• Environmental Engineering Research
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• v.25 no.3
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• pp.366-373
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• 2020

The autonomous vehicles (AVs) could make a positive or negative impact on reducing mobile emissions. This study investigated the changes of mobile emissions that could be caused by large-scale adoption of AVs. The factors of road capacity increase and speed limit increase impacts were simulated using a conceptual modeling approach that combines a hypothetical speed-emission function and a traffic demand model using a virtual transportation network. The simulation results show that road capacity increase impact is significant in decreasing mobile emissions until the market share of AVs is less than 80%. If the road capacity increases by 100%, the mobile emissions will decrease by about 30%. On the other hand, driving speed limit increase impact is significant in increasing mobile emissions, and the environmentally desirable speed limit was found at around 95 km/h. If the speed limit increases to 140 km/h, the mobile emissions will increase by about 25%. This is because some vehicles begin to bypass the congested routes at high speeds as speed limit increases. Based on the simulation results, it is clear that the vehicle platooning technology implemented at reasonable speed limit is one of the AV technologies that are encouraging from the environmental point of view.

• Korea Journal of Hospital Management
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• v.25 no.1
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• pp.58-72
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• 2020

Purposes: This study aims to investigate the determinants of change-oriented organizational citizenship behavior(CO-OCB) of hospital employees and test the mediating effect of the job satisfaction and organizational commitment on the CO-OCB. Methods: Data were collected from the self-administered questionnaire survey for hospital employees of ten hospitals located in five regions, including Seoul. Out of 1,100 questionnaires which were distributed through the administrative routes, a total of 617 copies were returned(response rate 56.1%) and analyzed by frequency analysis, t-tests, correlation analysis, multiple regression, and path analysis using SPSS 21.0 and AMOS 21.0. Findings: The study results revealed that the explanatory power(56.4%) of the model was most significantly increased by the variables of psychological attributes(R²-change 33,5%). Also, the variables of self-efficacy, followed by hope, the organizational climate for innovation, the psychological safety climate, team-member exchange, and leader-member exchange were found to have positive total effects on CO-OCB, through the mediating variables of job satisfaction and organizational commitment. Practical Implications: The study results imply that, in order to improve the CO-OCB of hospital employees, the administrators have to take the integrated approach considering the various domains of factors including the psychological attributes, job characteristics, interpersonal relations, and organizational climate simultaneously.

• Journal of Korean Society of Rural Planning
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• v.2 no.2
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• pp.81-90
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• 1996

In this paper, the basic planning for the creation of consolidated agricultural institutions of Choongcheongnam -Do and its management schemes were established. These institutions, including rural development office, farmers'training institution, original seeding field of farm crops, agriculturial information center, packing design center, agricultural machinery repair center, agricultural scientific conference hall, agricultural museum, agricultural park, farmers'hall and event plaza, are planned to be created. The required area for the site is 1,246,781 m2. 281-22 Jongkyung-Ri, Sinam-Myun, Yesan-Gun, Choongcheongnam-Do and its surroundings is a proper site for the creation of'consolidated agricultural institution because the actual conditions of the soil, traffic network, irrigation and drainage, tourist routes and human resources are very good. The layout of the facilities that would comprise an agricultural institution was organized in consideration of the functions and roles of each facility and the relationships among facilities in this consolidated agricultural institution. It is desirable that the headquaters of consolidated agricultural institution oversees the management department, the planning $.$ administration $.$ information department, the rural development office, the farmers'training institution, the original seeding field of farm crops and the agricultural park.

• Journal of Veterinary Clinics
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• v.3 no.2
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• pp.317-324
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• 1986

A total of 600 Holstein cows in Chonnam province were examined to make a diagnosis on the ovarian diseases. By clinical signs and rectal examinations, 120 cows were founded to have ovarian diseases such as 40 cows with suboestrus, 40 cows with persistent corpus luteum, 40 cows with luteal cysts. The Prostaglandin $F_{2{\alpha}}$ (PG $F_{2{\alpha}}$) was administered intramuscularly and intradermic vaginally ; also intraovarian injections and intrauterine infusions was made. Comparisons were made on the effect of PG $F_{2{\alpha}}$ on the ovarian diseases. The results obtained were summarized as follows. 1. Induction of normal estrum after PG $F_{2{\alpha}}$ treatment was 75.0～82.5%(mean 78.3%). The conception rate was 83.3～84.8% (mean 84.0%) and average services per conception was 1.6～l.8(mean 1.7). Days from treatment to estrum was 3.9～4.3(mean 4.1) days. 2. Average conception rate was different according to the routes of administration: intraovary 91.7%, intra-uterus 88.0%, intramuscle 80.9% and intradermic vagina 75.0%, respectively.

