• Journal of The Korea Institute of Healthcare Architecture
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• v.26 no.4
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• pp.49-57
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• 2020

Purpose: In our country, the aged population accounted for about 13% of the total population in 2018. In addition, it is expected to exceed 20% in 2026, entering an super-aged society. However, the senior welfare housing in Korea currently accommodates only 0.08% of the elderly population, and the increasing amount of the elderly population is very small. Accordingly, this study aims to analyze the causes of supply shortages and to propose directions for revitalizing the supply of welfare housing for the elderly in the private sector. Methods: First, the causes and problems of the poor supply of welfare housing for the elderly were analyzed. Next, the direction was proposed through institutional and case-by-case surveys and expert interviews. Results: It suggested directions such as legal and institutional improvement, inducing the use of REITs, preparing policies to support consumers, allocating a certain percentage of senior welfare housing for the elderly in the reconstruction project, improving awareness of monthly living expenses, and re-discussing sales permits. Implications: Experts said that the direction proposed in this study can have a positive effect on supply activation. However, there were many opinions that re-discussion on permission for sales was necessary due to the excessive impact of the inability to sell. In addition, further research is needed for specific application of the proposed direction.

• Korean Journal of Materials Research
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• v.32 no.6
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• pp.307-312
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• 2022

Metal halide perovskite (MHP) nanocrystals (NCs) have emerged as promising materials for various optoelectronic applications including photovoltaics, light-emitting devices, and photodetectors because of their high absorption coefficient, high diffusion length, and photoluminescence quantum yield. However, understanding the morphological evolution of the MHP NCs as well as their controlled assembly into optoelectronic devices is still challenging and will require further investigation of the colloidal chemistry. In this study, we found that the amount of n-octylamine (the capping agent) plays a crucial role in inducing further growth of the MHP NCs into one-dimensional nanowires during the aging process. In addition, we demonstrate that the dielectrophoresis process can permit self-alignment of the MHP nanowires with uniform distribution and orientation on interdigitated electrodes. A strong light-matter interaction in the MHP NWs array was observed under UV illumination, indicating the photo-induced activation of their luminescence and electrical current in the self-aligned MHP nanowire arrays.

• International Journal of Computer Science & Network Security
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• v.22 no.10
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• pp.237-245
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• 2022

The prominence of IoTs (Internet of Things) and exponential advancement of computer networks has resulted in massive essential applications. Recognizing various cyber-attacks or anomalies in networks and establishing effective intrusion recognition systems are becoming increasingly vital to current security. MLTs (Machine Learning Techniques) can be developed for such data-driven intelligent recognition systems. Researchers have employed a TFDNNs (Tensor Flow Deep Neural Networks) and DCNNs (Deep Convolution Neural Networks) to recognize pirated software and malwares efficiently. However, tuning the amount of neurons in multiple layers with activation functions leads to learning error rates, degrading classifier's reliability. HTFDNNs ( Hybrid tensor flow DNNs) and MRNs (Modified Residual Networks) or Resnet CNNs were presented to recognize software piracy and malwares. This study proposes HTFDNNs to identify stolen software starting with plagiarized source codes. This work uses Tokens and weights for filtering noises while focusing on token's for identifying source code thefts. DLTs (Deep learning techniques) are then used to detect plagiarized sources. Data from Google Code Jam is used for finding software piracy. MRNs visualize colour images for identifying harms in networks using IoTs. Malware samples of Maling dataset is used for tests in this work.

• Advances in concrete construction
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• v.17 no.3
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• pp.167-177
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• 2024

Disposal of waste glass derived from bottle or packaging glass, flat glass, domestic glass is one of the major environmental defies. Moreover, the remnants of bricks resulting from the remnants of buildings are also considered an important factor in polluting the environment due to the difficulty of filling or getting rid it. The aim of this study is to valorize these wastes through chemical activation to be an environmentally friendly material. The Microstructure, compressive strength, setting time, drying shrinkage, water absorption of different pastes produced by clear glass (CG), green glass (GG) and brick waste (BP) activated were tested and recorded after curing for 3, 7, 28 and 365 days. Five samples of pastes were mixed in proportions represented by: 100% GP (GP), 100% GGP (GGP), 100% BP (BP), 90% GP + 10% BP (GPB) and 90% GGP + 10% BP (GGPB). Various parameters considered in this study include sodium hydroxide concentrations (10 mol/l); 0.4 as alkaline liquid to binder ratio; 2.5 as sodium silicate to sodium hydroxide ratio and cured at 60℃ for 24 hours. Experimental results revealed that the addition of 10% of BP resulted in an increased strength performance of geopolymer paste especially with GGPB compared to GGP in 365 days. In addition, the 10% amount of BP increases the absorption and shrinkage rate of geopolymer pastes (GPB and GGPB) by reducing the setting time. SEM results revealed that the addition of BP and GP resulted in a dense structure.

