• The Journal of Korean Physical Therapy
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• 제21권2호
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• pp.109-116
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• 2009

Purpose: $17\beta$-estradiol is the most active endogenous estrogen, which is related to favorable changes in the plasma lipid profile, to relaxation of the coronary vessels, and to a decrease in platelet aggregation and vascular smooth muscle cell migration. However, although the beneficial effect of estrogens on plasma lipoproteins (ie, lowering low-density lipoprotein and increasing high-density lipoprotein cholesterol) contributes to cardiovascular protection, it does not fully account for the protective effect, particularly in the application of physical therapy, including low frequency electrical stimulation. Methods: The aim of this study was to demonstrate the inhibition of stressors, such as endothelin-1 (ET-1), serotonin (5-hydroxytryptamine, 5-HT), prostaglandin $F2\alpha$ ($PGF2\alpha$), and a protein kinase C (PKC) activator 12-deoxyphorbol 13-isobutyrate (DPB), induced isometric tension by $17\beta$-estradiol in vascular smooth muscle strips, respectively. In addition, the effects of low frequency electrical stimulation at the meridian points (CV-3, -4, Ki-12, SP-6, LR-3, BL-25, -28, -32, -52) on the indirect antihypertensive effect were examined by monitoring the changes in the serum $17\beta$-estradiol concentration in healthy volunteers. Results: Isometric tension analysis showed that the responses of inhibited tension by $17\beta$-estradiol were similar to the same stressors in rat aortic smooth muscle strips. Furthermore, although the continued amplitude modulation (AM) type of electrical stimulation was not increased significantly by electrical stimulation, the current of the frequency modulation (FM) type of low frequency electrical stimulation increased the serum $17\beta$-estradiol concentration in normal volunteers. Conclusion: These results, in part, suggest that $17\beta$-estradiol has the capacity to supress stressor-induced muscle tension, and electrical stimulation, particularly current of the FM type, has a modulatory effect on the sex steroid hormones, particularly $17\beta$-estradiol, in healthy volunteers.

• 한국유기농업학회지
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• 제27권4호
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• pp.463-477
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• 2019

This study was conducted to compare the community structure and biodiversity of epigeic spiders between pear fields cultivated by integrated pest management (IPM) and organic methods. This is the first study of this kind to be conducted in Korea. Eighty-four spider species from 22 families were identified among the collected 2,489 arthropods, with 754 individuals being sampled from IPM fields and 1,735 individuals from organic fields. Generally, Theridiidae, Linyphiidae, Lycosidae, Agelenidae, Gnaphosidae, and Salticidae were the dominant spider families in the pear orchard regardless of the farming methods, and species richness and abundance were higher in organic fields than in IPM fields. The dominant species were the wolf spiders (Lycosidae) and stone spiders (Gnaphosidae), and their cumulative abundance was 70.7% in IPM fields and 72.7% in organic fields. The community structure between organic and IPM fields was heterogeneous, with a 45% similarity level. Biodiversity, species richness, abundance, and species diversity index were higher in organic fields than in IPM fields, and significantly different between the farming methods. Seasonal fluctuations in biodiversity were similar in both IPM and organic fields. The species richness and species diversity index increased and the abundance decreased in the second half of the cultivation period. This study on the community structure and biodiversity of epigeic spiders, which form one of the most important predator groups, will provide principal ecological and faunistic information required to maintain the biodiversity of useful arthropods in agricultural ecosystems and help implement sustainable agriculture based on the active use of natural enemies.

• Journal of Pharmaceutical Investigation
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• 제39권4호
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• pp.263-267
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• 2009

The purpose of this study is to evaluate the efficacy of stipulated cleaning process, and the prohibition of cross-contamination and microbiological contamination, which inadequate cleaning in multi-production could occur, through cleaning validation of multi-purpose facility used to produce five biopharmaceutical products as sterile injection. After production of five biopharmaceutical products such as hGH, rhGCSF, rhEPO, rhFSH and rhIFN using vial filling machine, the cleaning validation such as residual analysis of active ingredients or human serum albumin, measurement of total organic carbon (TOC), residual analysis of detergent and microbiological contamination were carried out. In the case of rhGH and rhGCSF clean validations, drug residues were not detected. Furthermore, in the case of rhEPO, rhFSH and rhIFN clean validations, human serum albumin residues were not detected. At TOC (total organic carbon) analysis, all clean validations gave the TOC of about average 137.93%, not more than 150% of acceptance criteria. At sodium analysis for the checking of residues of cleaning agent, sodium residues were not detected. In sterility test, they showed no microbiological contamination of bacteria and fungi. Thus, this cleaning validation was determined as successful in protection of cross-contamination and induction of safety in multi-purpose facility.

