• Restorative Dentistry and Endodontics
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• 제21권1호
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• pp.375-384
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• 1996

The purpose of this study was to investigate the functional involvement of sympathetic nerve in the control of the microcirculation in the dental pulp with the aim of elucidation of the involvement of neuropeptides and sympathetic nerve in neurogenic inflammation. Experiments were done on the 7 cats anesthetised with sodium pentobarbital, and sympathetic nerve to the' dental pulp was stimulated electrically (10 Hz, 4 V, 1.5 ms, 3.5 mins). Ana-adrenoceptor antagonist phentolamine and a neuropeptide Y antagonist D-myo-inositol-1,2,6-trisphosphate (PP56) were injected close intra-arterially into the dental pulp without changing the systemic blood pressure. The probe of laser Doppler flowmeter was placed on the buccal surface of ipsilateral canine teeth to the stimulation, and pulpal blood flow was measured. Stimulation of the sympathetic nerve decreased pulpal blood flow by $55.24{\pm}7.74\;%$ (mean${\pm}$SEM, n = 13). Stimulation of the sympathetic nerve following the injection of the ${\alpha}$-adrenoceptor antagonist phentolamine ($0.1{\mu}g$/kg) caused decrease of pulpal blood flow by $14.35{\pm}3.43%$ (mean${\pm}$SEM, n=5). Phentolamine attenuated the sympathetic nerve-induced pulpal blood flow decrease by $74.02{\pm}9.32%$ (mean${\pm}$SEM) Stimulation of the sympathetic nerve following the injection of the neuropeptide Y antagonist PP56 (2.3 mg/kg) caused decrease of pulpal blood flow by $30.64{\pm}7.92%$ (mean${\pm}$SEM, n=6). PP56 attenuated the sympathetic nerve-induced pulpal blood flow decrease by $44.37{\pm}11.01%$ (mean${\pm}$SEM). These data provide evidences of the co-contribution of nerepinephrine and neuropeptide Y on the sympathetic nerve-induced vasoconstriction in the feline dental pulp. In addition, they show functional evidences that sympathetic nerve plays an active role in controlling the microcirculation of the dental pulp.

• Restorative Dentistry and Endodontics
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• 제21권1호
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• pp.366-374
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• 1996

The purpose of this study was to investigate whether D-myo-inositol-l,2,6-trisphosphate (PP56) can effectively antagonize vasoconstriction caused by neuropeptide Y in the dental pulp, and to understand involvement of neuropeptide Y in the regulation of microcirculation in the dental pulp with the aim of elucidating neurogenic inflammation. Experiments were performed on 7 cats anesthetised with sodium pentobarbital, and neuropeptide Y and a neuropeptide Y antagonist PP56 were injected close intra-arterially into the dental pulp. The probe of laser Doppler flowmeter was placed on the buccal surface of ipsilateral canine teeth to the drug administration and pulpal blood flow was measured. Intra-arterial injection of neuropeptide Y (1.3-$2.0\;{\mu}g$/kg) resulted in pulpal blood flow decrease of $37.73{\pm}5.73%$(mean${\pm}$SEM) (n=9). Intra-arterial injection of PP56(0.3 mg/kg) alone changed pulpal blood flow little by 1.03 % reduction. The effect of neuropeptide Y in the presence of PP56 resulted in significantly less decreases in pulpal blood flow ranging from $27.17{\pm}5.37$ to $16.63{\pm}3.48%$ from control as compared with neuropeptide Y alone(n = 13). In effect, PP56 attenuated pulpal blood flow caused by neuropeptide Y. Results of the present study have provided evidences that a non-peptide PP56 is capable of antagonizing vasoconstriction caused by neuropeptide Y in the feline dental pulp. In addition, they show functional evidences that neuropeptide Y plays an active role in modulating the microcirculation of the dental pulp.

