• 대한한방내과학회지
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• 제44권4호
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• pp.803-813
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• 2023

Objective: This case report outlines an investigation into the efficacy of Korean medicine treatment in a patient who presented with acute cholangitis accompanying common bile duct stones. The patient underwent percutaneous transhepatic gallbladder drainage and subsequently experienced resolution of the common bile duct stones. Methods: The patient was treated with Shihosogan-tang, general acupuncture, ear acupuncture, moxibustion, and cupping therapy. Changes in symptoms were evaluated using a self-reported numerical rating scale (NRS) score and a visual analog scale (VAS) score each morning. Laboratory tests were conducted to examine serum amylase, serum lipase, and liver function. Results: After 29 days, the NRS scores for indigestion and fatigue and the VAS score for abdominal pain all decreased. Additionally, the laboratory test results showed improvement. Discussion: The results suggest that Korean medicine could be effective in treating symptoms of acute cholangitis. However, further research is necessary.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제24권2호
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• pp.164-172
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• 2021

Purpose: The use of Endoscopic ultrasonography (EUS) in pediatric patients is not as common as in adults. The aim of this study is to evaluate the role of EUS in the diagnosis of pancreatobiliary disease in childhood. Methods: Between December 2016 and January 2018, the findings of patients who underwent EUS were evaluated retrospectively. Results: Of the 41 patients included in the study 25 were girls (61.0%), mean age was 12.2±4.2 years. EUS was performed for biliary colic in 21 (51.2%), for recurrent pancreatitis in 12 (29.2%), for cholecystitis/cholangitis in 5 (12.2%), and for acute pancreatitis in 3 (7.4%) patients. EUS had a significant clinical effect in the decision of treatment and follow-up of 6/21 biliary colic cases, in diagnosis and follow-up of 6/12 recurrent pancreatitis cases, in decision-making and monitoring of invasive procedures (ERCP/surgery) of 3/5 acute cholecystitis/cholangitis and 2/3 of acute pancreatitis cases as well as in follow-up of the other cases. The effectiveness of EUS in determining direct treatment and invasive intervention was 43.9%. None of the patients had complications related to the EUS procedure. Conclusion: Although current guidelines show that EUS can be used in pediatric patients, this is limited to a few published studies. In this study, it is shown that EUS is a safe method for the diagnosis, follow-up and treatment of common pancreatobiliary pathologies in childhood.

• Journal of Yeungnam Medical Science
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• 제35권1호
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• pp.109-113
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• 2018

A 75-year-old man with chronic cholangitis and a common bile duct stone that was not previously identified was admitted for right upper quadrant pain. Acute cholecystitis with cholangitis was suspected on abdominal computed tomography (CT); therefore, endoscopic retrograde cholangiopancreatography with endonasal biliary drainage was performed. On admission day 5, hemobilia with rupture of two intrahepatic artery pseudoaneurysms was observed on follow-up abdominal CT. Coil embolization of the pseudoaneurysms was conducted using percutaneous transhepatic biliary drainage. After several days, intrahepatic artery pseudoaneurysm rupture recurred and coil embolization through a percutaneous transhepatic biliary drainage tract was conducted after failure of embolization via the hepatic artery due to previous coiling. After the second coil embolization, a common bile duct stone was removed, and the patient presented no complications during 4 months of follow-up. We report a case of intrahepatic artery pseudoaneurysm rupture without prior history of intervention involving the hepatobiliary system that was successfully managed using coil embolization through percutaneous transhepatic biliary drainage.

• Advances in pediatric surgery
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• 제3권2호
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• pp.93-97
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• 1997

Extended porta hepatis dissection and hepatic portojejunostomy was performed on 14 biliary atresia patients during last 13 years by a single surgeon. The average age at operation was 68 days(range from 37 days to 98 days). The patients were admitted for 8 weeks postoperatively for administration of parenteral antibiotics. There was one operative mortality due to acute hepatic necrosis. Among 13 patients remaining, 12(92.5 %) became chemically jaundice-free within 36 weeks postoperatively(average 16.8 weeks). the earliest 8 weeks, and in one patients jaundice persisted. Five(38.5 %) patients developed cholangitis after operation. Among jaundice-free patients, one patient died of unrelated disease 2 years after hepatic portojejunostomy, who underwent left lateral segmentectomy because of a biloma. Eleven survivors(78.6 %) are jaundice-free. The oldest one is 13 years old, enjoying a normal life. The mean period of follow-up is 7 years and 3 months.

• Journal of Digestive Cancer Research
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• 제5권1호
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• pp.55-57
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• 2017

A 64-year-old man was admitted due to jaundice for 2 weeks. Radiologic findings revealed biliary stricture at the hepatic hilum with intrahepatic duct dilation suggesting Bismuth type IV Klatskin tumor. Jaundice improved spontaneously several days after hospitalization. Surgical treatment was considered but he only wanted to observe without specific treatment. Ten months later, he was re-admitted due to the recurrence of jaundice. Computed tomography (CT) showed no significant difference compared to previous results. Serum cancer antigen 19-9 and Immunoglobulin G4 were normal. Endoscopic forcep biopsy during endoscopic retrograde cholagiopancreatography (ERCP) revealed chronic inflammation. After steroid use under possible diagnosis of IgG4 related cholangiopathy, biliary stricture improved slightly. Four years later, he was hospitalized with the occurrence of acute cholangitis. Endoscopic retrograde biliary drainage was performed following endobiliary forcep biopsy. Pathology revealed well-differentiated adenocarcinoma at this time. Combined chemotherapy based on gemcitabine and cisplatin was performed. Six months later, CT revealed partial response.