• 한국환경농학회지
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• 제36권1호
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• pp.36-42
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• 2017

BACKGROUND: Yuza seed by-product has been produced in a large amount from the agricultural farms in the southern area of Korea. It has been mostly abandoned after commercial process for the production of juice, jam and tea. The study on the reuse of the yuza seed by-product has received much attention as a bio-resource material for the production of active compound in agriculture. METHODS AND RESULTS: Insecticidal rhamnolipid-producing Pseudomonas sp. EP-3 was grown in mineral salt media with the yuza seed by-product at 2, 20, 50 and 100 g/L. The growth of EP-3 was accompanied by a increase in insecticidal activity against green peach aphid. The highest insecticidal activity was observed when EP-3 was grown in the medium containing 50 g/L of the seed sample, producing approximately 996 mg/L of rhamnolipid at 96 h. Palmitic acid, stearic acid, oleic acid and linoleic acid were determined as the major fatty acids of the seed sample. The EP-3 cultures grown on the fatty acid mixture extracted from the seed sample showed a aphid mortality similar to that of cultures grown on the seed sample. The EP-3 cultures grown on 50 g/L of the seed sample showed aphid mortality more than 90% under greenhouse conditions. CONCLUSION: This study suggested that the yuza seed by-product may be used as a renewable material for microbial production of rhamnolipid against green peach aphid.

• 한국항공우주학회지
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• 제48권4호
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• pp.311-321
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• 2020

최근 초소형위성, 소형위성에 대한 혁신적인 기술 발전으로 인해 거대 군집임무(Mega Constellation)가 활발하게 이루어지고, 재활용 우주발사체로 인한 우주 접근 비용이 급격하게 낮아지면서, 우주 개발은 지금까지와는 다른 'New Space Age' 시대로의 전환을 앞두고 있다. 이에 따라, 활발한 우주 개발의 필연적인 부수물인 '우주쓰레기'들의 증가로 인한 우주환경 악화 문제 역시 국제적인 관심사로 떠오르고 있다. 본 논문에서는 국가 우주정책의 변화를 앞두고 우주환경 보호를 위한 국제기구들과 각 국가들의 '우주쓰레기 경감 가이드라인' 제정 내용과 동향들을 살펴보고, 국제 사회의 향후 움직임에 대해 전망하였다. 또한, 우리나라의 현실에 맞는 가이드라인 예시 및 적용 방안에 대해서도 제안하였다.

• 복식
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• 제56권9호
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• pp.143-156
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• 2006

The purpose of this study is to analyze changes in military uniform design according to the type of war in history and to suggest factors to be considered when designing military uniforms. Military uniform in this study has been limited to uniforms of land active soldiers and not only includes battle dress but also bombproof helmets, combat boots and webbing systems. Western military uniform was investigated starting from World War I focusing on the United States, United Kingdom, Germany and the Soviet Union, and Korean military uniform was analyzed starting from the Korean Day of Independence. Historical research, case studies and in-depth interviews were included in the study. World War I was a trench war. Khaki colors began to be used in battle dress, and steel helmets and gas masks were invented. World War II was a full-stale war. Many kinds of uniform were designed with various environments and roles of soldiers in mind, and camouflage was adopted in military uniform. Modern wars were wars of technique. Strong protectors were invented and diverse camouflages were adopted as rifles became increasingly accurate and biochemical weapons started to be used. Korea referred largely to the uniforms of the United States because it lacked both information on war and the financial power to invest in development of military uniforms. Finally, this study presents 5 factors to be considered when designing military uniforms: protection, camouflage, mobile and utility convenience, compatibility and symbolism. Wars of the future are predicted to be information wars utilizing realtime information collected through computers. Therefore new military uniforms with computers, communication devices and strong protective capacities need to be developed. This study aims to provide a theoretical basis for designing military uniforms of the future.

• 약학회지
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• 제40권1호
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• pp.102-111
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• 1996

LB10522 is a new parenteral broad spectrum cephalosporin with a catechol moiety at C-7 position of beta-lactam ring. This compound can utilize tonB-dependent iron transp ort system in addition to porin proteins to enter bacterial periplasmic space and access to penicillin-binding proteins (PBPs) which are the lethal targets of ${\beta}$-lactam antibiotics. The chelating activity of LB10522 to metal iron was measured by spectrophotometrically scanning the absorbance from 200 to 900nm. When $FeCl_3$ was added, optical density was increased between 450 and 800nm. LB10522 was more active against gram-negative strains in iron-depleted media than in iron-replete media. This is due to the increased expression of iron transport channels in iron-depleted condition. LB10522 showed a similar activity against E. coli DC2 (permeability mutant) and E. coli DCO (wild type strain) in both iron-depleted and iron-replete media, indicating a minimal permeaility barrier for LB10522 uptake. LB10522 had high affinities to PBP 3 and PBP 1A, 1B of E. coli. By blocking these proteins, LB10522 caused inhibition of cell division and the eventual death of cells. This result was correlated well with the morphological changes in E. coli exposed to LB10522. Although the in vitro MIC of LB10522 against P. aeruginosa 1912E mutant (tonB) was 8-times higher than that of the P. aeruginosa 1912E parent strain, LB10522 showed a similar in vivo protection efficacy against both strains in the mouse systemic infection model. This result suggested that tonB mutant, which requires a high level of iron for normal growth, might have a difficulty in surviving in their host with an iron-limited environment.

