• YAKHAK HOEJI
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• v.50 no.3
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• pp.145-153
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• 2006

The adverse events which do not appear in the approval process tend to occur more frequently at the early stage of the use. Therefore new drugs, drugs with different active substances or routes of administration, or drugs with explicitly different efficacy added are particularly chosen for re-examination, and go through a study, which is conducted on 600 to 3,000 subjects over 4 to 6 years. Since the re-examination system was implemented in January 1995, 880 drug products have been designated as the subject of re-examination and among them 194 drugs have been completed their re-examination as of until March 2005. Post Marketing Surveillance to insure drug safety should be correlated with re-examination of new drug, re-evaluation of drug, and adverse event monitoring system. And the first labeling change should reflect all information collected for a defined period of time after the marketing authorization is granted. Furthermore centralized management through spontaneous reporting system of adverse event for whole period of time would be the most desirable type of system.

• The Journal of Korean Physical Therapy
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• v.28 no.5
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• pp.279-285
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• 2016

Purpose: This study was conducted to investigate the effects of joint mobilization and kinesio taping on pain, range of motion and knee function in patients with knee osteoarthritis. Methods: Thirty subjects were selected and divided into three groups: group 1 was treated with joint mobilization, group 2 was treated with kinesio taping and group 3 was treated with joint mobilization and kinesio taping. Joint mobilization was performed for 20 minutes three times a week for a period of 4 weeks, after which tape was applied for the same period of time and it was not exceeded 24 hours. Pain, range of motion and knee function were then assessed to identify the effectiveness. A visual analog scale (VAS) was used for pain assessment, while active and passive range of motion (AROM, PROM) were assessed using smart phones application, and knee injury and osteoarthritis outcome score (KOOS) was used to assess knee function. Results: After intervention, the joint mobilization group and kinesio taping group showed significant improvements in VAS, AROM, PROM and KOOS (Symptom, Pain, ADL, QOL), whereas no significant difference was found in sport/recreation. The joint mobilization with kinesio taping group showed significant improvements in all items, and a significant increase was found in AROM and PROM compared to the other two groups. Conclusion: We found that joint mobilization and kinesio taping effectively improved pain, range of motion and knee function in patients with knee osteoarthritis, but that application of joint mobilization with kinesio taping was most effective.

• Journal of Aquaculture
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• v.15 no.1
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• pp.43-48
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• 2002

We investigated the gonadosomatic index (GSI), germ cell development, reproductive cycle of the Afriean lungfish Protorierus annecteus (Owen) by histological observations and morphometric data. Samples were collected from the river Orie and its flood of Nigeria, from January to December 2000. The fish is dioecious and oviparous. Monthly changes in the gonadosomatic index (GSI) showed a similar pattern to change in the mean oocyte diameter and the reproductive cycle. The reproductive period occurred from March to July-August; the spawning period was once a year between truly and August, and the main spawning occurred in August when active and voracious feeding occurred during the rainy season. In the resting (dormant) stage after spawning, fish stopped feeding and aestivated during the dry season from December to February. The reproductive cycle of the species can be divided into five successive stages, quiescent stage (March to April), developing/maturing stage (April to lune), ripe/spawning stage (July to August), post-spawning stage (September to November), and resting (dormant) stage (December to February).

• Journal of the Korean Institute of Rural Architecture
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• v.20 no.1
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• pp.53-60
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• 2018

The purpose of this study is to present the basic data for the active use of closed schools by analyzing the actual conditions of closed schools in Gyeongnam area. As a method of this study, we examined the population change in Gyeongnam area through the literature survey and the internet site survey, and grasped the characteristics of the policies related to the closed school. Through the homepage survey of the local education financial alerts, we analyzed the contents, location, period after the closure, land area, and total floor area of the closed schools that have been in use or invaluable as of March 2017. As the results, In the case of self-utilization, the utilization rate of educational facilities was overwhelmingly high. In the case of lease utilization, the utilization ratio was higher in the order of education facilities, income increase facilities, and cultural facilities. Overall, 62.8% of the closed schools are located in the base towns (urban areas). The average of the period after the closure was 16.2 years, the land area average was $9,291.1m^2$, and the total area average was $1,153.8m^2$.

• The Journal of Engineering Geology
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• v.7 no.1
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• pp.81-90
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• 1997

The Korean historical 1iteratures describe that great eaathquakes with destructive damages occurred mainly in Kyongju-Ulsan areas during the period of 1 to 8 century and 16 to 17 century. It seems that the Ulsan fault system shows a little curved ttend with N-S strike in the southern part and diverges into three directions from the mid-northern lart of the fault. The dominant trends of the lineaments are NNE-SSW, NE-SW and NS directions. Trench excavation in the mid-northern part of the Ulsan fault shows thrust facies cutting slope deposit containing a compacted laminar structure whose origin may due to severe cryogenic activities of the last cold period(ahout 25OOO B.P.). Detailed observation of the facies gives some evidences related to two earthquake episodes of thrust components along the Ulsan fault system. Fault outcrop and trench study suggest that Ulsan fault seems to he one of the active fault which has reworked several times even in the late Quaternary.

