of the left cingulum, compared to the control. It seems that the sustained memory impairment of this patient might be related to injury of the cingulum and fornix.

• 응용통계연구
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• 제29권5호
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• pp.859-872
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• 2016

초분광 영상 데이터는 픽셀마다 수백 개의 스펙트럼 밴드에 대한 정보가 주어지는 고차원 데이터로, 농업, 식품처리, 광물학, 물리학, 환경학, 지리학 등 광범위한 분야에 활용되고 있다. 그 중 하나는 토지 피복의 분류 문제인데, 이는 자연 재해 예방, 자연 자원 감시, 환경에 대한 정보 수집에 있어서 중요한 문제이다. 하지만 차원의 저주, 시공간적 변동성, 레이블된 데이터의 부족 때문에 토지 피복의 정확한 분류에는 어려움이 따른다. 이 논문에서는 이러한 문제를 해결하기 위해 컨볼루션 신경망에 기반한 새로운 심층 학습 구조를 제안한다. 제안된 구조는 원하는 지점 주변 픽셀의 정보를 컨볼루션 신경망을 통해 처리하고, 그 지점의 스펙트럼 정보를 강조하기 위해 컨볼루션 층의 출력과 스펙트럼 정보를 함께 소프트맥스 분류기의 입력으로 사용한다. 이 구조는 추가적인 특징 추출 과정을 필요로 하지 않고, 그래픽 처리 장치 등을 이용한 병렬화가 간편하다는 점에서 기존 방법들보다 유리하다. 실험 결과, 제안된 구조는 기존에 가장 좋은 성능을 보인 분류기와 비슷하거나 더 좋은 분류 정확도를 보여 좋은 일반화 성능을 보이는 것을 확인할 수 있었다.

• Journal of Oral Medicine and Pain
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• 제33권4호
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• pp.395-399
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• 2008

측두하악장애 증상으로 나타나는 구강안면부의 통증 및 개구제한 증상은 대부분 관련 구조물 자체의 구조적이거나 기능적인 변화에 의해 유발되지만, 드물게 다른 병적인 상태로 인하여 발생할 수도 있으므로 진단 및 치료에 있어서 주의가 요구된다. 특히 통증 양상 및 임상 소견, 전신적 동반 증상, 치료에 대한 반응 등에 대한 평가에서 두경부 종양과 같이 다른 질환에 의한 측두하악장애 증상이 의심되거나 일반적인 측두하악장애와 다른 소견이 나타나는 경우에는 전산화단층촬영 또는 자기공명영상 등의 부가적인 방사선학적 검사를 적극적으로 시행하여 부가적인 정보를 얻는 것이 필요하다. 본 증례에서는 측두하악장애 증상으로 내원하였던 비인두암종 환자의 진단 및 치료 과정을 통해, 측두하악장애의 진단 및 치료에 있어서 비인두암종 등 두경부 종양의 가능성을 고려해야 할 임상적 소견에 대해 고찰하고자 한다.

• 한국광학회지
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• 제20권4호
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• pp.223-229
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• 2009

자동 광검사 장비의 검사 영상 획득과정을 전산모사하는 시뮬레이터를 개발하였다. 시뮬레이터는 광선 추적법을 기반으로 조명 광학계, 검사 대상체 및 결상 광학계의 3가지 모듈로 구성하였다. 각 모듈이 갖는 광학적 특성을 실제와 일치시키기 위해, 다양한 물리적 모델과 실측 결과를 반영하여 주요 인자들의 종류와 범위를 결정하였다. 전산모사 결과의 타당성은 논리적인 검증과정과 실험 결과와의 비교를 통해 확인할 수 있었다.