• Parasites, Hosts and Diseases
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• 제45권4호
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• pp.301-306
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• 2007

We attempted to identify parasite DNA in the biliary stones of humans via PCR and DNA sequencing. Genomic DNA was isolated from each of 15 common bile duct (CBD) stones and 5 gallbladder (GB) stones. The patients who had the CBD stones suffered from cholangitis, and the patients with GB stones showed acute cholecystitis, respectively. The 28S and 18S rDNA genes were amplified successfully from 3 and/or 1 common bile duct stone samples, and then cloned and sequenced. The 28S and 18S rDNA sequences were highly conserved among isolates. Identity of the obtained 28S D1 rDNA with that of Clonorchis sinensis was higher than 97.6%, and identity of the 18S rDNA with that of other Ascarididae was 97.9%. Almost no intra-specific variations were detected in the 28S and 18S rDNA with the exception of a few nucleotide variations, i.e., substitution and deletion. These findings suggest that C. sinensis and Ascaris lumbricoides may be related with the biliary stoneformation and development.

• Asian Pacific Journal of Cancer Prevention
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• 제15권18호
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• pp.7673-7677
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• 2014

Background: Patients with long-standing inflammatory bowel disease (IBD) have an increased risk of developing colorectal cancer (CRC). Colon cancer risk in IBD increases with longer duration and greater anatomic extent of colitis, the presence of primary sclerosing cholangitis, family history of CRC and degree of inflammation of the bowel. This study aimed to characterize the histopathological pattern of benign colorectal diseases among Saudi patients and to highlight age and gender variations of lesions as base line data for future studies to investigate the link between benign/IBD and colorectal cancers in the local population. Materials and Methods: The materials consisted of 684 biopsies, reported as benign (excluding malignancies and polyps) at the Department of Pathology, King Fahad Hospital, Madinah, Saudi Arabia from January 2006 to December 2013. Data collected and entered in MS-Excel and were analyzed using SPSS-20. Results: Of 684 colorectal tissues reviewed, 408 specimens (59.6%) were from male patients and 276 specimens (40.4%) were from females giving a male: female ratio of 1.5:1. Age of the patients ranged from 4 to 75 years with a mean of 39.6 years. The most frequent histologic diagnosis was a chronic non specific proctocolitis followed by ulcerative colitis, accounting respectively for 52.6% and 31.7% of all cases. These were followed by Crohn's disease 22 (3.2%), ischemic bowel disease 20 (2.9%), diverticular disease 14 (2%), eosinophilic colitis 12 (1.7%) and solitary rectal ulcer 12 (1.7%). A minority of 21 patients (3.1%) were cases of acute nonspecific proctocolitis, schistosomiasis, tuberculosis, volvulus and pseudomembranous colitis. Conclusions: These data show that although chronic non specific proctocolitis and ulcerative colitis were the dominant diagnoses, Crohn's disease, ischemic bowel disease and diverticular disease also existed to a lesser extent and should be considered in the differential diagnosis of benign colorectal diseases. This study provides a base line data for future studies which would be taken up to investigate the link between benign/IBD and colorectal cancers in the local population.

• Investigative Magnetic Resonance Imaging
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• 제6권2호
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• pp.129-136
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• 2002

목적 : 총담관 확장을 유발하는 원인 중 결석과 종양을 제외한 여러 원인을 평가하는데 있어서 MRCP의 진단적 유용성을 알아보고자 하였다. 대상 및 방법 : ERCP와 MRCP를 모두 시행받은 환자 26명 (남:여=15:11, 평균연령 62세)을 대상으로 하였으며, 이들 중 12명은 역동적 MRCP를, 10명은 조영증강 MRI를 추가로 시행하였다. 총담관, 간내 담도, 췌관 등의 확장 정도, 간내 담도 결석, 췌장 가성낭종, 유두부의 부종이나 결절성 종대 등을 관찰하였다. 총담관은 T2-강조 관상영상에서 담낭절제술을 받지 않은 경우 7 mm 이상, 절제술을 받은 경우 10 mm 이상을 비정상적인 확장으로 판정하였다. 결과 : 담낭절제술을 받지 않은 환자의 총담관 평균 직경은 12.7mm(n=21, 9-19 mm)였고, 절제술을 받은 환자의 평균 직경은 13.0 mm(n=5, 10-15mm)였다(p〉0.05). MRCP에서 담관염 11명(42.3%), 만성 췌장염 8명(30.8%), 원위부 총담관 협착 6명(23.1%), 팽대부 주위 게실 3명(11.5%), Vater 팽대부 협착, 오디 괄약근 기능장애, 췌장 두부의 국소적 췌장염이 각각 2명 (7.7%), 유두염, 췌장 두부 가성낭종에 의한 총담관 확장, 총담관 내 회충이 각각 1명(3.8%) 있었다. 췌관의 확장은 10명(38.5%)에서 보였고, 십이지장 게실은 3명(11.5%)에서 관찰되었다. 역동적 MRCP(n=12)에서 2명(16.7%)은 일반 MRCP에서 보이지 않던 원위부 총담관이 관찰되었고, 조영증강 MRI를 시행한 10명 중 1명 (10.0%)만이 유두염의 소견을 보였다. 결론 : 비결석, 비종양성 총담관 확장의 원인을 찾는데 있어서 MRCP는 총담관 원위부 협착 및 만성 췌장염, 역동적 MRCP를 이용한 생리적 총담관의 확장, 조영증강 MRI 를 통한 담관염 및 담관 외 병소의 발견 등에 있어서 도움이 되는 것으로 생각된다.