• 가정과삶의질연구
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• 제7권2호
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• pp.199-212
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• 1989

The main purpose of this paper is to investigate the factors which affect the alienation of the aged, and to study the relative importance of these factors. This study focused on the following research questions: 1) How do the demographic variables(sex, marital status, family structure, religion, economics, prior occupation, education level) affect the alienation of the aged? 2) How the alienation of the aged is affected by their involvement in social activities? 3) Does the degree of satisfaction with family relationship have a perceivable impact on the alienation of the aged? 4) How does the self-rated senescence affect the alienation of the aged? The research was practiced from the 18th Sept. 1999 to the 30th Sept. 1988, through individual interviews with 300 elderly people, all living in Seoul area. Among them only 285 were used in the analysis. The major findings of the study are as follows; 1) The sex of the respondents makes no difference in the alienation of the age . 2) Marital status is found to be relatively significant in determining the alienation. The degree of alienation of old people with spouse is substantially lower than that of those without spouse. 3) Family structure was found to have no significantly effect on the alienation of the aged. 4) Involvement in religion was found to significantly reduce the alienation of the aged. 5) Econimic factors seems to be critical in defermining the aged. The amount of pocket money avaliable for daily use has direct relationship with alienation. 6) Prior occupation was found to be another significant factor affecting alienation professionals experience far lower alienation than nonprofessionals. 7) The higher is education level, the lower is the alienation of the aged. 8) Active participation in social activities and good relationship with other family members were founded to contribute to lowering the alienation of the aged. Whereas, too much concern over one's senescence appears to hav negative effects on the alienation. The regression analysis shows that the satisfaction with the family relationship has the most important influence upon the alienation of the aged. Following are the factors of self-rated senescence, pocket money in a descending order. All these factors, which explain 42.65% of the total variance of alienation variable are statistically significant(p<.001)

• 대한가정학회지
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• 제27권3호
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• pp.13-28
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• 1989

With the purpose of identifying clothing for persons with special needs one of new directions in Clothing and Textiles, this pater comparatively analyzed current curriculum and research trends related to this field between Korea and America. Questionaire was distributed to 25 Korean colleges with Clothing and Textiles department and 4 American colleges known for special clothing study. Questions regarded the name of course, level (grade), number of credit houre, prerequisits and supporting courses, subjects of lecture and projects, way of managing lecture and projects, evaluation system, other special characteristics. Resources for analyzing research trends are Thesis and Dissertations in Clothing and Textiles, Research Journal of Clothing & Textiles/Home Economics Association, College Professors' research reports collection, of both Korea and America. Years of publications are 1972∼1986 (America), 1978∼1988 (Korea). Findings are as follows; 1. Clothing for special needs can be classified into various groups; Clothing for physically handicapped, mentally retarded, elderly, unusual-sized, pregnant/nursing mothers, institutionalized, protective clothing, uniform/career apparel. 2. Management of coursework related to special clothing has several common characteristics specially in America; Building-up coursework, problem-solving orientation, cooperative team-preject, interdisciplinary approach, client-versus-designer preference, community involvement. In Korea, a few school only has special clothing coursework and its scope of study was very limited. 3. Majority of research reports done with the subjects of special clothing had made for physically handicapped people and the elderly. Protective clothing and uniform have recently been paid much interests. 4. Researchers had mainly concerned on Design and Construction Aspects and nextly on social-psychological aspects. However, in America, selection and care aspects and marketing aspects of special clothing have been very procuctive issues recently. 5. Study on clothing for special needs has several opportunities to be stressed and improvements to be strengthened. Opportunities included active participation to the welfare of community society, strong publicity of accurate professional image, share with business and industry, interdisciplinary approach and new job market. Improvements were discussed in terms of strengthening supporting courses/prerequistes, intensifying interdisciplinary cooperation, provoking strong community involvement and securing financial support and research funds.