• Journal of Animal Science and Technology
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• v.66 no.2
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• pp.266-278
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• 2024

Antibiotic resistance (AR) is a complex, multifaceted global health issue that poses a serious threat to livestock, humans, and the surrounding environment. It entails several elements and numerous potential transmission routes and vehicles that contribute to its development and spread, making it a challenging issue to address. AR is regarded as an One Health issue, as it has been found that livestock, human, and environmental components, all three domains are interconnected, opening up channels for transmission of antibiotic resistant bacteria (ARB). AR has turned out to be a critical problem mainly because of the overuse and misuse of antibiotics, with the anticipation of 10 million annual AR-associated deaths by 2050. The fact that infectious diseases induced by ARB are no longer treatable with antibiotics foreshadows an uncertain future in the context of health care. Hence, the One Health approach should be emphasized to reduce the impact of AR on livestock, humans, and the environment, ensuring the longevity of the efficacy of both current and prospective antibiotics.

• Journal of fish pathology
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• v.24 no.2
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• pp.153-160
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• 2011

The specific antibody response of olive flounder, Paralichthys olivaceus to change in rearing-environmental conditions post immunization with antigen (bovine serum albumin, BSA) and different routes of antigen administration were investigated by enzyme-linked immunosorbent assay (ELISA). To test the effect of routes of antigen administration, flounder were injected intraperioneally or intramuscularlly with 1 mg of BSA. In addition, to test the effect of change in environmental condition post immunization, flounder were injected intraperioneally with 1 mg of antigen, and then were exposed to acute thermal change (the water temperature (WT) was decreased from $21^{\circ}C$ to $15^{\circ}C$ within 30 min and maintained at $15^{\circ}C$ for 3 h), handling (fish were caught and subsequently held out of water for 1 min) or heavy oil (76 g/200 L for 2 days). Consequently, there was no significant difference between intraperioneal (IP) and intramuscular (IM) injections except at 10 days post-immunization. With these results, it suggests that both 1M and IP injections may be used as route of vaccination. Furthermore, no significant difference was observed in the antibody response among the groups exposed to heavy oil, handling, sudden drop of WT and positive control except at 10 days post-immunization. From these results, it was confirmed that specific antibody response was not affected by the above mentioned rearing-environmental conditions, suggesting that vaccination can be employed at changing rearing-environmental conditions.

• Journal of the korean academy of Pediatric Dentistry
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• v.28 no.3
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• pp.441-446
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• 2001

Flumazenil is a competitive antagonist of benzodiazepines. It is usually administered intravenously. However, if the intravenous route is not available then other routes of drug administration should be considered. This study was designed to evaluate the reversal effects of flumazenil after nasal administration. Twenty-five young, healthy adult volunteers participated in this clinical trial. The dosage of 0.08mg/kg midazolam was administered intravenously to induce deep sedation. Ten minutes after midazolam administration, 0.5mg of flumazenil was dropped nasally, over a period of one minute. Blood samples were taken to measure the concentration of midazolam and flumazenil at 0, 5, 10, and 20min after nasal administration of flumazenil, using High Performance Liquid Chromatography. The degree of sedation was evaluated with sedation score and bispectral index (BIS), Statistical analysis was performed by multivariate ANOVA and correlation analysis (P<0.05). Peak serum flumazenil concentration was reached in 10min. Sedation score decreased after midazolam administration and showed a significant increase after flumazenil administration. However, BIS decreased during the first 10min after midazolam administration and then no significant changes after flumazenil administration. There were two instances representing rapid and complete reversal of midazolam after intranasal administration of flumazenil. In conclusion, intranasal flumazenil administration may be effective in some patients when intravenous route is not available in condition of benzodiazepine overdose.