• 대한영상의학회지
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• 제85권3호
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• pp.661-667
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• 2024

들장관증후군은 위장 재건술을 동반한 위절제술 후 발생하는 드문 합병증이다. 이 질환은 담관염, 췌장염, 복막염을 동반한 십이지장 천공과 같은 치명적인 상태에 이를 수 있어서, 즉각적인 감압 치료가 필요하다. 담관 확장이 없는 들장관증후군 환자를 위한 대체 감압 치료법으로 경담낭 십이지장 배액술을 시행한 두 건의 증례를 보고하고자 한다. Billroth II 문합술과 위원위절제술을 시행한 2명의 환자가 상복부 통증과 구토를 주소로 응급실에 내원하였다. 컴퓨터단층촬영에서 급성 췌장염을 동반한 들장관증후군으로 진단되었다. 담관 확장이 없어 담도를 통한 접근이 어려워, 경담낭 접근을 통해 담낭관을 통과한 후 들장관을 감압하기 위한 십이지장 배액 카테터를 설치하였다. 환자들은 배액술 시행 후 각각 2주와 1개월째에 추가적인 수술적 치료 없이 퇴원하였다.

• Tuberculosis and Respiratory Diseases
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• 제47권2호
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• pp.184-194
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• 1999

연구배경: 페니실린의 출현으로 폐렴구균 감염증의 사망률이 현저히 감소하기는 했으나 폐렴구균 균혈증의 사망률은 여전히 높다. 최근 페니실린 내성 폐렴구균이 증가하고 있는 추세이며 이는 치료 항생제 선태에 어려움을 주고 있다. 한국은 페니실린 내성 폐렴 구균의 빈도가 세계에서 가장 높은 나라로 알려져 있으며 이에 대한 연구가 더 필요한 상황이다. 저자 등은 서울대학병원에서 폐렴 구균 균혈증의 임상상과 페니실린 내성 여부가 사망에 미치는 영향을 알아보기 위해 본 연구를 시행하였다. 방법: 서울대학교 병원에서 1990년 1월에서 1997년 7월까지 혈액배양에서 폐렴 구균이 증명되었던 66예 중에서 병록 검토가 가능했던 50예를 대상으로 후향적 연구를 시행하였다. 결과: 연령의 중앙값은 56세였고, 50세 이상이 62%를 차지했다. 폐렴구균 예방접종을 시행한 기왕력이 있었던 예는 없었다. 기저 질환은 48예(96%)에서 있었다. 동반된 국소 병변으로는 폐렴이 21예(42%)로 가장 많았고, 자발성 세균성 복막염이 7예(14%), 담도염 5예(10%), 뇌막염 4예(8%), 간농양 2예(4%), 인두편도염 2예(4%), 부비동염 1예(2%), 봉와직염이 1예(2%)에서 관찰되었고, 원발성 균혈증이 7예(14%)가 있었다. 총 사망 예는 12예(24%)였다. 이 중 폐렴은 9예로 총 폐렴 예의 42%가 사망하였고, 뇌막염 2예, 원발성 균혈증 1예가 사망하였다. 페니실린 내성군은 내성 여부를 확인할 수 있었던 63예 중 25예(40%)를 차지하였다. 페니실린 내성률은 1991년 이후 급격한 증가를 보였다. 페니실린 내성군에서 최근 3개월 내 항생제 사용 예가 많았고 (p=0.022) 최근 입원 예가 많아(p=0.030) 페니실린 내성 감염의 위험 인자로 작용함을 알 수 있었다. 감수성 군과 내성군 간의 연령, 기저 질환의 중증도, 병원 감염 여부, 면역 억제 여부, 속이나 급성신부전의 빈도 등은 양 군에서 통계적으로 유의한 차이가 없었다. 사망률은 페니실린 감수성군에서 23%, 내성군에서 29%로 통계적으로 유의한 차이가 없었다. 결론: 페니실린 내성 여부는 사망률에 영향을 미치지 못했으나 폐렴구균 균혈증의 사망률은 전반적으로 높았다. 따라서 폐렴구균 예방 접종의 적응증이 되는 경우에는 적극적인 예방 접종이 필요하리라 사료된다.