• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2006년도 Asia Navigation Conference
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• pp.203-212
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• 2006

The purpose of this research is to suggest the activation plan of Busan port. In the past years, Busan port enjoyed the golden days because of the China's rapid economic growth. But China's continuous development of ports, the trend of increasing container ship size and increasing direct call to China are coming threats to Busan port. So Korea needs to revise the 'Northeast Logistics Hub' strategy because it is considered that Korea ports continuously will handle China's transshipment cargoes. But now China's transshipment cargo share has decreased by direct call to China ports. It means that China has a lot of its local cargoes, so many ship companies change liner service route to handle China cargoes except Bussan ports although Busan port is included in the main trunk route. In the future, Bussan port will not be able to compete again about throughput with China ports if Busan port's transshipment cargo share decreases. So we must find out and develop Busan port's strength which is the competitive edge. By good luck, Busan port has a few opportunities such as the developed feeder network service and geographical advantages. Busan port has many feeder network service like spider's web in any northeast countries so we can suggest that if Japanese shippers use Busan port to distribute their cargoes to Japanese local areas, its transport costs are cheaper than when they use Japan's main ports. In this paper analyzed side of cost when they use Bussan port like hub to distribute their cargo to their local areas. Because most companies tried to reduce the total cost about logistics. Finally, this paper suggests when northeast shippers(China, Japan) use Bussan port which is more economical than their local main ports.

• 한국통신학회논문지
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• 제37A권12호
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• pp.1085-1092
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• 2012

이동통신 시스템은 무선 자원과 배터리 전력을 효율적으로 관리하기 위해 사용자 상태 천이 방식을 정의하고 있다. 이러한 상태 천이 방식에서는 에너지 소비가 많은 상태가 기본적으로 짧은 접속 지연을 제공하므로 에너지와 지연 성능 사이에 트레이드오프 관계가 존재한다. 본 논문에서는 이동 응용 서비스의 트래픽 속성을 고려하여 UMTS 시스템의 사용자 상태 천이 방식을 분석한다. 상태 천이 방식의 마르코프 모델링을 통하여 에너지 소비량과 활성 지연을 수학적으로 도출하고 운용 파라미터에 따라 이들의 트레이드오프 관계를 파악한다. 분석 결과로 도출된 에너지-지연 트레이드오프 곡선은 주어진 상태 천이 방식이 달성 가능한 성능 한계를 보여주며 지연 요구사항을 보장하면서 에너지 소비를 최소화하는 최적 운용 전략을 제시한다.

• Nuclear Engineering and Technology
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• 제43권6호
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• pp.583-592
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• 2011

The radiological characteristics for waste classification were assessed for neutron-activated decommissioning wastes from a CANDU reactor. The MCNP/ORIGEN2 code system was used for the source term analysis. The neutron flux and activation cross-section library for each structural component generated by MCNP simulation were used in the radionuclide buildup calculation in ORIGEN2. The specific activities of the relevant radionuclides in the activated metal waste were compared with the specified limits of the specific activities listed in the Korean standard and 10 CFR 61. The time-average full-core model of Wolsong Unit 1 was used as the neutron source for activation of in-core and ex-core structural components. The approximated levels of the neutron flux and cross-section, irradiated fuel composition, and a geometry simplification revealing good reliability in a previous study were used in the source term calculation as well. The results revealed the radioactivity, decay heat, hazard index, mass, and solid volume for the activated decommissioning waste to be $1.04{\times}10^{16}$ Bq, $2.09{\times}10^3$ W, $5.31{\times}10^{14}\;m^3$-water, $4.69{\times}10^5$ kg, and $7.38{\times}10^1\;m^3$, respectively. According to both Korean and US standards, the activated waste of the pressure tubes, calandria tubes, reactivity devices, and reactivity device supporters was greater than Class C, which should be disposed of in a deep geological disposal repository, whereas the side structural components were classified as low- and intermediate-level waste, which can be disposed of in a land disposal repository. Finally, this study confirmed that, regardless of the cooling time of the waste, 15% of the decommissioning waste cannot be disposed of in a land disposal repository. It is expected that the source terms and waste classification evaluated through this study can be widely used to establish a decommissioning/disposal strategy and fuel cycle analysis for CANDU reactors.

• 농업생명과학연구
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• 제45권6호
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• pp.33-40
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• 2011

본 연구는 산림복합경영사업의 관리와 활성화를 위한 정책적 시사점을 찾기 위하여 참여 작목반원들의 의식조사, 산림복합경영사업 관리 등에 대하여 중요도 만족도 분석을 실시하였다. 그 결과 국유림에서 추진중인 산림복합경영사업에 대한 작목반원의 만족도는 매우 높게 나타났다. 또한, 총 15개의 항목중에서 중요도 만족도 분석을 통해 산림복합경영사업에서 집중적 관리전략이 필요한 분야로 전자상거래 및 직거래 활성화, 생산 및 판매 유통정보 2개 항목이 도출되었다. 그리고 현 상태의 지속적 유지가 필요한 분야는 6개 항목, 낮은 우선순위를 가지는 분야는 3개 항목, 과잉노력을 지양해 할 분야는 4개 항목으로 도출되었다. 이러한 연구결과를 바탕으로 산림복합경영사업의 추진방향 설정 및 제도개선을 위한 기초자료로 활용할 수 있을 것으로 판단된다.

