• The Korean Journal of Pain
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• v.22 no.1
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• pp.1-15
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• 2009

Neuropathic pain is often refractory to intervention because of the complex etiology and an incomplete understanding of the mechanisms behind this type of pain. Glial cells, specifically microglia and astrocytes, are powerful modulators of pain and new targets of drug development for neuropathic pain. Glial activation could be the driving force behind chronic pain, maintaining the noxious signal transmission even after the original injury has healed. Glia express chemokine, purinergic, toll-like, glutaminergic and other receptors that enable them to respond to neural signals, and they can modulate neuronal synaptic function and neuronal excitability. Nerve injury upregulates multiple receptors in spinal microglia and astrocytes. Microglia influence neuronal communication by producing inflammatory products at the synapse, as do astrocytes because they completely encapsulate synapses and are in close contact with neuronal somas through gap junctions. Glia are the main source of inflammatory mediators in the central nervous system. New therapeutic strategies for neuropathic pain are emerging such as targeting the glial cells, novel pharmacologic approaches and gene therapy. Drugs targeting microglia and astrocytes, cytokine production, and neural structures including dorsal root ganglion are now under study, as is gene therapy. Isoform-specific inhibition will minimize the side effects produced by blocking all glia with a general inhibitor. Enhancing the anti-inflammatory cytokines could prove more beneficial than administering proinflammatory cytokine antagonists that block glial activation systemically. Research on therapeutic gene transfer to the central nervous system is underway, although obstacles prevent immediate clinical application.

• Journal of the Korean Applied Science and Technology
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• v.22 no.4
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• pp.349-354
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• 2005

It is interesting to discover the reaction kinetics of the newly developed molybdenum containing catalysts. The dissociation/adsorption of nitrogen on molybdenum surface is known to be structure sensitive, which is similar to that of nitrogen on iron surface. The rates over molybdenum nitride catalysts are increased with the increase of total pressure. This tendency is the same as that for iron catalyst, but is quite different from that for ruthenium catalyst. The activation energies of the molybdenum nitride catalysts are almost on the same level, although the activity is changed by the addition of the second component. The reaction rate is expressed as a function of the concentration of reactants and products. The surface nature of $CO_3Mo_3N$ is drastically changed by the addition of alkali, changing the main adsorbed species from $NH_2$ to NH on the surface. The strength of $NH_x$ adsorption is found to be changed by alkali dopping.

• Transactions of the Korean Society of Automotive Engineers
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• v.13 no.1
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• pp.153-158
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• 2005

Titanium alloy has widely been used as material for automotive parts because it has high specific strength. It is also light and harmless to human body. But, we have little design data about the creep behaviors of the alloy. Therefore, in this study, creep tests under four constant stress conditions have been conducted with low different temperature conditions. A series of creep tests had been performed to get the basic design data and life prediction of titanium products and we have gotten the fallowing results. First, the stress exponents decrease as the test temperatures increased. Secondly, the creep activation energy gradually decrease as the stresses became bigger. Thirdly, the constant of Larson-Miller parameter on this alloy was estimated as about 7.5. And for the last, the fractographs at the creep rupture showed the ductile fracture due to the intergranullar rupture.

• Nuclear Engineering and Technology
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• v.18 no.1
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• pp.27-37
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• 1986

The neutron fluxes and dose rates due to radiation streaming from reactor cavities were evaluated at the KNU-1 reactor pressure vessel (RPY) head flange elevation. To find a suitable cross section data set for the evaluation, a benchmark test was performed for three data sets; DLC-23/CASK, DLC-31/FEWG, and DLC-47/BUGLE. The leakage fluxes from the KNU-1 RPV outer surface were calculated with two different methods: 1-D calculation with ANISN, and 2-D calculation with DOT3.5. The Monte Carlo procedures as embodied in the MORSE-CG code combined with the albedo option were applied to predict the radiation distributions in the cavity region. Finally, the activation analysis of the stud bolts was performed to identify the major activation products.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2017.05a
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• pp.156-157
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• 2017

Among the various sports, recognition of golf sport is changing the privileged classes sport into a popular sport. In this kind of sport area, there are many loyal customers of golf sport relatively compared to the other marketing products or sports. Therefore, in this paper, we have analyzed the online buying pattern of customers through the popularization of golf such as golf ball or accessories and want to promote activation marketing in the online environment. For these, we suggest the way to promote marketing activation by analyzing online data.