• Clinical and Experimental Pediatrics
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• 제53권12호
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• pp.994-999
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• 2010

Purpose: Mitochondrial dysfunction can present with various symptoms depending on the organ it has affected. This research tried to analyze the ophthalmologic symptoms and ophthalmologic examination (OE) results in patients with mitochondrial disease (MD). Methods: Seventy-four patients diagnosed with mitochondrial respiratory chain complex defect with biochemical enzyme assay were included in the study. They were divided into 2 groups based on the OE results by funduscopy and were analyzed on the basis of their clinical features, biochemical test results, morphological analysis, and neuroimaging findings. Results: Thirty-seven (50%) of the 74 MD patients developed ophthalmologic symptoms. Abnormal findings were observed in 36 (48.6%) patients during an OE, and 16 (21.6%) of them had no ocular symptoms. Significantly higher rates of prematurity, clinical history of epilepsy or frequent apnea events, abnormal light microscopic findings in muscle pathology, diffuse cerebral atrophy in magnetic resonance imaging, and brainstem hyperintensity and lactate peaks in magnetic resonance spectroscopy were noted in the group with abnormal OE results. Conclusion: Although the ophthalmologic symptoms are not very remarkable in MD patients, an OE is required. When the risk factors mentioned above are observed, a more active approach should be taken in the OE because a higher frequency of ocular involvement can be expected.

• The Plant Pathology Journal
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• 제30권2호
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• pp.168-177
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• 2014

Plant has possessed diverse stress signals from outside and maintained its fitness. Out of such plant responses, it is well known that mitogen-activated protein kinase (MAPK) cascade plays important role in wounding and pathogen attack in most dicot plants. However, little is understood about its role in wounding response for the economically important monocot rice plant. In this study, therefore, the involvement of MAPK was investigated to understand the wounding signaling pathway in rice. The OsMPK1 was rapidly activated by wounding within 10 min, and OsMPK1 was also activated by challenge of rice blast fungus. Further analysis revealed that OsMKK4, the upstream kinase of OsMPK1, phosphorylated OsMPK1 by wounding in vivo. Furthermore, OsMPK1 directly interacted with a rice defense-related transcription factor OsWRKY53. To understand a functional link between MAPK and its target transcription factor, we showed that OsMPK1 activated by the constitutively active mutant $OsMKK4^{DD}$ phosphorylated OsWRKY53 in vitro. Taken together, components involving in the wounding signaling pathway, OsMKK4-OsMPK1-OsWRKY53, can be important players in regulating crosstalk between abiotic stress and biotic stress.

• 가족자원경영과 정책
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• 제19권4호
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• pp.1-17
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• 2015

This study is aimed to discover the deciding factors in senior employment programs for improving the quality of life for the elderly. The dependent variable used in this study was the quality of elderly persons. Personal and familial characteristics, and the community involvement of the elderly were used as independent variables in a Multiple Regression analysis. First, the most influential factor encouraging the elderly to participate in a senior employment promotion program was previous experience of senior employment programs. Second, health condition, residence in city areas, experience of volunteer work, and knowledge of senior employment programs had positive effects on the continuous participation of the elderly men and women. However, living arrangements had an effect solely on elderly men, and home ownership and participation in economic activities had effects solely on elderly women. Third, the life quality of the elderly was affected differently by sex. Health condition had the greatest effect on male elderly persons, whereas, the effective variable, the composition of the family had the most effect on female elderly persons. Thus, active campaigns through various mass media and information sessions are needed to promote participation in senior employment programs, according to the above mentioned deciding factors. In particular infrastructure providing the elderly with more volunteer work opportunity needs to be built for baby boomers to improve their quality of life. In addition, diversified senior employment programs are needed. Because the elderly living in city areas are more willing to participate in senior employment programs, specialized programs suitable for the elderly in city areas are needed. The government should also prepare programs that help the elderly stay healthy while they are working.