• 디지털융복합연구
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• 제17권11호
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• pp.105-115
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• 2019

본 연구는 감성마케팅과 브랜드인지도가 구매의도에 미치는 영향을 분석하고, SNS 활용이 브랜드인지도와 구매의도 사이에 조절효과가 있는지 검증하여 초기 창업자들의 경영활성화에 도움을 주고자 하였다. 연구결과는 첫째, 감성마케팅이 구매의도에 미치는 영향을 분석한 결과, 감성마케팅의 주요 요인들 중에서 구매의도에 유의미한 영향을 미치는 요인은 미각요소와 시각요소로 나타났다. 둘째, 감성마케팅의 세부요인들 중 브랜드인지도에 통계적으로 유의미한 영향을 미치는 세부요인은 미각요소, 촉각요소, 시각요소, 청각요소 순으로 나타났다. 셋째, 브랜드인지도가 구매의도에 미치는 영향관계를 분석한 결과, 브랜드인지도는 구매의도에 통계적으로 유의한 정(+)의 영향을 미치는 것으로 나타났다. 넷째, 감성마케팅과 구매의도 사이에 SNS 활용이 어느 정도 조절효과가 있는지 SNS 활용의 조절효과를 분석한 결과, 감성마케팅의 세부요인인 시각, 후각, 청각, 미각, 촉각요소 모두 SNS 활용의 조절효과는 유의적인 효과(+)가 있는 것으로 나타났다. 따라서 초기 창업단계에서 감성마케팅과 SNS 등을 적극 활용하는 것이 경영활성화에 많은 도움이 될 것으로 판단된다.

• Journal of Animal Science and Technology
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• 제63권6호
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• pp.1453-1463
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• 2021

Feeding is the most important behavior that represents the health and welfare of weanling pigs. The early detection of feed refusal is crucial for the control of disease in the initial stages and the detection of empty feeders for adding feed in a timely manner. This paper proposes a real-time technique for the detection and recognition of small pigs using a deep-leaning-based method. The proposed model focuses on detecting pigs on a feeder in a feeding position. Conventional methods detect pigs and then classify them into different behavior gestures. In contrast, in the proposed method, these two tasks are combined into a single process to detect only feeding behavior to increase the speed of detection. Considering the significant differences between pig behaviors at different sizes, adaptive adjustments are introduced into a you-only-look-once (YOLO) model, including an angle optimization strategy between the head and body for detecting a head in a feeder. According to experimental results, this method can detect the feeding behavior of pigs and screen non-feeding positions with 95.66%, 94.22%, and 96.56% average precision (AP) at an intersection over union (IoU) threshold of 0.5 for YOLOv3, YOLOv4, and an additional layer and with the proposed activation function, respectively. Drinking behavior was detected with 86.86%, 89.16%, and 86.41% AP at a 0.5 IoU threshold for YOLOv3, YOLOv4, and the proposed activation function, respectively. In terms of detection and classification, the results of our study demonstrate that the proposed method yields higher precision and recall compared to conventional methods.

• 운동영양학회지
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• 제24권2호
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• pp.11-21
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• 2020

[Purpose] Doxorubicin (DOX) is a potent anti-cancer drug that appears to have severe myotoxicity due to accumulation. The skeletal muscle has a regeneration capacity through satellite cell activation when exposed to extracellular stimulus or damage. Endurance exercise (EXE) is a therapeutic strategy that improves pathological features and contributes to muscle homeostasis. Thus, this study investigated the effect of EXE training in mitigating chronic DOX-induced myotoxicity. [Methods] Male C57BL/6J mice were housed and allowed to acclimatize with free access to food and water. All the mice were randomly divided into four groups: sedentary control (CON, n=9), exercise training (EXE, n=9), doxorubicin treatment (DOX, n=9), doxorubicin treatment and exercise training (DOX+EXE, n=9) groups. The animals were intraperitoneally injected with 5 mg/kg/week of DOX treatment for 4 weeks, and EXE training was initiated for treadmill adaptation for 1 week and then performed for 4 weeks. Both sides of the soleus (SOL) muscle tissues were dissected and weighed after 24 hours of the last training sessions. [Results] DOX chemotherapy induced an abnormal myofiber's phenotype and transition of myosin heavy chain (MHC) isoforms. The paired box 7 (PAX7) and myoblast determination protein 1 (MYOD) protein levels were triggered by DOX, while no alterations were shown for the myogenin (MYOG). DOX remarkably impaired the a-actinin (ACTN) protein, but the EXE training seems to repair it. DOX-induced myotoxicity stimulated the expression of the forkhead box O3 (FOXO3a) protein, which was accurately controlled and adjusted by the EXE training. However, the FOXO3a-mediated downstream markers were not associated with DOX and EXE. [Conclusion] EXE postconditioning provides protective effects against chronic DOX-induced myotoxicity, and should be recommended to alleviate cancer chemotherapy-induced late-onset myotoxicity.