• Journal of Internet Computing and Services
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• v.16 no.4
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• pp.1-11
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• 2015

This study uses the contingent valuation method to estimate the switching cost for adopting the MVNO service. The findings are as follows.: First, Willingness To Switch(WTS) increases as users' using pattern and perceived degree of MVNO service, but satisfaction with current service provider does not play a significant role in predicting Switching Cost. This means that as amount of money users can save exceeds a certain level, users decide to willingly change their service provider to MVNO regardless of their level of satisfaction with current service provider. Second, there are differences in WTS among service subscribers in SKT, KT and LGU+. It means that there will be a difference in the tendency to switch to MVNO among subscribers of service providers. This study suggest the following mangerial perspective to effectively promote the MVNO and boost the MVNO market for activation of mobile data services.: First, MVNOs are better off applying differentiated pricing scheme at attractive rates than using a differentiation of service product and quality. Second, regulators should consider how to implement an MVNO regulatory policy when there is an asymmetric customer loyalty among MNOs. This research will be used to set the MVNO's pricing strategy and to build up a successful regulatory policies.

• Journal of Korean Traditional Oncology
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• v.16 no.2
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• pp.25-34
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• 2011

Objectives : Citrus is the fruit that is readily available around us. Therefore, we investigated the anti-inflammatory effects of fraction isolated from the Citrus hassaku pericarp in RAW264.7 macrophage cells. Methods : The effects of fraction from Citrus hassaku pericarp on cell viability on RAW264.7 cells were measured by the MTT assay. The mRNA levels of iNOS and COX-2, its protein level by fraction of Citrus hassaku pericarp treatment in RAW264.7 macrophage cells were investigated by RT-PCR and immunoblots. Nitrite accumulation in the culture was measured colorimetrically by the Griess reaction using a Griess reagent. The amount of IL-6 and TNF-${\alpha}$ production was determined using an enzyme-linked immunosorbent assay (ELISA) kit. Results : The results indicated that the fraction of Citrus hassaku pericarp concentration highly suppressed lipopolysaccharide (LPS)-induced nitric oxide (NO) and IL-6 productions without a cytotoxic effect on RAW264.7 cells. fraction of Citrus hassaku pericarp inhibited the expressions of LPS-induced iNOS and COX-2 protein and their mRNA in a dose-dependent manner. Particularly, fraction of Citrus hassaku pericarp suppressed the level of nuclear factor-${\kappa}B$ (NF-${\kappa}B$) activity, which was linked with the suppression of LPS-induced phosphorylation of p65 at serine 276 and p65 translocation into nuclei, but not MAPK signaling. In addition, treatment with fraction of Citrus hassaku pericarp inhibited the production of IL-6 and TNF-${\alpha}$ in LPS-stimulated RAW264.7 cells. Conclusion : Our results indicate that fraction of Citrus hassaku pericarp potentially inhibits the biomarkers related to inflammation through the blocking of NF-${\kappa}B$ p65 activation, and it may be a potential therapeutic candidate for the treatment of inflammatory diseases.

• Journal of Life Science
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• v.25 no.10
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• pp.1184-1195
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• 2015

The zebrafish is an emerging vertebrate model organism in reproductive biology. The oocyte maturation of zebrafish is triggered by maturation inducing hormone (MIH, 17α,20β-Dihydroxy-4-pregnen-3-one). In almost all animals, the oocyte maturation is governed by activation of pre-MPF which consists of cyclinB and inactive Cdk1. In the oocyte of Xenopus and mice, the activity of Cdk1 is regulated in two ways, one is the interaction with cyclinB and the other is phosphorylation/dephosphorylation of T14/Y15 residues on the Cdk1 by Wee1 and Cdc25. Unlike Xenopus and mice that have a sufficient amount of pre-MPF, pre-MPF is absent in GV oocyte of most teleost including zebrafish. Therefore, the activation of MPF during zebrafish oocyte maturation might totally depend on de novo synthesis of cyclinB proteins. It is reported that the translation of maternal mRNA is regulated by combination of several RNA binding proteins such as CPEB, Dazl, Pum1/Pum2, and insulin-like growth factor2 mRNA-binding protein 3 in the zebrafish oocytes. However, the definitive mechanism of these proteins to regulate the translation of stored maternal mRNAs remains to be elucidated. Therefore, the investigation of the maturation process of the zebrafish oocyte will provide new information that can help identify the role of translational control in early vertebrate oocyte maturation.