• Natural Product Sciences
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• v.13 no.4
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• pp.283-288
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• 2007

Acanthopanacis Cortex (AC) has been popularly used as an herbal medicine for medical treatment of rheumatoid arthritis, insomnia, impotence and diabetes. Here, we investigated immunostimulating effects of the aqueous extract of AC on macrophage. We studied nitric oxide (NO) and tumor necrosis factor (TNF)-${\alpha}$ release in response to AC treatment, as they are important secretory products of macrophage. AC alone induce the NO and TNF-${\alpha}$ production. AC increase c-Jun NH2-terminal kinase 1/2 (JNK) and extracellular signal-regulated kinase (ERK) phosphorylation but does not p38 activation in RAW 264.7 cells. Also AC resulted in the enhanced cell-surface expression of CD80 and CD14. In addition, AC resulted in enhanced T cell-stimulatory capacity and increased T cell secretion of interferon (IFN)-gamma. After feeding with AC to mouse for 10 days, the change of $CD28^+$ and $CD40^+$ population was analyzed. AC increased $CD28^+$ population in splenocytes in vivo. These studies indicate that AC induces macrophage activation and suggest the possible use of AC in macrophage-based immunotherapies.

• Korean Journal of Food Science and Technology
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• v.4 no.2
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• pp.61-71
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• 1972

The selenium content of a wide variety of Korean food was determined by neutron activation analysis. Most fruits and vegetables contained quantities of selenium less than $0.4{\mu}g/g$. Grain products varied widely in their selenium content with $0.5{\mu}g/g$ and barley cereal as high as $0.7{\mu}g/g$. Dried milk powder sample ranged from $0.7\;to\;0.15{\mu}g/g$. Chicken muscle contained about $0.7{\mu}g/g$. The content of sea food was generally higher, ranging from $0.3\;to\;3.65{\mu}g/g$. These values suggest that a diet well balanced in other nutrients is probably also nutritionally adequate with regard to selenium, although possible effects of cooking and biological availability remain to be investigated.

• Biomedical Science Letters
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• v.25 no.1
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• pp.60-65
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• 2019

Toll-like receptors (TLRs) are one of the families of pattern recognition receptors (PRR) operating in the innate immunity. TLRs have the ability to recognize relatively conserved microbial components, which are generally referred to as pathogen-associated molecular patterns (PAMPs). The activation of TLRs signaling leads to the activation of $NF-{\kappa}B$ and the expression of pro-inflammatory gene products such as cytokines and inducible nitric oxide synthase (iNOS). To evaluate the therapeutic potential of pristimerin, which is a naturally occurring triterpenoid compound from Celastraceae plants, iNOS expression induced by MALP-2 (TLR2 and TLR6 agonist), Poly[I:C] (TLR3 agonist), or LPS (TLR4 agonist) were examined. Pristimerin suppressed the iNOS expression induced by MALP-2, Poly[I:C], or LPS. These results suggest that pristimerin can modulate TLRs signaling pathways leading to decreased inflammatory gene expression.

• Journal of Multimedia Information System
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• v.9 no.1
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• pp.1-10
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• 2022

China is a big country in animal fur industry. The total production and consumption of fur are increasing year by year. However, the recognition of fur in the fur production process still mainly relies on the visual identification of skilled workers, and the stability and consistency of products cannot be guaranteed. In response to this problem, this paper proposes a feature fusion-based animal fur recognition network on the basis of typical convolutional neural network structure, relying on rapidly developing deep learning techniques. This network superimposes texture feature - the most prominent feature of fur image - into the channel dimension of input image. The output feature map of the first layer convolution is inverted to obtain the inverted feature map and concat it into the original output feature map, then Leaky ReLU is used for activation, which makes full use of the texture information of fur image and the inverted feature information. Experimental results show that the algorithm improves the recognition accuracy by 9.08% on Fur_Recognition dataset and 6.41% on CIFAR-10 dataset. The algorithm in this paper can change the current situation that fur recognition relies on manual visual method to classify, and can lay foundation for improving the efficiency of fur production technology.

• Archives of Pharmacal Research
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• v.25 no.6
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• pp.895-902
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• 2002

Monocytes and macrophages playa major role in defense mechanism of the host response to tumor, in part through the secretion of several potent products and macrophage cytokines. Monocytes and tissue macro phages produce at least two groups of protein mediators of inflammation, interleukin 1 (IL-1) and tumor necrosis factor (TNF). Recent studies emphasizes that TNF and IL-1 modulate the inflammatory function of endothelial cells, leukocytes, and fibroblasts. In this study, our work is directed toward studying the in vitro effects of Korean propolis on the ability to induce cellular and secretory responses in murine macrophage cell line, RAW 264.7. It was found that Water Extract of Korean Propolis (WEP) could activate macro phages by producing cytokines. The production of the macrophage cytokines, IL-1 and TNF-$\alpha$, by RAW 264.7 treated with WEP was examined from 2.5 $\mu\textrm{g}$/ml up to 25 $\mu\textrm{g}$/ml with dose dependent manner. Nitric oxide (NO) production was also increased when cells were exposed to combination of LPS and WEP from 2.5 $\mu\textrm{g}$/ml up to 25 $\mu\textrm{g}$/ml. At high dose of WEP (50 to 100 $\mu\textrm{g}$/ml) used to prescribe for anti-inflammatory and analgesic medicine showed inhibition of NO production in LPS-stimulated macrophage. Besides cytokine production, NO release, surface molecule expression and cell morphologic antigen expression were increased in response to the stimulation by WEP. These results suggested WEP may function through macrophage activation.