• 고려인삼학회:학술대회논문집
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• 고려인삼학회 2004년도 추계 학술대회 및 정기총회
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• pp.7-11
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• 2004

We previously reported that ginseng inhibited NMDA receptors in cultured hippocampal neurons. Here, we further examined the detailed mechanism of ginseng-mediated inhibition using its main active ingredient, ginsenoside Rg$_3$. Co-application of ginsenoside Rg$_3$ with increasing concentrations of NMDA did not change the EC$_{50}$ of NMDA to the receptor, suggesting ginsenoside Rg$_3$ inhibits NMDA receptors without competing with the NMDA-binding site. Ginsenoside Rg$_3$-mediated inhibition also occurred in a distinctive manner from the well-characterized NMDA receptor open channel blocker, MK-801, However, ginsenoside Rg$_3$ produced its effect in a glycine concentration-dependent manner and shifted the glycine concentration-response curve to the right without changing the maximal response, suggesting the role of ginsenoside Rg$_3$ as a competitive NMDA receptor antagonist. We also demonstrated that ginsenoside Rg$_3$ significantly protected neurons against NMDA insults. Therefore, these results suggest that ginsenoside Rg$_3$ protects NMDA-induced neuronal death via a competitive interaction with the glycine-binding site of NMDA receptors in cultured hippocampal neurons.

• 영어어문교육
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• 제17권1호
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• pp.125-146
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• 2011

Within a framework of sociocultural approaches to writing process, this study examined six ESL graduate students' writing processes in depth based on individual interviews and their narratives of writing process. The narratives and interviews were analyzed to discover salient aspects of the students' writing processes and to understand the socially situated nature of the writing processes. First, it was observed that these six students displayed multiplicity in terms of their representations of writing process, episodes, textual practices, and concerns. Several factors including the writing task, students' familiarity with genre, literacy skills, attitude toward writing, and involvement in interaction contributed to individualized trajectories of writing process. It was also revealed that writing is unavoidably a socially situated practice. Students were situated in their cultural arenas as well as their disciplinary arenas, and these contexts helped the students serve as active agents producing and sharing knowledge. The confluence of personal, cognitive, and social factors observed in their writing processes suggests that writing process should be understood from multiple perspectives.

• IMMUNE NETWORK
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• 제5권3호
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• pp.144-149
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• 2005

Background: Fc receptor-mediated phagocytosis is a complex process involving the activation of kinases and phosphatases. FcgammaRIIB has been known to transduces inhibitory signals through an immunoreceptor tyrosine-based inhibitory motif (ITIM) in cytoplasmic domains. In this study, we examined the involvement of inositol-phosphatase in the Fc receptor-mediated phagocytosis. Methods: J774 cells were infected using vaccinia viral vector containing SH2 domain-containing inositol-phosphatase (SHIP) cDNA and stimulated with the sensitized sheep red blood cells. Results: Stimulation of J774 cells induced the tyrosine phosphorylation of SHIP which was maximal at 5 minutes. Phosphatidylinositol-3 (PI-3) kinase inhibitor (wortmannin) inhibits J774 cell phagocytosis of sensitized sheep red blood cells in a dose-dependent manner. Heterologious expression of SHIP in J774 cells inhibits phagocytosis of sensitized sheep red blood cells in a dose-dependency manner, but catalytically dead mutants of SHIP has no effect on phagocytosis. Conclusion: These results strongly suggest that the active signals mediated by PI-3 kinase are opposed by inhibitory signals through SHIP in the regulation of Fc receptor-mediated phagocytosis.

• 한국초등과학교육학회지:초등과학교육
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• 제26권2호
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• pp.209-215
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• 2007

The purpose of this study was to investigate the characteristics of the contents which were presented in the physics exhibits of the following three museums; Seoul National Science Museum, National Science Museum and the Exploration Center. The main findings of this research were as follows: Firstly, it was found that 73.7% of the exhibits were composed of 'dynamic exhibits', 87.6% of the exhibits were 'active involvement type exhibits', 48.3% of the exhibits were 'interest induction type exhibits' and 42.8% of the physics exhibits were composed of exhibits related to optics. Secondly, it was found that many elementary students seemed to have difficulty in understanding and executing the activities in the physics exhibits.