• 한국유통학회지:유통연구
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• 제4권3호
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• pp.65-86
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• 2000

관계마케팅 파라다임에서 판매원은 단순히 판매뿐 아니라 고객에게 가치를 창조해 주고 장기적인 관계를 발전시키는 중요한 역할을 한다. 본 연구는 판매원에 대한 선행연구에서 다루어지지 않았던 소매상황에서 의류판매원의 평가속성을 파악하고, 이의 측정도구를 우리나라 상황에 맞게 개발하고, 그 속성의 중요도를 파악하는데 있다. 아울러 백화점 의류판매원 속성 평가에 영향을 미치는 소비자 변인으로 소비자 지식과 제품관여 및 인구통계적 특성의 영향을 살펴보았다. 백화점 의류판매원의 속성차원은 개별면접과 선행연구를 바탕으로 개발되었으며, 이를 백화점 고객을 대상으로 실증 조사하였다. 그 결과 우리나라 백화점 의류판매원의 평가속성은 서비스 마인드, 판매노력, 수수한 인상, 판매유도기술 및 제품지식의 5차원으로 밝혀졌다. 백화점 고객은 의류판매원의 서비스 마인드를 가장 중요시하였으며, 그 다음으로는 판매노력, 제품지식, 수수한 인상, 판매유도기술의 순으로 중요시하는 것으로 나타났다. 소비자 지식, 제품관여 및 인구통계적 변인은 소비자의 의류판매원 속성 지각에 부분적인 영향을 미치는 것으로 나타났다. 본 연구의 결과에 근거하여 학문적, 경영적인 시사점을 제시하였다.

• 한국산업정보학회논문지
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• 제12권5호
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• pp.98-109
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• 2007

최종사용자 중심의 웹 플랫폼을 제공하는 웹 환경인 웹2.0시대가 도래했다. 또한 UCC(User Created Contents) 환경에 대한 관심의 증가로 사용자들의 멀티미디어 콘텐츠 참여가 급속도로 확산되고 있는 실정이다. "사용자의 능동적 참여"라는 웹2.0의 목적을 고려할 때, 노약자나 시각장애인과 같은 기반 정보접근에 있어 많은 어려움이 따르는 사용자들의 접근성 고려에 대한 인식과 필요성 역시 증가하고 있다. 본 연구에서는 시각장애 사용자들의 웹 기반 UCC 서비스 활용에 있어 문제점을 파악 분석하여 그들의 원활한 접근이 가능한 웹 기반 UCC 서비스에 대한 효율적인 구현방안을 제시한다. 특히 본 연구에서는 제시된 구현방안에 의한 테스트 페이지 구현을 통해 시각장애 사용자들의 반응시간을 기존 UCC 서비스와 비교.분석함으로써 제시한 방법론에 대한 타당성을 검증하였다.

• Investigative Magnetic Resonance Imaging
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• 제23권2호
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• pp.100-113
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• 2019

Sarcoidosis is a multisystem disease characterized by noncaseating granulomas. Cardiac involvement is known to have poor prognosis because it can manifest as a serious condition such as the conduction abnormality, heart failure, ventricular arrhythmia, or sudden cardiac death. Although early diagnosis and early treatment is critical to improve patient prognosis, the diagnosis of CS is challenging in most cases. Diagnosis usually relies on endomyocardial biopsy (EMB), but its diagnostic yield is low due to the incidence of patchy myocardial involvement. Guidelines for the diagnosis of CS recommend a combination of clinical, electrocardiographic, and imaging findings from various modalities, if EMB cannot confirm the diagnosis. Especially, the role of advanced imaging such as cardiac magnetic resonance (CMR) imaging and positron emission tomography (PET), has shown to be important not only for the diagnosis, but also for monitoring treatment response and prognostication. CMR can evaluate cardiac function and fibrotic scar with good specificity. Late gadolinium enhancement (LGE) in CMR shows a distinctive enhancement pattern for each disease, which may be useful for differential diagnosis of CS from other similar diseases. Effectively, T1 or T2 mapping techniques can be also used for early recognition of CS. In the meantime, PET can detect and quantify metabolic activity and can be used to monitor treatment response. Recently, the use of a hybrid CMR-PET has introduced to allow identify patients with active CS with excellent co-localization and better diagnostic accuracy than CMR or PET alone. However, CS may show various findings with a wide spectrum, therefore, radiologists should consider the possible differential diagnosis of CS including myocarditis, dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy, amyloidosis, and arrhythmogenic right ventricular cardiomyopathy. Radiologists should recognize the differences in various diseases that show the characteristics of mimicking CS, and try to get an accurate diagnosis of CS.