• The korean journal of orthodontics
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• v.35 no.4 s.111
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• pp.262-274
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• 2005

Tooth movement is a result of mutual physiologic responses between the periodontal ligament and alveolar bone stimulated by mechanical strain. The PDL cell and osteoblast are known to have an influence on bone formation by controlling collagen synthesis and alkaline phosphatase activation. Moreover. recent studies have shown that the PDL cell and osteoblast release osteoprotegerin (OPG) and the receptor activator of nuclear factor ぉ ligand (RANKL) to control the level of osteoclast differentiation and activation which in turn influences bone resorption. In this study. progressively increased, continuous tensional force was applied to PDL cells. The objective was to find out which kind of biochemical reactions occur after tensional force application and to illuminate the alveolar bone resorption and apposition mechanism. Continuous and progressively increased tensile force was applied to PDL cells cultured on a petriperm dish with a flexible membrane The amount of $PGE_2$ and ALP synthesis were measured after 1, 3, 0 and 12 hours of force application. Secondly RT-PCR analysis was carried out for OPG and RANKL which control osteoclast differentiation and MMP-1 -8, -9, -13 aud TIMP-1 which regulate the resolution of collagen and resorption of the osteoid layer According to the results. we concluded that progressively increased, concluded force application to human PDL cells reduces $PGE_2$ synthesis, and increases OPG mRNA expression.

• The Korean Journal of Physiology
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• v.28 no.2
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• pp.215-224
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• 1994

The presence of a calcium current $(i_{Ca^{2+}})$ passed via a specific channel was examined in the unfertilized hamster egg using the whole-cell voltage clamp technique. Pure inward current was isolated using a $Ca^{2+}-rich$ pipette solution containing 10 mM TEA. This current was independent of external $Na^+$ and was highly sensitive to the $Ca^{2+}$ concentration in the bathing solution, indicating that the inward current is carried by $Ca^{2+}$. The maximal amplitude was $-4.12{\pm}0.58nA\;(n=12)$ with 10mM $Ca^{2+}$ at -3OmV from a holding potential of -8OmV. This current reached its maximum within 20ms beyond -3OmV and decayed rapidly with an inactivation time constant $({\tau})$ of 15ms. Activation and inactivation of this $i_{Ca^{2+}}$ was steeply dependent on the membrane potential. The $i_{Ca^{2+}}$ began to activate at the lower voltage of -55 mV and reached its peak at -35 mV, being completely inactivated at potentials more positive than -40 mV. These result suggest that $i_{Ca^{2+}}$ in hamster eggs passes through channels with electrical properties similar to low voltage-activated T-type channels. Other results from the present study support this suggestion; First, the inhibitory effect of $Ni^{2+}\;(IC_{50}=13.7\;{\mu}M)$ was more potent than $Cd^{2+}\;(IC_{50}=123\;{\mu}M)$. Second, $Ba^{2+}$ conductance was equal to or below that of $Ca^{2+}$. Third, $i_{Ca^{2+}}$ in hamster eggs was relatively insensitive to nifedipine $(IC_{50}=96.6\;{\mu}M)$, known to be a specific t-type blocker. The physiological role of $i_{Ca^{2+}}$ in the unfertilized hamster eggs remains unclear. Analysis from steady-state inactivation activation curves reveals that only a small amount of this current will pass in the voltage range $(-70{\sim}-30\;mV)$ which partially overlaps with the resting membrane potential. This current has the property that it can be easily activated by a weak depolarization, thus it may trigger a certain kind of a intracellular event following fertilization which may cause oscillations in the membrane potential.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.28 no.6
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• pp.579-585
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• 2006

Introduction: The fibular free flap is now considered as the first choice for long mandibular discontinuity defect. In spite of its good bone quality for implant installation, its diameter is too narrow to rehabilitate the masticatory function with implant installation. In this report, distraction osteogenesis was used for the augmentation of bone to install the dental implant in the mandible which was reconstructed with a vascularized fibular free flap. Patients and Methods: Three patients undertook the vertical augmentation of grafted fibular bone and dental implants were installed. On the day 8 post-surgery, the activation of the distractor was started at the rate of 1 mm twice a day. The total amount of distraction was 15 mm in two patients and 12.5 mm in one patient. Twelve implants were installed in three patients. Dental implants were simultaneously installed during removal of the distraction device in two patients. In one patient, the implant installation was delayed after device had been removed. All three patients showed the symptoms of mild to severe postoperative infection during the activation and consolidation. However, the distracted site showed undisturbed bone regeneration. Conclusion: The distraction osteogenesis showed the reliable results for the vertical augmentation of fibular bone which was used for the mandibular reconstruction. However, the great tendency of postoperative infection must be considered and clinically controlled.