• 복식
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• 제54권7호
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• pp.107-120
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• 2004

In this study. with the discovery of adolescents' dissatisfaction factors and preferred images of underwear, the Potentiality of adolescents' underwear market was illuminated. For the purpose of this study, focused group interviews were performed to develop a questionnaires. And data was collected from 309 adolescents female consumer in the age of 13-18 living in busan. The fellowing are the results from the study. First. the female adolescents' dissatisfaction with underwear was analyzed into seven factors. such as buying decision, deformation after laundring, feeling from putting on, price/product variety, the lack of effective design considering body shape, inconvenience for activity and aesthetics. And degree of dissatisfaction was significant different among groups classified by consumer's level of product involvement and consumer's age. Second, the female adolescents' preferred images of underwear are gorgeous/elegant, simple/plain, pure & innocent/modest. active and lovely. From these results, it can be concluded that adolescents' desires of underwear product are different from adults'. Managerial Implications are provided for adolescents' underwear market.

• 근관절건강학회지
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• 제10권2호
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• pp.119-130
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• 2003

Illness intrusiveness(illness induced lifestyle disruption) was investigated in 902 patients with arthritis and compared between rheumatoid arthritis(N=439) and osteoarthritis(N=463) patients. Arthritis patients were reported to perceive illness intrusiveness similar to patients with ESRD(end stage renal disease), bipolar disorder and peritoneal dialysis. Especially they were intrusive into health, work, and active recreation domains. And patients with rheumatoid arthritis were significantly more intrusive into activities, especially in diet, financial situation, family relations, other social relations, self-expression/self improvement, religious expression, and community and civic involvement. Differences in treatment regimens and age were hypothesized to account for these differences in illness intrusiveness.

• BMB Reports
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• 제49권8호
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• pp.403-404
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• 2016

The Wnt/β-catenin signaling is an evolutionarily conserved pathway that plays a pivotal role in embryonic development and adult homeostasis. However, we have limited information about the involvement of Wnt/β-catenin signaling in the lymphatic vascular system that regulates fluid homeostasis by absorbing interstitial fluid and returning it to blood circulation. In this recent publication we report that canonical Wnt/β-catenin signaling is highly active and critical for the formation of lymphovenus valves (LVVs) and lymphatic valves (LVs). β-catenin directly associates with the regulatory elements of the lymphedema-associated transcription factor, FOXC2 and activates its expression in an oscillatory shear stress (OSS)-dependent manner. The phenotype of β-catenin null embryos was rescued by FOXC2 overexpression. These results suggest that Wnt/β-catenin signaling is a mechanotransducer that links fluid force with lymphatic vascular development.

• 한국지역사회생활과학회지
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• 제19권4호
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• pp.581-595
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• 2008

This study attempts to provide the main reasons and decision-making processes for marriage migration from a Vietnamese' perspective. For this purpose, in-depth interviews were conducted in Vietnam. Interviewees are those who got married to foreigners but are waiting for visas and parents whose daughters are marriage migrants. According to 23 interviewees, the main reasons of marriage migration are as follows: individual aspiration, sacrifice for others, and the circumstantial effects or love. Individual aspiration, in particular, leads to an active pursuit of international marriage. Parental involvement in the decision-making process is rarely found. Decision seems to be wholly made by the female migrant herself based on an individualistic orientation.

• BMB Reports
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• 제50권6호
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• pp.299-307
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• 2017

Mitophagy is a process of selective removal of damaged or unnecessary mitochondria using autophagic machinery. Mitophagy plays an essential role in maintaining mitochondrial quality control and homeostasis. Mitochondrial dysfunctions and defective mitophagy in neurodegenerative diseases, cancer, and metabolic diseases indicate a close link between human disease and mitophagy. Furthermore, recent studies showing the involvement of mitophagy in differentiation and development, suggest that mitophagy may play a more active role in controlling cellular functions. A better understanding of mitophagy will provide insights about human disease and offer novel chance for treatment. This review mainly focuses on the recent implications for mitophagy in human diseases and normal physiology.

• 한국수학교육학회지시리즈D:수학교육연구
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• 제3권1호
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• pp.9-21
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• 1999

In mid 1980s, open education arrived in Korea. It was influenced by the educational reforms implemented in American primary schools. Currently, the Ministry of Education is appealing to teachers for their active involvement in educational reform by using open education methodology. Often teachers in Korea complain that they do not know what to do or how to change in order to practice the open education. It is time to review the state of open education in Korea and the United States. This paper contains the following segments: 0) Introduction, 1) Beginning of open education, 2) A brief history of open education in Korea, 3) The current status of open education in the United States, 4) A glance at open mathematics classroom in Korea, 5) Lessons from the review, and 6) Conclusion.