• Architectural research
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• v.14 no.1
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• pp.35-44
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• 2012

Build-Transfer-Lease (BTL) was introduced to the domestic construction market in 2005. Now, seven years later, the BTL model is most active for educational facilities. In 2011, 93 educational facility projects entered the maintenance stage. Considering the characteristics of today's BTL projects for educational facilities, the main issues are the initial performance and maintenance of educational facilities and the service-providing status for the 20-year operational management period, in relation to providing safety and convenience to students, the facility users. Seeking a solution, local education offices and departments in charge of BTL under the Ministry of Education, Science, and Technology have been exploring various methods of evaluating operational maintenance performance from various perspectives. For educational facility BTL projects, however, the appropriateness of initial operation performance evaluation, rather than considering the 20-year operational management period, is controversial in regards to sustainability. On this account, performance evaluation items in four areas-operational maintenance evaluation, facility performance status evaluation, maintenance subject evaluation, and sustainable change response evaluation-should be extracted. An indicator of facility performance evaluation is presented in this study through an AHP survey targeting experts, as part of establishing an operation performance evaluation system for educational facility BTL projects.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.48 no.5
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• pp.739-744
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• 2015

The sexual maturation and spawning time of female ocean sunfish Mola mola in Korean waters were studied by observing the gonads histologically. Specimens were purchased in a fish market in October 2013 and May, June, and October 2014. Nine females (total length 100-250 cm, gonad weight 31-3,470 g) and one male (total length 131 cm, gonad weight 60 g) were studied. Histologically, the ovaries became active in May and spawning began in July and continued until October. In July, mature oocytes and yolk globule stage oocytes were observed; parts of the gonad showed traces of spawning, while others had degenerated and absorbed any oocytes. By October, many oocytes had degenerated and been absorbed. Therefore, the approximate spawning period of ocean sunfish is from July to October based on histological changes in the gonads. The asynchronous oocyte development suggests that the ocean sunfish is a multiple spawner, as reported previously. The catch distribution data suggest that the waters around Jeju Island are a sunfish spawning area.

• Journal of information and communication convergence engineering
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• v.15 no.1
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• pp.62-71
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• 2017

This paper presents a low-power voltage converter based on a reconfigurable capacitor array. Its energy recycling capacitor array stores the energy during a charge stage and supplies the voltage during an energy recycle stage even after the power source is disconnected. The converter reconfigures the capacitor array step-wise to boost the lost voltage level during the energy recycle stage. Its energy saving is particularly effective when most of the energy remaining in the charge capacitors is wasted by the leakage current during a longer sleep period. Simulations have been conducted using a voltage source of 500 mV to supply a $V_{DD}$ of around 800 mV to a load circuit consisting of four 32-bit adders in a 65-nm CMOS process. Results demonstrate energy recycling efficiency of 85.86% and overall energy saving of 40.14% compared to a conventional converter, when the load circuit is shortly active followed by a long sleep period.

• The Bulletin of The Korean Astronomical Society
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• v.41 no.2
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• pp.67.1-67.1
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• 2016

We examined the relations between CME speed and properties of magnetic helicity in the source region such as helicity injection rate and total unsigned magnetic flux, which reflect the magnetic energy in the active region. For this, we selected 22 CMEs occurred during the increasing phase of solar cycle 24, which shows extremely low activities and classified them into two groups according to evolution pattern of helicity injection rate. We then compared the relations with those from previous study based on the events in solar cycle 23. As the results, we found several properties as follows: (1) Both of CME speed and helicity parameters have very small values since we only considered increasing phase; (2) among 22 CMEs, only 6 events (27%) are classified as group B, which show sign reversal of helicity injection and they follow behind of appearance of group A events. This fact is well coincide with the trend of solar cycle 23 that only group A events was observed in the first 3 years of the period; (3) as the solar activity is increasing, the CME speed and helicity parameters are also increasing. Based on the observations of solar cycle 23, the helicity parameters was still increasing in spite of decreasing solar activity after maximum period.

• Journal of the korean society of oceanography
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• v.33 no.4
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• pp.137-145
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• 1998

In order to investigate the paleotidal structure and current pattern in the Yellow and East China seas (YECS) since the late Wisconsin, which is the last glacial maximum period, a two-dimensional version of the Princeton ocean model is used. We assume that subtracting the sea-level differences from the present one can produce paleobasins and that the paleotide did not differ greatly from the present one in the adjacent deep seas, the northwestern Pacific Ocean and the East Sea. We could successfully simulate the paleo-M$_2$ tides and tidal currents of 9000, 11000 and 13000 yr B.P. The result of the model shows considerable differences in the tidal pattern in each period. As the eustatic sea level rose, the amplitudes of the paleotides and the number of the amphidromic points generally increased, but the tidal currents in each paleobasin were strong and about the same order as the present day's. Based on these paleotide calculations, we suggest that there should have been active erosion in the paleobasin as in the present YECS, and the erosion should have played an important role on widening the paleobasin to the present shape, YECS.