• Korean Journal of Medicinal Crop Science
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• v.1 no.1
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• pp.74-80
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• 1993

Survey on the status of cultivation and production of medicinal crop was studied on 18 medicinal herbs and 5 medicinal trees in 66 major crop producing complexes. Native seeds or seedlings of the crops obtained from self-seed or neighbored farmer were cultivated and organic fertilizer was preferred to chemical fertilizer in the complexes. More than 60.7% of farmers were applied compost among the organic fertilizers, while 34.8% of them cultivated without any organic fertilizers. Both of using the compound chemical fertilizers and urea and urea only used were showed 51. 5% and 40.9%, respectively. Ostericum koreanum, Angelica gigas, Phellopterus littoralis, and Bupleurum fulcatum belonging to the family Umbeliferae and Aralia continentalis, Polygonatum sibiricum and Eucommia ulmoides in the complexex were not damaged by insect pests and plant diseases. Mite, aphid, grub, cutworm, onion magot fly and european corn borer were known to as major insect pests and anthracnose, powdery mildew, brown leaf spot, leaf blight and root rot as major plant diseases. Productivity and income of a farm by medicinal crops in the complex were greatly different from seeding time, planting distance, year yielded, and selling routes even in the same cultivation method and in the same cultivated area.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.19
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• pp.8377-8382
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• 2014

Background: Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy worldwide. Cancer development and progression require inactivation of tumor suppressor genes and activation of proto-oncogenes. The well recognized mechanism of action demonstrated for chemotherapeutic agents is induction of apoptosis via reactivation of p53. In this context, we evaluate the efficacy of IV and oral routes of our novel PH and temperature sensitive doxorubicin-methotrexate-loaded nanoparticles (DOX-MTX NP) in affecting p53 profile in an OSCC rat model. Methods: In this study, 120 male rats were divided into 8 groups of 15 animals each. The new formulated DOX-MTX NP and free doxorubicin were IV and orally given to rats with 4-nitroquinoline-1-oxide induced OSCC. Results: Results showed that both DOX and DOX-MTX-NP caused significant increase in mRNA levels of P53 compared to the untreated group (p<0.000). With both DOX and DOX-MTX NP, the IV mode was more effective than the oral (gavage) route (p<0.000). Surprisingly, in oral mode, p53 mRNA was not affected in DOX treated groups (p>0.05), Nonetheless, both IV and oral administration of MTX-DOX NP showed superior activity (~3 fold) over free DOX in reactivation of p53 in OSCC (p<0.000). The effectiveness of oral route in group treated with nanodrug accounts for the enhanced bioavailability of nanoparticulated DOX-MTX compared to free DOX. Moreover, in treated groups, tumor stage was markedly related to the amount of p53 mRNA (p<0.05). Conclusion: Both oral and IV application of our novel nanodrug possesses superior activity over free DOX-in up-regulation of p53 in a OSCC model and this increase in p53 level associated with less aggressive tumors in our study. Although, impressive results obtained with IV form of nanodrug (-21 fold increase in p53 mRNA level) but both forms of nanodrug are effective in OSCC, with less toxicity normal cells.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.28 no.3
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• pp.39-52
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• 2010

The royal tombs of the Joseon dynasty are very important cultural heritage with the palaces and Jongmyo. They being promoted as World Heritage of UNESCO and are archaeological sites that need to complex approach. The purpose of this study is to propose the restoration plan of Ureung Gunreung. The results are as follows: First. In the area of Ureung Gunreung, there are many land-use except the royal tombs such as a new town development site and industrial districts, cultural assets districts, They have to be removed and new routes have to be established same as the original form. Second The traditional trees such as a pine tree, a fir tree, a big cone pine and a rhododendron etc. have to be planted In the traditional forest We introduce upper trees and lower trees in the entrance part and religious service part, and pine tree forest in burial mound part and maintain the lawn. Third, The traditional buildings and facilities such as Jaesil, Subokbang have to be restored maintained, and we planed some convinient facilities and rest facilities for visitors.