• 한국프랜차이즈경영연구
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• 제2권2호
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• pp.24-44
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• 2011

최근 인터넷 상에서는 SNS(Social Network Service) 시장 쟁탈전이 불붙고 있다. SNS는 사람과 사람을 연결하는 커뮤니티형 회원제 서비스 또는 이러한 서비스를 제공하는 웹 사이트를 말한다. 이러한 온라인 마케팅의 도구인 SNS를 활용하는 업체들이 증가하고 있고, 온라인 마케팅 활성화가 경쟁업체와의 차별화 전략으로 각광받고 있다. 본 연구에서는 이런 SNS를 활용한 기업의 온라인 마케팅 사례를 분석하여 프랜차이즈 기업의 마케팅에 활용하는 방안에 대해 연구하였다. 그래서 과, 페이스북 사례를 바탕으로 프랜차이즈 기업의 마케팅에 적용할 수 있는 방법으로는, 첫째, 개인 및 프랜차이즈 기업, 단체의 홈페이지로서의 역할, 둘째, 관심사 관련 커뮤니티, 공동체 모임의 조직화 수단으로서의 역할, 셋째, 점포나 본사의 위치를 알려주는 위치 지도 도구로서의 역할이다. 또한, 트위터를 프랜차이즈 기업의 마케팅에 적용할 수 있는 방법으로는, 첫째, 프랜차이즈 기업 및 브랜드 홍보로서의 역할, 둘째, 오프라인 영업의 한계를 트위터를 통해 극복할 수 있고, 셋째, 프랜차이즈 기업 및 브랜드의 기획과 개발의 역할이다.

• IMMUNE NETWORK
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• 제23권2호
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• pp.14.1-14.14
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• 2023

Immune status including the immune cells and cytokine profiles has been implicated in the development of endometriosis. In this study, we analyzed Th17 cells and IL-17A in peritoneal fluid (PF) and endometrial tissues of patients with (n=10) and without (n=26) endometriosis. Our study has shown increased Th17 cell population and IL-17A level in PF with endometriosis patients. To determine the roles of IL-17A and Th17 cells in the development of endometriosis, the effect of IL-17A, major cytokine of Th17, on endometrial cells isolated from endometriotic tissues was examined. Recombinant IL-17A promoted survival of endometrial cells accompanied by increased expression of anti-apoptotic genes, including Bcl-2 and MCL1, and the activation of ERK1/2 signaling. In addition, treatment of IL-17A to endometrial cells inhibited NK cell mediated cytotoxicity and induced HLA-G expression on endometrial cells. IL-17A also promoted migration of endometrial cells. Our data suggest that Th17 cells and IL-17A play critical roles in the development of endometriosis by promoting endometrial cell survival and conferring a resistance to NK cell cytotoxicity through the activation of ERK1/2 signaling. Targeting IL-17A has potential as a new strategy for the treatment of endometriosis.

• Molecules and Cells
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• 제46권11호
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• pp.675-687
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• 2023

Accumulation of pathogenic amyloid-β disrupts the tight junction of retinal pigment epithelium (RPE), one of its senescence-like structural alterations. In the clearance of amyloid-β, the autophagy-lysosome pathway plays the crucial role. In this context, mammalian target of rapamycin (mTOR) inhibits the process of autophagy and lysosomal degradation, acting as a potential therapeutic target for age-associated disorders. However, efficacy of targeting mTOR to treat age-related macular degeneration remains largely elusive. Here, we validated the therapeutic efficacy of the mTOR inhibitors, Torin and PP242, in clearing amyloid-β by inducing the autophagy-lysosome pathway in a mouse model with pathogenic amyloid-β with tight junction disruption of RPE, which is evident in dry age-related macular degeneration. High concentration of amyloid-β oligomers induced autophagy-lysosome pathway impairment accompanied by the accumulation of p62 and decreased lysosomal activity in RPE cells. However, Torin and PP242 treatment restored the lysosomal activity via activation of LAMP2 and facilitated the clearance of amyloid-β in vitro and in vivo. Furthermore, clearance of amyloid-β by Torin and PP242 ameliorated the tight junction disruption of RPE in vivo. Overall, our findings suggest mTOR inhibition as a new therapeutic strategy for the restoration of tight junctions in age-related macular degeneration.