• 디지털융복합연구
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• 제14권3호
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• pp.227-234
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• 2016

본 연구에서는 지식재산과 금융의 융합을 살펴보고, 다이아몬드 모델을 이용하여 국가별 지식재산 금융 경쟁력을 비교 분석한다. 분석을 위해 국가별 통계자료를 바탕으로 9개 하위요인, 41개 측정지표를 선정하였다. 분석의 주요 결과는 다음과 같다. 첫째, 한국의 지식재산 금융 경쟁력을 1로 가정하였을 때 미국은 1.63으로 비교 대상 국가 중 가장 높고, 이스라엘 1.49, 일본 1.37 순으로 나타났다. 둘째, 수요조건, 전략 구조 및 경쟁 영역에서 우리나라와 비교 대상 국가 간의 차이가 큰 것으로 나타났다. 셋째, 하위 요인에서는 금융 수요 및 수요 충족 정도, 지식확산 및 해외투자자의 투자 활성화, 투자자 및 지식재산 보호, 지식재산 비즈니스에 우호적인 환경 구축을 위한 정부 정책 등이 비교 대상 국가에 비해 열위에 있는 것으로 나타났다. 이러한 요인들은 공공 정책의 영역에 포함될 수 있는 항목들이 대부분이기 때문에 지식재산 금융의 경쟁력 강화를 위해 정부의 적극적인 지원과 기반 구축이 필요하다.

• Journal of Ginseng Research
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• 제34권4호
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• pp.327-335
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• 2010

We reported previously that the administration of Korean red ginseng water extract (KRG-WE) protected the guinea pig testis against damage induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (a potent endocrine disruptor). We also found that crude saponin from ginseng was the active ingredient responsible for this protection. Here, we examined the biological role of KRG-WE in an animal model of age-induced dysfunction of spermatogenesis. Twenty-four male Sprague-Dawley (six 2-month-old and eighteen 12-month-old) rats were used. The young and old control groups received only vehicle. The ginseng saponin (GS)- and KRG-WE-treated groups received GS (40 mg/kg body weight/day) and KRG-WE (200 mg/kg body weight/day), respectively, for 4 months. The number of cells, Sertoli cell index, Johnsen's score, and sex hormone levels decreased significantly with age. However, the administration of KRG-WE and GS markedly improved the number of germ cells, seminiferous tubular size, and Johnsen's score in the old rats. Ginseng produced a distinct testicular histological improvement in old rats. KRG-WE and GS elevated testosterone levels, while attenuating the aberrant increase in follicle stimulating hormone and luteinizing hormone levels. Sperm kinematics evaluated by a computer-assisted sperm analyzer demonstrated improvement in the percentage of motile sperm, progressive sperm motility, and curvilinear velocity associated with sperm quality, supporting the beneficial role of red ginseng in senile spermatogenesis. Overall, the total water extract had a more potent effect than the corresponding saponin fraction. In conclusion, Korean red ginseng rejuvenated age-induced testicular dysfunction. Additionally, the total water extract was more potent than the corresponding saponin fraction.

• 대한수의학회지
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• 제49권1호
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• pp.91-99
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• 2009

The concept about zoo is changing from the animal exhibition which simply contained the animals to the ecological zoo which has the function of preserving the animal species. At the central point of maintaining such role, the basic principle called the animal welfare lies obviously. Korea has applied the animal welfare principles such as carrying out the enrichment in the zoos since 2003, but there has not been any institutional device to evaluate and examine the application of the animal welfare so far. This study aims to confirm the level of animal welfare in Korea and suggest a developmental direction. For the purpose of the study, 12 zoos in Korea were evaluated according to 68 evaluating categories. 'Five Principles of Animal Welfare' in the Secretary of State's Standards of Modern Zoo Practice were selected and carried out as the evaluation categories, and the result, from the highest to lowest score given, was 'provision of food and water', 'provision of protection from fear and distress', 'provision of health care', 'provision of an opportunity to express most normal behaviours', and 'provision of a suitable enrichment' with the overall score of the entire Korean zoos being 2.86 (${\pm}$ 0.56). It was also confirmed that in order to improve the animal welfare of the Korean zoos, the animal management system must be standardized and organized. The evaluation and feedback, the active practice of animal welfare and its legislative support should be provided to establish an effective institutional device as well.